Quinolizidine Alkaloids from Cylicomorpha
solmsii
Posted on 2021-02-19 - 20:44
Five new quinolizidine alkaloids
were isolated from the leaves
of Cylicomorpha solmstii (Urb.) Urb. (Caricaceae)
and named cylicomorphins A–E (1–5). They all are ester derivatives of the same basic quinolizidine
skeleton bearing hydroxy, methyl, and ethanoic acid substituents.
Their structures were mainly established by NMR spectroscopy, and
the absolute configuration is proposed on the basis of VCD data and
Mosher ester derivatization. Compound 5 displayed cytotoxicity
in the 10 μM range against an HCT-116 cell line.
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Pouny, Isabelle; Long, Christophe; Batut, Muriel; Aussagues, Yannick; Jean Valère, Naubron; Achoundong, Gaston; et al. (2021). Quinolizidine Alkaloids from Cylicomorpha
solmsii. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.0c01261
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AUTHORS (9)
IP
Isabelle Pouny
CL
Christophe Long
MB
Muriel Batut
YA
Yannick Aussagues
NJ
Naubron Jean Valère
GA
Gaston Achoundong
BD
Bruno David
CL
Catherine Lavaud
GM
Georges Massiot
KEYWORDS
HCT -116 cell lineQuinolizidine Alkaloidsquinolizidine skeletonmethylCaricaceaeCylicomorpha solmstiiVCD databasisester derivativesNMR spectroscopyquinolizidine alkaloids10 μ M rangeUrbcylicomorphinMosher ester derivatizationconfigurationcytotoxicityethanoic acid substituentsCompound 5hydroxyCylicomorpha solmsii