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Antioxidant activities of aqueous leaf extract of Parquetina nigrescens in high-fat-diet-streptozotocin-induced diabetic male albino rats

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Abstract

Oxidation in living cells can be very detrimental, leading to the production of chemicals that can cause ill-health in these cells. These chemicals simply referred to as reactive oxygen species (ROS) have been implicated in causing different health problems, notably diabetes. Parquetina nigrescens is a medicinal plant that has been traditionally used in management of different kinds of ailments including diabetes over the years, but it lacks scientific proof. This study carried out the structural elucidation of aqueous leaf extract of P. nigrescens using HPLC. The study also investigated the antioxidant potentials of this extract in serum, liver, and kidney of diabetic male albino rats. The HPLC analysis revealed the presence of beta sitosterol, veraquensin, kaempferol, among others. Furthermore, aqueous leaf extract of P. nigrescens significantly (P < 0.05) improved the activities of antioxidant enzymes (catalase, glutathione peroxidase, superoxide dismutase, and reduced glutathione). Aqueous leaf extract of P. nigrescens may serve as an antioxidant to ameliorate activities of ROS that might cause advert effects in living cells. The coherent bioactive compounds in the aqueous leaf extract of this plant may be responsible for these antioxidant potentials.

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Authors and Affiliations

  1. Department of Biochemistry, Federal University Oye-Ekiti, Oye, Ekiti State, Nigeria

    Fisayo Abraham Bamisaye & Emenike Emmanuel Orji

  2. The Federal Polytechnic of Ado Ekiti, Ado Ekiti, Ekiti State, Nigeria

    Emenike Emmanuel Orji

  3. Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye, Ekiti State, Nigeria

    Basiru Olaitan Ajiboye

  4. Department of Plant Science and Biotechnology, Faculty of Science, Federal University Oye-Ekiti, Oye, Ekiti State, Nigeria

    Ayoola Olusegun Oluwajobi

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  1. Fisayo Abraham Bamisaye
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  2. Emenike Emmanuel Orji
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  3. Basiru Olaitan Ajiboye
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  4. Ayoola Olusegun Oluwajobi
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Correspondence to Basiru Olaitan Ajiboye.

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This study was approved by the FUOYE Faculty of Science Ethical Committee, Federal University Oye-Ekiti, Nigeria.

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Bamisaye, F.A., Orji, E.E., Ajiboye, B.O. et al. Antioxidant activities of aqueous leaf extract of Parquetina nigrescens in high-fat-diet-streptozotocin-induced diabetic male albino rats. Comp Clin Pathol 33, 239–246 (2024). https://doi.org/10.1007/s00580-023-03545-3

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