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An efficient heterogeneous iron oxide nanoparticle catalyst for the synthesis of 9-substituted xanthene-1,8-dione

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Abstract

An efficient and simple method for the synthesis of xanthene derivatives by using iron oxide nanoparticles (NPs) as a catalyst has been investigated. Synthesis of 9-substituted xanthene-1,8-dione derivatives involves one-pot reaction of dimedone and aldehyde in the presence of iron oxide nanoparticles using polar protic ethanol as a solvent. Interestingly, this catalyst has been recovered by simple filtration and reused for up to five cycles without much loss of its productivity. The merits of this protocol are cost-effectiveness of the catalyst, having no harmful side products, simple process, short reaction time, convenient product isolation and potential yields.

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Acknowledgements

We gratefully thank the Department of Science and Technology (DST), Government of India, for DST-INSPIRE fellowship (DST/INSPIRE Fellowship/2016/IF160736). We also acknowledge VIT-SAIF for NMR, IIT Madras and University of Madras for HRMS and single crystal XRD facility.

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  1. Department of Chemistry, Thiruvalluvar University, Vellore, Tamil Nadu, 632 115, India

    Dhakshanamurthy Thirumalai & Shanmugam Gajalakshmi

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  1. Dhakshanamurthy Thirumalai
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  2. Shanmugam Gajalakshmi
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Correspondence to Dhakshanamurthy Thirumalai.

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Thirumalai, D., Gajalakshmi, S. An efficient heterogeneous iron oxide nanoparticle catalyst for the synthesis of 9-substituted xanthene-1,8-dione. Res Chem Intermed 46, 2657–2668 (2020). https://doi.org/10.1007/s11164-020-04112-z

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