Spilanthes acmella is a medicinal plant that is mostly found in sub-tropical and tropical regions worldwide. It is also known as toothache plant as it is known to reduce pain related to toothaches. Various studies have reported that it possesses numerous biological properties including anti-inflammatory, antimicrobial, antipyretic, local anesthetic, antioxidantand analgesic effects. It has traditional uses in health care and in cuisines as a flavor. Its flowers and leaves can be eaten and causes saliva secretion and tingling sensation in the tongue. Spilanthol is the main constituent found in the plant and is used in oral and skin care. This review will summarize the phytochemistry, pharmacology, traditional uses and present dental uses of this plant.

Spilanthes acmellais an important medicinal plant, found in tropical and subtropical countries mainly India and South America. Popularly, it is known as toothache plant which reduces the pain associated with toothaches and can induce saliva secretion. Various extracts and active metabolites from various parts of this plant possess useful pharmacological activities. Literature survey proposed that it has multiple pharmacological actions, which include antifungal, antipyretic, local anaesthetic, bioinsecticide, anticonvulsant, antioxidant, aphrodisiac, analgesic, pancreatic lipase inhibitor, antimicrobial, antinociception, diuretic, vasorelaxant, anti-human immunodeficiency virus, toothache relieve and anti-inflammatory effects. This review is elaborately describing the traditional uses, phytochemistry, pharmacology, and toxicology of this plant. This review would assist researchers to search scientific information in the future.

Spilanthes acmella, belonging to family Asteraceae, is a well known genus comprising of over 60 species that are widely distributed in tropical and subtropical regions of the world. With high medicinal usage, it has been recognized an important medicinal plant with an increasing high demand worldwide. It is commonly known as antitoothache plant. From its traditional uses in health care and food, extensive phytochemical studies have been reported. Different types of bioactive compounds have been isolated from the plant from time to time. It has been reported very effective in various ailments including, anti-pyretic, anti-diuretic, anti-inflammatory, anti-oxidant, immunomodulatory, hepatoprotective, anti-cancer, antiAIDS and anti-toothache. The aim of the present review was to highlight the ethanobotanical knowledge of the plant used for ayurvedic preparations in relation to its use as therapeutic agent. Present reviewe also describes the endangered status of the plant and its possible conservation strategies through invitro regeneration practices. The data and information of this review can be utilized in drawing strategies for rational and more scientific use of medicinal plants in general and Spilanthes acmella in a particular way that can be extended for future scientific investigation in different aspects. The present review therefore aims to compile up to date and comprehensive information of Spilanthes acmella on its traditional, phytochemical, theraptic uses and its large-scale production.

Spilanthes mauritiana belonging to the family Asteraceae, was screened for biological activity against bacterial pathogen. Antibacterial activity of the plant was investigated using microbroth dilution assay and bioautography. Total phenols and tannins of the extract were 52.47 ± 2.29 and 23.9 ± 1.18 as mg of gallic acid equivalents, respectively. Total flavonoid content was 25.1 ± 0.79 as mg of quercetin equivalents. Free radical scavenging activity of constituents in all the extract, against 2,2-diphenyl-1-picrylhydrazyl showed minimal activity. All extracts contained compounds with antibacterial activity against tested pathogens. Hexane extract had an average minimum inhibitory concentration value of 2.50 mg/mL, followed by methanol extract (1.72 mg/mL), acetone and dichloromethane extracts (1.96 mg/mL). The present study revealed the presence of compounds in S mauritiana with potent antibacterial activity against tested pathogens that are exhibiting the observed activity indepen...

Herbal medicines find important market in India as nutraceuticals. Spilanthes acmella belonging to family Asteraceae is a well-known anti-toothache plant with high medicinal usages. From its traditional uses in health care and food, extensive phytochemical studies have been reported. Considering data from the literature, it could be demonstrated that S. acmella possesses diverse bioactive properties and immense utilization in medicine, health care, cosmetics and as health supplements. As a health food, it is enriched with high therapeutic value with high potential for further development. The traditional information revealed that various parts of this plant possess Therapeutic activities like diuretic, anti-inflammatory, analgesic, antioxidant and vasorelaxant. Need of the hour for extentensive research study on S. Acmella to find out its phytoconstituents, establishment of its Pharmacognostic properties. The review study also proposed to explore scientifically its various therapeutic values to prove its Folklore use by traditional people.

The leaves and roots of plant Spilanthes acmella murr, FamilyAsteraceae were investigated for its physicochemical and phytochemical screening. The whole plant of Spilanthes acmella murr is reported to exhibit good medicinal values in traditional system of medicines especially for the prophylaxis of various diseases. The present study deals with phytochemical investigations of determination of extracts (Petroleum ether extract, ethanol extract, Methanol extract, and aqueous extract). Total carbohydrate and tannin contents were studied. Ethanol soluble extractive value was found higher in the leaves while aqueous soluble extractive value were found to higher in the roots. Total carbohydrate percentage was found higher in the leaves. However, tannin contents were found at higher levels in the root portion of the plant. The preliminary phytochemical screening of Spilanthes acmella leaves and roots were carried out using qualitative chemical analysis. The observations revealed presence o...

The limitations of modern medicines and their drastic side effects have led the present generation to look back towards traditional herbal medicines. In the present investigation, one such plant-SpilanthusacmellaMurr. Has been screened. The fresh plant material was used for the analysis of primary metabolites. The plant material was dried, powdered and extracted in ethanol. The extracts of root, stem and leaf were used for preliminary qualitative and quantitative analysis of secondary metabolites. The isolated plant parts were converted to plant ash and the ash was used to prepare acid extracts. The acid extract was used for estimating calcium, magnesium, iron and phosphorus. The alkaloids, tannins, phenols, saponins and cardiac glycosides were found in root, stem and leaves whereas terpenoids and glycosides were found in stem and leaves only. The amount of Calcium, Magnesium, Iron and Phosphorus was found to be 1.10 mg, 4.9 mg, 5.62 mg and 1.115 mg/ 0.5 g. ash in stem while 2.05 mg...

Spilanthes is a genus of herbs belonging to Asteraceae family commonly known as '' Toothache plant". The inflorescence is used for treating sore throat, stammering and redness of gums and is known to have anti-malarial, anti-diuretic and anti-inflammatory properties. It has been reported that they show high antioxidant activity, in the present study, the antioxidant activity was measured in terms of Ferrous Reducing Antioxidant Power (FRAP) for six species of Spilanthes and total phenolic content. Spilanthes ciliata leaves were found to have highest total phenolic content (21.53 mg/g of GAE). Lowest value was recorded in Spilanthes oleracea. Leaves showed more phenols compared to the other parts. Inflorescence showed moderate activity with maximum recorded in S. oleracea. In roots, the total phenolic content was moderate with the maximum recorded in S. ciliata and minimum in S. radicans. In FRAP assay, the maximum activity was observed in S. ciliata followed by S. calva and minimum was observed in S. radicans. Among inflorescence, S. calva and S. oleracea showed higher activity compared to other parts of all other species. Inflorescence of all the other species showed moderate activity. In roots, the antioxidant activity was maximum in S. ciliata and S. uliginosa recorded least activity with maximum reading in S. calva leaves=0.381, minimum in S. uliginosa, root=0.23, among leaves highest frap reading was obtained in S. calva and in roots S. calva and S. oleracea both showed equal FRAP readings and in Inflorescence maximum was in S. calva followed by S. oleracea. This is the first report of comparison of six species of Spilanthes with different plant parts for total phenolic compounds and FRAP assay.