Journal of Natural Products
Journal of Natural Products
3 years ago

[ASAP] Quinolizidine Alkaloids from Cylicomorpha solmsii

[ASAP] Quinolizidine Alkaloids from Cylicomorpha solmsii
Isabelle Pouny, Christophe Long, Muriel Batut, Yannick Aussagues, Naubron Jean Valère, Gaston Achoundong, Bruno David, Catherine Lavaud, Georges Massiot
Five new quinolizidine alkaloids were isolated from the leaves of Cylicomorpha solmstii (Urb.) Urb. (Caricaceae) and named cylicomorphins A–E (1–5). They all are ester derivatives of the same basic quinolizidine skeleton bearing hydroxy, methyl, and ethanoic acid substituents. Their structures were mainly established by NMR spectroscopy, and the absolute configuration is proposed on the basis of VCD data and Mosher ester derivatization. Compound 5 displayed cytotoxicity in the 10 μM range against an HCT-116 cell line. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c01261. Full spectral data and complete VCD tables (PDF) This article has not yet been cited by other publications.

Publisher URL: http://feedproxy.google.com/~r/acs/jnprdf/~3/Zucib9X8z8k/acs.jnatprod.0c01261

DOI: 10.1021/acs.jnatprod.0c01261

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