Figure 1 - uploaded by Chinenye Jane Ugwah-Oguejiofor
Content may be subject to copyright.
Inhibitory effect of Amblygonocarpus andongensis on gastrointestinal motility. Data presented as mean%± SEM, n= 5 for all groups. *p<0.001 compared to the aqueous acacia suspension (AAS) control group.
Context in source publication
Context 1
... down the propulsion of the charcoal meal towards the caecum at all dose levels. At 400 mg/kg of the extract, the inhibition of the charcoal movement was comparable to that produced by atropine (0.1 mg/kg) the reference drug while at 600 mg/kg of the extract the inhibition produced was greater than the positive control (Figure 1). ...
Similar publications
Tez konusu bulmak araştırmacılar için her zaman zor bir süreç olmuştur. Eğitim
araştırmalarını incelemek, ilgili alanda çalışma yürütmek isteyen araştırmacılara yol
gösterebilir. Bu araştırmada amaç, ülkemizde 2020 yılında fen bilimleri eğitimi alanında
yapılan yüksek lisans ve doktora tezlerinin incelenmesidir. Bu incelemede; araştırmacıların
ve d...
Citations
... Ethnomedicinal studies have revealed the use of A. andongensis bark in the treatment of ulcers, diarrhea, inflammation [17], diabetes, and hypertension [18]. Previous studies have shown analgesic [19], antipsychotic [20], and antidiarrheal properties of A. andongensis stem bark extract [21]. In Cameroon, information from traditional therapists suggests the use of this plant for the treatment of wounds, inflammation, jaundice, and kidney failure. ...
Paracetamol is a commonly used analgesic/antipyretic whose long-term intake or overdose is associated with renal and hepatic injuries. The aim of this study was to determine the hepatonephroprotective mechanisms of the aqueous extract of Amblygonocarpus andongensis stem bark (AEAASB) on renal and hepatic failure resulting from paracetamol overdose. Forty-five rats were divided into nine groups (n=5); these were treated once daily for 8 days with 5 ml/kg distilled water (normal, negative, and satellite controls); 0.9% normal saline and 140 mg/kg N-acetyl-cysteine (positive controls); 125, 250, and 500 mg/kg AEAASB (test groups); and 500 mg/kg AEAASB (satellite test). On day 8 after different treatments, hepatonephrotoxicity was induced in all the groups except the normal group by oral administration of a single dose of paracetamol (1000 mg/kg). Urinary, hematological, serum, and oxidative stress parameters and in vitro antioxidant activity of AEAASB were evaluated. Histological sections of the liver and kidney were performed. AEAASB significantly decreased urea, creatinine, transaminases, alkaline phosphatase, and bilirubin (p
... The percentage of the distance moved by charcoal meal to the total length of the intestine (TLI) was calculated. [18] Peristalsis index and percentage inhibition of mobility were calculated as Peristalsis index = Distance travelled by charcoal meal/ Length of intestine × 100 % inhibition of mobility = (TLI -Distance travelled by test group)/ TLI × 100. ...
Background: Caralluma dalzielii N.E. Brown is commonly referred to as “Karan massalanci” in the Northwest Nigeria where it is used in treating several ailments including pain, diarrhea and stomach issues. Objectives: This study was aimed to investigate the antidiarrheal and antioxidant activities of aqueous aerial parts extract of Caralluma dalzielii. Materials and Methods: The aqueous aerial parts extract of Caralluma dalzielii (CDE) (100, 200 and 400 mg/kg) was evaluated for antidiarrheal properties against gastrointestinal motility, castor oil-induced and prostaglandin-E2 (PGE2) enteropooling models in Wistar rats. Its antioxidant properties were studied by determining the total phenolic content (TPC) using Folin-Ciocalteu reagent, its free radical scavenging activity using 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) and its ferric reducing antioxidant power (FRAP) assays using potassium ferrocyanide ferric chloride methods. Ascorbic acid was used as the reference. Spasmolytic effect was studied in isolated rabbit jejunum preparations in an organ bath experiment using acetylcholine (ACh). Results: CDE significantly (p<0.05) reduced gastrointestinal transit of charcoal meal and the total number of diarrheal feces in the animals. The total phenolic content was determined to be 36.67±3.33 mg GAE/g. IC50 value of 63.44 mg/mL was calculated in DPPH assay. The FRAP value was found to increase as the concentration of the extract increased. CDE inhibited acetylcholine-induced contraction of the rabbit jejunum in a concentration dependent manner with complete inhibition at 20.48 mg/mL of the extract. Conclusion: The extract of Caralluma dalzielii possesses antidiarrheal activities which may be related to its antimotility, antioxidant and antispasmodic properties.
... Nwinyi et al. (2006) reported that A. andongensis is ethnomedicinally used in Northern Nigeria for the relief of pain. According to Ugwah et al. (2014) a decoction prepared from roots is used to treat food poisoning and against colic, cough and as a vermifuge. The stem bark has been used to treat diarrhoea (Burkill, 1995) and breast cancer (Kubmarawa et al., 2007). ...
The effect of seed presowing treatment on Guibortia coleosperma and Amblygonocarpus andongensis was investigated. Seeds of both species were subjected to four experiments, containing 10 levels of presowing treatments: mechanical scarification, soaking in concentrated sulphuric acid (for 15, 30, 45 and 60 min), immersion in boiling water (for 1, 3 and 5 min), and soaking in boiling water (and cooling down for 24 h) and the control. The germination data were subjected to ANOVA followed by Tukey's HSD test to separate significantly different treatment means. The highest germination in G. coleosperma was recorded: mechanical scarified seeds, those soaked in sulphuric acid (15, 30, 45 and 60 min), hot water (and cooling down for 24 h) and the control seeds. For A. andongensis, seeds treated with mechanical scarification, exposure to sulphuric acid (15, 30, 45 and 60 min) and boiling water (1 min) had higher percent germination than the controls.
... The presence of tannin may be responsible for its antiulcer (Oluranti et al., 2012) and antidiarrchoeic activities (Ugwah et al., 2014). Saganuwan (2009) had earlier attributed the pharmacological property of plants to its chemical principles. ...
