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A New Ceramide from Cissus Aralioides Baker (Vitaceae) and its Antimicrobial Activity
Chemistry & Biodiversity ( IF 2.9 ) Pub Date : 2022-12-08 , DOI: 10.1002/cbdv.202200678
Romeo Desire T Nago 1 , James D Simo Mpetga 1 , Jean-De-Dieu Tamokou 2 , Serge A Tanemossu Fobofou 3, 4 , Gabin T Mbahbou Bitchagno 1 , Ludger A Wessjohann 3 , Mathieu Tene 1 , Augustin Silvere Ngouela 1
Affiliation  

Purification through repeated column chromatography over silica gel and Sephadex LH-20 of the ethanol extract of the stems of Cissus aralioides (Baker) Planch. resulted in the isolation of a new ceramide, aralioidamide A (1), along with five known compounds (2–6). Their structures were determined by the extensive analyses of their spectroscopic (1D and 2D NMR) and spectrometric data, and comparison with those reported in the literature. Aralioidamide A (1) displayed weak antibacterial activity (MIC=256 μg/mL) against Bacillus subtilis, Staphylococcus aureus and Shigella flexneri and was inactive (MIC>256 μg/mL) against the tested fungi.

中文翻译:

Cissus Aralioides Baker(葡萄科)的一种新神经酰胺及其抗菌活性

通过硅胶和 Sephadex LH-20 对Cissus aralioides (Baker) Planch 茎的乙醇提取物进行重复柱层析纯化。导致分离出一种新的神经酰胺,aralioidamide A ( 1 ),以及五种已知化合物 ( 2–6 )。它们的结构是通过对其光谱(一维和二维核磁共振)和光谱数据进行广泛分析,并与文献中报道的进行比较来确定的。Aralioidamide A ( 1 ) 对枯草芽孢杆菌金黄色葡萄球菌福氏志贺菌表现出较弱的抗菌活性 (MIC=256 μg/mL) ,对受试真菌无活性 (MIC>256 μg/mL)。
更新日期:2022-12-08
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