New macrocyclic pyrrolizidine alkaloids and a silphiperfolanol angelate ester were isolated from the Rwandan medicinal herb Solanecio mannii. The relative configuration of senaetnine was determined by NAMFIS analysis. Synthetic modification of 5 provided two new compounds, 2-angeloyloxy-4,8-epoxypresilphiperfolane and 2-angeloyloxy-4,8-epoxypresilphi-perfolane. Some of the compounds showed strong cytotoxicity but weak antibacterial activities.

中文翻译：

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大环吡咯里西啶生物碱和 Silphiperfolanol Angelate Esters from Solanecio mannii

从卢旺达药草Solanecio mannii中分离出新的大环吡咯里西啶生物碱和 silphiperfolanol angelate ester 。通过 NAMFIS 分析确定了塞奈宁的相对构型。5的合成修饰得到两个新化合物2-当归酰氧基-4,8-​​epoxypresilphiperfolane和2-angeloyloxy-4,8-​​epoxypresilphi-perfolane。部分化合物表现出较强的细胞毒性，但抗菌活性较弱。