The Diospyros villosa root extract (DVR) has the potential to treat oral cavity diseases (DOC), as confirmed by its frequent use as a toothbrush among Mozambicans. In the present work, a tablet with adhesive properties was developed with properties that have the potential to overcome the expected difficulties in delivering the drug into the oral cavity. The chemical profile of the extract marker secondary metabolites was established by TLC and LC-UV/DAD, and the quantification of its main classes was performed by UV and IR spectrophotometries. The size of the particles of the extract was determined by laser diffractometry. The tablets manufactured were evaluated to confirm the extract chemical stability based on the major marker secondary metabolite profile, throughout processing (differential scanning calorimetry, DSC and Fourier transform infrared spectroscopy, FTIR) and their performance based on adhesion forces (i.e., force required to remove a tablet from a flat surface) and for their ability to release the main marker secondary metabolites (dissolution test). The study has shown that the use of colloidal silica in the preparation of the extract delivered a powder containing particles with improved flow and by adding an adhesive polyacrylic acid derivative to the composite extract particles it was possible to obtain a blend enabling the manufacture of adhesive tablets by direct compression. Overall, the study demonstrated the ability to produce DVR-containing adhesive tablets for buccal use against DOC.

黑柿根提取物 (DVR) 具有治疗口腔疾病 (DOC) 的潜力，莫桑比克人经常将其用作牙刷就证实了这一点。在目前的工作中，开发了一种具有粘合特性的片剂，其特性有可能克服将药物输送到口腔中的预期困难。通过 TLC 和 LC-UV/DAD 建立了提取物标记次生代谢物的化学谱，并通过 UV 和 IR 分光光度法对其主要类别进行了定量。通过激光衍射法测定提取物颗粒的尺寸。对制造的片剂进行评估，以确认提取物的化学稳定性（基于主要标记物次级代谢物谱）、整个加工过程（差示扫描量热法、DSC 和傅里叶变换红外光谱、FTIR）以及基于粘附力（即去除所需的力）的性能。平坦表面的片剂）以及它们释放主要标志物次级代谢产物的能力（溶出度测试）。研究表明，在提取物的制备中使用胶态二氧化硅可提供具有改善流动性的颗粒粉末，并且通过在复合提取物颗粒中添加粘性聚丙烯酸衍生物，可以获得能够制造粘性片剂的混合物通过直接压缩。总体而言，该研究证明了生产含有 DVR 的口腔粘着片剂的能力，用于对抗 DOC。