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Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-06-30 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00255
Tsegaye Deyou 1, 2 , Makungu Marco 1 , Matthias Heydenreich 3 , Fangfang Pan 4, 5 , Amra Gruhonjic 2, 6 , Paul A. Fitzpatrick 6 , Andreas Koch 3 , Solomon Derese 1 , Jerry Pelletier 7 , Kari Rissanen 4 , Abiy Yenesew 1 , Máté Erdélyi 2, 8
Affiliation  

A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A–D (25), along with nine known compounds (614), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 μM, respectively.

中文翻译:

从叶中异黄酮和鱼藤酮类鸡血藤紫丁香SSP。Teitensis

一个新的异黄酮,8 prenylmilldrone(1),和四个新的鱼藤酮类,oblarotenoids A-d(2 - 5),具有九个已知化合物(沿6 - 14),从该通道隔离22 / CH 3 OH( 1:1)Millettia oblata ssp的叶子的提取物。通过色谱分离法检测特特斯。通过NMR光谱和质谱分析鉴定纯化的化合物,而类胡萝卜素的绝对构型是基于手性学数据并且在某些情况下通过单晶X射线晶体学确定的。马克西米黄酮J(11)和扁豆素C(4)显示出对人乳腺癌细胞系MDA-MB-231的弱活性,IC 50值分别为33.3和93.8μM。
更新日期:2017-06-30
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