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ASEAN Herbal and Medicinal Plants

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Compiled by Rasadah Mat Ali, Zainon Abu Samah,<br />

Nik Musaadah Mustapha, Norhara Hussein<br />

Association of Southeast Asian Nations<br />

Natural Resources <strong>and</strong> Environment<br />

2010<br />

Forest Research Institute Malaysia


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

The Association of Southeast Asian Nations (<strong>ASEAN</strong>) was established on 8 August 1967.<br />

The Member States of the Association are Brunei Darussalam, Cambodia, Indonesia, Lao PDR,<br />

Malaysia, Myanmar, Philippines, Singapore, Thail<strong>and</strong> <strong>and</strong> Viet Nam. The <strong>ASEAN</strong> Secretariat is based<br />

in Jakarta, Indonesia.<br />

For inquiries, contact:<br />

The <strong>ASEAN</strong> Secretariat<br />

Public Outreach <strong>and</strong> Civil Society Division<br />

70A Jalan Sisingamangaraja<br />

Jakarta 12110<br />

Indonesia<br />

Phone : (62 21) 724-3372, 726-2991<br />

Fax : (62 21) 739-8234, 724-3504<br />

E-mail : public.div@asean.org<br />

General information on <strong>ASEAN</strong> appears on-line at the <strong>ASEAN</strong> Website: www.asean.org<br />

Catalogue-in-Publication Data<br />

<strong>ASEAN</strong> <strong>Herbal</strong> <strong>and</strong> <strong>Medicinal</strong> <strong>Plants</strong><br />

Jakarta: <strong>ASEAN</strong> Secretariat, July 2010<br />

vii, 336p; 29.7cm x 21.0cm<br />

615.321<br />

1. Herbs – Therapeutic Use<br />

2. <strong>Herbal</strong> – Medical <strong>Plants</strong> – <strong>ASEAN</strong><br />

ISBN 978-979-3496-92-4<br />

The text of this publication may be quoted or reprinted with proper acknowledgment.<br />

Copyright <strong>ASEAN</strong> Secretariat © 2010<br />

All rights reserved<br />

Photo Credits: <strong>ASEAN</strong> Member States<br />

ii


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

FOREWORD<br />

I am pleased to present the first <strong>ASEAN</strong> <strong>Herbal</strong> <strong>and</strong> <strong>Medicinal</strong> <strong>Plants</strong>. This book<br />

marks our first attempt to produce a compilation of herbal <strong>and</strong> medicinal plants that are<br />

popular in the <strong>ASEAN</strong> region.<br />

This book is the result of hard work <strong>and</strong> collaborative efforts of the <strong>ASEAN</strong> Experts<br />

Group on <strong>Herbal</strong> <strong>and</strong> <strong>Medicinal</strong> <strong>Plants</strong> who has been appointed to undertake the task of<br />

compiling the information. The Experts Group was formed in 1997 <strong>and</strong> comprises<br />

representatives from the <strong>ASEAN</strong> Member States. Despite the delay, I would say that the<br />

outcome is worthwhile indeed.<br />

The book covers some 90 different medicinal plant species from <strong>ASEAN</strong> Member States<br />

(except Singapore) with information pertaining to their scientific names, vernacular names,<br />

plant description, propagation, geographical distribution, chemical constituents, medicinal<br />

usage by the <strong>ASEAN</strong> Member States as well as their illustrative profiles. I am sure that<br />

this book would serve as a valuable reference to members of the <strong>ASEAN</strong> countries who<br />

are involved in the research <strong>and</strong> development of herbal <strong>and</strong> medicinal plants.<br />

With an abundance of untapped natural resources rich in medicinal plants in the region,<br />

the work of the <strong>ASEAN</strong> Experts Group on <strong>Herbal</strong> <strong>and</strong> <strong>Medicinal</strong> <strong>Plants</strong> is never-ending.<br />

Identifying new plant species, exploring their therapeutic potential, validating new<br />

methodologies <strong>and</strong> establishing new st<strong>and</strong>ards for many untouched plant species will<br />

pose a challenging task. I urge the Experts Group to continue to carry out more collaborative<br />

work on other plant species of interest in the <strong>ASEAN</strong> region. Our biodiversity is a blessing<br />

<strong>and</strong> a heritage for our posterity. We should learn to benefit from it <strong>and</strong> conserve it with all<br />

our ability.<br />

I would like to congratulate the members of the <strong>ASEAN</strong> Experts Group on <strong>Herbal</strong> <strong>and</strong><br />

<strong>Medicinal</strong> <strong>Plants</strong> for their excellent efforts <strong>and</strong> the Forest Research Institute of Malaysia<br />

for their commitment to making this book possible.<br />

Thank you.<br />

Dr. Surin Pitsuwan<br />

Secretary-General of <strong>ASEAN</strong><br />

iii


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

TABLE OF CONTENTS<br />

LIST OF PLANTS<br />

BRUNEI DARUSSALAM<br />

1. Abelmoschus moschatus 1<br />

2. Agathis borneensis 3<br />

3. Aloe vera 5<br />

4. Amaranthus spinosus 7<br />

5. Andrographis paniculata 9<br />

6. Asplenium nidus 11<br />

7. Blumea balsamifera 13<br />

8. Caesalpinia crista 15<br />

9. Centratherum intermedium 17<br />

10. Corchorus capsularis 19<br />

11. Coscinium fenestratum 21<br />

12. Curcuma longa 23<br />

13. Donax gr<strong>and</strong>is 25<br />

14. Etlingera solaris 27<br />

15. Languas galanga 29<br />

16. Macaranga gigantea 31<br />

17. Melastoma malabathricum 33<br />

18. Orthosiphon aristatus 35<br />

19. Portulaca oleracea 37<br />

20. Zingiber aromaticum 39<br />

CAMBODIA<br />

1. Aegle marmelos 43<br />

2. Aquilaria crassna 45<br />

3. Caesalpinia sappan 47<br />

4. Cananga latifolia 49<br />

5. Capparis micracantha 51<br />

6. Cassia alata 53<br />

7. Combretum quadrangulare 55<br />

8. Coscinium usitatum 57<br />

9. Curcuma zedoaria 59<br />

10. Dracaena cambodiana 61<br />

11. Eurycoma longifolia 63<br />

12. Hopea odorata 65<br />

13. Hydnocarpus anthelminticus 67<br />

14. Melastoma sanguineum 69<br />

15. Melodorum fruticosum 71<br />

iv


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

16. Phyllanthus emblica 73<br />

17. Plumeria alba 75<br />

18. Syzygium jambos 77<br />

19. Terminalia chebula 79<br />

20. Terminalia triptera 81<br />

INDONESIA<br />

1. Acorus calamus85 85<br />

2. Aloe vera 87<br />

3. Arcangelisia flava 89<br />

4. Centella asiatica 91<br />

5. Curcuma mangga 93<br />

6. Curcuma zedoaria 95<br />

7. Justicia gendarusa 97<br />

8. Morinda citrifolia 99<br />

9. Orthosiphon aristatus 101<br />

10. Sauropus <strong>and</strong>rogynus 103<br />

LAO PDR<br />

1. Aegle marmelos 107<br />

2. Alstonia scholaris 109<br />

3. Asparagus cochinchinensis 111<br />

4. Caesalpinia sappan 113<br />

5. Calotropis gigantea 115<br />

6. Cassia alata 117<br />

7. Codonopsis pilosa 119<br />

8. Costus speciosus 121<br />

9. Dioscorea persimilis 123<br />

10. Eclipta prostrata 125<br />

11. Elephantopus scaber 127<br />

12. Eleutherine subaphylla 129<br />

13. Euodia lepta 131<br />

14. Morinda citrifolia 133<br />

15. Passiflora foetida 135<br />

16. Polygonum multiflorum 137<br />

17. Rauvolfia serpentina 139<br />

18. Solanum procumbens 141<br />

19. Stephania rotunda 143<br />

MALAYSIA<br />

1. Ardisia elliptica 147<br />

2 Chromolaena odorata 149<br />

3. Curcuma xanthorhiza 152<br />

4. Cymbopogon citratus 155<br />

5. Cymbopogon nardus 159<br />

v


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6. Elephantopus scaber 162<br />

7. Eurycoma longifolia 164<br />

8. Fibraurea tinctoria 166<br />

9. Gynura procumbens 168<br />

10. Kaempferia galanga 171<br />

11. Labisia pothoina 173<br />

12. Languas galanga 175<br />

13. Mitragyna speciosa 177<br />

14. Momordica charantia 180<br />

15. Ocimum bacilicum 185<br />

16. Phyllanthus amarus 190<br />

17. Rafflesia hasseltii 194<br />

18. Smilax myosotiflora 196<br />

19. Stemona tuberosa 198<br />

20. Zingiber officinale 200<br />

MYANMAR<br />

1. Barleria prionitis 205<br />

2. Dioscorea esculenta 207<br />

3. Elettaria cardamomum 209<br />

4. Gloriosa superba 211<br />

5. Millettia extensa 213<br />

6. Nervilia fordii 215<br />

7. Piper betle 217<br />

8. Rauvolfia serpentina 219<br />

9. Vitex negundo 221<br />

10. Vitis repens 223<br />

PHILIPPINES<br />

1. Aloe barbadensis 227<br />

2. Anacardium occidentale 229<br />

3. Annona reticulata 231<br />

4. Areca catechu 233<br />

5. Basella rubra 236<br />

6. Bixa orellana 238<br />

7. Caesalpinia pulcherrima 240<br />

8. Carmona retusa 242<br />

9. Cassia fistula 244<br />

10. Ceiba pet<strong>and</strong>ra 246<br />

11. Hibiscus rosa-sinensis 248<br />

12. Jatropha curcas 250<br />

13. Mimosa pudica 252<br />

14. Moringa oleifera 254<br />

15. Premna odorata 257<br />

16. Streblus asper 259<br />

17. Tinospora crispa 261<br />

18. Vitex negundo 263<br />

vi


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

THAILAND<br />

1. Artocarpus lakoocha 267<br />

2. Boesenbergia rotunda 271<br />

3. Cassia fistula 274<br />

4. Cassia tora 279<br />

5. Clinacanthus nutans 284<br />

6. Curcuma longa 286<br />

7. Eurycoma longifolia 289<br />

8. Hibiscus sabdariffa 293<br />

9. Impatiens balsamina 296<br />

10. Solanum violaceum 299<br />

VIET NAM<br />

1. Abrus precatorius 303<br />

2. Abutilon indicum 305<br />

3. Acanthopanax gracilistylus 307<br />

4. Acanthopanax trifoliatus 309<br />

5. Achyranthes aspera 311<br />

6. Aconitum fortunei 313<br />

7. Acorus gramineus 315<br />

8. Acronychia laurifolia 317<br />

9. Adenosma glutinosum 318<br />

10. Alisma plantago-aquatica 320<br />

11. Aquilaria crassna 322<br />

12. Artocarpus tonkinensis 324<br />

13. Illicium verum 325<br />

14. Litsea cubeba 327<br />

15. Schefflera octophylla 329<br />

LIST OF CONTRIBUTORS 333<br />

INDEX 335<br />

vii


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Abelmoschus moschatus Medik.<br />

Family : Malvaceae<br />

2.0 Vernacular Names : Bason-bason, langamit (Brunei Darussalam)<br />

3.0 Plant Description<br />

A semi-woody plant, up to about 2 m tall with few branches. Young stems pubescent. Leaves<br />

spirally arranged with stalks, up to 5 cm long; petiole hairy <strong>and</strong> bears stipules; blades deeply<br />

lobed to near palmate, about 6 cm across, pubescent on both surfaces <strong>and</strong> with toothed margins.<br />

Flower, singly from the leaf axil with a pair of stipules at the base; stalk, up to 6 cm long,<br />

pubescent; epicalyx with 10 separate sepals; calyx joined with 5 teeth; petals 5, bright yellowcoloured<br />

with deep maroon-crimson base; stigma 5-lobed, maroon-coloured <strong>and</strong> is on top of the<br />

staminal column which is made up of numerous stamens closely joined together. Capsule, up to<br />

6 cm long, hairy on the outside, 5-ridged with 5 cells containing many seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant grows well on both clay <strong>and</strong> loam soils in full sunlight.<br />

6.0 Chemical Constituents<br />

Distillation of the seed yields the volatile oil, farnesal. The seed coat contains palmitin which<br />

emits a musky scent <strong>and</strong> is used in perfumery. No information is available on the contents of the<br />

roots.<br />

1


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots are boiled <strong>and</strong> consumed orally as remedy for asthma, breathlessness <strong>and</strong><br />

general chest discomfort.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agricultural Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

2


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Agathis borneensis Warb.<br />

Family : Araucariaceae<br />

2.0 Vernacular Names : Tolong, kayu raja, entolong (Brunei Darussalam)<br />

3.0 Plant Description<br />

A big tree, up to 50 m tall <strong>and</strong> girth, up to as large as 5 m. Crown is normally conical. Bark<br />

lenticellate, scaly <strong>and</strong> grey-brown, inner bark whitish with white resin. Leaves opposite, oblongelliptic<br />

with blunt tips, up to 12 cm x 5 cm, glabrous, leathery <strong>and</strong> have parallel veins <strong>and</strong> short<br />

petioles. Pollen cones, axillary, sessile, cylindrical <strong>and</strong> each contains 10–12 pollen sacs on their<br />

undersurface. Ovulate cones at stem terminal, erect with many scales, each contains one ovule<br />

on the upper axil. Matured cones, ellipsoidal, 10 cm across, seed solitary on the scales in the<br />

middle section of the cone, ovoid with 2 unequal lateral wings.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant prefers drained clay soil <strong>and</strong> requires some shade when young.<br />

6.0 Chemical Constituents<br />

The trunk of this plant produces resin which is used in the manufacture of spirit varnishes in<br />

lacquers <strong>and</strong> linoleum. It is probably this resin that is responsible for the alleged therapeutic<br />

property. The chemical contents of the roots are not known.<br />

3


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The outer, rough layer of the bark is peeled <strong>and</strong> the smoothened branch is used to rub<br />

onto the affected area to relieve itchy skin condition. Infusion of the young roots is<br />

consumed to treat diabetes <strong>and</strong> high blood pressure.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agricultural Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam - Revised. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

4


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Aloe vera (L.) Burmann<br />

Family : Liliaceae<br />

2.0 Vernacular Name : Lidah buaya (Indonesia, Malaysia)<br />

3.0 Plant Description<br />

A rosette, perennial herb with several short branches forming a dense crown. Leaves narrowlanceolate,<br />

up to 40 cm long, fleshly with toothed margins. Inflorescence an elongated raceme,<br />

arises from the stem terminal; flowers tubular, up to 2.6 cm long, drooping <strong>and</strong> yellow-coloured.<br />

4.0 Propagation : Seedling<br />

5.0 Geographical Distribution/Ecology<br />

Commonly planted as an ornamental plant all over the world.<br />

6.0 Chemical Constituents<br />

Leaf contains barbaloin, which has the properties of an aperient. A polysaccharide obtained<br />

from the juice has been used for treating skin wounds, ulcers, insect bites <strong>and</strong> arthritis. An<br />

extract of the leaves is used as a cosmetic base for decreasing wrinkles <strong>and</strong> smoothing skin.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The juice has antimicrobial properties against Pseudomonas aeruginose, Proteus<br />

vulgaris, Esherichin coli, Streptococcus faecalis <strong>and</strong> Bacillus subtilis. It also has an<br />

antifungal activity.<br />

5


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The inner fleshy part of the leaves blended in water is used to make hair healthy <strong>and</strong><br />

shiny. For burns or sunburn, the mucilage of the leaves is applied directly to the affected<br />

skin. The fresh mucilage is also used for poultice wounds <strong>and</strong> as a skin conditioner.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

6


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Amaranthus spinosus L.<br />

Family : Amaranthaceae<br />

2.0 Vernacular Name : Bayam berduri (Brunei Darussalam, Malaysia)<br />

3.0 Plant Description<br />

A tender upright herb, up to 80 cm tall, with light green cylindrical stem <strong>and</strong> several branches.<br />

Leaves alternate, ovate, glabrous, size variable, normally to 7 cm x 4 cm with retuse tips; petioles,<br />

up to 7 cm long with two 1 cm long sharp thorns at each base. Inflorescence from both leafaxils<br />

<strong>and</strong> stem terminals, in dense spikes of 8 cm long; bracts greenish; sepals 5 <strong>and</strong> green;<br />

stamens 5. Fruits capsular with round, shiny black seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Tropical region. The plant thrives in the open, on rich, friable s<strong>and</strong>y loam soil.<br />

6.0 Chemical Constituents<br />

The roots contain potash. The above-ground parts <strong>and</strong> the roots contain saponin.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The roots contain potash which is the element responsible for their diuretic property. The<br />

above-ground parts <strong>and</strong> the roots contain saponin which is used as an emollient for bruises,<br />

inflammations <strong>and</strong> boils. It also acts as an expectorant for bronchitis <strong>and</strong> breathing<br />

problems.<br />

7


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

lt is traditionally used widely in many countries. Decoction of the roots boiled with Allium<br />

cepa (onion) bulbs <strong>and</strong> seeds of Nigella sativa (fennel flower, black cummin) is used to<br />

cure urinary problem of excessive salt in the urine (locally termed “kencing masin”).<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 1992. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Part I. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

8


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Andrographis paniculata Nees<br />

Family : Acanthaceae<br />

2.0 Vernacular Names : Daun pahit (Brunei Darussalam); hempedu bumi, akar cerita<br />

(Malaysia)<br />

3.0 Plant Description<br />

A small tender herb, up to 70 cm tall with many branches. Stems squarish <strong>and</strong> generally light<br />

green. Leaves opposite, up to 5 cm x 1.5 cm, simple, elliptic with acuminate tips. Inflorescences<br />

axillary <strong>and</strong> stem terminal in panicles with upright flowers; bracts, up to 2 mm long; sepals 5; up<br />

to 4 mm long, with white hairs; corolla tube, up to 6 mm long, white-coloured with 2 lips; lower<br />

lip, 2-lobes; upper lip, 3-lobes, white with purple stripes; stamens 2. Pods up to 1.7 cm long, 2-<br />

celled, containing 12 seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Tropical <strong>and</strong> subtropical areas. The plant prefers rich loamy soil with some shade.<br />

6.0 Chemical Constituents<br />

Andrographolide, <strong>and</strong>rographidine, 5-hydroxy-7,8,3’,3’-tetramethoxyflavone, <strong>and</strong>rographine,<br />

apigenin-4,6-dimethyl ether, â-sitosterol, 5-hydroxy-2’,3’,7,8-tetrametoxyflavone, <strong>and</strong>rographinin<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The whole plant has an antiinfectious property <strong>and</strong> can promote phagocytosis. Intensive<br />

research in Thail<strong>and</strong> shows that the plant is effective against sore throat. Toxic test on<br />

9


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

mice treated orally with 15 g/kg of the extract (LD 50 of the extract on mice was > 15 g/<br />

kg when treated orally, subcutaneously <strong>and</strong> 14.98 g/kg when administered intraperitoneally)<br />

has shown no detrimental effect.<br />

Andrographolide is an interesting pharmacophore with anticancer <strong>and</strong> immunomodulatory<br />

activities.<br />

7.2 Uses in traditional medicine:<br />

A decoction of the leaves is often taken orally to cure diabetes <strong>and</strong> to reduce high blood<br />

pressure. A leaf poultice is applied topically to relieve skin irritation <strong>and</strong> insect bites.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 1992. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Part I. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

Cheung, S. C., et al. 1978. Chinese <strong>Medicinal</strong> Herbs of Hong Kong, Vol. 1–5. Hong Kong.<br />

Rajagopal, S. et al. 2003. Andrographolide, a potential cancer therapeutic agent isolated from<br />

Andrographis paniculata. J. of Exp. Ther. Anco. 3(3):147–158.<br />

10


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Asplenium nidus L.<br />

Family : Aspleniaceae<br />

2.0 Vernacular Names : Lukut, selimbar (Brunei Darussalam); paku lansuyar (Malaysia)<br />

3.0 Plant Description<br />

A radical fern with a thick mass of rhizomes <strong>and</strong> roots. Fronds simple, linear, up to 95 cm x 20<br />

cm; midrib mostly black in colour, supports the lamina at an angle of about 20 degrees. Sori<br />

indusiate, brown-coloured, developed along two-third of all veins on the apical half of the lower<br />

surface of the frond.<br />

4.0 Propagation : Spores<br />

5.0 Geographical Distribution/Ecology<br />

Growing on trunk of trees in the shade or open of tropical forest.<br />

6.0 Chemical Constituents<br />

The plant contains acetylornthine, N-acetylornithine <strong>and</strong> L(+)-ornithine.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

A decoction or warm infusion of the frond is used to relieve pain associated with the<br />

appearance of blood in the stool. Three sq. cm of the leaf lamina is normally sufficient<br />

for each preparation, to be taken once a day. Macerated leaves can also be applied to<br />

wounds to stop bleeding.<br />

11


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 1992. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Part I. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

12


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Blumea balsamifera DC.<br />

Family : Asteraceae<br />

2.0 Vernacular Names : Nath luang (Lao PDR); sambung (Philippines, Brunei<br />

Darussalam), sembung, capa, telinga kerbau (Malaysia)<br />

3.0 Plant Description<br />

A subshrub perennial herb, up to 3 m tall, with hairy stem. Leaves alternate, lanceolateoblanceolate.<br />

Margin serrate, base usually rounded to tapering, petiole sessile or short, exstipulate,<br />

22 cm x 6 cm, hairy. Inflorescence branched with many reduced leaves, flower heads,<br />

up to 7 mm x 3 mm, bracts narrow <strong>and</strong> numerous, florets yellow; appus white with some brown<br />

tips.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

From India to Southeast Asia<br />

6.0 Chemical Constituents<br />

Essential oil is about 0.1–0.4% camphor <strong>and</strong> borneol, alcohol, cineol, limonene, phenolphloroacetophenone<br />

dimethyl ether <strong>and</strong> alkaloid<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

13


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

A decoction of the whole plant mixed with other herbs is popularly used in bath after<br />

childbirth for general health. The decoction mixed with allium cepa (onion) <strong>and</strong> Nigella<br />

sativa (fennel flower, black cumin) is consumed for aching joints <strong>and</strong> coughs. The decoction<br />

of the leaves is antiarrythmic, expectorant, antispasmodic, astringent, antigastralgic <strong>and</strong><br />

antihelmintic.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 1992. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Part I. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

Burkill I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry<br />

of Agriculture <strong>and</strong> Co-operative, Kuala Lumpur, Vol. I & II.<br />

14


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Caesalpinia crista L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Matahiang, padihiang (Brunei Darussalam)<br />

3.0 Description:<br />

A woody vine with long thorny stems. Leaves alternate, bipinnate with sharp thorns on the<br />

undersides of the ribs; leaflets elliptic, up to 6 cm x 3 cm <strong>and</strong> glabrous. Inflorescence in the form<br />

of racemes with many strongly scented flowers; sepals 5, brown-coloured; petals 5, yellow with<br />

red stripes on the st<strong>and</strong>ard; stamens numerous; ovaries superior <strong>and</strong> hairy. Fruit pods, up to 10<br />

cm x 5 cm, thorny with 2–4 smooth <strong>and</strong> hard seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It was introduced from tropical America. A native of Madagascar, it is widely distributed in<br />

tropical region.<br />

6.0 Chemical Constituents<br />

Bonducin in seed, bark <strong>and</strong> leaves, 17% fat<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

15


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

Kernel of the matured seeds, root or leaves is eaten fresh or pounded, mixed with a little<br />

cooking oil <strong>and</strong> rubbed onto the abdomen to treat spleen <strong>and</strong> liver diseases manifested by<br />

uncontrollable shivering symptom. The seeds are used in cosmetic preparation in India.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

16


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Centratherum intermedium L.<br />

Family : Asteraceae<br />

2.0 Vernacular Name : Bunga ungu (Brunei Darussalam)<br />

3.0 Plant Description<br />

A much-branched, slightly woody herb, about 60–70 cm tall, with ascending to upright scabrous<br />

stems. Leaves spiral; lamina to 6.5 cm x 3.5 cm, broadly elliptic <strong>and</strong> tapered towards the base of<br />

the petiole; margins double-serrated. Inflorescence, at stem terminal; flower head, about 1.5–<br />

1.8 cm across <strong>and</strong> supported at the base by a whorl of smaller leaves; bracts narrow, in 4–6<br />

whorls; florets purple-coloured, up to 1.2 cm long with 5 lobes <strong>and</strong> pappus of short fine bristles.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Brunei Darussalam<br />

6.0 Chemical Constituents<br />

No information on its contents has been cited. However, the herb gives off a strong acrid smell<br />

when crushed <strong>and</strong> a slight irritation may be felt when applied.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

17


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The crushed or pounded leaf is gently applied to the skin <strong>and</strong> over wounds to treat skin<br />

allergy, shingles, herpes <strong>and</strong> skin eczema. The treatment should be carried out twice a<br />

day in 2–3 weeks for effectiveness.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

18


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Corchorus capsularis L.<br />

Family : Tiliaceae<br />

2.0 Vernacular Names : Penawar upas (Brunei Darussalam); kancing baju (Malaysia)<br />

3.0 Plant Description<br />

An annual undershrub, up to 1.7 m tall, with a few slender branches. Stems glabrous, reddish<br />

brown <strong>and</strong> easily peeled. Leaves simple, alternate; petioles, up to 1.2 cm long, with 2 fine, 7 mm<br />

long stipules at the node; lamina lanceolate, up to 10.5 cm x 3 cm, with serrate margins <strong>and</strong> base<br />

pair of teeth forming fine bristles. Flowers, 2 from each node with 4 yellow, separated sepals<br />

<strong>and</strong> numerous stamens; ovary superior. Capsules round, flat at the top <strong>and</strong> split into 5 parts to<br />

release the angular seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It thrives on most soils in direct sunlight.<br />

6.0 Chemical Constituents<br />

Corosin, b-sitosterol, capsularin, glucoside, corchorin, oleic acid, linolic acid, arachidic acid, palmitic<br />

acid, stearic acid <strong>and</strong> strophanthidine, cerotic acid, lignoceric acid, behenic acid, raffinose,<br />

corchsularose <strong>and</strong> glycosides<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

19


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

An infusion of the roots is taken orally to neutralize poison (from upas tree) usually<br />

applied to the dart of a blowpipe, as well as agrichemical poisons. Besides orally consumed,<br />

it is applied topically onto the wound. A decoction of the leaves is taken orally to reduce<br />

hypertension.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

20


BRUNEI DARUSSALAM<br />

1.0 Scientific name : Coscinium fenestratum Colebr.<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Ambok segubang, perawan, akar penawar (Brunei<br />

Darussalam); akar mengkunyit (Malaysia)<br />

3.0 Plant Description<br />

A perennial, moderate twining liana. Roots, 5–7, tuberous <strong>and</strong> attached closely to the base, each<br />

up to 10 cm long <strong>and</strong> 2 cm in diameter with bright yellow inner bark. Stem, up to 4 m long <strong>and</strong> 2<br />

mm in diameter, green-coloured. Leaves alternate; petiole, up to 8 cm long, pubescent with<br />

swollen base <strong>and</strong> bent; blade cordate with broadly acuminated rip, up to 10 cm x 11 cm, upper<br />

surface glabrous with 5 sunken main veins, underneath hairy along prominent veins. Inflorescence,<br />

in tomentose panicle of 8 cm long <strong>and</strong> 4 cm across; outer sepals short, inner sepals oblong <strong>and</strong><br />

longer. Fruit, a drupe, to 2 cm in diameter.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution<br />

It thrives on s<strong>and</strong>y or clay loam under shade.<br />

6.0 Chemical Constituents<br />

Saponins could be present in the roots.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

21


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The root is chewed <strong>and</strong> swallowed in order to alleviate the effect of food <strong>and</strong> other<br />

chemical poisonings. The root is sliced, soaked in clean water <strong>and</strong> the infusion consumed<br />

as a follow-up antidote. A patient who is unconscious may be force-fed with a strong<br />

infusion of the tubers. For blowpipe poisoning, the mashed tuber is immediately applied to<br />

the wound directly. The infusion is also traditionally drunk to treat dizziness of the head<br />

<strong>and</strong> dazed sight. This plant is quite well known as an antidote for poisons, but evaluation<br />

is required to ascertain this claim.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

22


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Curcuma longa L.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Kunyit biasa, tamu kunyit (Indonesia, Malaysia)<br />

3.0 Plant description<br />

A clumped herb with ellipsoidal, 6 cm x 2.7 cm primary tubers <strong>and</strong> many, 4–7 cm long, 1.5 cm<br />

thick rhizomes. Rhizome brownish <strong>and</strong> scaly outside <strong>and</strong> bright orange inside. Shoots erect, up<br />

to 90 cm tall with 6–8 leaves <strong>and</strong> their sheaths form the pseudostem; leaf-lamina lancleota,<br />

acuminate, up to 28 cm x 7 cm. Inflorescences cylindrical spikes, up to 13 cm x 5 cm; bracts<br />

elliptic-lancleolate, up to 5 cm x 2.3 cm, upper bracts white-coloured <strong>and</strong> lower bracts light<br />

green; calyx toothed unequally <strong>and</strong> divided; corolla tube whitish, divides into 3 petals with dorsal<br />

lobe hooded; staminodes 2; labellum obovate with a yellow b<strong>and</strong> long the centre, side lobes<br />

white-coloured; ovary inferior.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Commonly cultivated as a spice <strong>and</strong> usually harvested annually. It grows well on rich moist<br />

s<strong>and</strong>y loam or alluvial soils. Flowers in March, without setting fruit.<br />

6.0 Chemical Constituents<br />

The rhizome contains curcumin which gives the yellow-orange colour, essential oil, fixed oil,<br />

bitter principles, resin, protein, cellulose, pentosans, starch <strong>and</strong> minerals. It also contains cycloisopropenmycren,<br />

P-tocylmethyl carbinol, demethoxycurcumin <strong>and</strong> bisdemethoxycurcumin.<br />

23


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The rhizome is useful as a remedy to relieve uncontrolled <strong>and</strong> frequent urination, probably<br />

due to infection of the urinary system. The skin of a rhizome is peeled <strong>and</strong> is used to rub,<br />

with an upward motion, the lower abdomen. A small portion of the skin can be chewed<br />

<strong>and</strong> swallowed after each rubbing session.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

24


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Donax gr<strong>and</strong>is Ridley<br />

Family : Marantaceae<br />

2.0 Vernacular Names : Bamban batu, bemban (Brunei Darussalam)<br />

3.0 Plant Description<br />

A sprawling half-herbaceous plant about 2 m tall. Stem, straight between nodes, up to 1.5 cm in<br />

diameter at the base, very smooth <strong>and</strong> green-coloured; branches, leaf-opposed. Leaves alternate,<br />

sheath, up to 12 cm long, enclosing the stem; laminar ovate with abruptly acuminate tips, up to<br />

13 cm x 7.5 cm, leathery <strong>and</strong> glabrous. Panicle leaf-opposed, up to 24 cm long, with 2 flowers on<br />

each branch which also bears a 4 cm long bract. Flower white, epicalyx 3–5 mm long <strong>and</strong><br />

translucent, sepals 3–2.5 cm x 5 mm, corolla-tube to 2.5 cm long, 3-lobed with 2 narrow lobes<br />

<strong>and</strong> one broad lobe, style hooked <strong>and</strong> partly covered by the corolla-tube, ovary inferior. Fruit,<br />

bowl-shaped outline <strong>and</strong> bearing 3 seeds.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

The plant thrives on clay loam <strong>and</strong> soon forms a thick colony.<br />

6.0 Chemical Constituents<br />

Saponins have been detected in the rhizomes of the plants in Brunei Darussalam. The same<br />

phytochemicals have been found in plants in Malaysia. The juice of the stem has been regarded<br />

as an antidote for snake bites <strong>and</strong> blood poisoning in Malaysia.<br />

25


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Decoction of the rhizomes is consumed to treat diabetes <strong>and</strong> high blood pressure. The<br />

white flowers are picked fresh <strong>and</strong> eaten by children.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agricultural Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

Goh, S.H. et. al., 1990. Phytochemical Guide to Malaysia Flora. IPT. University of Malaya,<br />

Malaysia.<br />

26


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Etlingera solaris (Bl.) R. M. Sm.<br />

Synonym : Phaeomeria solavis (Bl.) K. Sehura<br />

Family : Zingiberaceae<br />

2.0 Vernacular Name : Tepus kantan<br />

3.0 Plant Description<br />

A rhizomatous, clumbed plant growing up to 5–6 cm tall. Pseudostem swollen at the base,<br />

consists of layers of leaf-sheaths. Leaves, in 2 rows, alternate; petiole up to 5 mm long; lamina,<br />

linear, glabrous, up to 50 cm long <strong>and</strong> broad with narrow acuminate tip <strong>and</strong> rounded base.<br />

Inflorescence in upright, torch-shape spike; stalk, up to 20 cm long with overlapping greencoloured<br />

scales; bracts many <strong>and</strong> overlapping, pinkish-red, waxy, outside oblong <strong>and</strong> larger (8<br />

cm x 3 cm), smaller <strong>and</strong> narrower toward the centre; epicalyx tubular with 2 lobes, thin <strong>and</strong><br />

papery; calyx tubular, up to 3 cm long with 2 sepals <strong>and</strong> red-tipped; corolla tube, up to 2 cm long<br />

with 3, 2 cm long petals, labellum anther 2-lobed, thin <strong>and</strong> papery; calyx tubular, up to 3 cm long<br />

with 2 sepals <strong>and</strong> spathaceous, red-coloured <strong>and</strong> folds the stamen <strong>and</strong> the pistil; anther 2-lobeb;<br />

ovary inferior. Fruits, tightly packed in a sphere 7–8 cm across, Irregularly-shaped with flattened<br />

top <strong>and</strong> a persistent flower remains; seeds many, black <strong>and</strong> embedded in mucilage. It flowers<br />

regularly.<br />

4.0 Propagation : Normally propagated from rhizome-cuttings. The seed can also<br />

be germinated.<br />

5.0 Geographical Distribution/Ecology<br />

The terrestrial plant is occasionally grown in gardens. It thrives on clay loam in the open lowl<strong>and</strong><br />

<strong>and</strong> quickly establishes into a big clump.Widely planted in house gardens in Southeast Asia.<br />

27


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0 Chemical Constituents<br />

Not available<br />

7.0 Reports on <strong>Medicinal</strong> Uses<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The young inflorescence <strong>and</strong> sometimes the fruits are used as food flavourings. With<br />

the introduction of the plant, its traditional medicinal uses are also adopted. The juice of<br />

the young fruits is dropped into the ears to treat certain ear-aches. Decoction of the<br />

rhizome is used as an antiseptic for external wounds. The flowers are sometimes<br />

included in the herbal bath for a mother after childbirth.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

28


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Languas galanga stuntz<br />

Synonym : Alpinia galanga (L.)Willd.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Languas, lengkuas (Brunei Darussalam, Indonesia Malaysia);<br />

galangal (English)<br />

3.0 Plant Description<br />

A perennial herb with pseudostem, up to 2.2 m high, <strong>and</strong> thick underground rhizomes. Leaves<br />

alternately arranged in two rows, oblong-elliptic, up to 45 cm x 12 cm with short petioles; margins<br />

ciliated with a thin light green marking all around; stipule brownish green marking all around;<br />

stipule brownish green with patches of vicious hairs. Inflorescences in terminal panicles, corolla<br />

tube, up to 10 cm long <strong>and</strong> divides into 3 petals, each 1.9 cm x 1.6 cm; lip, up to 2 cm, with 2 deep<br />

limbs, white with red streaks. Fruits round, up to 1.4 cm <strong>and</strong> orange-red when ripe.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Commonly planted in open areas in backyards. Widely distributed in all over Southeast Asian<br />

region.<br />

6.0 Chemical constituents<br />

Rhizome contains galangol which on distillation yields cineol, the latter responsible for the medicinal<br />

properties. Pinene <strong>and</strong> eugenol are also present. The amount of oil in the fresh rhizome was<br />

quoted at 0.04%. The decoction is warm <strong>and</strong> hot-tasting.<br />

29


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

A decoction of the rhizomes <strong>and</strong> base of pseudostem is taken to cure stomach-ache,<br />

vomiting, diarrhea <strong>and</strong> indigestion. It is a common spice used in many local dishes. Some<br />

local herbalists regard the pseudostem as a useful aphrodisiac.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

30


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Macaranga gigantea (Rchb. f. & Zoll.) M.A.<br />

Family : Euphorbiaceae<br />

2.0 Vernacular Names : Mangkubong sedaman, merakubong, telinga gajah (Brunei<br />

Darussalam); mahang (Malaysia)<br />

3.0 Plant Description<br />

A small to medium-sized tree, up to about 9 m tall, usually with straight trunk <strong>and</strong> dome-shaped<br />

crown. Bark smooth <strong>and</strong> grey. Wood soft <strong>and</strong> white. Leaves spiral <strong>and</strong> peltate; stipules<br />

papery <strong>and</strong> persistant; blade shallowly 3-lobed <strong>and</strong> without yellow granular gl<strong>and</strong>, large to about<br />

40 cm across. Inflorescences axillary or behind the leaves; a raceme of clustered flowers;<br />

bracts minute apetalous with no disc; flowers dioecious, male flowers with sepals not overlapping,<br />

stamens free, anthers celled with no spitillode; female flowers with ovary chambered, styles<br />

unbranched. Fruit, a leathery capsule with rough skin which splits into 2 parts when mature to<br />

release many black seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Brunei Darussalam, Malaysia <strong>and</strong> Indonesia. Often found growing by roadside clearings,<br />

secondary forests <strong>and</strong> on wastel<strong>and</strong>s.<br />

6.0 Chemical Constituents<br />

The root-bark contains tannin; kino glue comes from the sap <strong>and</strong> alkaloids from the fruit; the<br />

leaves <strong>and</strong> stem contain terpenoids.<br />

31


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots of a young tree are boiled <strong>and</strong> the resultant decoction is consumed to relieve<br />

diarrhea. The stem is cut <strong>and</strong> the fresh latex is carefully applied to sores on lips or mouth<br />

cavity.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas 1992. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Part II. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary Resources.<br />

Burkill, I. H., 1996. A Dictionary of the Economic Products of the Malay Peninsula.<br />

Ministry of Agriculture <strong>and</strong> Co-operative, Kuala Lumpur, Vol. I & II.<br />

32


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Melastoma malabathricum L.<br />

Family : Melastomataceae<br />

2.0 Vernacular Names : Kuduk-kuduk (Brunei Darussalam); Senduduk (Malaysia)<br />

3.0 Plant Description<br />

A rhizomatous perennial herb with pseudostems, up to 80 cm tall. Leaves 16–18, narrowly<br />

elliptic, up to 25 cm x 5.5 cm <strong>and</strong> glabrous. Inflorescences, a cylindrical spike from the rhizome,<br />

up to 16 cm long on an equal length of stalk; bracts overlapping, lower light green, upper red;<br />

flowers singly from bract-axil; calyx tubular, up to 2.5 long, spathaceous, 3-toothed, faint-yellow<br />

<strong>and</strong> translucent; corolla tube, up to 3 cm long, 3-lobed dosal lobe, up to 2 cm x 0.8 cm <strong>and</strong> curved<br />

over the anther; labellum dull purplish-yellow with yellow spots, <strong>and</strong> connected to the side lobes<br />

at half length; anther, up to 1cm long with a narrow beak-like appendage protruding 1 cm above<br />

<strong>and</strong> containing the style; ovary inferior.<br />

4.0 Propagation : Stem cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Commonly found growing on wastel<strong>and</strong>, along roadsides <strong>and</strong> in orchards. It thrives on most soils<br />

in direct sunlight, flowers <strong>and</strong> fruits readily <strong>and</strong> can be propagated from stem cuttings. This plant<br />

is widely distributed.<br />

6.0 Chemical Constituents<br />

Not available<br />

33


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The decoction of the twig mixed with 7–10 herbs is used in herbal baths after childbirth to<br />

revitalize the body system. The fresh petals are used to rub on dried wounds in order to<br />

accelerate healing <strong>and</strong> to reduce permanent scaring.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

34


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Orthosiphon aristatus (Blume) Miquel<br />

Family : Lamiaceae<br />

2.0 Vernacular Names : Janggut kucing, misai kucing (Brunei Darussalam)<br />

3.0 Plant Description<br />

A tender herb, up to about 1 m tall with squarish ascending stems. Leaves opposite, broadly<br />

elliptic, crenate, up to 7 cm x 3.5 cm with both surfaces pubescent, petioles, up to 2 cm long.<br />

Inflorescence in terminal raceme, up to 10 cm long, sepals 5, corolla white-coloured, 2-lips,<br />

upper-lip with 4 limbs, lower-lip narrow, stamens 4 with styles protruding 6 cm long resembling<br />

cat’s whiskers.<br />

4.0 Geographical Distribution/Ecology<br />

The plant thrives well in moist, s<strong>and</strong>y loam soil with some shade.<br />

5.0 Propagation : Stem<br />

6.0 Chemical Constituents<br />

The herb is sweet <strong>and</strong> mildly bitter. No information on the constituents of this plant has been<br />

found.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

35


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

A decoction of the leaves mixed with Nagella sativa (fennel flower, black cummin) <strong>and</strong><br />

Allium cepa (onion) is taken orally after meals to control diabetes. For children, honey<br />

may be added to the decoction.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agricultural Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

36


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Portulaca oleracea L.<br />

Family : Portulaceae<br />

2.0 Vernacular Name : Lingiruh (Brunei)<br />

3.0 Physical description<br />

An annual <strong>and</strong> often with fleshy purplish red stems, old stems decumbent,up to 7 mm thick <strong>and</strong><br />

50 cm long. Leaves opposite or in whorls, lamina near spatulate, to 2 cm x 1.2 cm <strong>and</strong> glabrous.<br />

Inflorescence at stem terminal, in tight bunch of several flowers; bracts 4 <strong>and</strong> very thin; sepals<br />

2 <strong>and</strong> green; petals 5, up to 4 mm long <strong>and</strong> yellow; ovary half-superior. Fruits capsular <strong>and</strong><br />

containing many black, 1 mm thick seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Commonly found growing on moist fertile soils as weeds in vegetable gardens <strong>and</strong> along sides of<br />

drains.<br />

6.0 Chemical Constituents<br />

The whole herb contains cyanophoric constituent, fats, vitamins, alkaloid, antraquinone, glycosides,<br />

cardiac glycosides, coumarins <strong>and</strong> flavones <strong>and</strong> norepinephrine. The leaf has essential oil.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

37


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The whole herb is boiled <strong>and</strong> eaten to relieve high blood pressure. It is often consumed<br />

as a vegetable.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agricultural Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

38


BRUNEI DARUSSALAM<br />

1.0 Scientific Name : Zingiber aromaticum Valeton<br />

Family : Zingiberaceae<br />

2.0 Vernacular Name : Lempuyang (Brunei)<br />

3.0 Plant Description<br />

A shrub, up to 2 m tall with squarish <strong>and</strong> often reddish stems; young bark rough with small bristly<br />

scales; old bark dark brown-coloured with netlike markings. Leaves opposite, narrowly elliptic,<br />

up to 9 cm x 2 cm, surface scurfy with 3 distinct ribs <strong>and</strong> 2 less prominent outer ribs. Flowers at<br />

stem terminals on short stalks; bracts 3, red with a green tinge, up to 1.5 cm x 1.0 cm; calyx<br />

reddish green, hairy with 5 sepals; petals 5, maroon-coloured, up to 2.5 cm x 1.5 cm; stamens<br />

10; style protruding <strong>and</strong> pink-coloured. Fruits with numerous small seeds embedded in purplish<br />

pulp.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Often grown in gardens <strong>and</strong> house compounds. It thrives on s<strong>and</strong>y loam <strong>and</strong> alluvial soils in full<br />

sunlight <strong>and</strong> flowers in September. Widely planted in house gardens in Southeast Asia.<br />

6.0 Chemical Constituents<br />

Other related species contain camphene, zingiberene, essential oils <strong>and</strong> many volatile oils in their<br />

rhizomes. It is likely that Z. aromaticum has similar constituents.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

39


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The rhizomes are boiled <strong>and</strong> the resultant decoction is used as a herbal bath after childbirth.<br />

The leaves are warmed over a fire <strong>and</strong> wrapped around the joints of the limbs to relieve<br />

pain due to arthritis.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Brunei Darussalam Agriculture Research Centre, Kilanas. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Brunei<br />

Darussalam. Revised edition. Department of Agriculture, Ministry of Industry <strong>and</strong> Primary<br />

Resources.<br />

40


CAMBODIA<br />

1.0 Scientific Name : Aegle marmelos (L.) Correa ex. Roxb.<br />

Family : Rutaceae<br />

2.0 Vernacular Names : Phnov, golden apple, bael fruit tree, bengal quince, bel<br />

3.0 Plant Description<br />

Tree, 10–15 m high. The leaves are trifoliolate <strong>and</strong> alternate. The leaflets are elliptic or lanceolateovate,<br />

2–7 cm wide <strong>and</strong> 4–13 cm long with inflorescence in terminal or axillary raceme. The<br />

aromatic flowers are greenish white on the inner side <strong>and</strong> green on the outer side. The orangecoloured<br />

fruits are fleshy <strong>and</strong> globose or ellipsoid with a hard pericarp. The flesh is reddish, with<br />

numerous seeds covered in a gummy layer. The taste is mucilaginous <strong>and</strong> slightly acidic.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant grows wild throughout the forests <strong>and</strong> domestically around Buddhist monasteries for<br />

its fruits in Cambodia.<br />

6.0 Chemical Constituent<br />

Coumarins, including xanthotoxol <strong>and</strong> alloimperatorin methyl ether, flavonoids, rutin <strong>and</strong> marmesin.<br />

The alkaloids include á-fargarine(=allocryptopine), O-isopentenylhalfordinol, O-methylhafordinol<br />

<strong>and</strong> essential oils.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Recent investigations have shown that the coumarins present may have potential antiulcer<br />

properties.<br />

43


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

Parts used are bark, rood, leaves, dried, unripe <strong>and</strong> ripe fruit.<br />

<strong>Medicinal</strong> properties include stomachic, digestive <strong>and</strong> astringent activity. Infusion of the<br />

dried unripe fruit is reputedly used as an antidiarrhoeal, antidysenteric, antifungal <strong>and</strong><br />

antimicrobial. The ripe fruits possess laxative properties <strong>and</strong> promote digestion. Juice<br />

from the crushed leave is reported to relieve bronchitis. The common preparation is a<br />

liquid extract, with a dose of 4–8 ml. Infusion of the dried leaves also reputedly possesses<br />

hypoglycaemic properties. Recent investigations have shown that the coumarins present<br />

may have potential antiulcer properties.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Banerji, N., Maiti, M., Sem, S. & Datta, P.C. 1982. Pharmacognosy of Aegle marmelos (L.)<br />

Correa seed. A new protein source. Acta. Pharm. Hung. 52(3): Pp. 97–101.<br />

Goel, R.K., Maiti, R.N., Manickam, M. & Ray, A.B. 1997. Anti-ulcer activity of naturally occurring<br />

pyrano-coumarin <strong>and</strong> isocoumarins <strong>and</strong> their effect on prostanoid synthesis using human colonic<br />

mucosa (Aegle marmelos). Indian J .Exp. Biol. 35(10): Pp. 1080–1083.<br />

Karunanayake, E.H., Welihinda, J., Sirimanne, S.R. & Sinnadorai, G. 1984. Oral hypoglycaemic<br />

activity of some medicinal plants of Sri Lanka (Aegle marmelos). J. Ethnopharmacol. 11(2):<br />

Pp. 223–231.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 19–<br />

20.<br />

44


CAMBODIA<br />

1.0 Scientific Name : Aquilaria crassna Pierre ex. Lecomte<br />

Family : Thymelaeaceae<br />

2.0 Vernacular Names : Daem chan kroessnaa, agar wood (English)<br />

3.0 Plant Description<br />

Tree, 30–40 m tall. Leaves are alternate <strong>and</strong> the flowers are scented. Burnt wood also gives off<br />

a characteristic fragrance.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Mostly found in Viet Nam, Lao PDR <strong>and</strong> Cambodia in primary <strong>and</strong> secondary forest.<br />

6.0 Chemical Constituents<br />

Volatile oil, baimuxinol <strong>and</strong> baimuxinic acid<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

In traditional Cambodian medicine, the wood is mixed with other drugs <strong>and</strong> used against<br />

malaria. Another variety called A. sinensis is used in medicine for its active principles<br />

baimuxol <strong>and</strong> dehydrobaimuxinol.<br />

45


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 63 pp.<br />

Okugawa, H., Ueda, R., Matsumoto, K., Kawanishi, K. & Kato, A. 1993. Effects of agar wood<br />

(Aquilaria crassna) extracts on the central nervous system. Planta Med. 59(1):Pp. 32–36.<br />

Yang, J.S. & Chen, Y.W. 1986. [Studies on the chemical constituents of Aquilaria sinensis<br />

(Lour.) Gilg. II. Isolation <strong>and</strong> structure of baimuxol <strong>and</strong> dehydrobaimuxinol]. Yao Xue Xue Bao<br />

21(7): Pp. 516–620.<br />

Yang, J.S. & Chen, Y.W. 1983. [Studies on the constituents of Aquilaria sinensis (Lour.) Gilg.<br />

I. Isolation <strong>and</strong> structure elucidation of two new sesquiterpenes, baimuxinal]. Yao Xue Xue<br />

Bao 18(3): Pp. 191–198.<br />

Yang, J.S., Wang, Y.L. & Su, Y.L. 1990. [Studies on the chemical constituents of Aquilaria<br />

sinensis (Lour.) Gilg. V. Isolation <strong>and</strong> characterisation of three 2-(2-phenylethyl) chromone<br />

derivatives]. Yao Xue Xue Bao 25(3): Pp. 186–190.<br />

Yang, J.S., Wang, Y.L. & Su, Y.L. 1989. [Studies on the chemical constituents of Aquilaria<br />

sinensis (Lour.) Gilg. IV. Isolation <strong>and</strong> characterisation of 2-(2-enylethyl) chromone derivatives].<br />

Yao Xue Xue Bao 24(9): Pp. 678–683.<br />

46


CAMBODIA<br />

1.0 Scientific Name : Caesalpinia sappan L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Sbaeng, sappan wood<br />

3.0 Plant Description<br />

A small tree, 7–10 m tall, trunk <strong>and</strong> branchlets spiny. Leaves are bipinnate compound. Flowers<br />

are yellow, young flowering branchlets densely covered with ferruginous pubescence. The fruits<br />

are flat, oblong <strong>and</strong> woody pods, each with a pointed tip.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This species is naturally distributed in tropical Asia. In Cambodia, it is sparsely found at forest<br />

edges, or in secondary forests <strong>and</strong> around villages. Also grown in many mountainous provinces<br />

in the northern part of Lao PDR, especially in Luangprabang, at the altitude of at least 800 ft.<br />

6.0 Chemical Constituents<br />

Brasillin, brasillenin hydrocyanic acid, ocimene, saponin, shikimic acid, tannin<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

47


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The heartwood is used to treat haemostasis, bruises <strong>and</strong> diarrhea. It is generally given to<br />

women after labour. A decoction of the wood is used in many Asian countries to treat<br />

problems related to blood, because of its red colour.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. Pp. 218–219.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

48


CAMBODIA<br />

1.0 Scientific Name : Cananga latifolia (Finet & Gapnep.)<br />

Family : Annonaceae<br />

2.0 Vernacular Name : Chhke sreng<br />

3.0 Plant Description<br />

A branchy shrub, 8–15 m tall. The bark is grey with white inner portion. The leaves are ovate,<br />

denticulate <strong>and</strong> alternate. The fragrant flowers are sometimes used to make necklaces. Shortlasting<br />

wood, used for temporary structures.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

It is native to Cambodia <strong>and</strong> grows near clear <strong>and</strong> semi-dense forests.<br />

6.0 Chemical Constituents<br />

Polyphenol glycosides<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Amoebicidal activity has been investigated from extracts of this plant.<br />

7.2 Uses in traditional medicine:<br />

Infusion of the wood is considered a febrifuge. The bark forms one of the components of<br />

a remedy against dizziness. The scrapings from the wood are reputedly smoked to treat<br />

49


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

allergic rhinitis. Cananga latifolia is one the three main herbs that are used in combination<br />

with Zeylamica for the treatment of tuberculosis. Amoebicidal activity has been investigated<br />

from extracts of C. latifolia.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Chu, D.M., Miles, H., Toney, D., Nguyen, C. & Marciano Cabral, F. 1998. Amoebicidal activity<br />

of plant extracts from Southeast Asia on Acanthamoeba spp. (Cananga latifolia). Parasitol.<br />

Res. 84(9): Pp. 746–752.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp.117–<br />

118.<br />

Wood, S.H., Reynolds, M.C., Sun, N.J., Cassady, J.M. & Snapka, R.M. 1997. Inhibition of<br />

topoisomerase II by liriodenine (Cananga latifolia). Biochem. Pharmacol. 54 (4): Pp. 467–<br />

473.<br />

50


CAMBODIA<br />

1.0 Scientific Name : Capparis micracantha DC.<br />

Family : Capparaceae<br />

2.0 Vernacular Name : Kanchee baaydaac<br />

3.0 Plant Description<br />

2–3 m tall bush with thorny ends. The green leaves are lanceolate with an acute apex, 10–20 cm<br />

long <strong>and</strong> 5–7 cm wide. The barriers are oval <strong>and</strong> 2–3 cm wide with numcrous seeds. The<br />

berries are edible.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This species grows in the open forests of Cambodia.<br />

6.0 Chemical Constituents<br />

Alkaloids <strong>and</strong> â-carotene<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Roasted seeds are infused <strong>and</strong> taken against coughs. Infusion of the roots is used as a<br />

diuretic. Leaf mixed with other medicinal plant leaves is used for body steam-bath. Young<br />

stem or branch is used to cure polyps of the nose caused by smoking or drinking.<br />

51


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Chaturvedi, Y. & Nagar, R. 2001. Levels of â-carotene <strong>and</strong> effects of processing of selected<br />

fruits (Capparis micracantha) <strong>and</strong> vegetables of the arid zone of India. Plant Food. Hum.<br />

Nutr. 56(2): Pp. 127–132.<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Guan,R.J., Zheng, J.M., Hu, Z. & Wang, D.C. 2000. Crystallization <strong>and</strong> preliminary X-ray<br />

analysis of the thermostable sweet protein mabinlin II (Capparis micracantha). Acta. Crys.<br />

D. Biol. Crystall. 56(Pt.7): Pp. 918–919.<br />

Jankowski, W.J. & Chojnacki, T. 1991. Long chain polyisoprenoid alcohols in leaves of Capparis<br />

species. Acta. Biochim. Pol. 38(2): Pp. 265–276.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 124 pp.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

52


CAMBODIA<br />

1.0 Scientific Name : Cassia alata L.<br />

Family : Caesalpiniaceae<br />

2.0 Vernacular Names : Danghet, ringworm cassia<br />

3.0 Plant Description<br />

A small shrub, about 1–2 m tall. The leaves are simple pinnate alternate with leaflets oblong or<br />

obovate. The flowers are orange. Fruits are black pods with two broad wings.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Originating in tropical American, it is now widespread in Southeast Asian countries <strong>and</strong> cultivated<br />

near houses for ornamental <strong>and</strong> for utilitarian purposes in Cambodia. In Lao PDR, it can be<br />

found in all parts of the country, with an increasing frequency southwards, especially in<br />

Champasack province.<br />

6.0 Chemical Constituents<br />

Anthraquinone, chrysarobini, cinnamaldehyde, decanal, hydrocyanic acid, ricinoleic acid, saponin<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

In traditional Cambodian medicine, the crushed leaves are mixed with quicklime <strong>and</strong><br />

water to treat sores <strong>and</strong> eczemas. The plant is toxic, commonly used to treat ringworm.<br />

53


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. Pp. 137–138.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

54


CAMBODIA<br />

1.0 Scientific Name : Combretum quadrangulare Kurz<br />

Family : Combretaceae<br />

2.0 Vernacular Name : Sanke<br />

3.0 Plant Description<br />

Tree, 2–10 m tall. The branchlets are acutely quadrangular or very narrowly quadrialate. The<br />

leaves are simple, opposite, obovate, 3–8 cm wide <strong>and</strong> 6–15 cm long. The flowers are small,<br />

yellowish to white. The fruits are thinly quadrialate with brownish-red seeds. The leaves, dried<br />

<strong>and</strong> well spread under mattress or mast, are used as cigarette paper. The plant may host lacquer<br />

insects, which produces lacquer-gum, a natural dye for silk.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant grows in deforested regions, <strong>and</strong> is common along riversides <strong>and</strong> banks of paddy<br />

fields throughout Cambodia.<br />

6.0 Chemical Constituents<br />

Triterpenes, tannin, combretol, daucosterol<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Recent studies have investigated possible hepatoprotective properties from the triterpenes<br />

present.<br />

55


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

In traditional Cambodian medicine, the fruits are used to remove ascaris. The bark is part<br />

of an ointment used to b<strong>and</strong>age ulcerations. Veterinarians reputedly use it as tonic for<br />

oxen <strong>and</strong> horses. The seeds are reputedly used as an anthelmintic for roundworms <strong>and</strong><br />

threadworms in children. The leaves are used to relieve muscular pains. Recent studies<br />

have investigated possible hepatoprotective properties from the triterpenes present.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Adnyana, I.K., Tezuka, Y., Banskota, A.H., Tran, K.Q. & Kadota, S. 2001. Three new triterpenes<br />

from the seeds of Combretum quadrangulare <strong>and</strong> their hepatoprotective activity. J. Nat.<br />

Prod. 64(3): Pp. 360–363.<br />

Banskota, A.H., Tezuka, Y., Tran, K.Q., Tanaka, K., Saiki, I. & Kadota, S. 2000. Methyl<br />

quadrangularates A- D <strong>and</strong> related triterpenes from Combretum quadrangulare. Chem. Pharm.<br />

Bull. (Tokyo) 48(4): Pp.496–504.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 175–<br />

176.<br />

McGaw, L.J., Rabe, T., Sparg, S.G., Jager, A.K., Eloff, J.N. & van Staden, J. 2001. An<br />

investigation on the biological activity of Combretum species. J. Ethnopharmacol. 75(1): Pp.45–<br />

50.<br />

56


CAMBODIA<br />

1.0 Scientific Name : Coscinium usitatum Pierre<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Voa romiet thom; yellow vine (English)<br />

3.0 Plant Description<br />

Large climbing liana, often climbing on rocks or large trees up to 40 m high. The leaves are<br />

green, alternate <strong>and</strong> hairy underneath. The flowers are bright red <strong>and</strong> found in clusters. Incision<br />

of the trunk of the tree is bright yellow with a very bitter taste.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Native to Cambodia, it is distributed thoroughly Pursat, Siem Reap, Kampot <strong>and</strong> Koh Kong<br />

provinces.<br />

6.0 Chemical Constituents<br />

Alkaloids, mainly berberine<br />

7.0 Report on <strong>Medicinal</strong> Usage:<br />

7.1 Uses supported by experimental/clinical data:<br />

This plant reportedly contains analgesic <strong>and</strong> antipyretic properties. The antiinflammatory<br />

effect of berberine was confirmed through subcutaneous injection. Results showed a<br />

dose-dependant relationship against inflammation. Coscinium usitanum is also reputedly<br />

used as an antihypertensive agent in a dose-dependant manner. In Cambodia, the<br />

commercial extraction of berberine from C. usitanum is well documented, making the<br />

species rare.<br />

57


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

All parts can be used. The plant is used to stop dysentery by drinking the decoction<br />

obtained by boiling with water.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 180–<br />

181.<br />

Singh, G.B., Singh, S., Bani, S. & Malhotra, S. 1990. Hypotensive action of Coscinium<br />

fenestratum stem extracts. J. Ethnopharmacol. 30(2): Pp. 151–155.<br />

58


CAMBODIA<br />

1.0 Scientific Name : Curcuma zedoaria Rosc.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Bratiel preah a*kool, kranchura, kachura, shati, sati; round<br />

zedoary (English)<br />

3.0 Plant Description<br />

Herb, 1–2 m tall, with long sheathing leaves at the bottom, 30–60 cm long <strong>and</strong> 7–8 cm wide, red<br />

spotted along the median vein. The flowers are red or yellowish white, generally appearing<br />

before the leaves. The rhizomes are larger than C. longa <strong>and</strong> are yellow.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is cultivated in Cambodia as a decorative plant.<br />

6.0 Chemical Constituents<br />

Essential oils with cineol, borneol, d-camphor, camphene <strong>and</strong> d-á-pinene as the main constituents.<br />

A bitter soft resin, organic acids, gum, starch, sugar, curcumin arabins, albuminoids, crude fiber,<br />

curcumemone, curcumol, curdione<strong>and</strong> sesquiterpens are also present.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Rhizome <strong>and</strong> leaves<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The roots are useful for flatulence <strong>and</strong> dyspepsia. In cases of cold <strong>and</strong> fevers, treatment<br />

is given in a decoction together with long pepper, cinnamon, liquorice <strong>and</strong> honey or sugar<br />

c<strong>and</strong>y to relieve coughs <strong>and</strong> bronchitis. The pounded root is combined with alum <strong>and</strong> is<br />

applied to bruises. Fresh roots dispel leucorrhoeal <strong>and</strong> gonorrheal discharges. The dry<br />

root powdered <strong>and</strong> mixed with the powdered wood of Caesalpinia sappan makes the<br />

red powder called abir, which is mixed with water. For worms, the juice from the tubers<br />

is given to children. Curcuma zedoaria is used similarly as ginger to relieve indigestion,<br />

nausea <strong>and</strong> bloating <strong>and</strong> generally improves digestion. Studies have shown anticancer,<br />

antifungal <strong>and</strong> antiinflammatory activities in plant extracts. Dried grind bulb is used to<br />

increase human power <strong>and</strong> cure illness. It is boiled as tea or soaked in white wine before<br />

drinking or mixed with honey to make into tablets for swallowing.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Gupta, S.K., Banerjee, A.B. & Achari, B. 1976. Isolation of ethyl p-methoxycinnamate, the<br />

major antifungal principle of Curcuma zedoaria. Loydia. 39(4): Pp. 218–222.<br />

Jang, M.K., Sohn, D.H. & Ryu, J.H. 2001. A curcuminoide <strong>and</strong> sesquiterpenes as inhibitors of<br />

macrophage TNF-alpha release from Curcuma zedoaria. Planta. Med. 67(6): Pp. 550–552.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodi. Select Books Pte. Ltd., Australia. Pp. 195–<br />

196.<br />

Kim, K.I., Kim, J.W., Hong, B.S., Shin, D.H., Cho, H.Y., Kim, H.K. & Yang, H.C. 2000.<br />

Antitumor, genotoxicity <strong>and</strong> anticlastogenic activities of polysaccharide from Curcuma zedoaria.<br />

Mol. Cells. 10(4): Pp. 392–398.<br />

Latif, M.A., Morris, T.R., Miah, A.H., Hewitt, D. & Ford, J.E. 1979. Toxicity of shoti (Indian<br />

arrowroot: Curcuma zedoaria) for rats <strong>and</strong> chicks. Br. J. Nutr. 41(4):Pp.57–63.<br />

National Center of Traditional Medicine, 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

Syu, W.J., Shen, C.C., Don, M.J., Ou, J.C., Lee, G.H. & Sun, C.M. 1998. Cytotoxicity of<br />

curcuminoids <strong>and</strong> some novel compounds from Curcuma zedoaria. J. Nat. Prod. 61(12): Pp.<br />

1531–1534.<br />

Yoshioka, T., Fujii, E., Endo, M., Wada, K., Tokunaga, Y., Shiba, N., Hohsho, H., Shibuya, H. &<br />

Muraki, T. 1998. Anti-inflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene<br />

(Curcuma zedoaria). Inflamm. Res. 47(12): Pp. 476–481.<br />

60


CAMBODIA<br />

1.0 Scientific Name : Dracaena cambodiana Pierre ex Gagnep.<br />

Family : Dracaenaceae<br />

2.0 Vernacular Name : A*ree daek<br />

3.0 Plant Description<br />

Shrub, 2–3 m tall. The leaves are slender spikes radiating from a central axis with an aerial<br />

inflorescence. The fruits are red <strong>and</strong> round with one seed. It is cultivated mainly indoors for its<br />

leaves grouped in bundles; the staples of the mature leaves are used to weave hammocks.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Found in dense forests, especially in the mountain regions of Cambodia, mainly on Bokor mountain,<br />

especially on the calciferous rocks in Kampot province.<br />

6.0 Chemical Constituents<br />

1,2,4,5-tetrachloro-3,6-dimethoxy-benzene, docosyl acohol, octadecyl acetate, eicosyl acetate,<br />

resveratrol, 4-7-dihydroxy-flavone <strong>and</strong> saponins<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Stalks<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

In traditional Cambodian medicine, the stalks are cut, macerated in alcohol <strong>and</strong> used as<br />

blood purifier for arthritic <strong>and</strong> joint pains. The recommended dosage is an infusion of 8–<br />

12 grams of the bark taken up three times daily.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bruck, M. 1999. [Dragon’s blood (Dracaena species). A glance into the history of<br />

phamacognosy]. Bull. Soc. Sci. Med. Gr<strong>and</strong> Duche. Luxemb. 1: Pp. 96–101.<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 227 pp.<br />

Miller, L.R. & Murashige, T. 1976. Tissue culture propagation of tropical foliage plants (Dracaena<br />

cambodiana). In vitro 12(12): Pp. 797–813.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

Nong, X. 1997. [Hemostatic effect of Dracaena cochinensis (Lour.) S.C. Chen]. Zhongguo<br />

Zhong Yao Za Zhi 22(4): Pp. 240–243, 256.<br />

Okunji, C.O., Iwu, M.M., Jackson, J.E. & Tally, J.D. 1996. Biological activity of saponins from<br />

two Dracaena species. Adv. Exp. Med. Biol. 404: Pp.415–428.<br />

Tang. R., Wen, D., Wei, H. & Bi, N. 1995. [Constituents of the petroleum ether <strong>and</strong> ethyl<br />

acetate extract fractions from Dracaena cochinensis (Lour.) S.C. Chem]. Zhongguo Zhong<br />

Yao Za Zhi 20(7): Pp. 421–423, 448.<br />

Wei, H., Wen, D., Liu, X. & Tang, R. 1998. [Constituents in petroleum ether <strong>and</strong> ethyl acetate<br />

extract fractions of Dracaena cochinensis (Lour.) S.C. Chen.]. Zhongguo Zhong Yao Za<br />

Zhi 23(10): Pp. 616–618, 640.<br />

62


CAMBODIA<br />

1.0 Scientific Name : Eurycoma longifolia Jack<br />

Family : Simaroubaceae<br />

2.0 Vernacular Name : Antung sa; eurycoma (English)<br />

3.0 Plant Description<br />

A shrub, 2–5 meters tall unbranched, leaves up to 100 cm long, leaflets lanceolate to obovatelanceolate<br />

5–20 cm X 1.5–6 cm, flower bisexual or unisexual, fruits 10–17 mm X 5–12 mm.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

This shrub is common in understorey primary <strong>and</strong> secondary forests on a wide range of soils<br />

<strong>and</strong> locally abundant throughout tropical Southeast Asia.<br />

6.0 Chemical Constituent<br />

Eurycomanol, quassianoids, cytotoxic<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Bark, fruit, seed, root<br />

7.2 Uses in traditional medicine:<br />

In Cambodian traditional medicine, the barks are used to treat digestive troubles, the<br />

fruits are antidysenteric, ans the roots are used as antidote against drunkenness. The<br />

roots are used to increase human, power taken by boiling or soaking in white wine before<br />

drinking.<br />

63


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 422 pp.<br />

Locher, C.P., Burch, M.T., Mower, H.F., Berestecky, J., Davis, H., Van Poel, B., Lasure, A.,<br />

V<strong>and</strong>en Berghe, D.A. & Vlietinch, A.J. 1995. Anti-microbial activity <strong>and</strong> anti-complement activity<br />

of extracts obtained from selected Hawaiian medicinal plants (Psychotria reversii.). J.<br />

Ethnopharmacol. 49(1): Pp. 23–32.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

64


CAMBODIA<br />

1.0 Scientific Name : Hopea odorata Roxb.<br />

Family : Dipterocarpaceae<br />

2.0 Vernacular Name : Kokii<br />

3.0 Plant Description<br />

Tree, 20–35 m tall with small ovate leaves. The durable wood is much in dem<strong>and</strong> for the<br />

construction of ships <strong>and</strong> houses. It is used especially to make Cambodian pirogues.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Grows in dense forests <strong>and</strong> is often cultivated along the avenues in some major provinces in<br />

Cambodia. It is occasionally found around Buddhist monasteries, due to its large shading properties.<br />

6.0 Chemical Constituents<br />

Tannins <strong>and</strong> resins<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The bark, rich in tannins, is used to treat diarrhea. It may also replace areca nut in betel<br />

liquid. It forms part of a remedy in the treatment of inflamed gums <strong>and</strong> incontinence. In<br />

powdered form, it is a popular styptic. Bark is used for curing dysentery or held in the<br />

mouth to cure toothache.<br />

65


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 291–<br />

292.<br />

66


CAMBODIA<br />

1.0 Scientific Name : Hydnocarpus anthelminthicus Pierre ex Laness.<br />

Family : Flacourtiaceae<br />

2.0 Vernacular Names : Krabav plae thum, chaulmoogra tree<br />

3.0 Plant Description<br />

Tree, 7–30 m tall. The leaves are simple, alternate <strong>and</strong> oblong. The flowers, solitary or short<br />

inflorescence, are reddish purple. The edible fruits are globose berries with a thick pericarp<br />

covered with brownish hairs. The wood is yellow-reddish, resistant <strong>and</strong> not affected by insects.<br />

The oil expressed has been used for illumination <strong>and</strong> in the manufacture of soap. There are<br />

approximately 30–40 seeds in a pod.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Native to Cambodia, this tree grows in dense forest on s<strong>and</strong>y <strong>and</strong> rocky soils near water, especially<br />

in Kampot province.<br />

6.0 Chemical Constituents<br />

Cyclopentenylglycine, cyclopentenyl fatty acids <strong>and</strong> hydnocapric acid<br />

7.0 Report on <strong>Medicinal</strong> Usage:<br />

7.1 Uses supported by experimental/clinical data:<br />

The seeds yield an oil which is reputedly used in the treatment of leprosy, dermatitis <strong>and</strong><br />

tuberculosis. The bark is reportedly effective against incontinence <strong>and</strong> is also used as an<br />

antibacterial agent.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The oil is used in the treatment of rheumatism, sprains, bruises <strong>and</strong> chest complaints.<br />

Stem <strong>and</strong> bark are used to treat women after finishing their menstrual flow.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Desai, A.C. & Bhide, M.B. 1977. Hynocarpus oil as an antileprotic agent in footpad technique.<br />

Lepr. India 49(3): Pp. 154–158.<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 293–<br />

294.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

Oommen, S.t., Rao, M. & Raju, C.V. 1999. Effect of oil of hynocarpus on wound healing. Int.<br />

J. Other. Mycobact. 67(2): Pp. 154–158.<br />

Oommen, S.T. 2000. The effect of oil of hynocarpus on excision wounds. Int. J. Lepr. Other.<br />

Mycobact. 68(1): Pp. 69–70.<br />

Spener, F., Staba, E.J. & Mangold, H.K. 1974. Lipids in plant tissue cultures. II. Unusual fatty<br />

acids in lipids of Hydnocarpus anthelminthica. Chem. Phys. Lipids 12(4): Pp. 344–350.<br />

68


CAMBODIA<br />

1.0 Scientific Name : Melastoma sanguineum Pav. ex D. Don<br />

Family : Melastomaceae<br />

2.0 Vernacular Name : Riec dãas<br />

3.0 Plant Description<br />

Branchy shrub, 1–2 m tall. The leaves are hairy, oblong <strong>and</strong> alternate. The flowers are dark<br />

pink.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

It grows all over the country, especially on wastel<strong>and</strong>s.<br />

6.0 Chemical Constituents<br />

Unknown<br />

7.0 Report on <strong>Medicinal</strong> Usage:<br />

7.1 Uses supported by experimental/clinical data:<br />

Roots <strong>and</strong> leaves<br />

7.2 Uses in traditional medicine:<br />

In traditional Cambodian medicine, the roots are given as an infusion in cases of dizziness<br />

<strong>and</strong> vertigo. It is also a constituent of a remedy for the treatment of hepatic diseases such<br />

as jaundice. Another species, M. malabathricum L., has been used for indigestion <strong>and</strong><br />

nervous disorder <strong>and</strong> in hemorrhoids.<br />

69


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Alen, Y., Nakajima, S., Nitoda, T., Baba, N., Kanzaki, H. & Kawazu, K. 2000. Antinematodal<br />

activity of some tropical rainforest plants (Melastoma sanguineum) against the pinewood<br />

nematode, Bursaphelenchus xylophilus. Z. Naturforsch [C]. 55(3–4): Pp. 295–299.<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 342 pp.<br />

National Center of Traditional Medicine, 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

Sharma, H.K., Chhangte, L. & Dolui, A.K. 2001. Traditional medicinal plants (Melastoma<br />

sanguineum) in Mizoram, India. Fitoterapia 72(2): Pp. 146–161.<br />

70


CAMBODIA<br />

1.0 Scientific Name : Melodorum fruticosum Lour.<br />

Family : Annonaceae<br />

2.0 Vernacular Name : Rumduel<br />

3.0 Plant Description<br />

Tree, up to 8 m high. The leaves are simple, alternate, oblong-lanceolate, 2–3 cm wide <strong>and</strong> 7–15<br />

cm long. The flowers are solitary, axillary, pale yellow <strong>and</strong> fragrant. The fruits are aggregate<br />

<strong>and</strong> edible. The black berries when ripe, grow in bunches.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

This plant grows wild in dry regions or on top of hills, especially in Siem Reap province. The<br />

flowering season is around March to April.<br />

6.0 Chemical Constituents<br />

Essential oils <strong>and</strong> bioactive heptenes.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The dried flowers are considered a general tonic, particularly a cardiac tonic. It is also<br />

reputedly used to treat faintness. The stem is used to cure mothers after childbirth. It is<br />

taken by boiling or soaking in white wine before drinking.<br />

71


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 344–<br />

345.<br />

Jung, J.H., Chang, C.J., Smith, D.L., McLaughlin, J.L., Pummangura, S., Chaichantipyuth, C. &<br />

Patarapanich, C. 1991. Additional bioactive heptenes from Melodorum fruticosum. J. Nat.<br />

Prod. 54(2): Pp. 500–505.<br />

National Center of Traditional Medicine, 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

72


CAMBODIA<br />

1.0 Scientific Name : Phyllanthus emblica L.<br />

Family : Euphorbiaceae<br />

2.0 Vernacular Names : Kantuat prey, Indian gooseberry, emblic myrobalan (English)<br />

3.0 Plant Description<br />

Tree, 2–8 meters tall. The leaves are simple, alternate, oblong, 0.25–0.5 cm wide <strong>and</strong> 0.8–1.2<br />

cm long. The inflorescence is in fascicle with staminate clusters at base <strong>and</strong> pistillate flowers<br />

upwards. The acidic fruits, rich in vitamin C, are eaten either fresh or as a condiment. Eaten<br />

fresh, they have a sweet taste. The bark, leaves <strong>and</strong> fruits give a yellow dye.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This plant grows in the clear forests of Cambodia. It is found abundantly in Kompong Speu<br />

province <strong>and</strong> the southeastern province of Cambodia on the hillsides, especially in Mondol Kiri<br />

province.<br />

6.0 Chemical Constituents<br />

Polyphenols including gallic acid, phyllemblin, emblicol, chebulagic acid, emblican A <strong>and</strong> B <strong>and</strong><br />

querectin, organic acids, cytokinins, fatty acids, arachidic acid <strong>and</strong> behenic acid<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The leaves of P. emblica have inhibitory activity on polymorphonuclear neutrophils (PMN)<br />

<strong>and</strong> platelets, which supports the antiinflammatory <strong>and</strong> antipyretic properties of this plant.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The fresh fruit is used for inflammatory conditions of the pubic region, lungs <strong>and</strong> eyes. A<br />

paste of the fruit is reputedly effective when applied over the irritable bladder in urinary<br />

retention problem <strong>and</strong> to the forehead in cephalgia. The fruit possesses expectorant,<br />

diuretic, antidiarrhoeal, antipyretic, <strong>and</strong> antiscurvic activities. The fruit is also carminative<br />

<strong>and</strong> stomachic.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

B<strong>and</strong>yopadhyay, S.K., Pakrashi, S. & Pakrashi, A. 2000. The role of antioxidant activity of<br />

Phyllanthus emblica fruits on prevention from indomethecin induced gastric ulcer [short<br />

communication]. J. Ethnopharmacol. 70(2): Pp. 171–176.<br />

Ghosh, A., Sharma, A. & Talukder, G. 1992. Relative protection given by extract of Phyllanthus<br />

emlica fruit <strong>and</strong> a equivalent amount of vitamin C against a known clastogen-caesium chloride.<br />

Food. Chem. Toxicol. 30(10): Pp. 865–869.<br />

Ithantola Vormisto, A., Summanen, J., Kankaanranta, H., Vuorela, H., Asmawi, Z.M. & Moilanen,<br />

E. 1997. Anti-inflammatory activity of extracts from leaves of Phyllanthus emblica. Planta<br />

Med. 63(6): Pp. 518–524.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 400–<br />

401.<br />

74


CAMBODIA<br />

1.0 Scientific Name : Plumeria alba L.<br />

Family : Apocynaceae<br />

2.0 Vernacular Names : Champy saa, kshira, champaka, white frangipani<br />

3.0 Plant Description<br />

The white flowers form part of ritual offering to the deities; necklaces are sometimes made to<br />

decorate coffins. They are also edible, under the form of fritters.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Introduced into Cambodia, it is often cultivated as a decorative plant, especially around Buddhist<br />

monasteries.<br />

6.0 Chemical Constituents<br />

Alkaloids <strong>and</strong> glycosides<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Studies conducted have shown potential antiviral properties.<br />

7.2 Uses in traditional medicine:<br />

The heart of the wood is used as a vermifuge. The plant’s milky bark is applied as a<br />

plaster over hard tumours <strong>and</strong> used to dispel indolent swellings. Internally, the root <strong>and</strong><br />

bark are strong purgatives <strong>and</strong> used as laxatives. The stem, bark <strong>and</strong> flower are used to<br />

75


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

cure fever <strong>and</strong> to stop dysentery. It is boiled before drinking. Its resin mixed with coconut<br />

oil is used to cure wounds.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia, Phnom Penh, Cambodia. 286 pp.<br />

Hamburger, M.O., Cordell, G.A. & Ruangrungsi, N. 1991. Traditional medicinal plants of Thail<strong>and</strong>.<br />

XVII. Biological active constituents of Plumeria alba. J. Ethnopharmacol. 33(3): Pp. 289–<br />

292.<br />

National Center of Traditional Medicine. 1999. List of <strong>Medicinal</strong> <strong>Plants</strong> in Cambodia. Phnom<br />

Penh, Cambodia.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 413–<br />

414.<br />

Radford, D.J., Gillies, A.D., Hind, J.A. & Duffy, P. 1986. Naturally occurring cardiac glycosides<br />

(Plumeria alba). Med. J. Aust. 144(10):Pp. 540–544.<br />

Tan, G.T., Pezzuto, J.M., Kinghorn, A.D. & Hughes, S.H. 1991. Evaluation of natural products<br />

as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (Plumeria<br />

alba). J. Nat. Prod. 5491: Pp. 143–154.<br />

76


CAMBODIA<br />

1.0 Scientific Name : Syzygium jambos (L.) Alston<br />

Family : Myrtaceae<br />

2.0 Vernacular Names : Chumpuu saa, jambu; rose apple (English)<br />

3.0 Plant Description<br />

Small branchy tree, 6–15 m tall.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

This species is cultivated in Cambodia for its edible fruits. It is found most abundantly in K<strong>and</strong>al<br />

province, Phnom Penh.<br />

6.0 Chemical Constituents<br />

Phenolic glycosides <strong>and</strong> tannins.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Leaves <strong>and</strong> bark extracts of S. jambos showed antibacterial activities.<br />

7.2 Uses in traditional medicine:<br />

In Cambodian the juice yielded by macerating the leaves is reputedly antipyretic <strong>and</strong><br />

antimicrobial. The pulverized leaves are rubbed on the body in cases of smallpox.<br />

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8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Djipa, C.D., Delmee, M. & Quertin L. J. 2000. Antimicrobial activity of bark extracts of Syzygium<br />

jambos (L.). Alston (Mytraceae). J. Ethnophamacol. 71(1–2): Pp. 307–313.<br />

Dy Phon Pauline. 2000. <strong>Plants</strong> Used in Cambodia. Phnom Penh, Cambodia. 286 pp.<br />

Frame, A.D., Rios Olivares, E., De Jesus, L., Ortiz, D., Pagan, J. & Mendez, S. 1998. <strong>Plants</strong><br />

(Syzygium jambos) from Puerto Rico with anti-mycobacterium tuberculosis. P.R. Health.<br />

Sci. J. 17(3): Pp. 243–252.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 472 pp.<br />

Teixeira, C.C., Rava, C.A., Mallman da Silva, P., Melchior, R., Argenta, R., Anselmi, F., Almeida,<br />

C.R. & Fuch, F.D. 2000. Absence of antihyperglycemic effect of jambolan (Syzygium jambos)<br />

in experimental <strong>and</strong> clinical models. J. Ethnophamacol. 71(1-2): Pp.343–347.<br />

78


CAMBODIA<br />

1.0 Scientific Name : Terminalia chebula Retz.<br />

Family : Combretaceae<br />

2.0 Vernacular Names : Sraamaa, chebulic myrobolan<br />

3.0 Plant Description<br />

Tree with a grayish bark, 15–20 m tall. The leaves are simple, opposite or subopposite, elliptic,<br />

6–10 cm wide <strong>and</strong> 8–10 cm long. Inflorescence is axillary or terminal, raceme, bisexual with<br />

yellow flowers. Fruit fleshy, ovoid, 5-ribbed. The bitter black fruits are eaten raw with roasted<br />

fish. The fruits are 1–3 cm long. The wood is in much dem<strong>and</strong> for cabinetwork <strong>and</strong> construction.<br />

The bark produces a gum <strong>and</strong> tannins used to dye fishing nets.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This plant grows in the dense deciduous forests of Cambodia <strong>and</strong> is cultivated for its fruits.<br />

6.0 Chemical Constituents<br />

Triterpenoid glycosides including chebulosides I <strong>and</strong> II, argunin, arjunglucoside, 2a-hydroxyursolic<br />

acid <strong>and</strong> 2a-hydroxymicromiric acid, tannins chebulic acid, ellagic acid <strong>and</strong> gallic acid. Punicalin,<br />

terflavins A, B, C <strong>and</strong> D, maslinic acid, synergic acid, terchebulin I, ß- sitosterol, anthraquinones<br />

<strong>and</strong> fixed oils are also present.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The leaves are used against diarrhea in children. The dose of the dried powder of the fruit<br />

is 1–6 grams per day. The infusion, 56–112 ml, is taken daily.<br />

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7.2 Uses in traditional medicine:<br />

The tannin <strong>and</strong> anthraquinone constituents in the green fruits make the fruits both astringent<br />

<strong>and</strong> cathartic which are often used as laxative. They are also reputedly carminative,<br />

deobstruent, antibacterial, expectorant <strong>and</strong> a remedy for salivation <strong>and</strong> heartburn. The<br />

green fruits are also used as purgative. The dry green fruits are infused as tea to increase<br />

appetite.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Jagtap, A.G. & Karkera, S.G. 1999. Potential of the aqueous extract of Terminalia chebula as<br />

an anticaries agent. [Short communication]. J. Ethnopharmacol. 68(1-3): Pp.299–306.<br />

Joshi, A.R. & Joshi, K. 2000. Indigenous knowledge <strong>and</strong> uses of medicinal plants (Terminalia<br />

chbula) by local communities of the Kali G<strong>and</strong>aki Watershed Area, Nepal. J. Ethnopharmacol.<br />

73(1–2): Pp. 175–183.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. Pp. 485–<br />

486.<br />

80


CAMBODIA<br />

1.0 Scientific Name : Terminalia triptera Stapf.<br />

Family : Combretaceae<br />

2.0 Vernacular Name : Preah phnov<br />

3.0 Plant Description<br />

A large deciduous tree, up to 10–30 m in height. Bark grayish, with white <strong>and</strong> black speckles,<br />

many lenticels <strong>and</strong> spines. Leaves opposite or subopposite ovate or lanceolate, 5–12 cm long<br />

<strong>and</strong> 2–4 cm wide. Flowers abundant, minute, white-yellow, slightly fragrant, tetramerous. Fruit<br />

3 winged, wing thin, bright green, 2.5 cm long <strong>and</strong> 1.7–1.9 cm wide.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This plant grows wild in the dense forests, especially along the coastal provinces of Cambodia.<br />

6.0 Chemical Constituents<br />

Tannins, especially catchintannic acid <strong>and</strong> phlobaphene<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

During 1970, one of the manufacturers, Angkor Laboratories, produced an elixir of T.<br />

triptera phnov, which has a comparable effect to the elixir paregoriqe.<br />

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7.2 Uses in traditional medicine:<br />

The bark is used as astringent <strong>and</strong> may replace areca nut to chew betel. In traditional<br />

Cambodian medicine, the bark has reportedly been used as a decoction or infusion to<br />

treat dysentery. In combination with other ingredients, it is reputedly an effective remedy<br />

for diarrhea.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Fyhrquist, P., Mwasumbi, L., Haeggstrom, C.A., Vuorela, H., Hiltunen, R. & Vuorela, P. 2002.<br />

Ethnobotanical <strong>and</strong> antimicrobial investigation on some species of Terminalia <strong>and</strong> Combretum<br />

(Combretaceae) growing in Tanzania. J. Ethnopharmacol. 79(2): Pp.169–177.<br />

Kham, L. 2004. <strong>Medicinal</strong> <strong>Plants</strong> of Cambodia. Select Books Pte. Ltd., Australia. 487 pp.<br />

Munasinghe, J., T.C., Seneviratne, C.K., Thabrew, M.I. & Abeysekera, A.M. 2001. Antiradical<br />

<strong>and</strong> antilipoprotective effects of some plants extracts (Terminalia triptera) used by Sri Lankan<br />

tradition medical practitioners for cardioprotection. Phytother. Res. 15(6): Pp. 519–523.<br />

Saleem, A., Ahotupa, M. & Pihlaja, K. 2001. Total phenolic concentration <strong>and</strong> antioxidant potential<br />

of extracts of medicinal plants of Pakistan (Terminalia triptera). Z. Naturforsch. [C]. 56(11–<br />

12): Pp. 973–978.<br />

82


INDONESIA<br />

1.0 Scientific Name : Acorus calamus L.<br />

Family : Acoraceae<br />

2.0 Vernacular Names : Sweet flag, sweet root, calamus (English); dringo (general);<br />

daringo (Sundanese-Indonesia); dringo (Javanese-Indonesia);<br />

jerango (Sumatra-Indonesia)<br />

3.0 Plant Description<br />

A perennial glabrous herb up to 150 cm tall; rhizome creeping, extensively branched, up to 3 cm<br />

in diameter, pale yellowish to pinkish brown outside, whitish <strong>and</strong> sometimes slightly pinkish<br />

inside. Leaves erect, linear ensiform, with obliquely acuminate apex, distinct midrib <strong>and</strong> numerous<br />

parallel veins, glossy green, often reddish toward base <strong>and</strong> aromatic. Inflorescence arises from<br />

rhizome, erect, with a cylindrical straight or slightly curved spadix up to 10 cm long. Flowers<br />

densely arranged on a spadix, bisexual. Fruits a 2–3 celled berry, few seeded, reddish. Seeds<br />

ellipsoid.<br />

4.0 Propagation : Rhizome (vegetative part)<br />

5.0 Geographical Distribution/Ecology<br />

Sweet flag is probably native to China <strong>and</strong> India. In the Malesian region, it is considered<br />

naturalized, not truly wild. It is found in many parts of Indonesia, Malaysia, Papua New Guinea<br />

<strong>and</strong> locally in the Philippines, <strong>and</strong> outside Malesia in Indo-China <strong>and</strong> Thail<strong>and</strong>.<br />

6.0 Chemical Constituents<br />

The rhizome contains pale yellow to pale brown essential oil. Major chemical constituents are<br />

phenylpropanes, monoterpenes, <strong>and</strong> thermolabile sesquiterpenoids. The major volatile components<br />

in the oil include â-asarone, (cis-isoasarone), methyleugenol, cis-methylisoeugenol, geranylacetate,<br />

â-farnese, shyobunone, epishyobunone, isoshyobunone, calamusenone <strong>and</strong> acorenone.<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The rhizomes are usually used externally to treat inflammation, rheumatism, lumbago <strong>and</strong><br />

skin diseases <strong>and</strong> after child birth, are used as part of “jamu”. Also known to be antibacteria,<br />

analgesic, antidepressant, diuretic <strong>and</strong> antipyretic.<br />

8.0 Contraindication<br />

Not available<br />

9.0 Bibliography<br />

Darmawan, E., Maryanto & Katno. 2003. Aktivitas anti-inflamasi minyak atisir daun dringo<br />

(Acorus calamus L.) hasil budidaya basah dan hasil pengeringan pada tikus jantan putih.<br />

Prosiding Seminar Tumbuhan Obat Indonesia 23. Jakarta, 25–26 March 2003.<br />

Dharma, A.P. 1985. Tanaman Obat Tradisional Indonesia. PN Balai Pustaka, Jakarta. 291<br />

pp.<br />

Ika, Y.A. & Diniatik. 2003. Efek anti-depresi ekstrak methanol rimpang dringo (Acorus calamus<br />

L.) terhadap mencit (Mus muculus) galus Swiss dan uji fitokimianya. Prosiding Seminar<br />

Tumbuhan Obat Indonesia 23. Jakarta, 25–26 March 2003.<br />

Kloppenburg-Versteegh, J. 1983. Petunjuk Lengkap Mengenai Tanaman-Tanaman di<br />

Indonesia dan Khasiatnya Sebagai Obat-Obatan Tradisionil. Yayasan Dana Sejahtera<br />

dan CD R.S. Bethesda, Yogyakarta. 199 pp.<br />

Mardisiswoyo, M. & Rajakmangunsudarso, H. 1985. Cabe Puyang Warisan Nenek Moyang.<br />

PN Balai Pustaka, Jakarta. 129 pp.<br />

Nuratmi, B., Adjirni & Tri Wahyuni L. 2003. Efek anti-diare jus rimpang dringo (Acorus calamus<br />

L.) pada tikus putih. Prosiding Seminar Tumbuhan Obat Indonesia 23. Jakarta, 25–26<br />

March 2003.<br />

Rakhmawati, E., Widowati, L.E. & Teguh Setiawan, W. 2003. Uji efek dan potensi analgetik<br />

ekstrak air dringo (Acorus calamus L.) dengan metode induksi termal. Prosiding Seminar<br />

Tumbuhan Obat Indonesia 23. Jakarta, 25–26 March 2003.<br />

86


INDONESIA<br />

1.0 Scientific Name : Aloe vera (L.) Burm. f.<br />

Family : Liliaceae<br />

2.0 Vernacular Name : Lidah buaya (Malaysia, Indonesia)<br />

3.0 Plant Description<br />

Succulent shrubby perennial, often with very short stem <strong>and</strong> fleshy fibrous roots. Leaves arranged<br />

spirally in a rosette, sometimes distichous, linear to lanceolate or triangular, very thick <strong>and</strong> fleshy,<br />

sheathing at the base margins, entire; surface sometimes spiny, containing colourless sap.<br />

Inflorescence a pseudo-lateral, simple or branches, long-cylindrical raceme. Flowers bisexual,<br />

prot<strong>and</strong>rous, pedicillate; sepals usually connate into a tube, sometimes outer 3 free, fleshy, apices<br />

acute to obtuse; stamens 6, in two rows of three; ovary superior, 3-locular, style filiform, longer<br />

than stamens; stigma small. Fruit a loculicidal capsule, many seeded. Seeds elongate <strong>and</strong> ovoid,<br />

grey or black, arillate.<br />

4.0 Propagation<br />

It can be propagated vegetatively through sucker offsets or cutting, or by seed. Micropropagation<br />

through invitro culture of vegetative meristems as well as invitro regeneration of leaf base<br />

explants appears to be possible.<br />

5.0 Geographical Distribution/Ecology<br />

Approximately 330 species of Aloe vera originated from Africa, Madagascar <strong>and</strong> Arabia, <strong>and</strong><br />

over 100 species are cultivated. All Malaysian Aloe vera have been introduced <strong>and</strong> are popular<br />

garden <strong>and</strong> pot plants. Aloe vera was formerly produced in Barbados, where it had been introduced<br />

early in the 16th century. Nowadays, it is cultivated widely <strong>and</strong> commercially in Malaysia,<br />

Indonesia, Thail<strong>and</strong>, the United States, the Caribbeans, Australia, <strong>and</strong> other regions.<br />

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6.0 Chemical Constituents<br />

Aloe leaf juice contains a pyrone derivative (aloenine) <strong>and</strong> resins, free <strong>and</strong> 8-C-glucosylated-2-<br />

acetonyl-7-hydroxy-5-methylchromones. The aloe drug contains 15-40% aloe-emodin-athrone<br />

10-C-glucosides (hydroxy-anthraquinone derivatives) such as aloin, hydroxyaloins <strong>and</strong> aloinoside.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Aloe gel has proven effective in the treatment of skin burns by X-ray radiation.<br />

7.2 Uses in traditional medicine<br />

Aloe juice is used to make the laxative drug known as aloe, aloes or bitter aloes. Aloe gel,<br />

the mucigel from polyhedral cells is claimed to have healing properties. Aloe vera gel has<br />

gained popularity as a folk remedy worldwide.<br />

8.0 Contraindication<br />

Not available<br />

9.0 Bibliography<br />

Aguilar, N. O. & Brink, M. 1992. Aloe L. In De Padua, L. S., Bunyapraphatsara, N. <strong>and</strong><br />

Lemmens, R.H.M.J. (Eds). <strong>Medicinal</strong> <strong>and</strong> Poisonous <strong>Plants</strong> 1. Plant Resources of South-<br />

East Asia No. 12(1): PROSEA, Bogor, Indonesia.<br />

Grindlay, D. & Reynolds, T. 1986. The Aloe vera phenomenon: A review of the properties <strong>and</strong><br />

modern uses of the leaf parenchyma gel. J. of Ethnopharmacol. 16(2-3):117–151.<br />

Hodge, H. 1953. The drug aloes of commerce, with special reference to the Cape species.<br />

Economic Botany 7:99–129.<br />

88


INDONESIA<br />

1.0 Scientific Name : Arcangelisia flava Merr.<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Yellow fruited moonseed (English); akar kuning, tali kuning<br />

(general); ki koneng (Sundanese-Indonesia); sirawan (Javanese-<br />

Indonesia); daun bulan (Moluccas-Indonesia)<br />

3.0 Plant Description<br />

A large, woody, glabrous, dioecious liana up to 20 m long. Stem up to 5 cm in diameter; wood<br />

yellow, exuding yellow sap when cut. Leaves usually ovate, coriaceous palmately 5-veined at<br />

the base. Petioles swollen at both ends, stipulate absent. Inflorescence axillary or cauliflorous,<br />

paniculate, slender, 10–50 cm long; lateral branches spicate to subspicate. Flowers unisexual<br />

with 3–4 outer sepals <strong>and</strong> 6 large inner sepals; petals absent; male flower subsessile with a<br />

sessile globose cluster of 9–12 anthers; female flowers with 3 carples <strong>and</strong> a number of staminodes.<br />

Fruits are slightly laterally compressed; drupe transversely subovoid, 2–3 cm in diameter; yellow<br />

with a club-shaped stalk; endocarp woody, covered with a dense mat of radial fibres. Seeds<br />

broadly ellipsoidal with ruminate endosperm, cotyledons much folded.<br />

4.0 Propagation : Seed or stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Yellow fruited moonseed occurs up to 1000 m, in seaside, riverbanks, or in secondary forests.<br />

It is widely distributed from China, Indo-China, Thail<strong>and</strong>, Peninsular Malaysia, Sumatra, Java,<br />

Borneo, Sulawesi, Moluccas to the Philippines.<br />

6.0 Chemical Constituents<br />

Main stem contains alkaloids such as berberine, columbamine, jatrorrhizine, palmatine, shobakunine,<br />

dehydrocorydalmine, 8-hidroxyberberine, thalifendine, (-) RR limacine, (+) R,S homoaromaline<br />

<strong>and</strong> pycnarrhine. Seeds contain saponin.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses support by experimental /clinical data:<br />

Not available<br />

7.2 Uses described in traditional medicine:<br />

The stems are used to treat sprue, stomach problem <strong>and</strong> jaundice. In Sumatra, local<br />

people use the plant as aphrodisiac, <strong>and</strong> for treatment of rheumatism <strong>and</strong> broken bones.<br />

8.0 Contraindication<br />

Not available<br />

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9.0 Bibliography<br />

Departemen Kesehatan. 1999. Inventaris Tumbuhan Obat Indonesia (5). Badan Penelitian<br />

dan Pengembangan Kesehatan, Jakarta.<br />

Hernani. 2001. Akar kuning. In: Supriadi (ed.) Tumbuhan Obat Indonesia: Penggunaan<br />

dan Khasiatnya. Pustaka Populer Obor, Jakarta. Pp. 6–8.<br />

Kloppenburg-Versteegh. J. 1983. Petunjuk Lengkap Mengenai Tanaman-Tanaman di<br />

Indonesia dan Khasiatnya Sebagai Obat-Obatan Tradisionil. Yayasan Dana Sejahtera<br />

dan CD R.S. Bethesda, Yogyakarta. 199 pp.<br />

M<strong>and</strong>ia, E.H., Ridsdale, C.E., Horsten, S.F.A.J & Aguinaldo, A.M. 1999. Arcangelisia flava<br />

(L.) Merr. In: de Padua, L.S., N. Bunyapraphatsara <strong>and</strong> R.H.M.J Lemmens (Eds.) Plant<br />

Resources of Southeast Asia 12(1) <strong>Medicinal</strong> <strong>and</strong> Poisonous plants (1). Prosea, Bogor,<br />

Indonesia. Pp. 129–132.<br />

Mardisiswoyo, M. & Rajakmangunsudarso, H. 1985. Cabe Puyang Warisan Nenek Moyang.<br />

PN Balai Pustaka, Jakarta. 29 pp.<br />

90


INDONESIA<br />

1.0 Scientific Name : Centella asiatica L. Urb.<br />

Family : Apiaceae<br />

2.0 Vernacular Names : Daun kaki kuda, pegagan, antanan (Indonesia); pegaga<br />

(Malaysia), asiatic pennywort (English)<br />

3.0 Plant Description<br />

A small perennial herb, creeping with long stolons (up to 2.5 m long), rooting at the nodes, young<br />

parts more or less puberulous. Leaves in rosettes, simple, lamina orbicular-reniform, 1–7 cm in<br />

diameter; regularly crenate or crenate dentate, palmately veined, subglabrous; petiole 1–50 cm<br />

long, glabrous to puberulous, broadening at the base into a leaf-sheath; stipules absent.<br />

4.0 Propagation<br />

Can be easily propagated vegetatively by runners, which root on the nodes, although reproduction<br />

by seed is possible. It often regenerates from fragments of stems buried in the soil during<br />

hoeing.<br />

5.0 Geographical Distribution/Ecology<br />

Centella comprises approximately 40 species. Found abundantly in South Africa, C. asiatica is<br />

a pantropical <strong>and</strong> distributed in Southeast Asia <strong>and</strong> in some subtropical regions. Pegaga occurs<br />

in sunny or slightly shaded, fertile soils (preferring s<strong>and</strong>y loams with much organic matter) up to<br />

2,500 m above sea-level.<br />

6.0 Chemical Constituents<br />

Triterpenoid compounds, such as asiaticoside, madecasoside, asiatic acid <strong>and</strong> madecassic acid<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses support by experimental /clinical data:<br />

Not available<br />

7.2 Uses described in traditional medicine:<br />

Asiatic pennywort has been used for a wide range of complaints, but the most important<br />

use is in skin-related diseases. The leaf extract is used effectively in the treatment of<br />

keloids, leg ulcers, phlebitis, slow-healing wounds, scleroderma, lupus, leprosy, surgical<br />

lesions, striae distensae, cellulitis <strong>and</strong> aphthae. Purified extracts are known to accelerate<br />

cicatrizing <strong>and</strong> skin grafting. It has also been known as a medicinal plant with tonic <strong>and</strong><br />

cooling properties. Orally, the extract is indicated to relieve the symptoms of nervous <strong>and</strong><br />

lymphatic vessel insufficiency, <strong>and</strong> used to treat atonic wounds <strong>and</strong> for hypertrophy.<br />

Asiatic pennywort is a relished vegetable in many Southeast Asian countries. The slightly<br />

bitter leaves are eaten raw or cooked.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Buwalda, P. 1949. Umbelliferae. In van Steenis, C.G.G.J. (Eds): Flora Malesiana. Series 1<br />

Vol. 4. Noordhoff-Kolff N. V., Djakarta, Indonesia.<br />

Hargono, D. P., Lestari, Y., Astuti & van den Bergh M. H. 1999. Centella asiatica. (L.) Urb.<br />

In L. S. De Padua, N. Bunyapraphatsara <strong>and</strong> R.H.M.J. Lemmens (Eds). Plant Resources of<br />

South-East Asia No. 12(1): <strong>Medicinal</strong> <strong>and</strong> Poisonous <strong>Plants</strong> 1. PROSEA, Bogor, Indonesia.<br />

92


INDONESIA<br />

1.0 Scientific Name : Curcuma mangga Valeton & Zijp<br />

Family : Zingiberaceae<br />

2.0 Vernacular Name : Temu mangga (Indonesia, Malaysia)<br />

3.0 Plant Description<br />

A herb with branched rhizome, yellowish outside, top white inside lemon-coloured to sulphuryellow<br />

with a white outer layer. Leaf-sheaths 30–65 cm long; blades elliptical-oblong to oblongoblanceolate,<br />

15–95 cm x 5–23 cm, green; inflorescence on a separate shoot; bract green, coma<br />

bracts white at base, purple toward the top; corolla 3–4 cm long, white; labellum 15–25 mm x<br />

14–18 mm; white with a yellow median b<strong>and</strong>; other staminodes longitudinally folded, white;<br />

anther with long, narrow spurs.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Southeast Asia, cultivated in Indonesia <strong>and</strong> Malaysia<br />

6.0 Chemical Constituents<br />

Not available<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses support by experimental/clinical data:<br />

Not available<br />

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7.2 Uses described in traditional medicine:<br />

The rhizomes are used to treat fever <strong>and</strong> chewed by women to strengthen the womb<br />

after childbirth. The starch of the rhizome is recommended by traditional healers to treat<br />

abdominal illness. Curcuma mangga is also edible.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill, I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry<br />

of Agriculture <strong>and</strong> Cooperatives, Kuala Lumpur, Malaysia.<br />

Sara, N. & R.H.M.J. Lemmens (Eds.). 1994. <strong>Medicinal</strong> <strong>and</strong> Poisonous <strong>Plants</strong> 1. Plant<br />

Resources of Southeast Asia 12(1): PROSEA Bogor, Indonesia.<br />

Valeton, T. 1918. New notes on the Zingiberaceae of Java <strong>and</strong> Malayan Archipelago. Bulletin<br />

du Jardin Botanique de Buitezorg. 27:57–61.<br />

94


INDONESIA<br />

1.0 Scientific Name : Curcuma zedoaria Rosc.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Temu putih (general); koneng tegal (Sundanese-Indonesia)<br />

3.0 Plant Description<br />

A herb with branched rhizome, outside grey, inside pale yellowish to bright yellow; leaf-sheaths<br />

35–60 cm long; blades oblong to oblong lanceolate, 25–75 cm x 7–20 cm, green with a purple<br />

b<strong>and</strong> along the midrib; bract green or green with a purple margin, some bracts purple or dark<br />

pink; corolla 3.5–4.5 cm long, yellowish-white with a darker yellow median b<strong>and</strong>; other stamidones<br />

longitudinally folded, yellowish-white; anthers with long spurs.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Temu putih is found in various shady, damp localities on various soils but prefers well-drained<br />

s<strong>and</strong>y soils, up to 1,000 m above sea level. It is widely distributed in South Asia, Southeast Asia<br />

to China <strong>and</strong> Taiwan.<br />

6.0 Chemical Constituents<br />

Rhizome of C. zedoaria contains essential oil with cineol, borneol, d-camphor, camphene, <strong>and</strong><br />

d-á-pinene.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Water extract inhibits the growth of mouse L5178Y leukaemia cells in a dose dependantmanner.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicines:<br />

Uses described in folk medicine are not supported by experimental or clinical data: The<br />

plant is believed to repair blood circulation,act as stimulant, stomachic, increase appetite,<br />

<strong>and</strong> to be anticancer, diuretic, carminative, antidiarrhoeal, antiemetic antipyretic <strong>and</strong><br />

depurative.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Darwis, S.N., Indo, M. & Hasiyah, S. 1992. Tumbuhan obat famili Zingiberaceae. Seri<br />

Pengembangan Tanaman Perkebunan, No. 17. Puslitbangtri, Bogor.<br />

Hadad, E.A. & Noviyanti, R. 2001. Temuputih (Curcuma zedoaria). In: Supriadi (Ed.)<br />

Tumbuhan Obat Indonesia: Penggunaan dan Khasiatnya. Pustaka Populer Obor, Jakarta.<br />

Hutapea, J.R. 1993. Inventaris Tumbuhan Obat Indonesia (2). Departemen Kesehatan,<br />

Jakarta.<br />

Kardinan, A. & Taryono. Tanaman Obat Penggempur Kanker. Agromedika Pustaka,<br />

Jakarta.<br />

Kloppenburg-Versteegh, J. 1983. Petunjuk Lengkap Mengenai Tanaman-Tanaman di<br />

Indonesia dan Khasiatnya sebagai Obat-Obatan Tradisionil. Yayasan Dana Sejahtera<br />

dan CD R.S Bethesda, Yogyakarta. 199 pp.<br />

Makhmud, A.I. & Tobo, F. 2002. Isolasi dan karakterisasi komponen kimia ekstrak rimpang<br />

temu putih (Curcuma zedoaria). Prosiding Seminar Tumbuhan Obat Indonesia 21.<br />

Surabaya, March 2002.<br />

Nuratmi, B., Nugrobo, Y.A. & Sundari, D. 2002. Efek antidiare jus temu putih dan temu<br />

mangga pada tikus putih. Prosiding Seminar Tumbuhan Obat Indonesia 21. Surabaya,<br />

March 2002.<br />

Sunardi. 2002. Studi aktivitas anti mikroba minyak atsiri dari rimpang Kaempferia rotunda,<br />

Curcum zedoaria dan Curcuma mangga. Prosiding Seminar Tumbuhan Obat Indonesia<br />

21. Surabaya, March 2002.<br />

Wardini, T.H. & Prakoso, B. 1999. Curcuma zedoaria (Christm.) Roscoe. In: de Padua, L.S.,<br />

N. Bunyapraphatsara <strong>and</strong> R.H.M.J Lemmens (Eds.) Plant Resources of Southeast Asia<br />

12(1) <strong>Medicinal</strong> <strong>and</strong> Poisonous plants (1). Pp. 218–219. Prosea, Bogor, Indonesia.<br />

96


INDONESIA<br />

1.0 Scientific Name : Justicia gendarussa Burm.f.<br />

Family : Acanthaceae<br />

2.0 Vernacular Names : G<strong>and</strong>arusa (general); besi-besi (Aceh), kawo (Seram)<br />

3.0 Plant Description<br />

Shrub up to 150 cm tall; young twig usually dark purple; leaves linear lanceolate, 5–20 cm x 1–<br />

3.5 cm, with up to 1 cm petiole; inflorescence a spike, bracts lanceolate, about 4 mm long;<br />

flowers 1.5–2 cm long, white with purplish streaks <strong>and</strong> spots inside. Fruit clavate to ellipsoid,<br />

about 1.3 cm long, glabrous.<br />

4.0 Propagation : Seed <strong>and</strong> cutting<br />

5.0 Geographical Distribution/Ecology<br />

Pakistan, India, Sri Lanka, Indo-China, Thail<strong>and</strong>, Peninsular Malaya, Jawa, the Moluccas <strong>and</strong><br />

the Philippines. It is naturally found in forests, forest borders <strong>and</strong> on river banks in Java, up to<br />

1,500 m altitude.<br />

6.0 Chemical Constituents<br />

The leaves contain four simple o-disubstitute aromatic amines: 2-amino benzyl alcohol, 2-(2’amino<br />

berzylamino) benzyl alcohol <strong>and</strong> their respective O-methyl esters, also â-sitosterol.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

The leaves are used to treat headache, rheumatism <strong>and</strong> pain.<br />

8.0 Contraindication<br />

Not available<br />

9.0 Bibliography<br />

Kloppenburg-Versteegh, J. 1983. Petunjuk Lengkap Mengenai Tanaman-Tanaman di<br />

Indonesia dan Khasiatnya sebagai Obat-Obatan Tradisionil. Yayasan Dana Sejahtera<br />

dan CD R.S.Bethesda, Yogyakarta. 199 pp.<br />

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Sangat-Roemantyo, H. 1999. Justica gendarussa. In: de Padua, L.S., N. Bunyapraphatsara<br />

<strong>and</strong> R.H.M.J Lemmens (Eds.) Plant Resources of Southeast Asia 12(1) <strong>Medicinal</strong> <strong>and</strong><br />

Poisonous <strong>Plants</strong> (1). Prosea, Bogor, Indonesia.<br />

Wijayakusuma, H., Wirian, A.S., Yaputra, T., Dalimartha, S. & Wibowo, B. 1996. Tanaman<br />

berkhasiat obat di Indonesia. Fifth edition. Pustaka Kartini, B<strong>and</strong>ung. 44 pp.<br />

98


INDONESIA<br />

1.0 Scientific Name : Morinda citrifolia L.<br />

Family : Rubiaceae<br />

2.0 Vernacular Names : Mengkudu (Malaysia); pace (Javanese-Indonesia), cengkudu<br />

(Sundanese-Indonesia)<br />

3.0 Plant Description<br />

Morinda citrifolia grows to 5 m in height, with a short trunk <strong>and</strong> a head ovoid in outline; it bears<br />

ellipsoid fruits of a greyish transparent white, in appearance anything but appetizing, <strong>and</strong> in<br />

flavour as of soap <strong>and</strong> sugar mixed, with a smell like decaying cheese. Apparently in Indo-China<br />

it is eaten with salt. It is common in gardens throughout Indonesia <strong>and</strong> Malaysia.<br />

4.0 Propagation : Morinda.citrifolia can be propagated by seed. It grows well<br />

in well-tilled soil.<br />

5.0 Geographical Distribution/Ecology<br />

Morinda citrifolia is a native of Queensl<strong>and</strong> (Australia). It may have been distributed by man<br />

<strong>and</strong> carried westwards into the Indian Ocean by sea currents, reaching the Pacific between<br />

30ºN <strong>and</strong> 30ºS altitude, into the Marquesas, Hawaii <strong>and</strong> Easter Isl<strong>and</strong>s. It is present through<br />

Southeast Asia both wild <strong>and</strong> cultivated. It often occurs wild in coastal zones. It is naturalized in<br />

the Caribbean region <strong>and</strong> cultivated in villages throughout Southeast Asia <strong>and</strong> Malaysia. Mengkudu<br />

is commonly found up to altitude of 1,500 m in humid <strong>and</strong> seasonal climates of the region.<br />

6.0 Chemical Constituents<br />

The basis of the morindone dyeing matter, called Turkish red, is the hydrolyzed (red) form of the<br />

glycoside morindine. This is the most abundant anthraquinone which is mainly found in the root<br />

bark which reaches a concentration of 0.25–0.5% in fresh bark in 3–5 years. It is similar to that<br />

found in Rubia tinctorum <strong>and</strong> to synthetic alizarin. The curative properties of the plant parts<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

are ascribed to the presence of medicinally active anthraquinone derivatives. The fruit contains<br />

rancid smelling capric acid <strong>and</strong> unpleasant tasting caprilic acid. It is though that antibiotically<br />

active compounds are present. The leaves are a rich source of vitamin A.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

The overripe fruit is stated to be used as an emmenagogue both in Indonesia, Malaysia,<br />

<strong>and</strong> in Indo-China. In the Medical Book of Malayan Medicine, the juice is recommended<br />

for leucorrhea <strong>and</strong> sapraemia. It is also recommended by the Rumpt for dysuria <strong>and</strong> the<br />

fruit for diabetes. The fruit is sometimes used internally in various preparations for swollen<br />

spleen, liver disease, beri-beri, haemorrhage <strong>and</strong> coughs. It is also reported that in Java<br />

the ripe fruits are taken <strong>and</strong> their seeds removed, the pulp mashed with sugar <strong>and</strong> drunk,<br />

as a slightly laxative preparation.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Abbot, I. A. & Shimazu, C. 1985. The geographic origin of plants most commonly used for<br />

medicine by Hawaiians. Journal of Ethnopharmacology. 14(2/3):213–222.<br />

Groenendijk, J. J. 1992. Morinda citrifolia L. Pp. 94–96 in: Plant Resources of Southeast<br />

Asia 3: Dye <strong>and</strong> Tannin-producing <strong>Plants</strong>. PROSEA Foundation, Bogor, Indonesia.<br />

Hidayat, E. Morinda citrifolia L. <strong>and</strong> its special use as a traditional drug. Bulletin Kebun<br />

Raya. 3(4):141–144.<br />

100


INDONESIA<br />

1.0 Scientific Name : Orthosiphon aristatus (Blume) Miq.<br />

Family : Lamiaceae<br />

2.0 Vernacular Names : Java tea (English); kumis kucing (general); kumis kucing<br />

(Sundanese-Indonesia), remuk jung (Javanese-Indonesia)<br />

3.0 Plant Description<br />

A perennial herb, up to 2 m tall with quadrangular, poorly ramified ascending stem. Leaves<br />

decussately opposite, ovate or rhombic cuneate at base acute or acuminate at apex; serrate<br />

glabrous or minutely pubescens, gr<strong>and</strong>ular punctuate petiole 0.5–2 (–4.5) cm long. Flowers<br />

pedicellate calyx 2.5–4.5 mm long, bilabiate, gl<strong>and</strong>-dotted; corolla 10–20 mm long, tubular, bilabiate,<br />

white or pale lilac; stamens 4, long-protruding from the corolla tube; ovary superior, style long<br />

protruding, slender, with enlarged, club-shaped <strong>and</strong> shallowly cleft stigma. Fruits splitting into 4<br />

oblong-ovoid nutlets, 1.5–2 mm long, brownish, rugose.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Java tea is distributed in India, Indo-China, Thail<strong>and</strong>, through Malaysia, Indonesia to Australia.<br />

It is grown in Southeast Asia, Africa, Georgia (Caucasus) <strong>and</strong> Cuba. In Indonesia it grows at<br />

100–1,200 m.<br />

6.0 Chemical Constituents<br />

Sinensetin, flavonol glycosides, caffeic acid derivatives (mainly rosmarinic acid <strong>and</strong> 2,3 dicaffeoyltartaric<br />

acid), inositol, phytosterols (â-sitosterol), saponins <strong>and</strong> about 0.7% essential oil<br />

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7.0 Reports on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

The leaves are used as diuretic <strong>and</strong> against various kidney complaints <strong>and</strong> illnesses, renal<br />

calculi, phosphaturic catarrh of the bladder, <strong>and</strong> gout. They are used in combination with<br />

other plant species (Sonchus <strong>and</strong> Sericoccalyx spp.) to stimulate the kidney <strong>and</strong> as a<br />

medicine for kidney stones.<br />

8.0 Contraindication<br />

Not available<br />

9.0 Bibliography<br />

Dharma, A.P. 1985. Tanaman Obat Tradisional Indonesia. PN Balai Pustaka, Jakarta. 291<br />

pp.<br />

Dzulkarnae, B., Widowati, L., Isnawati, A. & Thijssen, H.J.C. 1999. Orthosiphon aristatus<br />

(Blume) Miq. In: de Padua, L.S., N. Bunyapraphatsara <strong>and</strong> R.H.M.J Lemmens (Eds.) Plant<br />

Resources of Southeast Asia. 12(1) <strong>Medicinal</strong> <strong>and</strong> Poisonous plants (1). Pp. 368–371.<br />

Prosea, Bogor, Indonesia.<br />

Kloppenburg-Versteegh, J. 1983. Petunjuk lengkap mengenai tanaman-tanaman di<br />

Indonesia dan khasiatnya sebagai obat-obatan tradisionil. Yayasan Dana Sejahtera dan<br />

CD R.S.Bethesda, Yogyakarta. 199 pp.<br />

Mardisiswoyo, M. & Rajakmangunsudarso, H. 1985. Cabe Puyang Warisan Nenek Moyang.<br />

PN Balai Pustaka, Jakarta. 129 pp.<br />

Wijayakusuma, H., Wirian, A.S., Yaputra, T., Dalimartha, S. & Wibowo. B. 1992. Tanaman<br />

berkhasiat obat di Indonesia. Fifth edition. Pustaka Kartini, B<strong>and</strong>ung. 44 pp.<br />

102


INDONESIA<br />

1.0 Scientific Name : Sauropus <strong>and</strong>rogynus (L.) Merrill<br />

Family : Euphorbiaceae<br />

2.0 Vernacular Names : Daun katuk (Indonesia); cekur manis (Malaysia)<br />

3.0 Plant Description<br />

An erect, glabrous, perennial, monoecious shrub which can reach a height of 3.5 m, but is kept<br />

much lower in cultivation. Branches terete <strong>and</strong> flaccid, lateral ones at first tetragonous; with<br />

many small short-period leaves <strong>and</strong> persistent stipules. Leaves buseriate, alternate, oblong to<br />

orbicular, 1–7.5 cm x 1–3 cm, entire, glaucous, above dark green. Often with vague greyish<br />

spots, beneath light green. Inflorescence dense, <strong>and</strong> in branches, axillary, first producing one or<br />

a few female flowers, afterwards several male ones; flowers without corolla, but with more or<br />

less intensely red-coloured persistent calyx; calyx of the male flower disciform, 6–20 mm in<br />

diameter; stamens 3, connate; calyx of the female flower 6-cleft more than halfway down, lobe<br />

6–8 mm broad; stigma 3-branched, red, each branch bilobed. Fruit a globose to faintly 6-angular<br />

capsule, about 1.5 cm in diameter, white or purplish, dehiscing with 3 valves.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

The exact origin of Sauropus <strong>and</strong>rogynus is unknown, but it occurs in Sri Lanka <strong>and</strong> India to<br />

southern China in Indo-China <strong>and</strong> throughout Southeast Asia, mainly cultivated, but also found<br />

wild. In Indonesia <strong>and</strong> Malaysia, Sauropus <strong>and</strong>rogynus is cultivated from sea-level up to 1300<br />

m altitude, but it is most abundant at low elevation.<br />

6.0 Chemical Constituents<br />

Sauropus <strong>and</strong>rogynus is a very nutritious vegetable with a higher protein content than most<br />

other leafy vegetables. Per 100 g edible leaf portion, it contains: water 79.8 g, protein 7.6 g, fat<br />

103


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.8 g, carbohydrates 6.9 g, fibre 1.9 g, vitamin A 10000 IU, vitamin B1 0.23 mg, vitamin B2 0.15<br />

mg, vitamin C 136 mg, Ca 234 mg, P 64 mg, <strong>and</strong> Fe 3.1 mg.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

Sauropus <strong>and</strong>rogynus is claimed to stimulate breast milk production. In Indonesia,<br />

especially in Java, the young leaves with the flowers or fruits are consumed raw as well<br />

as cooked.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Martin, F. W. & Ruberte, R. M. 1975. Edible Leaves of the Tropics. Antillian College<br />

Press, Mayaguez, Puerto Rico, United States. Pp. 35–37.<br />

Ochse, J. J. & Van Den Brink, R. C. B. 1980. Vegetables of the Dutch East Indies. 3rd<br />

English Edition. Asher <strong>and</strong> Co., Amsterdam. The Netherl<strong>and</strong>s. Pp. 290–292.<br />

Van Den Bergh, M. H. 1994. Souropus <strong>and</strong>rogynus (L.) Merriill. In Siemonsma J. S. <strong>and</strong><br />

Piluek, K. (Eds). Plant Resources of South-East Asia No. 8: Vegetables. PROSEA<br />

Foundation, Bogor, Indonesia. Pp. 244–246.<br />

104


LAO PDR<br />

1.0 Scientific Name : Aegle marmelos (L.) Corrêa ex Roxb.<br />

Family : Rutaceae<br />

2.0 Vernacular Names : Bael tree, bel-fruit tree, Bengal quince, bilak, golden apple, Holy<br />

fruit, stone apple (English); marmelos de Bengal (French); bael,<br />

bel, sirphal (Hindu); phneau, pha-nong (Cambodia); mark toom<br />

(Lao PDR); kawista, maja, maja batu, maja gedang, maja ingus,<br />

maja kalepung, maja lumut, maja pait (Java-Indonesia); bila,<br />

bilak, bel (Malaysia); bilvam, sriphala (Sanskrit); kathan ta then,<br />

mapin, matum, tum (Thail<strong>and</strong>); trái m1m (Viet Nam)<br />

3.0 Plant Description<br />

Bael tree is a small to moderate-sized tree, bark darkish grey, slightly corky, twigs having strong<br />

axillary thorn. Leaves alternate, 3-foliate. Flowers white, sweet scented. Fruit globose, yellowish<br />

grey, shell woody. Seeds numerous, oblong, compressed, with a wooly mucous testa, embedded<br />

in a clear mucilage <strong>and</strong> a mass of yellow sweet <strong>and</strong> agreeable aromatic mealy pulp.<br />

4.0 Propagation : Seed (vegetative part)<br />

5.0 Geographical Distribution/Ecology<br />

Globally, A. marmelos is distributed in the Indo-Malaysian region. It grows sparsely in<br />

dipterocarpous forest in Lao PDR. It is also planted for its fruit for making drink.<br />

6.0 Chemical Constituents<br />

The fruit pulp possesses sugars <strong>and</strong> tannins. The seeds contain bitter oil. Marmolosine,<br />

cloramarmine <strong>and</strong> aegline are 7-Geranyloxy coumarine derivatives, <strong>and</strong> many lignane glycosides<br />

are isolated from the stem bark. Anthraquinone derivatives are also reported. The leaf contains<br />

contains essential oil having antifungal effect.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Lao indigenous medicine broadly uses different parts of A. marmelos for completing<br />

many traditional remedies. The ripe fruits are raw material for making normal tea; the tea<br />

has a delicious taste <strong>and</strong> an agreeable odour.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Krup, P. N. V. 1977. H<strong>and</strong> Book of <strong>Medicinal</strong> <strong>Plants</strong>, Vol. 1. Research in Indian Medicine<br />

<strong>and</strong> Homoeopathy, New Delhi.<br />

Nang Sothy, Vu Ngoc Lo, Nguyen Xuan Dung, Nguyen Thanh Do. 1989. These de Doctorat<br />

en Pharmacie, Contribution a L’etude des Plantes <strong>Medicinal</strong>es du Kampuchea, Avec<br />

Etude Chimique de Huit Plantes a Huiles Essentielles. Phaculte de Pharmacie de Ha<br />

Noi, Ha Noi.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR,<br />

Tame XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

108


LAO PDR<br />

1.0 Scientific Name : Alstonia scholaris (L.) R. Br.<br />

Family : Apocynaceae<br />

2.0 Vernacular Names : Tinpet (Lao PDR); pulai (Malaysia)<br />

3.0 Plant Description<br />

Big evergreen tree about 10–20 m high with whorled branching. Bark thick, lenticellate, much<br />

fluted, greyish brown. Leaves ablong, rounded at the apex, 5–8 verticillate, but usually crowded<br />

at the end of branches, 8–15 long, 2.5–4.5 cm wide, shining dark green above, glaucous beneath,<br />

secondary nerves parallel. Flowering period, September–October. Fruiting period, November–<br />

March.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is widely found in the tropical regions of Asia. In Lao PDR, the plant is found in most<br />

parts of the country including the city.<br />

6.0 Chemical Constituents<br />

The bark contains ditaine, echitenine, echitamine (ditamine) <strong>and</strong> echitamidine.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

109


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine<br />

In Lao PDR, the plant in the form of decoction <strong>and</strong> elixir is used to treat fever, coughs,<br />

diarrhea <strong>and</strong> dysentery. The bark is used to treat diabetes, stomach-ache, coughs, malaria<br />

<strong>and</strong> cold. The leaves are used in treating cold, diarrhea <strong>and</strong> consumed as tonic.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bounhong Southavong et. al. 1993. The Medicines in Your Garden. Volume I. Research<br />

Institute of <strong>Medicinal</strong> <strong>Plants</strong>, Ministry of Public Health, Vientiane.<br />

Nanthavanh Bounyapraphat et al. <strong>Medicinal</strong> <strong>Plants</strong> of Thail<strong>and</strong>. Volume 2, Pp. 243, 2542.<br />

National Institute of Materia Medica, 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in Viet Nam. Volume<br />

1. Science <strong>and</strong> Technology Publishing House, Ha Noi.<br />

Vasilalangsy, Chalune et al. 1985. Recipe of Traditional Medicine in Lao PDR. State Council<br />

of Science <strong>and</strong> Technology, Vientiane.<br />

Vidal, J. 1963. Premiere Partie Noms Vernaculaires – Noms Scientifique en Usage au<br />

Lao PDR.<br />

110


LAO PDR<br />

1.0 Scientific Name : Asparagus cochinchinensis Merr.<br />

Family : Asparagaceae<br />

2.0 Vernacular Names : Cochinchinese asparagus; shiny asparagus (English), moeum<br />

sam seb (Cambodia), cheon-moon-dong (Korea), phark xee<br />

xang, ya nang xang (Lao PDR); thiên môn, tiên môn dông, tóc<br />

tiên leo (Viet Nam)<br />

3.0 Plant Description<br />

Perennial sc<strong>and</strong>ent shrub with tuberous roots. Stems glabrous, spinous. Branchlets reduced to<br />

leaves (cladophyllus), falciform, angular. Flowers white, small, arising in the leaf-axils. Berry<br />

globose, pale green at first, finally white. Seeds black.<br />

4.0 Propagation : Seed (vegetative part)<br />

5.0 Geographical Distribution/Ecology<br />

It grows wild among shrubs. In Lao PDR, it is found in Saravane province.<br />

6.0 Chemical Constituents<br />

The root contains asparagine, spirostanol saponin: asparacochinchinenside A; spirosteroids:<br />

asparacochinchinensins A <strong>and</strong> B, phenolic compounds: 3'-methoxy-asparenydiol <strong>and</strong> 3'-methoxynyasol,<br />

polysaccharide, methyl-protogracillin.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The roots are used for fever in the form of decoction.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

National Institute of Materia Medica, Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR,<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

112


LAO PDR<br />

1.0 Scientific Name : Caesalpinia sappan L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Farng daeng (Lao PDR); sapan wood, bukkum wood,<br />

brasil-wood (English)<br />

3.0 Plant Description<br />

There are 373 species belonging to the Caesalpinia genus; 4 species have been found in Lao<br />

PDR. Caesalpinia sappan, small tree, 5–10 m in height; stem bark prickly; young shoots<br />

tomentose; leaves pinate, leaflets glabrous, above, tomentose beneath. Inflorescence in terminal<br />

raceme; corolla 5-lobed, yellow; stamens 10; filaments tomentose at lower part. Pod ovoid,<br />

compressed with hard shell <strong>and</strong> sharp horn. Seeds 3-4, yellowish brown.<br />

4.0 Propagation : Not available<br />

5.0 Geographical Distribution/Ecology<br />

Caesalpinia sappan grows in many mountainous provinces in the northern part of Lao PDR,<br />

especially in Luang Prabang province, at the altitude of at least 800 ft. It has been found in lowl<strong>and</strong><br />

area.<br />

6.0 Chemical Constituents<br />

The lignin of old plants consists of phenolic compounds. The most important active compounds<br />

are brasilin <strong>and</strong> sappanin. An essential oil (D-a-phell<strong>and</strong>rene, ocimene), gallic acid <strong>and</strong> saponosides<br />

are also present in this species.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

SAPPANIN<br />

BRASILIN<br />

7.0 Reports on medicinal usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The hardwood of C. sappan possesses antibacterial activities. It is used for treating<br />

many intestinal-related diseases caused by various bacteria such as Shigella dysenteriae,<br />

S. flexneri, Bacillus subtilis <strong>and</strong> Escherichia coli etc. It also shows haemeostatic <strong>and</strong><br />

demulcent properties.<br />

7.2 Uses in traditional medicine:<br />

Sappan wood is indicated for the treatment of diarrhoea, type of bacillary dysenteria,<br />

colic <strong>and</strong> hemorrhoides with a dose of 8–16 g per day. Recently, the Pharmaceutical<br />

Development Center (PDC) Ministry of Health of Lao PDR, produced 0.5 g tablets from<br />

the dry extract of sappan wood under the trade name Tanin. This tablet is used for the<br />

treatment of acute dysentery <strong>and</strong> diarrhoea.<br />

It is orally administrated for adults at a dose of two tablets per time, thrice a day.<br />

The decoction of sappan wood is used in post-partum, contusions, <strong>and</strong> blood stasis caused<br />

by trauma. It is also used for ameliorating blood flow <strong>and</strong> eliminating high blood pressure.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Index Kewensis, Kew Garden, London.<br />

Jeffrey, B. H. et al. 1993. Phytochemical Dictionary. Taylor & Francis, London. Pp. 542.<br />

National Institute of Materia Medica Ha Noi, Viet Nam. 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi. Pp. 151–158.<br />

Vidal, J. 1959. Noms Vernaculaires des Plantes Lao, Meo, Kha. Ta. XLIX, Fascicule 2,<br />

Ecole Francaise D’ Extreme Orient, Paris. Pp. 570.<br />

114


LAO PDR<br />

1.0. Scientific Name : Calotropis gigantea (L.) (W. T. Aiton)<br />

Family : Asclepiadaceae<br />

2.0. Vernacular Names : Niujiaogua (China); crown flower, giant Indian milkweed, giant<br />

milkweed (English); asclepiade gigantesque, faux arbre de soie,<br />

mercure végétal (French); biduri, saduri, sidaguri widuri (Java-<br />

Indonesia); dok hack (Lao PDR); rembega, lembega, kayu<br />

(Malaysia); dok rak, pan thuean, po thuean (Thail<strong>and</strong>); b(ng<br />

b(ng, cây lá hen, nam t+ bà (Viet Nam)<br />

3.0. Plant Description<br />

Calotropis gigantea is a shrubby plant, stem woody, grows up to 3 m high. Leaves opposite,<br />

obovate, thick, sessile with the base clasping the stem, lobe clothed with fine cotton tomentum<br />

beneath. Inflorescence in axillary; flowers arranged in umbellate cyme, white; calyx, 5 sepals<br />

ovate; 5 stamens; ovary superior. The fruit is a swollen follicle, short <strong>and</strong> turn back. Seeds<br />

numerous with silky tuft of hair.<br />

4.0. Propagation : Stem (vegetative parts)<br />

5.0. Geographical Distribution/Ecology<br />

It is planted in Lao PDR in front of houses for their leaves <strong>and</strong> flowers for praying on ceremonial<br />

<strong>and</strong> wedding days <strong>and</strong> also for medicinal purposes. It is also found in other countries in Asia like<br />

Cambodia, India, Myanmar, Sri Lanka, Thail<strong>and</strong> <strong>and</strong> Viet Nam. It can be propagated by vegetative<br />

multiplication, planting the healthy cuttings at the beginning of rainy season.<br />

6.0. Chemical Constituents<br />

All parts of the plant contain white latex, rubber matter <strong>and</strong> resins. The latex comprises the<br />

esters valerianic <strong>and</strong> acetic of two alcohols, á <strong>and</strong> â-calotropeol. Cardioactive steroidic glycoside<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

or cardenolides, namely calotropin, calactin <strong>and</strong> usharidin, are also reported. The roots contain<br />

of triterpenic saponines.<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

The leaves <strong>and</strong> powder of the flower are used for coughs <strong>and</strong> asthma.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR,<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

116


LAO PDR<br />

1.0 Scientific Name : Cassia alata L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : KhyLeck (Lao PDR); gelenggang (Malaysia)<br />

3.0 Plant Description<br />

Small shrub, about 1.5 m high or more; stem stout branches horizontally spreading, strait <strong>and</strong><br />

minutely pubescent. Leaves paripinnate, big sized, alternate 30–40 cm long, leaflets 8–12 pair,<br />

rectangular or oval 5–13 cm long, 2.5–7 cm wide, increasing in size from the base, broadly<br />

rounded oblique at the base, glabrous on both sides; petiole slightly winged; stipule erect, acute,<br />

persistent; twigs <strong>and</strong> petioles usually reddish brown. Inflorescence in axillary <strong>and</strong> terminal erect<br />

spike 20–30 cm long, 3–4 cm wide; peduncle stout; bracts caduceus; flower yellow; sepals 5<br />

unequal; glabrous petals 5 oblong. Pod long, slightly compressed with winged margins 8–16 cm;<br />

seed numerous, rhombiform, black. Flowering <strong>and</strong> fruiting period: October–December.<br />

4.0 Propagation : Plant cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

Cassia alata is one of the typical tropical plants, widespread in Southeast Asian countries. In<br />

Lao PDR, it can be found on both mid- <strong>and</strong> highl<strong>and</strong>s in all parts of the country, with an increasing<br />

frequently southwards, especially in Champasack province.<br />

6.0 Chemical Constituents<br />

Anthraquinones, chrysophanol, aleo-emodin, thein <strong>and</strong> emodin. The total anthraquinones are<br />

0.2% in the leaf <strong>and</strong> 1.3% in the fruit, anthraquinone I <strong>and</strong> II were isolated from the root.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The leaves have diuretic <strong>and</strong> anti-inflammatory action. The leaf extract, given orally,<br />

produces no effects on blood glucose in normoglycaemic rats, but lowers blood glucose in<br />

rats made hyperglycemic by streptozotocin.<br />

7.2 Uses in traditional medicine:<br />

A combination of C. alata leaves with Combretum quadrangulare seeds is applied to<br />

treat ascariasis. The purgative action of C. alata leaves enhances the vermifuge effect<br />

of C. quadrangulare seeds, the rate of ascarid excretion attaining 50–60%. An ointment<br />

made from C. alata leaves has been tried for drug safety <strong>and</strong> fungicide activities.<br />

The stem bark is used to treat skin diseases, diarrhea, parasitic skin diseases, scabies,<br />

dehydration <strong>and</strong> hemorrhoids. Cassia alata is employed to treat constipation, oedema,<br />

hepatalgia <strong>and</strong> jaundice. Its external application cures ringworm, tinea imbricata (tokelau)<br />

<strong>and</strong> circinate herpes. The juice of crushed leaves is topically applied to washed <strong>and</strong><br />

scaled infected parts. Crush fresh leaves can also be rubbed directly to diseased parts.<br />

For the therapy of constipation: C. alata 20 g, Rumex wallichii 20 g <strong>and</strong> rhubarb 4–6 g.<br />

Their decoction is given orally per day.<br />

8.0 Contraindications<br />

Cassia alata is not advisable for pregnant women.<br />

9.0 Bibliography<br />

1998. <strong>Medicinal</strong> <strong>Plants</strong> in the South Pacific. WHO Regional Publication. Western Pacific<br />

Series No. 19, Regional Office for the Western Pacific, Manila.<br />

Bounhong Southavong, Sisouk Vorlasing & Somsanith. 1993. The Medicines in Your Garden.<br />

Volume I, Research Institute of <strong>Medicinal</strong> <strong>Plants</strong>, Ministry of public Health, Vientiane.<br />

Nanthavanh Bounyapraphat. et al. <strong>Medicinal</strong> <strong>Plants</strong> of Thail<strong>and</strong>. Volume 2. Pp. 852, 2542.<br />

National Institute of Materia Medica. 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in Viet Nam. Volume<br />

I, Science <strong>and</strong> Technology Publishing House, Ha Noi.<br />

Vasilalangsy, Chalune et al. 1985. Recipe of Traditional Medicine in Lao PDR. State Council<br />

of Science <strong>and</strong> Technology, Vientiane.<br />

Vidal, J. 1963. Premiere partie noms vernaculaires – noms scientifique en usage Au<br />

Lao PDR.<br />

118


LAO PDR<br />

1.0. Scientific Name : Codonopsis pilosa (Franch.) Nannf.<br />

Family : Campanulaceae<br />

2.0. Vernacular Names : Dangshen (China); man kha kay, mak Kon thuay (Lao PDR);<br />

=3ng sâm, =ông =3ng sâm, phong =3ng sâm (Viet Nam)<br />

3.0. Plant Description<br />

Codonopsis pilosa is a slender perennial twining herb. Roots tuberous, cylindrical <strong>and</strong> yield<br />

milky juice. Leaves opposite; base cordate; apex acuminate; margins entire or denticulate or<br />

wavy. Flowers solitary at the leaf-axil; corolla campanulate, ivory yellow with violet-veined<br />

inside. Berry globose, violet, seeds numerous.<br />

4.0. Propagation : Seed<br />

5.0. Geographical Distribution/Ecology<br />

Codonopsis pilosa is found in some provinces of the northern part of Lao PDR, especially<br />

abundant in Hua Phanh <strong>and</strong> Xieng Khuang provinces. It grows at the altitude of more than 1,000<br />

m above sea level, preferring to grow in the bedding grass fields in mountainous region.<br />

6.0. Chemical Constituents<br />

According to foreign literature, the roots of C. pilosa possess taraxerol, friedelin, n-<br />

butylallophanate <strong>and</strong> some micro-elements including K, Na, Ca, Mg, Fe, Cu, Co, Zn, Mn, Cr,<br />

Mo, Sn, Al <strong>and</strong> Sr.<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2. Uses in traditional medicine:<br />

Codonopsis pilosa is used for treating general debility, fatigue, anemia, jaundice, dyspepsia,<br />

diarrhoea, etc.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR,<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’Extreme Orient, Paris.<br />

120


LAO PDR<br />

1.0. Scientific Name : Costus speciosus (Koenig) Sm.<br />

Family : Costaceae<br />

2.0. Vernacular Names : Pi-ch’iao-chiang (China); cane-reed, crape ginger, elegant<br />

costus, malay ginger, spiral flag (English); costus élégant<br />

(French); tabar-tabar, setawa, tawa-tawa (Indonesia), dok uong,<br />

uong Bon (Lao PDR); setawar, tawar, tawar-tawar, tawaga,<br />

stengteng, tenge (Malaysia); ueang chang, ueang mai na, ueang<br />

yai, ban dai sawan (Thail<strong>and</strong>); cát l(i, =8t =7ng, mia dò (Viet<br />

Nam)<br />

3.0. Plant Description<br />

Costus speciosus is a herbaceous perennial plant, up to 2 m high. Rhizome stout, fleshy, creeping<br />

up to 50 cm long. Stem hollow, less-branched. Leaves alternate, have tubular sheaths, oblongovoid,<br />

apex acminate, young leaves are spiral. Inflorescence in terminal panicled spike;<br />

zygomorphic flowers supported by thick haired bracts, flowers white, large, fragrant. Fruit globose<br />

or ovoid capsules. Seeds obovoid or subglobose, black, with a narrow fleshy aril.<br />

4.0. Propagation<br />

Costus speciosus can be propagated both by replanting rhizome cuttings <strong>and</strong> transplanting<br />

seedlings.<br />

5.0. Geographical Distribution/Ecology<br />

Costus speciosus is widely grown in Lao PDR. It is found also in other tropical countries.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0. Chemical Constituents<br />

The rhizome of C. speciosus consists of steroid saponin, dioscin <strong>and</strong> gracillin, genines diosgenin<br />

<strong>and</strong> tigogenin. â-sitosterol glycoside <strong>and</strong> curcuminoid, curcumin are also reported.<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

The juice of the burnt fresh stem is used as an ear drop for healing otitis.<br />

The decoction of the rhizome of C. speciosus is used for crushing kidneys <strong>and</strong> bladder<br />

stones. It is used also as a cholagogue, antiamoebic <strong>and</strong> for antiinflammation.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

National Institute of Materia Medica, Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

122


LAO PDR<br />

1.0 Scientific Name : Dioscorea persimilis Prain & Burk.<br />

Family : Dioscoreaceae<br />

2.0 Vernacular Names : Manh kap (Lao PDR)<br />

3.0 Plant Description<br />

Glabrous climber. Tuber single or paired, stout <strong>and</strong> slightly flat, with a round tip, resembling a<br />

gourd, 30–50 cm long or more, descending deep into the soil; stems glabrous, obscurely angular,<br />

sometimes purplish usually bearing axillary bulbils (aerial tubers). Leaves alternate or opposite,<br />

broadly ovate-cordate, 8–10 cm long, 6–8 m wide, apexacuminate; main nerves 5–7, radiating<br />

from the base; petiole 1.5–3.5 cm long. Inflorescence in axillary raceme; flowers small, yellow,<br />

unisexual, dioecious; perianth of 6 equal segments; stamen 6, male spike 40 cm long, female<br />

reaching 20 cm in length. Flowering period: May–July. Fruiting period: August–October.<br />

4.0 Propagation : Tuber<br />

5.0 Geographical Distibution/Ecology<br />

There are about 140 species identified worldwide, scattered mainly in tropical <strong>and</strong> sub-tropical<br />

regions. Dioscorea persimilis is found in Southeast Asia, South China <strong>and</strong> India. It is also<br />

common in the mountainous regions of Lao PDR <strong>and</strong> Viet Nam. This plant is regarded as food<br />

for the natives. It is hygrophilous <strong>and</strong> shade-tolerant. It usually climbs over different plants in<br />

secondary <strong>and</strong> limestone mountain forests at an altitude of up to 1,000 m. It grows vigorously in<br />

summer, withers in winter or in dry season <strong>and</strong> grows again in spring. Some varieties of Dioscorea<br />

have been cultivated in the northern part of Lao PDR for medicinal purposes.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0 Chemical Constituents<br />

In addition to starch as the main component, the tuber contains mucin (a viscous protein), allantion,<br />

amino acids (arginine, choline) <strong>and</strong> maltase. Analysis of the tuber yields 63.25% starch, 0.45%<br />

lipids <strong>and</strong> 6.75% proteins.<br />

7.0 Reports on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The hormonal activity of D. persimilis was studied in immature albino rats of both sexes.<br />

7.2 Uses in traditional medicine:<br />

It acts as a tonic <strong>and</strong> is good for the spleen <strong>and</strong> stomach, <strong>and</strong> invigorates the lung <strong>and</strong><br />

kidney. It is also useful for the treatment of dyspepsia, chronic enteritis, lientery, night<br />

sweating, polyuria, spermatorrhoea <strong>and</strong> metrorrhoea. As a tonic, it is used in the form of<br />

a decoction or powder, <strong>and</strong> given in combination with other plants. It also gives beneficial<br />

effects to children’s diseases such as ascariasis, emaciation, anorexia <strong>and</strong> nausea.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bounhong Southavong et al. 1993. The Medicines in Your Garden. Volume I, Research<br />

Institute of <strong>Medicinal</strong> <strong>Plants</strong>, Ministry of Public Health, Vientiane.<br />

National Institute of Materia Medica, 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in Viet Nam. Volume<br />

1. Science <strong>and</strong> Technology Publishing House, Ha Noi.<br />

Vasilalangsy, Chalune et al. 1985. Recipe of Traditional Medicine in Lao PDR. State Council<br />

of Science <strong>and</strong> Technology, Vientiane.<br />

Vidal, J. 1963. Premiere Partie Noms Vernaculaires – Noms Scientifique en Usage au<br />

Lao PDR.<br />

124


LAO PDR<br />

1.0 Scientific Name : Eclipta prostrata (L.) L.<br />

Synonyms : Eclipta alba (L.)<br />

Family : Asteraceae<br />

2.0 Vernacular Names : Dyer’s weed, dye-wed, false diasy, trailing eclipta, white eclipta,<br />

white heads, (English); éclipte droite (French); goman, urangaring<br />

(Java-Indonesia); smao khmanh (Cambodia); nha hom<br />

keo (Lao PDR); aghing-aghing, ari(ng)-aring, daun dakelin,<br />

dawah (Malaysia); bhingarajah, bhingaraj, tekarajah (Sanskrit/<br />

Hindu); ka meng, hom kiao (Thail<strong>and</strong>); nh8 n(i, c9 m0c, h!n<br />

liên th"o (Viet Nam)<br />

3.0 Plant Description<br />

Eclipta alba is slender, erect, prostrate, much branched, with rooted nodes. Leaves opposite,<br />

variable sessile linear, or oblong-lanceolate, narrowed at both ends, oppressed hairs on both<br />

sides. Inflorescence in axillary or terminal heads; flowers white; pappus 2–5, minute teeth,<br />

arches narrowly oblong, ribbed tipped with the pappus teeth.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Eclipta alba grows wildly in wet l<strong>and</strong>. It can be found almost everywhere in Lao PDR. It is<br />

found also in other Asian <strong>and</strong> Southeast Asian countries.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0 Chemical Constituents<br />

The whole plant contains thiophen, including derivatives of diethienyl acetylenester, thienyl such<br />

as á-terthienyl, á-terthienyl-methanol, aldehyd, ecliptal. Organic acid, echinocystic acid, <strong>and</strong><br />

wedelolactone are also found in the plant.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Lao traditional healers use E. alba to complete the following remedy for treating fever<br />

with convulsion: (1) fresh plant of Centella asiatica 50 g, (2) E. alba 50 g, (3) the roots<br />

of Strobilantes flaccidifolius (hom ban) 20 g <strong>and</strong> (4) the bark of Oroxylum indicum.<br />

All ingredients are thoroughly washed with clean water, adding 1 litre of clear water,<br />

grinding <strong>and</strong> filtering to get the juice.<br />

8.0 Contraindications<br />

Not available<br />

9. 0 Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

126


LAO PDR<br />

1.0. Scientific Name : Elephantopus scaber L.<br />

Family : Asteraceae<br />

2.0. Vernacular Names : Didancao (China); prickly-leaved elephant’s foot (English); pied<br />

d’éléphant, herbe de jouissance (French); misumi-gusa (Japan);<br />

tapak gajah, tapak liman, tapak tana, tapak tangan, tutupbumi<br />

(Java-Indonesia); prakrap thom (Cambodia); khi fay nok khum<br />

(Lao PDR); berseh hitam, chapa, sebongbong, tapak babi, tapak<br />

sulaiman (Malaysia); gojiha, karipadam, satamulika (Sanskrit);<br />

do may ru lom, nat pha, ya fay nok khum (Thail<strong>and</strong>); cây th#i<br />

l%a, ch$ thiên, kh# =&a ="m, ti'n h( nam (Viet Nam)<br />

3.0. Plant Description<br />

Elephantopus scaber is an erect, stout herb, 0.5–1.1 m high. Leaves radical forming a rosette<br />

on the ground 12–15 cm long, 5–6 cm broad, obovate oblong, rounded or subacute, coarsely<br />

serrate-dentate, hairy on both sides. Inflorescence in terminal <strong>and</strong> axillary heads. Flowers<br />

numerous clusters of heads surrounded at the base by 3 large stiff broadly ovate-cordate<br />

conspicuously nerved leafly bracts, flowers are violet. Fruits are pappus.<br />

4.0. Propagation : Seed (vegetative parts)<br />

5.0. Geographical Distribution/Ecology<br />

Elephantopus scaber grows wildly in almost all provinces of Lao PDR. It is found in grass<br />

fields, growing alternately with other species of grass in ab<strong>and</strong>oned l<strong>and</strong>, along the roads <strong>and</strong> at<br />

the edges of rice fields. It strongly endures drought. It is found also in other countries of Indo-<br />

China, India <strong>and</strong> Himalaya<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0. Chemical Constituents<br />

According to some foreign references, the whole plant of E. scaber contains elephantine,<br />

elephantopin, deoxyelephantopin, iso-deoxyelephantopine, epifriedelanol, lupeolacetate,<br />

dotriacontan-ol. Recently, aurantiamide <strong>and</strong> crepiside E have been also isolated from the plant.<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

Elephantopus scaber is traditionally used for treating liver diseases <strong>and</strong> coughs.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

128


LAO PDR<br />

1.0 Scientific Name : Eleutherine subaphylla Gagnep.<br />

Family : Iridaceae<br />

2.0 Vernacular Names : Phak boua luad (Lao PDR)<br />

3.0 Plant Description<br />

Perennial herb, 30–40 cm high. Bulb oblong-ovoid, about 5 cm long, 2.5–3 cm in diameter.<br />

Scale thin, brownish red. Leaves lanceolate, acute at both ends with numerous parallel nerves.<br />

Inflorescence in raceme arising from bulb, 20 cm long; bracts resembling leaves; flowers white<br />

long-pedicelled; sepals 3, thin linear; petals 3; stamens 3; anthers yellow; ovary obovoid, trigonous.<br />

4.0 Propagation : Bulb<br />

5.0 Geographical Distribution/Ecology<br />

The plant originates from America <strong>and</strong> is now commonly grown in Indonesia, the Philippines<br />

<strong>and</strong> other Southeast Asian countries. It is also planted widely in Lao PDR for medicinal uses.<br />

<strong>Plants</strong> growing in gardens endure shade. It is adaptable to various climatic conditions except<br />

the cold in high mountainous areas. The plants often wither in winter, the bulbs remain in the<br />

ground <strong>and</strong> re-sprout in the next spring. Flowers bloom every year, but seeds have not been<br />

observed.<br />

6.0 Chemical Constituents<br />

The bulbs contain quinoid substances, eleutherine, isoeleutherine, <strong>and</strong> eleutherol.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Extract with 40 alcohol of E. subaphylla markedly inhibits in vitro growth of various<br />

strains of Diplococcus pneumoniae, Streptococcus haemolyticus, Staphyloccoccus<br />

aureus <strong>and</strong> mildly depresses Shigella flexneri, S. dysenteriae, Bacillus anthracis<br />

<strong>and</strong> B. mycoides. The extract exerts beneficial effects for mild infectious diseases of the<br />

upper respiratory tract, especially when combined with Belamc<strong>and</strong>a chinensis extract.<br />

7.2 Uses in traditional medicine:<br />

In Lao PDR, the plant in the form of decoction <strong>and</strong> bills is used to treat jaundice, gastritis<br />

ulcer, headache, <strong>and</strong> as a tonic.<br />

8.0 Contraindications<br />

Not available.<br />

9.0 Bibliography<br />

Bounhong Southavong et al. 1993. The Medicines in Your Garden. Volume I, Research<br />

Institute of <strong>Medicinal</strong> <strong>Plants</strong>, Ministry of Public Health, Vientiane.<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

Vasilalangsy, Chalune et al. 1985. Recipe of Traditional Medicine in Lao PDR. State Council<br />

of Science <strong>and</strong> Technology, Vientiane.<br />

Vidal, J, 1963. Premiere Partie Noms Vernaculaires - Noms Scientifique en Usage au<br />

Lao PDR.<br />

130


LAO PDR<br />

1.0. Scientific Name : Euodia lepta L.<br />

Family : Rutaceae<br />

2.0. Vernacular Names : San-ya-k’u (China); vôr anhor (Cambodia); khom la van jo,<br />

kok khao may (Lao PDR); <strong>and</strong>ang, chabang tiga, medang<br />

ketimang, pepauh, setenggek (Malaysia); sam ngam (Thail<strong>and</strong>);<br />

cây d)u d1u, chè =7ng, ba g!c t7m gh- (Viet Nam)<br />

3.0. Plant Description<br />

Euodia lepta is a woody shrub, 3–5 m in height. Stem erect, glabrous, less branched; stem bark<br />

yellowish white; young twigs covered with smooth hairs. Leaves alternate, three leaflets, leaflet<br />

lanceolate. Infloresence in terminal or axillary cyme; flowers small, white; folicles one seeded,<br />

seeds black, shining.<br />

4.0. Propagation : Seed<br />

5.0. Geographical Distribution/Ecology<br />

Euodia lepta grows scarsely in secondary <strong>and</strong> dipterocarp forests. It is found in many provinces<br />

of Lao PDR, particularly in the northern part of the country. It is found also in the southern part<br />

of China, Viet Nam, Cambodia, in most parts of peninsula Malaysia <strong>and</strong> India.<br />

6.0. Chemical Constituents<br />

The roots of E. lepta contain alkaloids: edulinine, isoplatydesmine <strong>and</strong> ribalinine. The leaves<br />

contain flavonoid derivatives, tannin <strong>and</strong> organic acids.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

Euodia lepta is used in Lao traditional medicine in the treatment of asthma.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

132


LAO PDR<br />

1.0 Scientific Name : Morinda citrifolia L.<br />

Family : Rubiaceae<br />

2.0 Vernacular Names : Mark nho ban (Lao PDR); awltree, hag apple, ice leaf, India<br />

mulberry (English)<br />

3.0 Plant Description<br />

Medium to rather big-sized tree, 5–10 m high. Young twigs, quadrangular, slightly compressed<br />

<strong>and</strong> grooved. Leaves opposite, stipuliferous, shining above <strong>and</strong> pale below, undulate at margins.<br />

Inflorescence in dense ovoid head, white at the beginning of the flowering period <strong>and</strong> then<br />

yellow. Fruit ovoid, drupelets, pink when ripe, seed numerous.<br />

4.0 Propagation : Morinda citrifolia is planted by the villagers for its edible fruit<br />

<strong>and</strong> grows sparsely in many localities of Lao PDR, but no<br />

information about the method of propagation was found.<br />

5.0 Geographical Distribution/Ecology<br />

Morinda citrifolia grows abundantly in secondary forest at the altitude of about 700 ft. It also<br />

grows in many other provinces throughout the countries.<br />

6.0 Chemical Constituents<br />

Phytochemical screening shows that the roots, stem <strong>and</strong> leaves of M. citrifolia contain<br />

anthraquinone derivatives. Root bark contains morindine, morindone, alizarine derivative (alizarinea-ethylethr),<strong>and</strong><br />

flavonoid, rutine; hardwood contains morindone, physcion-8-O-[{a-L.<br />

arabinosy1(1 3)}{b-D-galactopyrannosy1(1 6)}(b-D-galactopyranoside)]. The flower contains<br />

anthraglycoside <strong>and</strong> flavonoside. The fruit contains a small amount of essential oil.<br />

133


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

MORINDIN<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Extracts of M. citrifolia show the following biological activities: antitumour, antitumourpromoting,<br />

hypotensive, antibacterial (Staphylococcus, but weak versus Bacillus subtilis),<br />

antiascariasis, antimutagenic (Salmonella), antinematode (Bursaphelenchus xylophilus).<br />

7.2 Uses in traditional medicine:<br />

The dry fruits of M. citrifolia are used for treatment of arthritis, diabetes <strong>and</strong> breast<br />

cancer. They are abortifacient <strong>and</strong> used as cardiotonic <strong>and</strong> emmenagogue. Aqueous leaf<br />

or root extracts are consumed for the treatment of acute malaria <strong>and</strong> cathartic. The<br />

leaves are used for stomach-ache, sore gums, sore throat, chest cold in infants, pleurisy,<br />

dysentery, induced abortion, infected wound healing, inflammation, broken bones <strong>and</strong><br />

leprosy sores. The fresh roots are used for ichtheotoxin/sting <strong>and</strong> external cancerous<br />

swelling. The decoction of the roots is used for treatment of coughs. The dried bark is<br />

used for urinary disorders.<br />

A decoction of the dried fruits <strong>and</strong> seeds of M. citrifolia is used for arthritis. Dried roots<br />

<strong>and</strong> fruits are beneficial in the form of decoction or infusion for hypertension. The roots<br />

are also used for treating lumbago <strong>and</strong> relieving body pain.<br />

Dose: 30 g dry root, 20-30 g dry fruit.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Index Kewensis. Kew Garden, London.<br />

Jeffrey, B. H. et al. 1993. Phytochemical Dictionary. Taylor & Francis, London. Pp. 542.<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi. Pp. 102–105.<br />

NAPRALERT = NAtural PRoduct ALERT A2230B database (www.napralert.org), University of<br />

Illinois at Chicago, Chicago.<br />

134


LAO PDR<br />

1.0 Scientific Name : Passiflora foetida L.<br />

Family : Passifloraceae<br />

2.0 Vernacular Names : Phack buang, kheua nian harng, phack ho harm, phack tarm<br />

nin thorng (Lao PDR); timun dendang (Malaysia)<br />

3.0 Plant Description<br />

Perennial climber with tendrils. Stem hollow, cylindrical. Leaves alternate, trilobed; margins<br />

wavy with ciliate silky hairs; nerves palmate; petiole doubly gl<strong>and</strong>ular; tendril axilary. Flowers<br />

bisexual, solitary at the axil of the leaves; corolla white, pale violet in the centre; coronal violet;<br />

stamens 5; ovary superior. Fruit ovoid or globose; pericarp crisp <strong>and</strong> yellow when ripe; seeds<br />

numerous, edible.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It grows wild in open places in tropical countries.<br />

6.0 Chemical Constituents<br />

The aerial parts of the plant contain indol alkaloid, tryptamine, 5-hydroxy indole <strong>and</strong> harman;<br />

tetraphylline B (sulphate) alicyclie; flavonols: ermanine <strong>and</strong> pachypodol. The leaves contain<br />

deidacline aicyclic, linamarine alkanol, 3-5-hydroxy-4-7-Di-O-methy1 flavonone, two apigenine<br />

derivatives: 4-7-dimethoxy flavone <strong>and</strong> 4-7-Di-O-methyl flavone. The fruit contains volkenine,<br />

<strong>and</strong> seed contains oil <strong>and</strong> linoleic acid.<br />

135


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

HARMAN<br />

APIGENIN 7,4-DIMETHYL FLAVONE<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The whole plant is used to treat hypertension, antispasmodic insomnia, headache, epilepsy,<br />

giddiness, emmenagogue, constipation, coughs, flu <strong>and</strong> sores. The dry roots are used to<br />

stimulate menstruation <strong>and</strong> for abortion. The fresh fruit is used as food, in relieving<br />

constipation, sores <strong>and</strong> cough.<br />

The plant is known to have a tranquilizing effect. A mixture of the plant with the young<br />

leaves of indian bean (Erythrina variegata), the embryo of sacred lotus (Nelumbo<br />

nucifera) <strong>and</strong> young leaves of mulberry tree (Morus alba) is used for treating insomnia.<br />

In the case of insomnia with heart trouble, a mixture of leaves of N. nucifera, P. foetida<br />

<strong>and</strong> the aerial part of Leonurus heterophyllus is used.<br />

A decoction of P. foetida is used as a natural tranquilizer <strong>and</strong> for hiccup. It is formulated<br />

in the form of 1.03–3.0 g per bowl, 2–3 bowls per time, <strong>and</strong> thrice a day. Young leaves of<br />

P. foetida are consumed as vegetable.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Jeffrey, B. H. et al. 1993. Phytochemical Dictionary. Taylor & Francis, London. Pp. 542.<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi. Pp. 164-169.<br />

NAPRALERT = NAtural PRoduct ALERT A2230B database (www.napralert.org), University of<br />

Illinois at Chicago, Chicago.<br />

136


LAO PDR<br />

1.0 Scientific Name : Polygonum multiflorum Thunb.<br />

Synonyms : Pleuropterus multiflorum, Pleuropterus multiflorus<br />

Family : Polygonaceae<br />

2.0 Vernacular Name : Man orn ling (Lao PDR)<br />

3.0 Plant Description<br />

Sc<strong>and</strong>ent perennial herb with big brownish red tuberous root. Stems elongate, branchlets <strong>and</strong><br />

petioles violet-purple. Leaves alternate, simple, ovate-cordate. Inflorescence in axillary or terminal<br />

panicle, flowers numerous, small, greenish white. Nutlet triangular, three winged, entirely closed<br />

by sepals. Flowering seasons from July to October.<br />

4.0 Propagation : Tuber<br />

5.0 Geographical Distribution/Ecology<br />

It grows wild in highl<strong>and</strong> or mountain thickets, especially in Huaphanh <strong>and</strong> Xieng Khouang<br />

provinces, Lao PDR.<br />

6.0 Chemical Constituents<br />

The tuber contains steroid, daucosterol; isoquinoline alkaloid, N-trans-ferulyl-3-methyl, dopamine;<br />

quinoid: emodin <strong>and</strong> its derivatives, emodine monomethylether, 2-acethyl emodin, emodin<br />

monoethylether, emodin-1-6-dimethlether, emodin-6-methylether, emodin-8-O-â-D-glucoside,<br />

juglone (6-acethy1-2-methoxy-7-methylquinone), chyrosphannol, rhein <strong>and</strong> physcion; triterpenic<br />

saponine; flavonol: quercitrin, foeniculin, hyperoside, etc. The entire plant contains resveratrol<br />

(3-5-4-trihydroxystilbene) <strong>and</strong> rhapontin.<br />

137


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

RESVERATROL<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

In China, the dry aerial part is used as decoction to treat insomnia, increases vigour <strong>and</strong><br />

fertility. The tuber possesses antihepatotoxic <strong>and</strong> antioxidant activities, <strong>and</strong> is used for<br />

treating coronary disease <strong>and</strong> hyperlipidemia. The extract of P. multiflorum also shows<br />

hair stimulant properties. Dose: 8–16 g daily.<br />

Decoctions of the roots are given to women after childbirth. A mixture of the plant <strong>and</strong><br />

Codonopsis javanica extracts has been used as tonic for neuralsthenia, insomnia,<br />

rheumatism, lumbago, hypogalactia, anemia, etc. The average daily dose is 20–30 g.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Jeffrey, B. H. et al. 1993. Phytochemical Dictionary. Taylor & Francis, London. Pp. 542.<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi. Pp. 202-207.<br />

NAPRALERT = NAtural PRoduct ALERT A2230B database (www.napralert.org), University of<br />

Illinois at Chicago, Chicago.<br />

138


LAO PDR<br />

1.0. Scientific Name : Rauvolfia serpentina Benth. ex Kurz<br />

Family : Apocynaceae<br />

2.0. Vernacular Names : Bon-ma-ya-zar (Burma); she gen mu, yin-tu lo-fu mu (China);<br />

rauwolfia, serpentine, serpentine root, serpent wood, snake<br />

wood, snake-root, (English); racine de serpent (French);<br />

chhotach<strong>and</strong>, sarap-g<strong>and</strong>ha (Hindu); Indo-Jyaboku (Japan); kha<br />

gnom phoo (Lao PDR); sarpag<strong>and</strong>ha, ch<strong>and</strong>rika (Sanskrit);<br />

rayom (Thail<strong>and</strong>); ba g!c _n =4 (Viet Nam)<br />

3.0. Plant Description<br />

Rauvolfia serpentina is an undershrub, 0.3–1 m high. Root much-fluted. Stem lanticellate, less<br />

branched. Leaves 3-verticilate, occasionally opposite, lanceolate, attenuate at both sides.<br />

Inflorescence in terminal or axillary umbellate cymes; flowers tubular, white to pink cymes.<br />

Drupes ovoid, purplish-black when ripe, glabrous, single-seeded. The plant yields milky juice.<br />

4.0. Propagation : Seed (vegetative parts)<br />

5.0. Geographic Distribution<br />

Rauvolfia serpentina prefers to grow in tropical or subtropical areas with mean annual rainfall<br />

of 1,500–2,000 mm <strong>and</strong> mean temperature ranging from 25º to 30º C. The plant is indigenous to<br />

Indo-China, Borneo, Sumatra, Sri Lanka <strong>and</strong> India. It is a rare plant, but is found in some<br />

provinces of Lao PDR, especially on the Nam Ngum river banks, in Veun Kham area, Vientiane<br />

capital city.<br />

6.0. Chemical Constituents<br />

The plant, especially the root bark, contains indol alkaloids; the total alkaloids range from 1 to<br />

3%. The alkaloids are classsified into four types:<br />

139


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1. Yohimbine-type: including reserpine, the main active compound of the plant, reserpinine,<br />

reserpidine, rescinnamine, yohimbines (á-yohimbine, b-yohimbine <strong>and</strong> ø-yohimbine), aniso<br />

rauhimbine.<br />

2. Heteroyohimbine-type: including ajmalicine, serpentine, serpentinine <strong>and</strong> raubasine.<br />

3. Sarpagan-type (sarpagine type): including raupine (sarpagine), a hypotensive active<br />

compound.<br />

4. Ajmalane-type (ajmaline type): including ajmaline, an antiarrhythmic compound, iso-ajmaline.<br />

7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

In Lao traditional medicine the root of R. serpentina combining with other materia medica<br />

is used for relieving headache. It used also for hypertension.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi. Pp. 227–231.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

140


LAO PDR<br />

1.0 Scientific Name : Solanum procumbens Lour.<br />

Synonym : S. Hainanense Hance<br />

Family : Solanaceae<br />

2.0 Vernacular Name : Khang khom kheua (Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

The plant is a straggling shrub, stem <strong>and</strong> branches numerous, short, stout <strong>and</strong> recurved prickles.<br />

Leaves simple, alternate, thin, ovate or oblong in texture; margins irregularly lobed. Inflorescence<br />

in axillary cyme, of 2–8 flowers, pale violet. Fruit globose, glabous, reddish yellow when ripe;<br />

seed numerous, yellow, reniform.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is widely distributed in every part of Lao PDR. It is also found in many Asian countries.<br />

6.0 Chemical Constituents<br />

The leaf contains tomatid-5-en-3-b-ol. Entire plant: glyco-alkaloids (solatunine or (b-solanine)<br />

or steroidal saponines. b-Solanine can be hydrolyzed to yield solanidine <strong>and</strong> solasodine.<br />

141


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

SOLASODINE<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The root, leaf or whole plant is used for treating some respiratory-related diseases such<br />

as coughs <strong>and</strong> asthma; they are also expectorant, detoxicant or antidote, antidiabetic,<br />

tonic <strong>and</strong> diuretic agents.<br />

The plant has been used for treating snake bites, phlegmatic <strong>and</strong> stingy wounds. A h<strong>and</strong>ful<br />

of the root segments is crushed <strong>and</strong> then macerated in about 200–300 ml cool drinking<br />

water, the macerate is immediately given to the victim. The treatment will continue for a<br />

couple of days by giving patients the decoction of the root.<br />

The fruit is an expectorant, cough relief. It is also used to stop bleeding in cases of<br />

hermorrhoids.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Farnswoth, N. R. et al. 1992. Thai <strong>Medicinal</strong> <strong>Plants</strong>. Prachachon Publishing, Bangkok. Pp.<br />

225.<br />

Index Kewensis, Kew Garden, London.<br />

Jeffrey, B. H. et al. 1993. Phytochemical Dictionary. Taylor & Francis, London. Pp. 542.<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris. Pp. 201.<br />

142


LAO PDR<br />

1.0 Scientific Name : Stephania rotunda Lour.<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Di bu rong (China); Indian tape-vine, moon seed creeper,<br />

(English); koma pich (Cambodia); hua tom ngeun, king kang<br />

dong (Lao PDR); daun nasi-nasi (Malaysia); pha nang nang<br />

(Thail<strong>and</strong>); bình vôi, c[ b(ng b'nh (Viet Nam)<br />

3.0 Plant Description<br />

Stephania rotunda is a perennial evergreen shrub, 2–10 m long; tuber stout, attaining 100 kg.<br />

Leaves alternate, thin, peltate; radiately nerved; glabrous on both sides; petioles long, inserted at<br />

one quarter from the base of the lamina. Inflorescence in axillary umbelllate cyme. Flowers<br />

orange, female <strong>and</strong> male on different plants. Drupes globose, compressed, red when mature.<br />

Seeds hippocrepiform with transverse rips.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Stephania rotunda prefers to grow in limestone mountains, <strong>and</strong> is found scarcely in deciduous<br />

forest, in lowl<strong>and</strong> forests. It can be shade-enduring. The plant is found in many localities in Lao<br />

PDR, <strong>and</strong> also in many countries of Southeast Asia, in the southern part of China, Viet Nam <strong>and</strong><br />

Cambodia.<br />

6.0 Chemical Constituents<br />

The main active compound of S. rotunda is l.tetrahydropalmaine (gindarine or hindarine),<br />

Roemerine is also reported.<br />

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7.0. Report on <strong>Medicinal</strong> Usage<br />

7.1. Uses supported by experimental/clinical data:<br />

Not available<br />

7.2. Uses in traditional medicine:<br />

In Lao traditional Medicine, Stephania tuber is used for serious dysentery (stool with<br />

blood); it is used as a decoction.<br />

8.0. Contraindications<br />

Not available<br />

9.0. Bibliography<br />

Ð\ Huy Bích et al. Cây thu2c và Ð4ng v5t làm thu2c 6 Viet Nam. TAP I VA II 2, National<br />

Institute of Meteria Medica, Sciences <strong>and</strong> Technology (Vietnamese version).<br />

Vidal, J. 1956. Noms Vernaculaires des <strong>Plants</strong> (Lao, Meo, Kha) en Usage Au Lao PDR.<br />

Tome XLIX, Fascicule 2, Ecole Francaise D’ Extreme Orient, Paris.<br />

144


MALAYSIA<br />

1.0 Scientific Name : Ardisia elliptica Thunb.<br />

Family : Myrsinaceae<br />

2.0 Vernacular Names : Mata pel<strong>and</strong>uk (Malaysia); sea-shore ardisia (English)<br />

3.0 Plant Description<br />

A bush or small tree. Leaves simple, alternate, leathery pink when young, elliptic or obovate<br />

obtuse, 5–12.5 cm long, 2.5–6 cm; margins entire. Flowers small in stalked cluster from the leaf<br />

axils, pink. Fruits berries rounded, flattened from above, green when young turning red when<br />

mature, edible with sweet taste.<br />

4.0 Propagation : Seed<br />

5.0 Geographic Distribution<br />

It grows wild <strong>and</strong> is widely distributed in lowl<strong>and</strong> to hill forest in Malaysia.<br />

6.0 Chemical Constituents<br />

Syringic acid, isorhamnetin <strong>and</strong> quercetin<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Syringic acid, isorhamnetin <strong>and</strong> quercetin obtained from dried fruit extract of A. elliptica<br />

showed antisalmonella activity.<br />

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7.2 Uses in traditional medicine:<br />

The roots are used by women with irregular menses <strong>and</strong> herbal tonic for body maintenance.<br />

The leaves are used in treatment of earache <strong>and</strong> mouth ulceration.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill, I.H. 1935. A Dictionary of the Economic Products of the Malay Peninsula. Crown<br />

Agents, London.<br />

Corner, E.J.H. 1988. Wayside Trees of Malaya. Vol. II. The Malayan Nature Society, Kuala<br />

Lumpur.<br />

Gimlette, G. D. 1939. A Dictionary of Malayan Medicine. Oxford Univ. Press, Kuala Lumpur.<br />

160 pp.<br />

Henderson, M.R. 1951. Malayan Wild Flowers: Dicotyledons. Malayan Nature Society.<br />

Kuala Lumpur. 478 pp.<br />

Phadungkit, M. & Luanratana, O. 2006. Anti-salmonella cativity of constituents of Ardisia<br />

elliptica Thunb. Nat. Prod. Research 20(7): Pp. 693–696.<br />

Ridley, H.N. 1967. The Flora of the Malay Peninsula. Vol. I <strong>and</strong> II. Reeve & Co., London.<br />

148


MALAYSIA<br />

1.0 Scientific Name : Chromolaena odorata (L.) R. King & H. Rob.<br />

Family : Asteraceae<br />

2.0 Vernacular Names : Pokok kapal terbang, pokok jerman (Malaysia);<br />

christmas bush, siam weed, baby tea (English)<br />

3.0 Plant Description<br />

Subshrub with long rambling branches; stems terete, pubescent. Leaves opposite, flaccidmembranous,<br />

velvety-pubescent, deltoid-ovate, acute, very coarsely toothed, each margin with<br />

1–5 teeth, or entire in youngest leaves; 1–1.5 cm long; blade mostly 5–12 cm long, 3–6 cm wide.<br />

Inflorescence subcorymbose axillary <strong>and</strong> terminal clusters; peduncles 1–3 cm long; bracteates,<br />

bracts slender, 10–12 mm long; involucre of about 4–5 series of bracts; pale with green nerves,<br />

acute, the lowest ones about 2 mm long, upper ones 8–9 mm long, all acute, distally ciliate, flat,<br />

appressed except the extreme divergent tip; florets all alike (disc-florets), pale purple to dull offwhite,<br />

the styles extending about 4 mm beyond the apex of the involucre, spreading radiately;<br />

receptacle very narrow; florets about 20–30 or a few more, 10–12 mm long; ovarian portion 4<br />

mm long; corolla slender trumpet form; pappus of dull white hairs 5 mm long. Seeds achenes<br />

glabrous.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution<br />

It grows wild in open <strong>and</strong> disturbed areas mainly in lowl<strong>and</strong>s all over Southeast Asia.<br />

6.0 Chemical Constituents<br />

(+)-eupaten, 2’,3’,4,4’,6’-pentahydrocxchalcone, acacetine, eupaten, isosakuranetine, mikanine,<br />

odoratine, sakuranetine, salvigenine, tamarixetine, velutine, á-sitosterol, anisic acid, â-amyrin, â-<br />

sitosterol, ceryl-alcohol, copper, epoxylupeol, eupatenol, ã-sitosterol, lupeol, magnesium,<br />

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manganese, phosphorus, tannin, protocatechuic, p-hydroxybenzoic, p-coumaric,ferulic, vanillic<br />

acids<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

i. From the flowers of C. odorata (Eupatorium odoratum) four flavanones,<br />

isosakuranetin (5,7-dihydroxy-4'-methoxyflavanone) (1), persicogenin (5,3'-<br />

dihydroxy-7,4'-dimethoxyflavanone) (2), 5,6,7,4'-tetramethoxyflavanone (3) <strong>and</strong> 4'-<br />

hydroxy-5,6,7-trimethoxyflavanone (4), two chalcones, 2'-hydroxy-4,4',5',6'-<br />

tetramethoxychalcone (5) <strong>and</strong> 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (6), <strong>and</strong><br />

two flavones, acacetin (5,7-dihydroxy-4'-methoxyflavone) (7) <strong>and</strong> luteolin (5,7,3',4'-<br />

tetrahydroxyflavone) (8) were isolated <strong>and</strong> identified. Compound 1 exhibited<br />

moderate antimycobacterial activity against mycobacterium tuberculosis with the<br />

MIC value of 174.8 microM, whereas compounds 4, 7, <strong>and</strong> 8 exhibited weak activity<br />

with the MIC values of 606.0, 704.2 <strong>and</strong> 699.3 microM respectively. Compound 7<br />

showed moderate cytotoxicity against human small cell lung cancer (NCI-H187)<br />

cells with the MIC value of 24.6 microM, whereas compound 8 exhibited moderate<br />

toxicity against NCI-H187 cells <strong>and</strong> week toxicity against human breast cancer<br />

(BC) cells with the MIC values of 19.2 <strong>and</strong> 38.4 microM respectively.<br />

ii. Clinical studies using this plant extract have shown antimicrobial <strong>and</strong> anticoagulation<br />

effects as well as the promotion of tissue remodelling in the wound healing process.<br />

However, the mechanism by which this agent affects cells involved in the wound<br />

healing process is unknown. Fibroblasts <strong>and</strong> endothelial cells, two cell types that<br />

play a crucial role in wound healing, were used to investigate some of the effects<br />

of eupolin extract in vitro. Cell growth was estimated by a colorimetric assay at<br />

different time intervals. Enhanced growth of fibroblasts <strong>and</strong> endothelial cells was<br />

found at concentrations of 10 microg/ml <strong>and</strong> 100 microg/ml of eupolin extract. This<br />

was particularly evident in medium supplemented with only 0.5% fetal calf serum<br />

where the cells were quiescent. Toxicity of the extract to fibroblasts was observed<br />

at 250 microg/ml in Dulbecco’s modified Eagle’s medium/0.5% fetal calf serum,<br />

but there was no significant damage at this dose to the endothelial cells. The results<br />

of the study demonstrated that eupolin extract increased fibroblast <strong>and</strong> endothelial<br />

cell growth, <strong>and</strong> this could explain in part the beneficial clinical effects that have<br />

been observed.<br />

7.2 Uses in traditional medicine:<br />

The leaves are used as wound healing <strong>and</strong> a local antiseptic agent, ailments including<br />

malaria, fever <strong>and</strong> infection <strong>and</strong> as a haemostatic agent.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bamba, D., Bessiere, J. M., Marion, C., Pelissier, Y. & Fouraste, I. 1993. Essential oil of<br />

Eupatorium odoratum. Planta Medica 59(2): Pp. 184–185.<br />

150


MALAYSIA<br />

Bose, P. H., Chakrabarti, P., Chakraverti, S., Dutta, S. P. & Barua, A. K. 1973. Flavonoid<br />

constituents of Eupatorium odoratum. Phytochemistry, 12. Pp. 667–671.<br />

Glasby, J.S. 1991. Dictionary of <strong>Plants</strong> Containing Secondary Metabolites. Great Britain:<br />

Bunges Science Press.<br />

Muhamad Zakaria, Mustafa Ali Mohd, 1994. Traditional Malay <strong>Medicinal</strong> <strong>Plants</strong>. Kuala<br />

Lumpur, Penerbit FajarBakti Sdn Bhd.<br />

Phan TT, Hughes MA, Cherry GW. 1998. Enhanced proliferation of fibroblasts <strong>and</strong> endothelial<br />

cells treated with an extract of the leaves of Chromolaena odorata (Eupolin), an herbal remedy<br />

for treating wounds. Plastic <strong>and</strong> Reconstructive Surgery. 101(3): Pp. 756–765.<br />

Phan, T T; Wang, L; See, P; Grayer, R J; Chan, S Y; Lee, S T, 2001. Phenolic compounds of<br />

Chromolaena odorata protect cultured skin cells from oxidative: implication for cutaneous<br />

wound healing, Biological & Pharmaceutical Bulletin 24: Pp. 1373–1379.<br />

Sam Teng Wah, 1995. Constituents <strong>and</strong> uses of Eupatorium odoratum L. Trends in Traditional<br />

Medicines Research, USM Penang.<br />

Suksamrarn A, Chotipong A, Suavansri T, Boongird S, Timsuksai P, Vimuttipong S, Chuaynugul<br />

A. 2004. Antimycobacterial activity <strong>and</strong> cytotoxicity of flavonoids from the flowers of<br />

Chromolaena odorata. Arch. Pharm. Res. 27(5): Pp. 507–511.<br />

Talapatra, S. K., Bhar, D. S. & Talapatra, B. 1977. Terpenoids <strong>and</strong> related compounds 13-<br />

epoxylupeol, a new triterpenoid from Eupatorium odoratum. Indian J. Chem. 15 (9): Pp.<br />

806–807.<br />

151


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Curcuma xanthorhiza Roxb.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Temu lawak (Malaysia); rimpang lawak (Indonesia)<br />

3.0 Plant Description<br />

A herb with branched rhizome, outside dark yellow to reddish-brown, inside orange or orangered;<br />

leaf sheaths up to 75 cm long, blades elliptical-oblong to oblong-lanceolate, 25–100 cm x 8–<br />

20 cm, green with reddish-brown b<strong>and</strong> along the midrib; inflorescence on a separate shoot,<br />

bracts pale green, coma bracts purple; corolla 4–6 cm long, pale red, labellum 2–2.5 cm x 1.5–<br />

2 cm, yellowish with darker yellow median b<strong>and</strong>, staminodes yellow-white, anther with long<br />

spurs.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

The plant is cultivated throughout the tropic.<br />

6.0 Chemical Constituents<br />

b-Atlantone, bisacumol, bisacurol, b-curcumene, 5’-methoxycurcumin, b-methoxycurcumin,<br />

curcuminoid, essential oil, germacrone, phenolic diarylheptanoid, sesquiterpenoid, ar-tumerone,<br />

a-tumerone, b-tumerone, xanthorrhizol<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Curcuma xanthorhiza showed antioxidant <strong>and</strong> antibacterial properties. Xanthorrhizol<br />

has a preventive effect on cisplatin-induced nephrotoxicity <strong>and</strong> exerts anti-metastatic<br />

activity in vivo.<br />

7.2 Uses in traditional medicine:<br />

Used as tonic, carminative <strong>and</strong> anti-inflammatory for constipation, colic, stomachache,<br />

vermifuge, fever, malaria, rheumatism, constipation, numb feet, gonorrhoea. Used as a<br />

poultice for swelling, cosmetic, mosquito repellent <strong>and</strong> ingredient in shampoo <strong>and</strong> perfume.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill, I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry<br />

of Agriculture <strong>and</strong> Cooperative, Kuala Lumpur. Vol. I & II.<br />

Choi M. A., Kim, S. H., Chung, W. Y., Hwang, J. K. & Park, K. K. 2004. Xanthorrhizol, a<br />

natural sesquiterpenoid from Curcuma xanthorhiza, has an anti-metastatic potential in<br />

experimental mouse lung metastasis model. Biochemical <strong>and</strong> Biophysical Research<br />

Communications 326(1): 210–217.<br />

Departemen Kesehatan Republik Indonesia. 1979. Materia Medika Indonesia Vol. III.<br />

<strong>Herbal</strong> Medicine Research Centre, Institute for Medical Research, Kuala Lumpur. 2002.<br />

Compendium of <strong>Medicinal</strong> <strong>Plants</strong> Used in Malaysia 1: 233–234.<br />

Hwang, J. K., Shim, J. S. & Pyun, Y. R. 2000. Antibacterial activity of xanthorrhizol from<br />

Curcuma xanthorhiza against oral pathogens. Fitoterapia 71(3): 321–323.<br />

Ibrahim, J., Abu Said, A., Mohd. Ali N.A., Ahmad, A., R. & Halijah I. 1999. Chemical composition<br />

of the rhizome oils of four Curcuma species from Malaysia. J. Essential Oil Research 11:<br />

719–723.<br />

Kim S. H., Hong, K. O., Chung, W. Y., Hwang, J. K. & Park, K. K. 2004. Abrogation of<br />

cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation<br />

of gene transcription. Toxicology <strong>and</strong> Applied Pharmacology 196(3): 346–355.<br />

Kim, S. H., Hong, K. O., Hwang, J. K. & Park, K. K. 2005. Xanthorrhizol has a potential to<br />

attenuate the high dose cisplatin-induced nephrotoxicity in mice. Food <strong>and</strong> Chemical<br />

Toxicology 43(1): 117–122.<br />

Masuda, T., Isobe, J., Jitoe, A. & Nakatani, N. 1992. Antioxidative curcuminoids from rhizomes<br />

of Curcuma xanthorhiza. Phytochemistry 31(10): 3645–3647.<br />

Padua, L.S., Bunyapraphatsara, N. & Lemmens, R.H.M.J. (Eds.) 1999. <strong>Medicinal</strong> <strong>and</strong> Poisonous<br />

<strong>Plants</strong> 1. Plant Resources of South-East Asia (PROSEA) No. 12 (1). Bogor, Indonesia.<br />

153


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P<strong>and</strong>ji C., Grimm, C., Wray, V., Witte, L. & Proksch, P. 1993. Insecticidal constituents from four<br />

species of the zingiberaceae. Phytochemistry 34(2): 415–419.<br />

Ruslay, S., Abas, F., Shaari, K., Zainal, Z., Maulidiani, Sirat, H., Israf, D. A. & Lajis, N. H. 2007.<br />

Characterization of the components present in the active fractions of health gingers (Curcuma<br />

xanthorhiza <strong>and</strong> Zingiber zerumbet) by HPLC–DAD–ESIMS. Food Chemistry 104(3): 1183–<br />

1191.<br />

Sirat, H. M., Hong, N. M., & Jauri, M. H. 2007. Chemistry of xanthorrhizol: synthesis of<br />

several bisabolane sesquiterpenoids from xanthorrhizol. Tetrahedron Letters 48(3): 457–<br />

460.<br />

Suksamrarn A., Eiamong, S., Piyachaturawat, P., & Charoenpiboosin, J. 1994. Phenolic<br />

diarylheptanoids from Curcuma xanthorhiza. Phytochemistry 36(6): 1505–1508.<br />

Yasni, S., Imaizumi, K., Nakamura, M., Aimoto, J. & Sugano, M. 1993. Effects of Curcuma<br />

xanthorhiza Roxb. <strong>and</strong> curcuminoids on the level of serum <strong>and</strong> liver lipids, serum apolipoprotein<br />

A-I <strong>and</strong> lipogenic enzymes in rats. Food <strong>and</strong> Chemical Toxicology 31(3): 213–218.<br />

Yasni, S., Imaizumi, K., Sin, K., Sugano, M., Nonaka, G. & Sidik. 1994. Identification of an<br />

active principle in essential oils <strong>and</strong> hexane-soluble fractions of Curcuma xanthorhiza Roxb.<br />

showing triglyceride-lowering action in rats. Food <strong>and</strong> Chemical Toxicology 32(3): 273–278.<br />

154


MALAYSIA<br />

1.0 Scientific Name : Cymbopogon citratus Stapf.<br />

Family : Poaceae<br />

2.0 Vernacular Names : Serai, serai makan (Malaysia); lemon grass (English); sereh,<br />

semiai, sere, sarai, sorai (Indonesia); chakai, takrai (Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

Perennial. Culms densely clumped <strong>and</strong> leafy at the base, up to 2 m tall; leaf-sheaths terete,<br />

glabrous; blades linear-acuminate up to 90 cm long by 2 cm wide; ligule 2 mm deep. Inflorescence<br />

a loose nodding panicle; racemes up to about 2 cm long; rachis-internodes <strong>and</strong> spikelet pedicels<br />

2.5–3 mm long; densely hairy.<br />

4.0 Propagation : Cutting<br />

5.0 Geographic Distribution/Ecology<br />

It is widely distributed in tropical regions <strong>and</strong> is cultivated in open <strong>and</strong> dry areas.<br />

6.0 Chemical Constituents<br />

a-Camphorene, caprylic acid, caryophyllene, cerylalcohol, 1,8-cineole, citronellal, citronellic acid,<br />

citronellol, citral, cymbopogone, cymbopogonol, a- <strong>and</strong> b-dihydropseudoionone, decanal, N-<br />

decylaldehyde, diacetyl, dipentene, farsenal, farsenol, furfural, geranic acid, geranial, geraniol,<br />

geranylacetate, hexacosanol, isopulegol, isovaleraldehyde, isovaleric acid, linalol, linalylacetate,<br />

limonene, luteolin, luteolin-C-glycoside, methylheptenone, methylheptenol, b-myrcene, neral, nerol,<br />

a-pinene, quercetin, rutin, b-sitosterol, a-terpineol, tricontanol, minerals <strong>and</strong> saponins<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

i. The objective of study was to test the efficacy of a slow-release citronella<br />

formulation as a repellent against the head louse. During four months in 2003 a<br />

r<strong>and</strong>omized, placebo-controlled double-blind clinical study was conducted in four<br />

elementary schools; 103 children were treated with the test formulation <strong>and</strong> 95<br />

with a placebo. A significant difference was observed during the second examination<br />

two months later, when 12.0% of the children treated with the test repellent <strong>and</strong><br />

50.5% of those treated with placebo were infested with lice. A significant difference<br />

was also observed at the third examination two months later, when 12.4% of the<br />

children treated with the test repellent <strong>and</strong> 33.7% treated with placebo were infested.<br />

Overall, there were significant differences between those treated with the repellent<br />

<strong>and</strong> those treated with the placebo (15.4% <strong>and</strong> 55.1% respectively, P < 0.0001).<br />

Side effects were observed in 4.4% of children who disliked the odour of the<br />

formulation, <strong>and</strong> an additional 1.0% who complained of a slight itching <strong>and</strong> burning<br />

sensation. Use of an effective repellent could significantly lower the incidence of<br />

reinfestations, which would lower expenditure on lice control, including pediculicides,<br />

combs <strong>and</strong> products for nit removal, <strong>and</strong> the time spent on treatment <strong>and</strong> removal<br />

of the nits.<br />

ii. The essential oils obtained by hydrodistillation from fresh leaves of C. citratus <strong>and</strong><br />

Ocimum gratissimum growing in Cameroon were analysed by GC <strong>and</strong> GC/MS.<br />

The main constituents of the oil of O. gratissimum were gamma-terpinene (21.9<br />

%), beta-phell<strong>and</strong>rene (21.1 %), limonene (11.4 %) <strong>and</strong> thymol (11.2 %), while the<br />

oil of C. citratus contained geranial (32.8 %), neral (29.0 %), myrcene (16.2 %)<br />

<strong>and</strong> beta-pinene (10.5 %). The effects of these oils on the growth of Plasmodium<br />

berghei were investigated. Both oils showed significant antimalarial activities in<br />

the four-day suppressive in vivo test in mice. At concentrations of 200, 300 <strong>and</strong><br />

500 mg/kg of mouse per day, the essential oil of C. citratus produced the highest<br />

activity with the respective percentages of suppression of parasitaemia: 62.1, 81.7<br />

<strong>and</strong> 86.6 %. The corresponding values for the oil of O. gratissimum at the same<br />

concentrations were 55.0, 75.2 <strong>and</strong> 77.8 %, respectively. Chloroquine (10 mg/kg<br />

of mouse, positive control) had a suppressive activity of 100 %.<br />

7.2 Uses in traditional medicine:<br />

Lemon grass is used as digestion aid, emmenagogue, fermentations <strong>and</strong> food flavouring.<br />

It is also used as a mild diuretic <strong>and</strong> tonic, promoting perspiration, treating kidney problems<br />

<strong>and</strong> herbal tea. The essential oils are used for flatulence, irregular bowel movement,<br />

gastric irritability, arresting vomiting, rheumatism, sprains <strong>and</strong> insect repellent.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Adegoke, G.O. & Odesola, B.A. 1996. Storage of maize <strong>and</strong> cowpea <strong>and</strong> inhibition of microbial<br />

agents of biodeterioration using the powder <strong>and</strong> essential oil of lemon grass (Cymbopogon<br />

citratus). International Biodeterioration & Biodegradation 37: Pp. 81–84.<br />

156


MALAYSIA<br />

Baratta, M.T.; Dorman, H.J.D.; Deans, S.G.; Figueiredo, A.C.; Barroso, J.G.; & Ruberto, G.<br />

1998. Antimicrobial <strong>and</strong> antioxidant properties of some commercial essential oils. Flavour <strong>and</strong><br />

Fragrance Journal 13: Pp. 235–244.<br />

Burkill, I.H. 1935. A Dictionary of the Economic Products of the Malay Peninsula. Crown<br />

Agents, London.<br />

Cheah, P.B., Ng, C.H. & Wong, C.F. 2001. Antioxidant activity of tropical lemon grass<br />

(Cymbopogon citratus) extracts in linoleic acid <strong>and</strong> chicken fat systems. Journal of Food<br />

Science <strong>and</strong> Technology 38: Pp. 62–64.<br />

De F. Melo, S.; Soares, S.F.; Da Costa, R.F.; Da Silva, C.R.; De Oliveira, M.B.N.; Bezerra,<br />

R.J.A.C.; Caldeira-de-Araújo, A.; & Bernardo-Filho, M. (2001). Effect of Cymbopogon citratus,<br />

Maytenus ilicifolia <strong>and</strong> Baccharis genistelloides extracts against the stannous chloride oxidative<br />

damage in Escherichia coli. Mutation Research 496: Pp. 33–38.<br />

De-Oliveira, A.C.A.X., Ribeiro-Pinto, L.F., Otto, S.S. Goncalves, A. & Paumgartten, F.J.R.<br />

1997. Induction of liver monooxygenases by b-myrcene. Toxicology 124: Pp. 135–140.<br />

De-Oliveira, A.C.A.X.; Ribeiro-Pinto, L.F.; & Paumgartten, F.J.R. 1997. In vitro inhibition of<br />

CYP2B1 monooxygenase by b-myrcene <strong>and</strong> other monoterpenoid compounds. Toxicology<br />

Letters 92: Pp. 39–46.<br />

Gillil<strong>and</strong>, H.B. 1971. A Revised Flora of Malaya: Grasses of Malaya. Vol. 3. Government<br />

Printing Office, Singapore. Pp. 294–299.<br />

Jaganath, I.B. & Ng, L.T. 2000. The Green Pharmacy of Malaysia. Vinpress Sdn. Bhd.,<br />

Kuala Lumpur.<br />

Kauderer, B., Zamith, H., Paumgartten, F.J. & Speit, G. 1991. Evaluation of the mutagenicity of<br />

beta-myrcene in mammalian cells in vitro. Environmental <strong>and</strong> Molecular Mutagenesis 18:<br />

Pp. 28–34.<br />

Kishore, N., Mishra, A.K. & Chansouria, J.P. 1993. Fungitoxicity of essential oils against<br />

dermatophytes. Mycoses 36: Pp. 211–215.<br />

Lima, E.O., Gompertz, O.F., Giesbrecht, A.M., & Paulo, M.Q. 1993. In vitro antifungal activity<br />

of essential oils obtained from officinal plants against dermatophytes. Mycoses 36: Pp. 333–<br />

336.<br />

Lorenzetti, B.B., Souza, G.E., Sarti, S.J., Santos Filho, D., & Ferreira, S.H. 1991. Myrcene<br />

mimics the peripheral analgesic activity of lemon grass tea. Journal of Ethnopharmacology<br />

34: Pp. 43–48.<br />

Mishra, A.K. & Dubey, N.K. 1994. Evaluation of some essential oils for their toxicity against<br />

fungi causing deterioration of stored food commodities. Applied <strong>and</strong> Environmental<br />

Microbiology 60: Pp. 1101–1105.<br />

Mumcuoglu KY, Magdassi S, Miller J, Ben-Ishai F, Zentner G, Helbin V, Friger M, Kahana F,<br />

Ingber A. 2004. Repellency of citronella for head lice: double-blind r<strong>and</strong>omized trial of efficacy<br />

<strong>and</strong> safety. Isr. Med. Assoc. J. 6(12): Pp. 756–759.<br />

157


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Perry, L.M. & Metzger, J. 1980. <strong>Medicinal</strong> <strong>Plants</strong> in East <strong>and</strong> Southeast Asia. The MIT<br />

Press, Cambridge & Massachusetts.<br />

Puatanachokchai, R., Kishida, H., Denda, A., Murata, N., Konishi, Y., Vinitketkummuen, U. &<br />

Nakae, D. 2002. Inhibitory effects of lemon grass (Cymbopogon citratus Stapf) extract on the<br />

early phase of hepatocarcinogenesis after initiation with diethylnitrosamine in male Fischer 344<br />

rats. Cancer Letters 183: Pp. 9–15.<br />

Rajapakse, R. & Van Emden, H.F. 1997. Potential of four vegetable oils <strong>and</strong> ten botanical<br />

powders for reducing infestation of cowpeas by Callosobruchus maculatus, C. chinesis <strong>and</strong><br />

C. rhodesianus. Journal of Stored Products Research 33: Pp. 59–68.<br />

Rao, V.S. Menezes, A.M. & Viana, G.S. 1990. Effect of myrcene on mociception in mice. The<br />

Journal of Pharmacy <strong>and</strong> Pharmacology 42: Pp. 877–878.<br />

Suaeyun, R.; Kinouchi, T.; Arimochi, H.; Vinitketkummuen, U.; & Ohnishi, Y. 1997. Inhibitory<br />

effects of lemon grass (Cymbopogon citratus Stapf) on formation of azoxymethane-induced<br />

DNA adducts <strong>and</strong> aberrant crypt foci in the rat colon. Carcinogenesis 18: Pp. 949–955.<br />

Tchoumbougnang F, Zollo PH, Dagne E, & Mekonnen Y. 2005. In vivo antimalarial activity of<br />

essential oils from Cymbopogon citratus <strong>and</strong> Ocimum gratissimum on mice infected with<br />

Plasmodium berghei. Planta Med. 71(1): Pp. 20–23.<br />

Vinitketkummuen, U., Puatanachokchai, R., Kongtawelert, P., Lartprasertsuke, N. & Matsushima,<br />

T. 1994. Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known<br />

mutagens in salmonella mutation assay. Mutation Research 341: Pp. 71–75.<br />

Zamith, H.P., Vidal, M.N., Speit, G. & Paumgartten, F.J. 1993. Absence of genotoxic activity of<br />

beta-myrcene in the in vivo cytogenetic bone-marrow assay. Brazilian Journal of Medical<br />

<strong>and</strong> Biological Research 26: Pp. 93–98.<br />

158


MALAYSIA<br />

1.0 Scientific Name : Cymbopogon nardus (L.) Rendle<br />

Family : Poaceae<br />

2.0 Vernacular Names : Serai wangi (Malaysia); citronella grass (English);<br />

sereh, wangi, seriwang (Indonesia)<br />

3.0 Plant Description<br />

Perennial. Tufted with fibrous roots from a thickened base. Culms erect up to 2.5 m high, the<br />

tops drooping; leaf-sheaths glabrous; blades, the lower up to 1 m long by 2 cm wide, the upper<br />

smaller, edges <strong>and</strong> surfaces rough, glabrous except near the base; ligule up to 5 mm deap,<br />

glabrous. Inflorescence ultimate branches slender; zig-zag internodes about 1.5–2.5 cm long<br />

with reduced leaf at each node <strong>and</strong> at its axil one or more short branches each bearing a pair of<br />

racemes.<br />

4.0 Propagation : Cutting<br />

5.0 Geographical Distribution/Ecology<br />

It is widely distributed in tropical regions including India, Ceylon <strong>and</strong> Southeast Asia.<br />

6.0 Chemical Constituents<br />

Citronellol <strong>and</strong> citronellal; geraniol; borneol, bournonene, camphene, camphor, 1-carvotanacetone,<br />

d-3-carene, citronellybutyrate, D-citronellolacetate, D-citronellol-N-butyrate, p-cymene, elemol,<br />

ethanol, farnesol, furfurol, geranylacetate, geranylbutyrate, geranylformate, hexanol, limonene,<br />

linalol, linalylacetate, methyleugenol, methylisoeugenol, methylheptanone, menthol, myrcene, nerol,<br />

nerolidol, cis-ocimene, perillaldehyde, phell<strong>and</strong>ral, a-phell<strong>and</strong>rene, a-pinene, b-pinene, sabinene,<br />

a-terpineol, terpinen-4-ol, terpinolene, tujylalcohol, trans-ocimene <strong>and</strong> tricyclene<br />

159


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The mosquito-repellent activity of 38 essential oils from plants at three concentrations<br />

was screened against the mosquito Aedes aegypti under laboratory conditions using<br />

human subjects. On a volunteer’s forearm, 0.1 mL of oil was applied per 30 cm 2 of<br />

exposed skin. When the tested oils were applied at a 10% or 50% concentration, none of<br />

them prevented mosquito bites for as long as 2 h, but the undiluted oils of C. nardus<br />

(citronella), Pogostemon cablin (patchuli), Syzygium aromaticum (clove) <strong>and</strong><br />

Zanthoxylum limonella (Thai name: makaen) were the most effective <strong>and</strong> provided 2 h<br />

of complete repellency.From these initial results, three concentrations (10%, 50% <strong>and</strong><br />

undiluted) of citronella, patchouli, clove <strong>and</strong> makaen were selected for repellency tests<br />

against Culex quinquefasciatus <strong>and</strong> Anopheles dirus. As expected, the undiluted oil<br />

showed the highest protection in each case. Clove oil gave the longest duration of 100%<br />

repellency (2–4 h) against all three species of mosquito.<br />

7.2 Uses in traditional medicine:<br />

The whole plant is used traditionally for stomach comfort <strong>and</strong> digestion aid, as well as an<br />

emmenagogue <strong>and</strong> a wash after childbirth. It is found to have diuretic, sudorific <strong>and</strong><br />

antiperiodic properties.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Blacow, N.W. & Wade, A. 1973. The Extra Pharmacopoeia. 26th ed. London : The<br />

Pharmaceutical Press.<br />

Burkill, I.H. 1935. A Dictionary of the Economic Products of the Malay Peninsula. Crown<br />

Agents, London.<br />

Chowdury, J.U., Yusuf, M., Begun, J., Mondello, L., Previti, P. & Dugo, G. 1998. Studies on the<br />

essential oil bearing plants of Bangladesh. Part IV. Composition of the leaf oils of three<br />

Cymbopogon species : C. flexuosus (Nees ex Steud.) Wats., C. nardus (L.) Rendle var.<br />

confertiflorus (Steud.) N. L. Bor <strong>and</strong> C. martini (Roxb.) Wats. var. martini. Journal of<br />

Essential Oil Research 10: Pp. 301–306.<br />

De Billerbeck, V.G., Roques, C.G., Bessière, J.M., Fonvieille, J.L., & Dargent, R. 2001. Effect<br />

of Cymbopogon nardus (L.) W. Watson essential oil on the growth <strong>and</strong> morphogenesis of<br />

Aspergillus niger. Canadian Journal of Microbiology 47: Pp. 9–17.<br />

Gillil<strong>and</strong>, H.B. A Revised Flora of Malaya: Grasses of Malaya. Vol. 3. Government Printing<br />

Office, Singapore. Pp. 294–299.<br />

Hasnah, H. 1980. Analisis dan pencirian minyak bauan dari Cymbopogon nardus dan<br />

Cymbopogon winteriansis (minyak serai wangi). Tesis Smsn. Jabatan Kimia, Fakulti Sains<br />

Fizis dan Gunaan. Universiti Kebangsaan Malaysia, Bangi.<br />

160


MALAYSIA<br />

Ibrahim, J. & Zaridah, M.Z. 1995. Development of environmentally-friendly insect repellents<br />

from the leaf oils of selected Malaysian plants. in Ghazali, I.; Murtedza, M. & Laily, B.D. (Ed.)<br />

Chemical Prospecting in the Malaysian Forest. Sarawak : Pel<strong>and</strong>uk Publication (M) Sdn<br />

Bhd. Pp. 205–212.<br />

Jaganath, I.B. & Ng, L.T. 2000. The Green Pharmacy of Malaysia. Vinpress Sdn. Bhd.,<br />

Kuala Lumpur.<br />

Jantan, I.; Zaki, Z.M.; Ahmad, A.R.; & Ahmad, R. 1999. Evaluation of smoke from mosquito<br />

coils containing Malaysian plants against Aedes aegypti. Fitoterapia 70: Pp. 237–243.<br />

Ketoh, G.K.; Glitho, A.I.; & Huignard, J. 2002. Susceptibility of the bruchid Callosobruchus<br />

maculatus (F.) (Coleoptera: Bruchidae) <strong>and</strong> its parasitoid Dinarmus basalis (Hymenoptera:<br />

Pteromalidae) to three essential oils. Journal of Economic Entomology 95: Pp. 174–182.<br />

Press, Cambridge & Massachusetts.<br />

Raja, N., Albert, S., Ignacimuthu, S., & Dorn, S. 2001. Effect of volatile oils in protecting stored<br />

cowpea Vigna unguiculata (L.) Walpers against Callosobruchus maculatus (F.) (Coleoptera:<br />

Bruchidae) infestation. Journal of Stored Products Research 37: Pp. 127–132.<br />

Ridley, H.M. 1925. The Flora of the Malay Peninsular. Vol. V. Reeve & Co. Ltd, London.<br />

Perry, L.M. & Metzger, J. 1980. <strong>Medicinal</strong> <strong>Plants</strong> in East <strong>and</strong> Southeast Asia. The MIT<br />

Trongtokit Y, Rongsriyam Y, Komalamisra N, Apiwathnasorn C. 2005. Comparative repellency<br />

of 38 essential oils against mosquito bites. Phytother Res 19(4): Pp. 303–309.<br />

161


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Elephantopus scaber L.<br />

Family : Asteraceae<br />

2.0 Vernacular Names : Tutup bumi, tapak sulaiman (Malaysia)<br />

3.0 Plant Description<br />

An upright, stiff herb about 20–40 cm high, very pubescent due to abundance of trichomes<br />

throughout the entire plant. Leaves crowded at stem; base forming a rosette close to the ground,<br />

oblong, or broadest near the rounded or bluntly pointed tip, tapered to the base 4–15 cm long, 1–<br />

5 cm wide; leaf stalk very short, white, hairy; leaf margins sometimes wavy. Flower heads at<br />

the end of white-woolly branches rising from the leaves, several heads in a cluster, surrounded<br />

by broad, pointed, leaf-like bracts which are often tinged purplish; petal protruding nearly 1 cm<br />

beyond the inner, narrow, pointed bracts, pink with a white tube.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is distributed in Malaysia, Southeast Asia, mainl<strong>and</strong> China, Japan <strong>and</strong> Indo-China.<br />

6.0 Chemical Constituents<br />

Dotriacontanol, epifriedelinol, triacontanol, potassium chloride, 11, 13 – dihydrodeoxyelephantopin,<br />

11,13-dihydroelephantopin, stigmasterol, deoxyelephantopin, isodeoxy- elephantopin,<br />

epifriedelanol <strong>and</strong> lupeol<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

162


MALAYSIA<br />

7.2 Uses in traditional medicine:<br />

As an antibacterial, diuretic <strong>and</strong> aphrodisiac. It is useful in the treatment of venereal<br />

disease for women, fever, vomiting, dropsy <strong>and</strong> inflammation of the scrotum, as a tonic<br />

for women after childbirth, <strong>and</strong> to ward away evil spirits.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill, I.H. & Haniff, M. 1930. Garden Bulletin Straits Settlement 6: 219.<br />

Ch<strong>and</strong>ler, R.F. & Hooper, S.N. 1979. Friedelin <strong>and</strong> rhoiptelenyl acetate, a new pentacyclic<br />

triterpenoid associated triterpenoids. Phytochemistry 18: Pp. 711–724.<br />

DeSilva, L., Herath W.H.M.W., Jennings, R.C., Mahendran, M. & Wannigama, G.E. 1982. A<br />

new sesquiterpene lactone from Elephantopus scaber. Phytochemistry 21: Pp. 1173–1175.<br />

Gimlettle, J.D., & Burkill, I.H. 1930. Garden Bulletin Straits Settlement 6: 494.<br />

Gimlette, J.D. & Thomsom, H.W. 1939. A Dictionary of Malayan Medicine. London. Oxford<br />

University Press. 234 pp.<br />

Govindachari, T.R., Jadhav, S.J., Joshi, B.S., Kamat, V.N., Mohamed, P.A., Parthasarathy, P.C.,<br />

Patankar, S.J., Prakash, D., Rane, D.F. & Viswanathan, N. 1969. Indian Journal of Chemistry<br />

7: 308–310.<br />

Govindachari,,T.R., Viswanathan, N. & Fuhrer, H. 1972. Isodeoxyele-phantopin, a new<br />

germacranediolide from Elephantopus scaber Linn. Indian Journal of Chemistry 10: Pp.<br />

272–279.<br />

Malaysia Monograph Committee. 1999. Malaysia <strong>Herbal</strong> Monograph Vol. 1. Kuala Lumpur.<br />

Republic of China & the National Science. 1978. Flora of Taiwan 4:853. Epoch Pub.Co.Ltd.,<br />

Taiwan.<br />

Perry, L. M. 1980. <strong>Medicinal</strong> <strong>Plants</strong> of East <strong>and</strong> Southeast Asia.. Massachusetts MIT<br />

Press. 92 pp.<br />

Pongboonrod, S., Mai-tet-muang-thai. 1979. Kasem Bannakich 222 pp.<br />

Sim, K.Y. & Lee, H.T. 1969. Constituents of Elephantopus scaber (Compositae)<br />

Phytochemistry 8(5): Pp. 934–935.<br />

163


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Eurycoma longifolia Jack<br />

Family : Simaroubaceae<br />

2.0 Vernacular Names : Tongkat ali, penawar pahit, bedara pahit, tongkat baginda,<br />

petala bumi, pasak bumi , setunjang bumi<br />

3.0 Plant Description<br />

A medium-sized slender shrub reaching 10 m in height, often unbranched with reddish brown<br />

petioles. Leaves compound, even pinnate reaching 1 m in length, each consists of 30–40 leaflets,<br />

lanceolate to obovate-lanceolate, each leaflet is about 5–20 cm long, 1.5–6 cm wide, much paler<br />

on the ventral side. Inflorescence axillary, in large brownish red panicle, very pubescent with<br />

very fine, soft, gl<strong>and</strong>ular trichomes. Flowers are hermaphrodite; petals small, very fine pubescent,<br />

drupe hard, ovoid, yellowish brown when young <strong>and</strong> brownish red when ripe.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Malaysia, lower Myanmar, Thail<strong>and</strong>, Indo-China to Sumatra <strong>and</strong> Borneo<br />

6.0 Chemical Constituents<br />

Aervin, stigmasterol, campesterol, b-sitosterol, 9-hydroxycanthin-6-one, 9-hydroxycanthin-6-one<br />

n-oxide, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one n-oxide, b-carboline-1-propionic acid,<br />

b-7-methoxycarboline-1-propionic acid, eurycomalactone, eurycomanol, eurycomanol<br />

2-O-b-D-glucoside, 13-b-18-dihydroeurycomanol,14-15-dihydroxyklaineanone eurycomanone,<br />

13-21-dihydroeurycomanone, 13-b-21-dihydroxyeurycomanone, 14-15-b-dihydroxyklaineanone,<br />

longilactone<br />

164


MALAYSIA<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Antimalarial <strong>and</strong> antihistaminic<br />

7.2 Uses described in traditional medicine:<br />

The roots are useful for fever, medication after birth, boils, wounds, ulcer, syphilis <strong>and</strong><br />

bleeding gums.<br />

8.0 Contraindications<br />

Not available.<br />

9.0 Bibliography<br />

Burkill I. H. 1966. A Dictionary of the Economic Product of the Malay Peninsula, Ministry<br />

of Agriculture, Malaysia , Volumes I & II: Pp. 1000.<br />

Burkill, I. H. & Haniff, M. 1930. Garden Bulletin Straits Settlement. 6: Pp.182.<br />

Chan K. L., O’Neill M. J., Phillipson J. D. & Warhurst D. C. 1986. <strong>Plants</strong> as sources of<br />

antimalarial drugs. Part 3: Eurycoma longifolia. Planta Medica 52: Pp. 105–107.<br />

Chan, K. L., Lee, S. P., Sam, T. H. & Han, B. H. 1989. A quassinoid glycoside from the roots of<br />

Eurycoma longifolia Phytochemistry 28: Pp. 857–2859.<br />

Chan, K. L., Lee, S. P., Sam, T. H. & Tan, S. C., Noguchi, H. & Sankawa, U. 1991. 13â, 18-<br />

dihydroeurycomano – a quassinoid from Eurycoma longifolia. Phytochemistry 30: Pp. 3138–<br />

3141.<br />

Darise, M., Kohda, H., Mizutani, K. & Tanaka, 0. 1982. Eurycomanone <strong>and</strong> eurycomanol,<br />

quassinoids from the roots of Eurycoma longifolia. Phytochemistry 21: Pp. 2091–2093.<br />

Gimlette J. D. & Burkill, I. H. 1930. Garden Bulletin Straits Settlement.6: 329.<br />

Gimlette, J. D. & Thomson, H. W. 1939. A Dictionary of Malayan Medicine, London:<br />

Oxford Univ. Press. Pp. 242.<br />

Kardono L. B. S., Angerhoper C. K., Tsauri S., Padmawinata K., Pezzuto J. M. & Kinghorn A.<br />

D. 1991. Cytotoxic <strong>and</strong> antimalarial constituents of the roots of Eurycoma longifolia. Journal<br />

of Natural Products 54: 1360–1367.<br />

Marziah Mohammad. 1987. Tanaman Perubatan Tradisional, Serdang : Universiti Pertanian<br />

Malaysia.<br />

Morita, H., Kishi, E., Takeya, K., Itokawa, H. & Tanaka, O. 1990. New quassinoids from the<br />

roots of Eurycoma longifolia. Chemistry Letters 5: Pp. 749–752.<br />

Oei-Koch A. & Kraus L. 1978. Constituents of Eurycoma longifolia. I. Sterols <strong>and</strong> saponins.<br />

Planta Medica. 34: Pp. 39.<br />

165


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Fibraurea tinctoria Lour.<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Kamin kura, kuma kua, manmiet, akar stupai, olor lobai<br />

(Thail<strong>and</strong>); areuj gember (Java), akar badi, akar kunyit, akar<br />

penawar, mengkunyit, akar kuning, akar mengkunyit, akar<br />

kencing kerbau (Malaysia)<br />

3.0 Plant Description<br />

Big liana. Leaves ovate oblong, base rounded, apex acuminate; nerves from base, prominent<br />

beneath, deep green coriaceous glabrous, 18 cm long, 10 cm wide; petioles 6.4 cm long. Flowers,<br />

male, white in lax panicles from old wood, 5 to 15.2 cm long. Bracts narrow linear cute. Sepals<br />

6, rounded-obovate. Inner petals narrower than outer ones, elliptic. Stamens 6, bluish green.<br />

Female flowers green. Carpels 3, obovoid bluish green. Drupe orange colour, elliptic smooth,<br />

pulp bitter, 3.8 cm long. Seed oblong, 2.5 cm long, grooved deeply on the lower surface, ends<br />

rounded.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographic distribution<br />

It is very common in secondary forest in lowl<strong>and</strong> to hill forest throughout Malaysia.<br />

6.0 Chemical constituents<br />

Berberrubine, fibleucin, fibraurin, 6-hydroxyfibraurin, palmatrubine, pseudojatrorrhizine,<br />

carboxyfibleucin, chasmatine, colombamine, jatrorrhizine, magnoflorine, palmatine<br />

166


MALAYSIA<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinicsl data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The stem <strong>and</strong> roots are used after childbirth, to treat stomach-ache, dysentery, diabetes,<br />

headache <strong>and</strong> eye-ache; smoke from dry wood is inhaled for ulceration of the nose. The<br />

yellow colour from the wood is used as colouring agent.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bakhari N. A., Wah S. T., Cinnakali K., Fu H.-K. & Razak I. A. 1999. Acta Cryst. C55: Pp.<br />

228–230.<br />

Gimlette, G. D. 1939. A Dictionary of Malayan Medicine. Oxford Univ. Press, Kuala Lumpur.<br />

Lemmens R.H.M.J. 1991. PROSEA 3. Dye <strong>and</strong> tannin-producing plants. Fibraurea<br />

tinctoria Lour. (Eds. Lemmens & Wulijarni-Soetjipto). Pudoc Wageningen. Pp. 74–75.<br />

Ridley, H.N. 1922. The Flora of the Malay Peninsula. Vol 1. Reeve & Co. Ltd, London. Pp.<br />

101–115.<br />

Unone. 2000. Dictionary of Natural Products. Chapman & Hall. UK.<br />

Van Steenis C. G. G .J. & De Wilde W. J. J. O. 1984-1989. Flora Malesiana. Kluwer<br />

Academic Pub. Dordrecht/Boston/London. Vol 10(2): Pp. 207–209.<br />

167


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Gynura procumbens Merr.<br />

Family : Asteraceae<br />

2.0 Vernacular Names : Sambung nyawa, daun dewa (Malaysia)<br />

3.0 Plant Description<br />

Herbaceous, fleshy, purple tinge stem. Leaves fleshy, hairy, oval to elliptic, up to 9 cm long, 3.7<br />

cm wide, <strong>and</strong> margin with small, widely spaced teeth. Flower heads about 1 to 2.5 cm long,<br />

narrow, hanging on long stalks in a branched inflorescence, tubular shaped, orange. Fruits narrow,<br />

with 10 ribs <strong>and</strong> a fine, white, silky pappus.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographic Distribution<br />

It is common in tropical countries <strong>and</strong> grows well in open places in lowl<strong>and</strong>s to hills.<br />

6.0 Chemical Constituents<br />

Gynurone, 4-hydroxy-4-methyl-2-pentanone, methyl hexadecanoate, methyl 9-octadecenoate,<br />

bis(2-ethylhexyl)-1,2-benzenedicarboxylate, dibutyl malonate, 6,10,14-trimethyl-2-pentadecanone,<br />

dctadecanal, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, stigmasterol, â-sitosterol, ethyl p-<br />

methoxycinnamate, 4-hydroxy-4-methyl-2-pentanone, stigmasterol acetate, flavonol quercitin,<br />

quercitin 3-O-rhamnosyl(1-6)galactoside, quercitin 3-O-rhamnosy(1-6)glucoside, nonadecane,<br />

phytyl valerate, kaempferol 3-O-glucoside, kaempferol 3-O-neohesperidoside, adenosine<br />

168


MALAYSIA<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

i. The crude ethanolic extract of G. procumbens has antiinflammatory action. To<br />

relate the activity to particular fractions using a croton oil-induced mouse ear<br />

inflammation model, the original ethanolic extract of G. procumbens was partitioned<br />

between water <strong>and</strong> ethyl acetate. The residues were subjected to antiinflammatory<br />

evaluation. While the water extract did not show any antiinflammatory activity, the<br />

administration of the original organic extract significantly inhibited the increase in<br />

ear thickness in response to croton oil (n = 5). The activity of 0.75 mg/ear original<br />

organic extract showed similar antiinflammatory activity (inhibition 65.2%) to that<br />

of 6 mg/ear hydrocortisone 21-hemisuccinate sodium salt (inhibition 64.8%). The<br />

organic extract was then fractionated with a series of solvents in order of increasing<br />

polarity. Each fraction was dried, dissolved in acetone <strong>and</strong> monitored using the<br />

same bioassay. These experiments showed that the hexane <strong>and</strong> toluene fractions<br />

showed significant inhibitions of 44.6% <strong>and</strong> 34.8%, respectively. These two fractions<br />

had similar activities to 4 mg/ear of hydrocortisone (inhibition 35.0%). The possible<br />

chemical constituents in the extracts <strong>and</strong> fractions were investigated using thin<br />

layer chromatography <strong>and</strong> specific color reagents. These tests showed that steroids<br />

might be one class of antiinflammatory compounds in this plant.<br />

ii. The ethanolic extract of the leaves of G. procumbens, at single doses of 50, 150<br />

<strong>and</strong> 300 mg/kg orally, significantly suppressed the elevated serum glucose levels in<br />

diabetic rats; 150 mg/kg was found to be the optimum hypoglycaemic dose. The<br />

extract, however, did not significantly suppress the elevated serum glucose levels<br />

in normal rats, unlike glibenclamide. Metformin, but not glibenclamide, improved<br />

glucose tolerance in the diabetic rats. When the optimum dose was given to diabetic<br />

rats for seven days, the extract significantly reduced serum cholesterol <strong>and</strong><br />

triglyceride levels in these rats. These results indicate that the leaves of G.<br />

procumbens may have biguanide-like activity.<br />

7.2 Uses in traditional medicine:<br />

The plant has antidiabetic <strong>and</strong> antimalarial properties. The leaves are used as a febrifuge<br />

in eruptive fever, to treat kidney problem, rheumatism <strong>and</strong> colon cancer.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Akowuah, A. G. 2000. Phytochemical <strong>and</strong> Hypoglycaemic Studies of Gynura procumbens<br />

(Lour.), Merr., Universiti Sains Malaysia, Penang.<br />

Aminah, H. I. 1994. Kajian Fitokimia Daun Sambung Nyawa. Universiti Sains Malaysia,<br />

Penang.<br />

Burkill, I. H 1996. A Dictionary of the Economic Products of the Malay Penisula. Ministry<br />

of Agriculture <strong>and</strong> Cooperative, Kuala Lumpur.<br />

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Christophe, W. 2000. <strong>Medicinal</strong> <strong>Plants</strong> of Southeast Asia. Pel<strong>and</strong>uk Pubs. Sdn Bhd. Kuala<br />

Lumpur.<br />

Henderson, M.R. 1951. Malayan Wild Flowers.: Dicotyledons. Malayan Nature Society.<br />

Kuala Lumpur. Pp. 478.<br />

Isk<strong>and</strong>er MN, Song Y, Coupar IM, Jiratchariyakul W. 2002. Antiinflammatory screening of the<br />

medicinal plant Gynura procumbens. Plant Foods Hum Nutr. 57(3-4): Pp. 233–244.<br />

Materia Medica Indonesia. Jilid 4. 1978. Departemen Kesehatan Republik Indonesia,<br />

Indonesia.<br />

Zhang XF, Tan BK. 2000. Effects of an ethanolic extract of Gynura procumbens on serum<br />

glucose, cholesterol <strong>and</strong> triglyceride levels in normal <strong>and</strong> streptozotocin-induced diabetic rats.<br />

Singapore Med. J. 41(1): Pp. 9–13.<br />

170


MALAYSIA<br />

1.0 Scientific Name : Kaempferia galanga L.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Kencur (Indonesia); cekur (Malaysia); dusol (Philippines); pro<br />

hom, waan hom, waan teen din (Thail<strong>and</strong>); dia lien, son nai,<br />

tam nai (Viet Nam)<br />

3.0 Plant Description<br />

Herbaceous with fleshy rhizomes. Leaves 2 or 3, spreading out close to the ground, usually<br />

more or less broadly elliptical in outline <strong>and</strong> asymmetrical, tip broadly pointed, base rounded,<br />

usually covering the earth, 8–10 cm long, 6–7 cm wide with wavy margins; petiole very short,<br />

3–10 mm long. Flowers white with a purple patch on one petal of the corolla. Corolla is about 3<br />

cm long, consists of 3 bracteas which are half as long as the corolla. Rhizomes short <strong>and</strong> stout,<br />

light brown, the rhizome consists of dense small tubers sometimes adhering to one another to<br />

form a larger tuber.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

It is cultivated throughout Malaysia <strong>and</strong> is also found in Indonesia, Southern China <strong>and</strong> Indo-<br />

China.<br />

6.0 Chemical Constituents<br />

The rhizome contains chlorogenic acid, p-hydroxybenzoic acid, vanillic acid, car-3-en-5-one,<br />

cinnamic acid ethyl ester, p-methoxycinnamic acid, p-methoxycinnamic acid ethyl ester, transp-methoxycinnamic<br />

acid ethyl ester, trans-p-methoxycinnamic acid, n-pentadecana, ethyl-pmethoxycinnamate,<br />

ethyl cinnamate, carene, camphene, borneol, p-methoxystyrene<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The rhizomes are carminative. They are useful for skin problems, leucorrhea, sinusitis,<br />

sore eyes, tonic, bruises, inflammation, childbirth, coughs, rheumatism, sore throat <strong>and</strong><br />

fever.<br />

8.0 Contraindications<br />

Not available.<br />

9.0 Bibliography<br />

Burkill, I. H. & Haniff, M. 1930. Garden Bulletin Straits Settlement 6: 264.<br />

Burkill, I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry<br />

of Agriculture <strong>and</strong> Cooperative, Kuala Lumpur. Vol. I & II.<br />

Duke, J. A. 1985. C.R.C. H<strong>and</strong>book of Medicine Herbs. Florida CRC Press.<br />

Gimlette, J. D. & Thomson, H. W. 1939. A Dictionary of Malayan Medicine, Oxford University<br />

Press, London.<br />

Gimlettle, J. D & Burkill, I. H. 1930. Gardens Bulletin Straits Settlement. 6: 451.<br />

Kiuchi, F., Nakamura, N. & Tsuda, Y. 1987. 3-Caren-5-one from Kaempferia galanga.<br />

Phytochemistry 26(12): 3350–3351.<br />

Kiuchi, F., Nakamura, N., Tsuda, Y., Kondo, K. & Yoshimura, H. 1988. Studies on crude drugs<br />

effective on visceral larva migrans. II. Larvicidal principles in Kaempferia galanga. Chemical<br />

<strong>and</strong> Pharmaceutical Bulletin 36(1): 412–415.<br />

Kosuge, T., Yokota, M., Sugiyama, K., Saito, M., Iwata, Y., Nakura, M. & Yamamoto, T. 1985.<br />

Studies on anticancer principles in Chinese medicine. II. Cytotoxic principles in Biota orientalis<br />

(L.) Endl. <strong>and</strong> Kaempferia galangal L. Chemical <strong>and</strong> Pharmaceutical Bulletin 33(12):<br />

5565–5567.<br />

Malaysian Monograph Committee. 1999. Malaysian <strong>Herbal</strong> Monograph. Vol. 1: 41–44.<br />

Merh, P. S., Daniel, M. & Sabnis, S. D. 1986. Chemistry <strong>and</strong> taxonomy of some members of the<br />

zingibererales. Current Science 55: 835–839.<br />

Noro, T., Miyase, T., Kuroyanagi, M., Ueno, A. & Fukushima, S. 1983. Monoamine oxidase<br />

inhibitor from the rhizomes of Kaempferia galangal L. Chemical <strong>and</strong> Pharmaceutical Bulletin<br />

31(8): 2708–2711.<br />

172


MALAYSIA<br />

1.0 Scientific Name : Labisia pothoina Lindl.<br />

Synonym : L. pumila Benth. & Hook.f.<br />

Family : Myrsinaceae<br />

2.0 Vernacular Names : Kacip fatimah, selusuh fatimah (Malaysia).<br />

3.0 Plant Description<br />

Small herbaceous under-shrub, rooting from the stem. Leaves few, usually 4–12, pointing<br />

upwards, elliptic-lanceolate <strong>and</strong> acuminate, tip pointed <strong>and</strong> base tapered or rather broad-rounded,<br />

the whole leaf is about 5–35 cm long <strong>and</strong> 2–8 cm wide, finely toothed with numerous veins, dark<br />

green on adaxial, lighter green on abaxial; petiole usually 2–8 cm but may reach 12 cm long;<br />

the leaf blade running down to form a broad or narrow wing, or often absent. Flowers are very<br />

small, pink or white, in spike like panicle of small clusters, 6–30 cm long; sepals, petals <strong>and</strong><br />

stamens 5; the petals wrapped round <strong>and</strong> enclosing the stamens. Fruit about 0.5 cm diameter,<br />

bright red or purple.<br />

4.0 Propagation : Not available<br />

5.0 Geographical Distribution/Ecology<br />

It is found in Malaysia <strong>and</strong> Indo-China <strong>and</strong> is common in dense forests all over the countries in<br />

the lowl<strong>and</strong>s, sometimes in the hills.<br />

6.0 Chemical constituents<br />

(Z)-5- (pentadec-4’-enyl)benzene-1,3-diol, (Z)-5- (pentadec-8’-enyl) benzene-1,3-diol, (Z)-5-<br />

(pentadec-10’-enyl) benzene-1,3-diol , pelargonidin<br />

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7.0 Reports on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Extract of L. pothoina roots showed antiinflammatory activity <strong>and</strong> antibacterial activity.<br />

7.2 Uses in traditional medicine:<br />

The plant is used for gynaecological problems, to quicken delivery, as after-birth medicine,<br />

for flatulence, dysentery, menstruation problem <strong>and</strong> venereal diseases.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill I. H. 1966. A Dictionary of the Economic Product of the Malay Peninsula. Ministry<br />

of Agriculture, Malaysia, , I & II, Pp. 1311.<br />

Fasihuddin,A., Rahman, A. H. Hasmah, R. 1995. <strong>Medicinal</strong> plants used by Bajau community in<br />

Sabah. In Trends in Traditional Medicine Research. Chan, K.L. et al. (Eds.). University<br />

Science Malaysia, Penang. Pp. 493–504.<br />

Gimlette J. D. & Thomson H. W. 1939. A Dictionary of Malayan Medicine. Oxford Univ.<br />

Press, London. Pp. 58.<br />

Ibrahim, J. Yong, H. K., Dae, Y. S. & Byung, H. H. 1996. Inhibitory effects of Malaysian<br />

medicinal plants on the platelet-activating factor (PAF) receptor binding. Natural Product<br />

Science 2(2): Pp. 86–89.<br />

Nik Musaadah, M., Nur Muna, H. A. M. & Rasadah, M. A. 2004. Topical anti-inflammatory<br />

activity of L. pumila. In Proceedings of the Seminar on <strong>Medicinal</strong> <strong>Plants</strong>, 20–21 Aug.<br />

2002. Chang, Y. S. et al. (Eds.) FRIM, Kepong. Pp.168–170.<br />

Perry L. M. <strong>Medicinal</strong> <strong>Plants</strong> of East <strong>and</strong> Southeast Asia. 1980. M.I.T. Press, Massachusetts.<br />

Pp. 282.<br />

174


MALAYSIA<br />

1.0 Scientific Name : Languas galanga Stuntz<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Lengkuas (Malaysia); khaa (Thail<strong>and</strong>); palla (Philippines);<br />

rieng, rieng kho, rieng nep, son nai (Viet Nam)<br />

3.0 Plant Description<br />

Grows from rhizomes. The young stem sprouts out from the base of the old stem. Stem non-woody,<br />

soft, watery, smooth <strong>and</strong> green in colour. Leaves lanceolate with pointed end, 24–27 cm long,<br />

3.5– 11.5 cm wide; upper surface of leaf is dark green <strong>and</strong> lighter green underneath; leaf margin<br />

is wavy; petiole short, 1–1.5 cm long; ligule (tongue shaped), brown with very fine hairs. Flower<br />

terminal with a large peduncle, bell shaped, 12 cm long, greenish white. The number of flowers<br />

lower down the stalk is more (3–6) compared with the upper part (1–2); bract lanceolate,<br />

pointed, thin <strong>and</strong> glabrous. The size of the bract decreases towards the peak of the peduncle.<br />

4.0 Geographical Distribution/Ecology<br />

It is cultivated in rather wet ground in Malaysia, Indo-China, Indonesia <strong>and</strong> Thail<strong>and</strong>.<br />

5.0 Propagation : Rhizome<br />

6.0 Chemical Constituents<br />

1-acetoxychavicol acetate, 1-hydroxychavicol acetate, a-terpineol, 4-hydroxybenzaldehyde, transconiferyl<br />

diacetate, trans-p-coumaryl diacetate, a-bergamotene, b-bisabolene, borneol, borneol<br />

acetate, butanol acetate, camphene, carveol I, carveol II, chavicol, chavicol acetate, citronellol<br />

acetate, a-copaene, curcumene, p-cymene, p-cymenol, eugenol methyl ether, 1-acetoxyeugenol<br />

acetate, trans-b-farnescene, geraniol acetate, a-humulene, limonene, myrcene, nerol acetate,<br />

pentadecane, linalool, propanol acetate, 2-methyl sabinene, santalene, b-sesquiphell<strong>and</strong>rene, g-<br />

terpinene, terpinolene, tridecane, caryophyllene oxide, 1-acetoxychavicol acetate, 1-hydroxycineol<br />

acetate, p-hydroxycinnamaldehyde, di-(p-hydroxy-cis-styryl)-methane, a-pinene, b-pinene,<br />

175


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

quercetin, kaempferol, quercetin-3-methyl ether, isorhamnetin, kaempferide, galangin <strong>and</strong> galangin-<br />

3-methyl ether<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Flavonoids from the rhizome showed antifungal activity against Trichophyton rubrum,<br />

T. mentagrophytes, Epidermophyton floccosum <strong>and</strong> other gram-positive <strong>and</strong> gramnegative<br />

bacteria.<br />

7.2 Uses in traditional medicine:<br />

The rhizome is antiseptic. It is useful for fever, pityriasis versicolor, afterbirth, colic,<br />

ringworm, puerpera, flatulence, headache, borborygmus, desquamation of soles <strong>and</strong> h<strong>and</strong>,<br />

stomach-ache <strong>and</strong> diarrhoea, insanity <strong>and</strong> menstrual pain. It strengthens stomach <strong>and</strong><br />

intestine, improves digestion <strong>and</strong> purifies blood.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

A. Samad Ahmad. 1988. Warisan Perubatan Melayu. Dewan Bahasa dan Pustaka, Kuala<br />

Lumpur. Pp. 126.<br />

Barik, B. R., Kundu, A. B. & Dey, A. K. 1987. Two phenolic constinuents from Alpinia galanga<br />

rhizome. Phytochemistry 26: Pp. 2126–2127.<br />

Burkill, I. H. & Haniff, M. 1930. Garden Bulletin Straits Settlement.6: Pp. 268.<br />

Burkill, I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Ministry<br />

of Agriculture, Malaysia. I & II: Pp. 1327–1332.<br />

De Pooter, H. L., Omar, M. N., Coolsaet, B. A. & Schamp, N. M. 1985. The essential oil of<br />

greater galanga (Alpinia galanga) from Malaysia. Phytochemistry 24: Pp. 93–96.<br />

Gimlette, J. D. & Haniff, M. 1930. Garden Bulletin Straits Settlement 6: Pp. 473.<br />

Gimlette, J. D. & Thomson, H. W. 1939. A Dictionary of Malayan Medicine, Oxford University<br />

Press. London. Pp. 145–146.<br />

Holtum, R. E. 1950. The Garden Bulletin Singapore 12: Pp. 142.<br />

Janssen, A. M. & Scheffer, J. J. C. 1985. Acetoxychavicol acetate, an antifungal component of<br />

Alpinia galangal. Planta Medica 50: Pp. 507–511.<br />

Janssen, A. M., Scheffeer, J. J. C. & Baerheim-Svendsen, A. 1985. Abstract International.<br />

Res. Congress Natural Product Coll. Pharm., University North Carolina. July 7–12. Pp.<br />

45.<br />

Leungsakul, S. 1987. Antipyogenic bacterial activities of extracts from six species of medicinal<br />

plants. 13th Symposium on Sciences <strong>and</strong> Technology of Thail<strong>and</strong>, Songkhla, Thail<strong>and</strong>, 20–22<br />

October 1987.<br />

176


MALAYSIA<br />

1.0 Scientific Name : Mitragyna speciosa Korth.<br />

Family : Rubiaceae<br />

2.0 Vernacular Names : Biak, biak-biak, ketom, kutum (Malaysia), kratom, krathom,<br />

ithang, kakuam or thom (Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

Large tree about 20 m height. Leaves orbicular or ovate blunt acuminate; base round cordate or<br />

narrowed, 5–15 cm long, 2.5–10 cm wide. Stipule obovate. Peduncles usually in threes, axillary,<br />

3–5.5 cm long; head 1.2 cm. Fruit head 1.2 cm, oblong-ovoid.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

It occurs is lowl<strong>and</strong>s throughout Malaysia <strong>and</strong> Thail<strong>and</strong>.<br />

6.0 Chemical Constituents<br />

Ajmalicine, ajmaliene, aquamigine, apigenin, apigenin-7-O-glucoside, apigenin-7-Orhamnoglucoside,<br />

caffeic acids, ciliaphylline, corynantheidine, corynoxeine, corynoxines, 3-<br />

dehyromitragynine, epicatechin, 3-epiisorotundifoline, 9-hydroxyryhncophylline-type oxindoles,<br />

hyperoside, 3-isoajmalicine, isocorynantheidine, isopaynantheine, isomitrafoline, isomitraphylline,<br />

isorotundifoleine, isospeciofoline, isoquercitrin, isospecionoxeine, javaphylline, kaempferol,<br />

kaempferol-3-glucoside, mitraciliatine, mitrafoline, mitragynine, mitrajavine, mitraphylline,<br />

mitraspecine, mitraversine, oxyindole alkaloids, paynantheine, quercitin, quercitin-3-galactoside-<br />

7-rhamnoside, quercitrin, rhynchociline, rhynchophylline, rotundifoleine, rutin, speciociliatine,<br />

speciofoline, speciogynine, specionoxeine, speciophylline, stipulatine, uncarine<br />

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7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Mitragyna speciosa possesses mild anti-narcotic activity. It has a morphine-like action<br />

on gastric acid secretion in the CNS (central nervous system). Its anti-depressant<br />

activity has no effect on the spontaneous motor activity. It has acute <strong>and</strong> long-term effects<br />

on food <strong>and</strong> water intake <strong>and</strong> body weight in rats.<br />

Alkaloid extract of the plant indicates an antinociceptive <strong>and</strong> /or antidepressive actions<br />

partly through activation of the dorsal raphe nucleus in rat CNS.<br />

7-hydroxymitragynine isolated from plant demonstrated induced more potent opioid<br />

antinociceptive effects <strong>and</strong> was less constipating than morphine.<br />

Indole-alkaloid mitragynine of the plant inhibits the contraction of the vas deferens produced<br />

by electrical transmural stimulation in guinea pig probably through its blockage of neuronal<br />

Ca 2+ channels.<br />

Administration mitragynine in mice contributes descending noradrenergic <strong>and</strong> serotonergic<br />

systems which are involved in the antinociceptive activity of supraspinally on the mechanical<br />

noxious stimulation, while the descending noradrenergic system predominantly contributes<br />

to the effect of supraspinal mitragynine on the thermal noxious stimulation <strong>and</strong> may differ<br />

from morphine in mice.<br />

7.2 Uses in traditional medicine:<br />

The leaves are used as poultice to treat wound, fever <strong>and</strong> expel worms in the stomach<br />

<strong>and</strong> enlarged spleen. They are also used as analgesic, antidiarrhoea, antihelmintic, stimulant,<br />

fumitory, masticatory, mild narcotic <strong>and</strong> remedy for opium addiction.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Abdul Karim, A. G., Alam Shah, S. & A. Hasimah, 1991. Tissue culture <strong>and</strong> alkaloid production<br />

from Mitragyna speciosa Korth. In <strong>Medicinal</strong> Products from Tropical Rain Forests:<br />

Proceedings of the Conference, May 13–15 1991. Khozirah, S. et al. (Eds.) FRIM, Kepong.<br />

Pp. 228–230<br />

Beckett, A. H., Shellard, E. J., Phillipson, J. D. Calvin & Lee, M. 1965. Alkaloids from Mitragyna<br />

speciosa (Korth.). Journal of Pharmacy <strong>and</strong> Pharmacology 17: 753–755<br />

Burkill I. H. 1966. A Dictionary of the Economic Product of the Malay Peninsula. Ministry<br />

of Agriculture <strong>and</strong> Cooperative, Kuala Lumpur. Vol. I & II.<br />

Burkill, I.H & Haniff, M. 1930. The Garden’s Bull. Straits Settlement. Vol. 6.<br />

Chaudhury, R. R. 1986. Folklore herbal contraceptive <strong>and</strong> remedies. Trends in Pharmacological<br />

Sciences 7(4): 120–123.<br />

Emboden, W. 1979. Narcotic <strong>Plants</strong>. Macmillan Pub. Co., New York.<br />

178


MALAYSIA<br />

Goh, S. H., Chuah, C. H., Mok, J. S. L. & Soepadmo, E. 1995. Malaysian <strong>Medicinal</strong> <strong>Plants</strong><br />

for the Treatment of Cardiovascular Disease. Pel<strong>and</strong>uk Pub., Kuala Lumpur.<br />

Harbone, J. B. & Baxter, H. 1993. Phytochemical Dictionary. Taylor & Francis, Baringstoke.<br />

Horie, S., Koyama, F., Takayama, H., Ishikawa, H., Aimi, N., Ponglux, D., Matsumoto, K. &<br />

Murayama, T. 2005. Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa that has<br />

opioid agonistic effect in guinea-pig ileum. Planta Medica 71(3): 231–236.<br />

Jansen, K. L. R. & Prast, C. J. 1988. Ethnopharmacology of kratom <strong>and</strong> the Mitragyna alkaloids.<br />

Journal of Ethnopharmacology 23: 115–119.<br />

Malaysian <strong>Herbal</strong> Monograph Committee. 2009. Malaysian <strong>Herbal</strong> Monograph. Vol. 2. FRIM,<br />

Kuala Lumpur.<br />

Matsumoto, K., Mizowaki, M., Suchitra, T., Takayama, H., Sakai, S., Aimi, N. & Watanabe, H.<br />

1996. Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal<br />

opioid receptors. Life Sciences 59(14): 1149–1155.<br />

Razak, H. L & Adenan, J. 2000. Siri Tumbuhan Beracun in Penawar Racun. PRN Bulletin,<br />

Penang. Vol. 30.<br />

Ridley, H. N. 1922. The Flora of the Malay Peninsula. Vol II. L. Reeve & Co. Ltd, London.<br />

Tsuchiya, S., Miyashita, S., Yamamoto, M., Horie, S., Sakai, S., Aimi, N., Takayama, H. &<br />

Watanabe, K. 2002. Effect of mitragynine, derived from Thai folk medicine, on gastric acid<br />

secretion through opioid receptor in anesthetized rats. European Journal of Pharmacology<br />

443(1-3): 185–188.<br />

Zarembo, J. E., Douglas, B., Valenta, J. & Jerry, A. W. 1974. Metabolites of Mitragynine.<br />

Journal of Pharmaceutical Sciences 63: 1407–1415.<br />

179


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Momordica charantia L.<br />

Family : Cucurbitaceae<br />

2.0 Vernacular Names : Bitter melon, balsam apple, peria katak (Malaysia)<br />

3.0 Plant Description<br />

Herbaceous, slender climber with tendril, slightly pubescent, the tendril up to 20 cm long. Leaves<br />

10–12 cm long, palmately 5–7 lobed; the lobes sinuate-dentate. Flowers yellow; peduncle with<br />

a reniform bracteole; corolla 1.5–2 cm long. Fruit obovoid or oblong-cylindric, coarsely ridged<br />

<strong>and</strong> bumpy-tuberculate, up to 20 cm long, orange or dark yellow when ripe. Seeds black covered<br />

with a soft, fleshy red aril, 12–16 mm long.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Native to tropical Africa <strong>and</strong> Asia, it grows wild or is planted in house gardens throughout<br />

Southeast Asia.<br />

6.0 Chemical Constituents<br />

5-a-stigmasta-7,25-dien-3-betalol, 5-hydroxytryptamine, alkaloids, a-elaeostearic-acid ascorbigen,<br />

b-sitosterol-d-glucoside, charantin, citrulline, cryptoxanthin, elasterol, flavochrome, fluoride, gaba,<br />

galacturonic-acid, lanosterol,Lutein, lycopene, momordicin, momordicoside-F-1, momordicoside-<br />

F-2, momordicoside-G, momordicoside-I, mutachrome, oxalate, oxalic-acid, pipecolic-acid,<br />

polypeptide-p, rubixanthin, stigmasta-5,25-dien-3-b-ol, sugars, zeaxanthin, speciophylline,<br />

stipulatine, uncarine<br />

180


MALAYSIA<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

In vivo studies<br />

i. Blood sugar-lowering effect of this bitter fruit. The fruit has also shown the ability<br />

to enhance cells’ uptake of glucose, to promote insulin release, <strong>and</strong> to potentiate<br />

the effect of insulin.<br />

ii. Bitter melon’s fruit <strong>and</strong>/or seed have been shown to reduce total cholesterol.<br />

Elevated cholesterol <strong>and</strong> triglyceride levels in diabetic rats were returned to normal<br />

after 10 weeks of treatment.<br />

iii. Antitumour activity of the entire plant of bitter melon. Water extract blocked the<br />

growth of rat prostate carcinoma; another study reported that a hot water extract<br />

of the entire plant inhibited the development of mammary tumours in mice.<br />

iv. The leaf extract increased resistance to viral infections <strong>and</strong> had an immunostimulant<br />

effect in humans <strong>and</strong> animals, increasing interferon production <strong>and</strong> natural killer<br />

cell activity.<br />

In vivo clinical studies<br />

i. The studies have demonstrated the relatively low toxicity of all parts of the bitter<br />

melon plant when ingested orally. However, toxicity <strong>and</strong> even death in laboratory<br />

animals have been reported when extracts were injected intravenously.<br />

ii. Other studies have shown extracts of the fruit <strong>and</strong> leaf (ingested orally) to be safe<br />

during pregnancy.<br />

iii. Other studies have shown extracts of the fruit <strong>and</strong> leaf (ingested orally) to be safe<br />

during pregnancy. The seeds, however, have demonstrated the ability to induce<br />

abortions in rats <strong>and</strong> mice, <strong>and</strong> the root has been documented as a uterine stimulant<br />

in animals.<br />

iv. The fruit <strong>and</strong> leaf of bitter melon have demonstrated an in vivo antifertility effect<br />

in female animals; <strong>and</strong> in male animals, to affect the production of sperm negatively.<br />

In vitro studies<br />

i. Numerous in vitro studies have also demonstrated the anticancerous <strong>and</strong> antileukemia<br />

activity of bitter melon against numerous cell lines, including liver cancer,<br />

human leukemia, melanoma, <strong>and</strong> solid sarcomas.<br />

ii. Antiviral activity against numerous viruses, including Epstein-Barr, herpes, <strong>and</strong><br />

HIV viruses.<br />

iii. The leaf extracts of bitter melon have demonstrated broad-spectrum antimicrobial<br />

activity. Various extracts of the leaves have demonstrated in vitro antibacterial<br />

activities against Escherichia coli, Staphylococcus, Pseudomonas, Salmonella,<br />

Streptobacillus <strong>and</strong> Streptococcus; an extract of the entire plant was shown to<br />

have antiprotozoal activity against Entamoeba histolytica. The fruit <strong>and</strong> fruit juice<br />

have demonstrated the same type of antibacterial properties <strong>and</strong>, in another study,<br />

a fruit extract demonstrated activity against the stomach ulcer-causing bacteria<br />

Helicobacter pylori.<br />

7.2 Uses in traditional medicine:<br />

The leaves or whole plant is abortifacient <strong>and</strong> carminative, <strong>and</strong> used to treat earache,<br />

headache, asthma, boil, burn, bilious problems, cancer, colic, dysmenorrhoea, colitis, coughs,<br />

catarrh, chilblain, dysentery, diabetes, eruption, fever, gout, halitosis, hepatitis, hyperglycemia,<br />

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itch, jaundice, leprosy, night-blindness, piles, poison, psoriasis, malaria, rheumatism,<br />

roundworms, sores, splenitis, stones, thrush, urethritis, <strong>and</strong> wounds. The plant is also used<br />

as astringent, lactogogue, refrigerant, soap, stomachic, tonic, depurative, emetic, laxative,<br />

purgative, styptic <strong>and</strong> vermifuge.<br />

8.0 Contraindications<br />

· Bitter melon traditionally has been used as an abortive <strong>and</strong> has been documented with<br />

weak uterine stimulant activity; therefore, it is contraindicated during pregnancy.<br />

· This plant has been documented to reduce fertility in both males <strong>and</strong> females <strong>and</strong> should<br />

therefore not be used by those undergoing fertility treatment or seeking pregnancy.<br />

· The active chemicals in bitter melon can be transferred through breast milk; therefore, it<br />

is contraindicated in women who are breast feeding.<br />

· All parts of bitter melon (especially the fruit <strong>and</strong> seed) have demonstrated in numerous in<br />

vivo studies that they lower blood sugar levels. As such, it is contraindicated in persons<br />

with hypoglycemia. Diabetics should check with their physicians before using this plant<br />

<strong>and</strong> use with caution while monitoring their blood sugar levels regularly as the dosage of<br />

insulin medications may need adjusting.<br />

· Although all parts of the plant have demonstrated active antibacterial activity, none have<br />

shown activity against fungi or yeast. Long-term use of this plant may result in the die-off<br />

of friendly bacteria with resulting opportunistic overgrowth of yeast (C<strong>and</strong>ida). Cycling<br />

off the use of the plant (every 21–30 days for one week) may be warranted, <strong>and</strong> adding<br />

probiotics to the diet may be beneficial if this plant is used for longer than 30 days.<br />

9.0 Bibliography<br />

Ahmad, N., Hassan, M. R., Halder, H. & Bennor, K. S. 1999. Effect of Momordica charantia<br />

(karolla) extracts on fasting <strong>and</strong> postpr<strong>and</strong>ial serum glucose levels in NIDDM patients.<br />

Bangladesh Medical Research Council Bulletin 25(1): 11–13.<br />

Ahmed, I., Edeghate, E., Sharma, A. K., Pallot, D. J. Singh, J. 1998. Effects of Momordica<br />

charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat.<br />

Diabetes Research <strong>and</strong> Clinical Practice 40(3): 145–151.<br />

Akhtar, M. S. 1982. Trial of Momordica charantia Linn (Karela) powder in patients with<br />

maturity-onset diabetes. Journal of Pakistan Medical Association 32(4): 106–107.<br />

Basaran, A. A., Yu, T. W., Plewa, M. J. & Anderson, D. 1996. An investigation of some<br />

Turkish herbal medicines in Salmonella typhimurium <strong>and</strong> in the COMET assay in human<br />

lymphocytes. Teratogenesis Carcinogenesis <strong>and</strong> Mutagenesis 16(2): 125–138.<br />

Bourinbaiar, A. S. & Lee-Huang, S. 1996. The activity of plant-derived antiretroviral proteins<br />

MAP30 <strong>and</strong> GAP31 against herpes simplex virus in vitro. Biochemical <strong>and</strong> Biophysical<br />

Research Communications 219(3): 923–929.<br />

Claflin, A. J., Taylor, B., Claflin, L, Rudikoff, S. & Hood, L. 1978. Inhibition of growth <strong>and</strong><br />

guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by anextract of the<br />

balsam pear (Momordica charantia abbreviata). Proceedings of National Academy of<br />

Sciences of USA 75(2): 989–993.<br />

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Gimlette, G. D. 1939. A Dictionary of Malayan Medicine. Oxford Univ. Press, Kuala Lumpur.<br />

http://www.rain-tree.com/bitmelon.htm. Database file for Bitter melon (Momordica charantia).<br />

7 August 2005.<br />

Lee-Huang S, Huang, P. L., Chen, H. C., Huang, P. L., Bourinbaiar, A. S., Huang, H. I. & Kung,<br />

H. F. 1995. Anti-HIV <strong>and</strong> anti-tumor activities of recombinant MAP30 from bitter melon. Gene<br />

161(2): 151–156.<br />

Lee-Huang S, Huang, P. L., Nara, P. L., Chen, H. C., Kung, H. F. Huang, P., Huang, H. I. &<br />

Huang, P. L. 1990. MAP 30: a new inhibitor of HIV-1 infection <strong>and</strong> replication. FEBS Lett.<br />

272(1-2): 12–18.<br />

Lee-Huang, S., Huang, P. L., Huang, P. L., Bourinbaiar, A. S., Chen, H. C. & Kung, H. F. 1995.<br />

Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti-HIV plant<br />

proteins MAP30 <strong>and</strong> GAP31. Proceedings of National Academy of Sciences of USA 92(19):<br />

8818–22.<br />

Matsuda, H, Li, Y., Yamahara, J., Yoshikawa, M. 1999. Inhibition of gastric emptying by triterpene<br />

saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, <strong>and</strong><br />

central nervous system. Journal of Pharmacology <strong>and</strong> Experimental Therapeutics 289(2):<br />

729–734.<br />

Matsuda, H., Li, Y., Murakami, T., Matsumura, N., Yamahara, J., Yoshikawa, M. 1998. Antidiabetic<br />

principles of natural medicines. III. Structure-related inhibitory activity <strong>and</strong> action mode of<br />

oleanolic acid glycosides on hypoglycemic activity. Chemical <strong>and</strong> Pharmaceutical Bulletin<br />

(Tokyo) 46(9): 1399–1403.<br />

Matsuda, H., Murakami, T., Shimada, H., Matsumura, N., Yamahara, J., Yoshikawa, M. 1997.<br />

Inhibitory mechanisms of oleanolic acid 3-O-monodesmosides on glucose absorption in rats.<br />

Biological <strong>and</strong> Pharmaceutical Bulletin 20(6): 717–719.<br />

Muhammed, M. & Prakash, L. 1997. Alternative medicine goes mainstream for better health<br />

care delivery. Paper presented at the 49th Indian Pharmaceutical Congress, Thiruvananthpuram,<br />

December 18–21, 1997.<br />

Platel, K. & Srinivasan, K. 1997. Plant foods in the management of diabetes mellitus: vegetables<br />

as potential hypoglycaemic agents. Nahrung 41(2): 68–74.<br />

Quisumbing, E. 1978. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Katha Publishing Co. Inc.<br />

Raza, H., Ahmad, I., John, A. & Sharma, A. K. 2000. Modulation of xenobiotic metabolism <strong>and</strong><br />

oxidative stress in chronic streptozotocin-induced diabetic rats fedwith Momordica charantia<br />

fruit extract. Journal of Biochemical <strong>and</strong> Molecular Toxicology 14(3): 131–139.<br />

Sarkar, S, Pranava, M. & Rosalind, M. A. 1996. Demonstration of the hypoglycemic action of<br />

Momordica charantia in a validated animal model of diabetes. Pharmacology Research<br />

33(1): 1–4.<br />

Takemoto, D. J., Jilka, C., Rockenbach, S. & Hughes, J. V.1983. Purification <strong>and</strong> characterization<br />

of a cytostatic factor with anti-viral activity from the bitter melon. Preparative Biochemistry<br />

<strong>and</strong> Biotechnology 13(4): 371–393.<br />

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Takemoto, D. J., Jilka, C., Rockenbach, S. & Hughes, J. V. 1983. Purification <strong>and</strong> characterization<br />

of a cytostatic factor with anti-viral activity from the bitter melon. Preparative Biochemistry<br />

<strong>and</strong> Biotechnology 13(5): 397–421<br />

Takemoto, D. J., Jilka, C. & Kresie, R. 1982. Purification <strong>and</strong> characterization of a cytostatic<br />

factor from the bitter melon Momordica charantia. Preparative Biochemistry <strong>and</strong><br />

Biotechnology 12(4): 355–375.<br />

Takemoto, D. J., Kresie, R. & Vaughn, D. 1980. Partial purification <strong>and</strong> characterization of a<br />

guanylate cyclase inhibitor with cytotoxic properties from the bitter melon (Momordica<br />

charantia). Biochemical <strong>and</strong> Biophysical Research Communications 94(1): 332–339.<br />

Takemoto, D.J., Dunford, C., Vaughn, D., Kramer, K, Smith, A. & Powell. 1982. Guanylate<br />

cyclase activity in human leukemic <strong>and</strong> normal lymphocytes. Enzyme inhibition <strong>and</strong> cytotoxicity<br />

of plant extracts. Enzyme 27(3): 179–788.<br />

Zhang, Q. C. 1992. Preliminary report on the use of Momordica charantia extract by HIV<br />

patients. J. Naturopath. Med. 3: 65–69.<br />

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1.0 Scientific Name : Ocimum bacilicum L.<br />

Synonyms : O. album L., O. americanum Jacq., O. barreleiri Roth.,<br />

O. caryophyllatum Roxb., O. citriodorum Blanco, O.<br />

graveolens R.Br., O. hispidum Lamk., O. integerrimim<br />

Willd., O. menthaefolium Benth., O. petitianum Rich. O.<br />

pilosum Willd.<br />

Family : Lamiaceae<br />

2.0 Vernacular Names : Selasih (Malaysia); sweet basil (English); tulsi (India)<br />

3.0 Plant Description<br />

A bushy, much branched, aromatic herb or shrublet, up to 1.3 m height. Stem <strong>and</strong> inflorescence<br />

often purplish. Leaves small, oval, 2–3 cm long, 1.2 cm wide; margins with tiny teeth or none.<br />

Inflorescence 7.7–20.5 cm long. Flowers in whorls spaced, white or purplish. Seeds small,<br />

black.<br />

4.0 Propagation : Seeds<br />

5.0 Geographical Distribution/Ecology<br />

Native to Asia. It is cultivated in house gardens in open <strong>and</strong> semi-shaded areas.<br />

6.0 Chemical Constituents<br />

Chemical constituents with commercial potential: Anethole, apigenin, b-bisabolene, carvone,<br />

caryophyllene, esculetin, esculin, myrcene, p-coumaric acid, essential oil (anethole, cineole, eugenol,<br />

linalol, methyl chavicol, ocimene, pinene, terpene hydrate)<br />

Other chemicals: Acetic acid, ascobic acid, a-amorphene, cis-anethole, trans-anethole,<br />

benzylacetate, benzy alcohol, a-bergamotene, a-bisabolol, borneol, borneol acetate, b-bourbonene,<br />

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a-bulnesene, butyric acid, a-, b-, d-, g-cadinene, 5,10(15)-cadinen-4-ol, b-cadinol, T-cadinol, caffeic<br />

acid, caffeic acid-N-butylester, calamene, camphene, camphor, caproic acid, b-carotene, b-<br />

caryophyllene, caryophyllene oxide, a- <strong>and</strong> b-cedrene, chavicol, chavicolmethylether, cinnamic<br />

acid-methylester, cis-cinnamic acid methylester, trans-cinnamic acid, trans-cinnamic acidmethylester,<br />

1,8-cineole, citral, citronellol, a-copaene, a- <strong>and</strong> b-cubebene, cyclosativene, b-cymene,<br />

p-cymene, a-p-dimethylstyrene, b- <strong>and</strong> g-elemene, elemol, epibicyclosesquiphell<strong>and</strong>rene, 1-epibicyclosesquiphell<strong>and</strong>rene,<br />

2-epi-a-cedrene, eriodictyol, eriodictyol-7-O-glucoside, estragole,<br />

eugenol, eugenol-methyl ether, farnesol, a-farnesene, (E)-b-farnesene, (Z)-b-farnesene, fenchone,<br />

a-fenchene, fenchyl acetate, fenchyl alcohol, furfural, D-galacturonic acid, geranial, geraniol,<br />

geranyl acetate, germacrene D, a- <strong>and</strong> d-guaiene, g-gurjunene, cis-3-hexenol, humulene, a-<br />

humulene, humulene epoxide, hydroxy benzoic acid-4-b-D-glucoside, isocaryophyllene, isoeugenol,<br />

isoeugenolmethylether, isoquercitrin, juvocimene-I, juvocimene-II, kaempferol, kaempferol-3-<br />

O-b-D-rutinoside, ledene, limonene, cis-limonene, linalyl acetate, luteolin, D-mannuronic acid,<br />

menthol, menthone, p-methoxycinnamaldehyde, methylchavicol, methylcinnamate, methylthymol,<br />

methyleugenol, mucilage, a- <strong>and</strong> g-muurolene, b-myrcene, neral, nerol, nerolidiol, nerolidol, niacin,<br />

b-ocimene, cisocimene, trans-ocimene, cis-allo-ocimene, trans-allo-ocimene, octanol, 1 -octen-<br />

3-ol, 3-octanone, oleanolic acid, orientin, phell<strong>and</strong>rene, phenylethyl alcohol, a- <strong>and</strong> b-pinene,<br />

planteose, propionic acid, quercetin, quercetin-3-O-diglucoside, riboflavin, rosmarinic acid,<br />

sabinene, cis-sabinenehydrate, trans-sabinene-hydrate, safrole, salicylic acid-2-b-D-glucoside,<br />

sambulene, a- <strong>and</strong> b-santalene, a- <strong>and</strong> b-selinene, sesquithujene, stigmasterol, b-sitosterol, suceinic<br />

acid, syringic acid-4-b-D-glucoside, syringoyl-glucose, tannin, a- <strong>and</strong> g-terpinene, terpinen-4-ol,<br />

a-terpineol, terpinolene, a-terpinylacetate, thiamin, a- <strong>and</strong> b-thujone, thymol, tricyclene,<br />

undecylaldehyde, ursolic acid valerie acid, vanillic acid-4-b-D-gIucoside, vicenin-2, xanthomicrol,<br />

xi-bulgarene; amino acids, fatty acids (linoleic acid, linolenic acid, oleic acid, palmitic acid, stearic<br />

acid); minerals, phytosterols, sugars (D-arabinose, D-galactose, D-glucose, D-mannose, L-<br />

rhamnose, xylose)<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

i. Pharmacological effects – In traditional Ayurvedic system of medicine, several<br />

medicinal properties have been attributed to this plant. Recent pharmacological<br />

studies have established the anabolic, hypoglycemic, smooth muscle relaxant, cardiac<br />

depressant, antifertility, adaptogenic <strong>and</strong> immunomodulator properties of this plant.<br />

ii. Antimicrobial effects – Essential oil of tulsi has antibacterial, antifungal <strong>and</strong> antiviral<br />

properties. It inhibits the growth of E. coli, B. anthracis, M. tuberculosis, etc. Its<br />

antitubercular activity is one-tenth the potency of streptomycin <strong>and</strong> one-fourth that<br />

of isoniazid. Preparations containing tulsi extract significantly shorten the course<br />

of illness, clinical symptoms <strong>and</strong> the biochemical parameters in patients with viral<br />

hepatitis <strong>and</strong> viral encephalitis.<br />

iii. Antimalarial effects – Essential oil of tulsi has been reported to possess 100%<br />

larvicidal activity against the Culex mosquitoes. Trials have shown excellent<br />

antimalarial activity of tulsi. Its extracts have marked insecticidal activity against<br />

mosquitoes. Its repellant action lasts for about two hours.<br />

iv. Antiallergic <strong>and</strong> immunomodulator effects – Essential oil of tulsi was found to<br />

have antiallergic properties. When administered to laboratory animals, the compound<br />

was found to inhibit mast cell degranulation <strong>and</strong> histamine release in the presence<br />

of allergen. These studies reveal the potential role of O. sanctum extracts in the<br />

management of immunological disorders including allergies <strong>and</strong> asthma.<br />

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MALAYSIA<br />

v. Antistress/adaptogenic effects - Extracts from the plant have been found to reduce<br />

stress.<br />

vi. Antifertility effect – One of the major constituents of the leaves, ursolic acid, has<br />

been reported to possess antifertility activity in rats <strong>and</strong> mice. This effect has been<br />

attributed to its antiestrogenic effect which may be responsible for arrest of<br />

spermatogenesis in males <strong>and</strong> inhibitory affection implantation of ovum in females.<br />

This constituent may prove to be a promising antifertility agent devoid of side<br />

effects.<br />

vii.<br />

viii.<br />

ix.<br />

Antidiabetic effect – A r<strong>and</strong>omized, placebo-controlled cross-over single blind trial<br />

on 40 human volunteers suffering from Type II diabetes was performed. During<br />

the four week trial, subjects alternately received a daily dose of 2.5 g of tulsi leaf<br />

powder or a placebo for two-week periods. The results showed 17.6 % reduction<br />

in fasting blood glucose <strong>and</strong> 7.3% decline in postpr<strong>and</strong>ial blood glucose on treatment<br />

with tulsi as compared with the blood glucose levels during treatment with placebo.<br />

For Heart ailments – As tulsi (basil) has a positive effect over blood pressure <strong>and</strong><br />

also is a detoxicant, its regular use prevents heart attacks. A tonic may be prepared<br />

by mixing 1 gm of dry leaves with a spoonful of butter <strong>and</strong> some c<strong>and</strong>y sugar or<br />

honey. Take twice a day first thing in the morning <strong>and</strong> before going to bed at night.<br />

Other effects – The leaves in the form of a paste are used in parasitical diseases<br />

of the skin <strong>and</strong> also applied to the finger <strong>and</strong> toe nails during fever when the limbs<br />

are cold. The juice of the leaves is given in catarrh <strong>and</strong> bronchitis in children. The<br />

plant is said to have carminative, diaphoretic <strong>and</strong> stimulant properties. A decoction<br />

of the plant is used for coughs <strong>and</strong> also as mouth wash for relieving toothache. It<br />

is good for headache, convulsions, cramps, fevers <strong>and</strong> cholera.<br />

7.2 Uses in traditional medicine:<br />

Uses described in pharmacopoeias <strong>and</strong> in traditional system of medicine:<br />

Basil oil combined with other oil is used in:<br />

i. wound treatment, rheumatic discomfort, colds, bruises, painful joints, irrigation<br />

therapy;<br />

ii. maintenance <strong>and</strong> stimulation of sexual capacity, prevention of sexual fatigue in<br />

male <strong>and</strong> female, prevention of frigidity in male <strong>and</strong> female;<br />

iii. supportive treatment for infections of lower urinary tract, as well as inflammations<br />

of kidneys, bladder <strong>and</strong> urethra;<br />

iv. nasal catarrh, temporary shortness of breath, fatigue, cough, congestion, muscle<br />

pain, nerve pain, pain in the limbs (neuralgia), lumbago, sprains, dislocations,<br />

contusions, heartburn, flatulence, bad breath, travel fatigue, inflammation, oral<br />

hygiene, air quality improvement, foot bath, bath additives;<br />

v. supportive therapy for massages used as warm-up procedures of the muscles<br />

before sports activities <strong>and</strong> particularly exertions in order to prevent muscle sprains<br />

<strong>and</strong> muscle spasms <strong>and</strong> their consequences, <strong>and</strong> for massages of hardened muscle<br />

parts.<br />

Uses described in folk medicine, not supported by experimental or clinical data:<br />

The juice of the leaves is used to cure ringworm infections, as cough remedy <strong>and</strong> a nasal<br />

douche in myosis <strong>and</strong> irregular menstrual cycles. Leaves are a diuretic <strong>and</strong> a stimulant<br />

for weak digestion. The leaf is used in treating high fever <strong>and</strong> after childbirth, to possess<br />

narcotic effect which helps to ease itchiness in the throat, to relieve stomach-ache <strong>and</strong><br />

stimulate bowel movement. The seed are mucilaginous <strong>and</strong> cooling, <strong>and</strong> used to treat<br />

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gonorrhoea, diarrhoea, <strong>and</strong> chronic dysentery. The jelly is used for treating intestinal<br />

troubles in children, kidney trouble <strong>and</strong> diarrhoea.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Adirukmini et al. 1995. Types of basil (Ocimum sp.) found in Malaysia. In Proceedings of the<br />

International Conference on the use of Traditional Medicine & Other Natural Products<br />

in Health Care.<br />

Barghava, K.P <strong>and</strong> Singh, N. 1981. Anti-stress activity of Ocimum sanctum Linn. Indian<br />

Journal of Medical Research 73: 443–451.<br />

Burkil I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula. Volume<br />

2. Ministry of Agriculture <strong>and</strong> Cooperatives, Kuala Lumpur, Malaysia.<br />

Rajasekaran, M. Sudhakaran, C., Pradhan, S. C., Bapna, J. S. & Nair, A. G. R. 1989. Mast cell<br />

protective activity of ursolic acid á-triterpene from the leaves of Ocimum sanctum. Journal of<br />

Drug Development 2(3): 179–182.<br />

Banerjee, S., Prashar, R., Kumar, A. & Rao, A. R. 1996. Modulatory influence of alcoholic<br />

extract of Ocimum leaves on carcinogen-metabolizing enzymes activities <strong>and</strong> reduced glutation<br />

leveld in mouse. Nutrition <strong>and</strong> Cancer 25(2): 205–217.<br />

Agarwal, P., Rai, V. & Singh, R. B. 1996. R<strong>and</strong>omised placebo – controlled, single blind trial of<br />

holy basil leaf in patients with noninsulin-dependent diabetes mellitus. International Journal of<br />

Clinical Pharmacology, Therapy <strong>and</strong> Toxicology 34(9): 406–409.<br />

Betty, P. J & Derek, W. S. 1974. Powdered Vegetable Drugs: An atlas of Microscopy for<br />

use in the Identification <strong>and</strong> Authentication of some Plant Materials Employed as<br />

<strong>Medicinal</strong> Agents. Stanley Thornes Ltd, London, Great Britain.<br />

Brown, D. 2002. The Royal Horticultural Society New Encyclopedia of Herbs & Their<br />

Uses. Dorling Kindersley Limited, Britain.<br />

Chavan, S. R. & Nikam S. T. 1982. Mosquito larvicidal activity of Ocimum basilicum Linn.<br />

Indian Journal of Medical Research 75: 220–222.<br />

Henderson, M.R. 1951. Malayan Wild Flowers: Dicotyledons. Malayan Nature Society,<br />

Kuala Lumpur.<br />

Indu, B. I. & Ng, L.T. 2000. Herbs: The Green Pharmacy of Malaysia, Malaysian Agriculture<br />

Research <strong>and</strong> Development Institute, Kuala Lumpur, Malaysia.<br />

Jayaweera, D. M. A. 1981. <strong>Medicinal</strong> <strong>Plants</strong> Used in Ceylon. Part 3,. The National Science<br />

Council of Sri Lanka, Colombo.<br />

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Kusamran, W. R., Ratanavila, A. & Tepsuwan, A. 1998. Effect of neem flowers, Thai <strong>and</strong><br />

Chinese bitter gourd fruits <strong>and</strong> sweet basil leaves on hepatic monooxygenases <strong>and</strong> glutathione<br />

s-transferase activities, <strong>and</strong> in vitro metabolic activation of chemical carcinogens in rats. Food<br />

<strong>and</strong> Chemical Toxicology 36(6): 475–484.<br />

Lachowicz, K. J., Jones, G. P., Briggs, D. R., Bienvenu, F. E., Wan, J., Wilcock, A. & Coventry,<br />

M. I 1998.The synergistic preservative effect of the essential oil of sweet basil (Ocimum basilicum<br />

L.). Letters in Applied Microbiology 26(3): 209–214.<br />

Ridley, H.N. 1922. The Flora of the Malay Peninsula. Vol II. L. Reeve & Co. Ltd, London.<br />

Simon JE, Quinn I & Murray RG. 1990. Basil: A source of essential oil. In: Janick I & Simon JE<br />

(Eds.). Advances in New Crops. Timber press, Portl<strong>and</strong>, USA. Pp. 484–489<br />

The Complete German Commission E Monographs. 1998. Therapeutic Guide to <strong>Herbal</strong><br />

Medicines. American Botanical Council, Austin, Texas, USA.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Phyllanthus amarus Schumach. & Thonn.<br />

Family : Euphorbiaceae<br />

2.0 Vernacular Names : Meniran, rami buah, dukung anak (Malaysia ); stone breaker,<br />

seed on the leaf, child pick-a-back (English)<br />

3.0 Plant Description<br />

Glabrous weedy herb 30 to 40 cm tall. Leaves distichous oblong or elliptic-obovate subsessile,<br />

0.5 cm long, 0.2 cm wide; petiole minute or none. Stipule subulate, base broad. Male flowers<br />

solitary or in pair, very minute. Female flowers twice as large. Fruit globose, smooth, on underside<br />

of leaf rachis. Seeds pale brown with 6–7 straight longitudinal ribs.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is widely distributed in tropical countries <strong>and</strong> easily grows at wet <strong>and</strong> shaded places.<br />

6.0 Chemical Constituents<br />

3,5,7-trihydroxyflavonal-4'-O-a-1(-)-rhamnopyranoside, 4-methoxynorsecuri-nine, 4-methoxysecurinine,<br />

5,3',4'-trihydroxyflavonone-7-O-a-1-(-)-rhamnopyranoside, astragalin, brevifolincarboxylic<br />

acid, cymene, hypophyllanthin, limonene, lintetralin, lupa-20(29)-ene-3-b-ol, lupa-20(29)-<br />

ene-3-b-ol-acetate, lupeol, methyl salicylate, niranthin, nirtetralin, niruretin, nirurin, niruriside,<br />

phyllanthin, phyllochrysine, phyltetralin, quercetin, quercetin-heteroside, quercetol, quercitrin, rutin,<br />

saponins, triacontanal, tricontanol, geraniin<br />

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MALAYSIA<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

i. In 1990, the Paulista School of Medicine in São Paulo, Brazil, conducted studies<br />

with humans <strong>and</strong> rats with kidney stones. They were given a simple tea of P.<br />

amarus for 1–3 months <strong>and</strong> it was reported that the tea promoted the elimination<br />

of stones. They also reported a significant increase in urine output as well as<br />

sodium <strong>and</strong> creatine excretion.<br />

ii. In a 1999 in vitro clinical study, a P. amarus extract exhibited the ability to block<br />

the formation of calcium oxalate crystals (the building blocks of most kidney stones)<br />

which indicates that it might be a useful preventative aid for people with a history<br />

of kidney stones.<br />

iii. In a 2002 in vivo study, researchers seeded the bladders of rats with calcium<br />

oxalate crystals <strong>and</strong> treated them for 42 days with a water extract. The results<br />

indicated that P. amarus strongly inhibited the growth <strong>and</strong> number of stones formed<br />

over the control group. Several of the animals even passed the stones which did<br />

form. In 2003 scientists confirmed in vitro that P. amarus could help prevent the<br />

formation of kidney stones.<br />

iv. In the mid-1980s the antispasmodic <strong>and</strong> muscle relaxant properties activity of P.<br />

amarus was observed. In 1990, Nicole Maxwell reported that Dr. Wolfram<br />

Wiemann (of Nuremburg, Germany) treated over 100 kidney stone patients with P.<br />

amarus obtained in Peru <strong>and</strong> found it to be 94% successful in eliminating stones<br />

within a week or two.<br />

v. In a 2002 study, Indian researchers reported that P. amarus increased bile acid<br />

secretion in the gallbladder <strong>and</strong> significantly lowered blood cholesterol levels in<br />

rats. The beneficial effects of lowering cholesterol <strong>and</strong> triglyceride levels was also<br />

confirmed by another in vivo (rat) study in 1985.<br />

vi. The hypotensive effects were first reported in a dog study in 1952. The hypotensive<br />

effects were attributed to a specific phytochemical in P. amarus called geraniin in<br />

a 1988 study. In 1995 Indian researchers gave human subjects with high blood<br />

pressure P. amarus leaf powder in capsules <strong>and</strong> reported a significant reduction in<br />

systolic blood pressure, a significant increase in urine volume <strong>and</strong> sodium excretion.<br />

vii. In the above 1995 study, researchers also reported that blood sugar levels were<br />

reduced significantly in human subjects studied. Two other studies with rabbits <strong>and</strong><br />

rats document the hypoglycemic effect of P. amarus in diabetic animals. Aldose<br />

reductases are substances that act on nerve endings exposed to high blood sugar<br />

concentration <strong>and</strong> can lead to diabetic neuropathy <strong>and</strong> macular degeneration.<br />

Substances which inhibit these substances can prevent some of the chemical<br />

imbalances that occur <strong>and</strong> thus protect the nerve.<br />

viii. Another area of research has focused on the pain-relieving effects of P. amarus<br />

<strong>and</strong> was performed at a Brazilian university. So far, they have published six studies<br />

on their findings. The first three studies reported strong <strong>and</strong> dose-dependent painrelieving<br />

effects in mice given extracts of chanca piedra against six different<br />

laboratory-induced pain models. In 1996, they isolated <strong>and</strong> tested P. amarus<br />

hypotensive plant chemical geraniin <strong>and</strong> reported that it was seven times more<br />

potent as a pain-reliever than aspirin or acetaminophen. Their last two studies<br />

(published in 2000) continued to document chanca piedra’s pain-relieving effects<br />

against normal pain models in mice, <strong>and</strong>, newly-tested nerve-related pain models.<br />

Again, they related this effect to the geraniin plant chemical <strong>and</strong> reported its ability<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

to inhibit several neurotransmitter processes that relay <strong>and</strong> receive pain signals in<br />

the brain.<br />

ix. The liver-protecting activity of P. amarus has been established with clinical research<br />

with animals <strong>and</strong> humans. These effects have been attributed to (at least) two<br />

novel plant chemicals in P. amarus named phyllanthin <strong>and</strong> hypophyllanthin. The<br />

researchers who reported the cholesterol-lowering effects also reported that P.<br />

amarus protected rats from liver damage induced by alcohol, <strong>and</strong> normalized a<br />

“fatty liver.” One in vitro study <strong>and</strong> four in vivo studies (with rats <strong>and</strong> mice)<br />

document that extracts of P. amarus effectively protect against liver damage from<br />

various chemical liver toxins. Two human studies reported P. amarus liver protective<br />

<strong>and</strong> detoxifying actions in children with hepatitis <strong>and</strong> jaundice. Indian researchers<br />

reported that P. amarus was an effective single drug in the treatment of jaundice<br />

in children, <strong>and</strong> British researchers reported that children treated with a P. amarus<br />

extract for acute hepatitis had liver function return to normal within five days.<br />

Researchers in China also reported liver protective actions when P. amarus was<br />

given to adults with chronic hepatitis.<br />

x. A 2000 study even documented that P. amarus increased the life-span of mice<br />

with liver cancer from thirty-three weeks (control group without treatment) to<br />

fifty-two weeks. Another research group tried to induce liver cancer in mice that<br />

had been pretreated with a water extract of P. amarus. Their results indicated the<br />

P. amarus extract dose-dependently lowered tumour incidence, levels of carcinogenmetabolizing<br />

enzymes, levels of liver cancer markers, <strong>and</strong> liver injury markers.<br />

Both studies indicate that the plant has a better ability to prevent <strong>and</strong> slow down<br />

the growth of tumours rather than a direct toxic effect or ability to kill cancer cells.<br />

7.2 Uses in traditional medicine:<br />

The whole plant is used as an antihepatotoxic, antihypertensive, antidysenteric, purgative,<br />

emmenagogue, febrifuge, stomachic <strong>and</strong> diuretic. It is used internally in treatment of<br />

jaundice, dropsy, genito-urinary infections, blennorrhagia, colic, diabetes, dysentery, fever,<br />

flu, tumours, jaundice, vaginitis <strong>and</strong> dyspepsia. It is used externally for cuts, bruises, ulcers,<br />

sores <strong>and</strong> swelling.<br />

8.0 Contraindications<br />

· Phyllanthus amarus has demonstrated hypotensive effects in animals <strong>and</strong> humans. People<br />

with a heart condition <strong>and</strong>/or taking prescription heart medications should consult their<br />

doctor before taking this plant. It may be contraindicated for some individuals with heart<br />

conditions <strong>and</strong>/or heart medications that may need monitoring <strong>and</strong> adjusting.<br />

· Phyllanthus amarus has been considered in herbal medicine to be abortive (at high<br />

dosages) as well as a menstrual promoter. While not studied specifically in humans or<br />

animals, animal studies do indicate it has uterine relaxant effects. It should therefore be<br />

considered contraindicated during pregnancy.<br />

· Phyllanthus amarus has been documented with female antifertility effects in one mouse<br />

study (the effect was reversed 45 days after cessation of dosing). While this effect has<br />

not been documented in humans, the use of the plant is probably contraindicated in women<br />

seeking pregnancy or taking fertility drugs. This effect has not been substantiated<br />

sufficiently to be used as a contraceptive, however, <strong>and</strong> should not be relied on for such.<br />

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MALAYSIA<br />

· Phyllanthus amarus has demonstrated hypoglycemic effects in animals <strong>and</strong> humans. It<br />

is contraindicated for people with hypoglycemia. Diabetics should consult their doctor<br />

before taking this plant as insulin medications may need monitoring <strong>and</strong> adjusting.<br />

· Phyllanthus amarus has been documented in human <strong>and</strong> animal studies with diuretic<br />

effects. Chronic <strong>and</strong> acute use of this plant may be contraindicated in various other<br />

medical conditions where diuretics are not advised. Chronic long-term use of any diuretic<br />

can cause electrolyte <strong>and</strong> mineral imbalance; however, human studies witj P. amarus<br />

(for up to three months of chronic use) has not reported any side effects. Consult your<br />

doctor if you choose to use this plant chronically for longer than three months concerning<br />

possible side effects of long term diuretic use.<br />

9.0 Bibliography<br />

Agrawal, S. S., Garg, A. & Agrawal, S. 1986. Screening of Phyllanthus niruri Linn. <strong>and</strong><br />

Ricinus communis Linn. on alcohol-induced liver cell damage in non- hepatectomized <strong>and</strong> partially<br />

hepatectomized rats. Indian Journal of Pharmacology 18(4): 211–214<br />

Duke, J. & Vasque, R. 1994. Amazonian Ethnobotanical Dictionary. CRC Press Inc., Boca<br />

Raton, FL.<br />

Goh, S. H., Chuah, C. H., Mok J. S. L. & Soepadmo, E. 1995. Malaysian <strong>Medicinal</strong> <strong>Plants</strong><br />

for the Treatment of Cardiovascular Diseases. Pel<strong>and</strong>ok Publication Sdn. Bhd. Kuala<br />

Lumpur.<br />

http://rain-tree.com/chanca.htm. Database file on Phyllanthus niruri. 8 August 2005.<br />

Indu B.J. & Ng, L. T. 2000. Herbs: The Green Pharmacy of Malaysia. Malaysian Agricultural<br />

Research <strong>and</strong> Development Institute (MARDI), Kuala Lumpur, Malaysia.<br />

Materia Medika Indonesia Jilid II. 1978. Departemen Kesehatan Republik Indonesia, Jakarta,<br />

Indonesia.<br />

Ridley, H.N. 1922. The Flora of the Malay Peninsula. Vol. III. L. Reeve & Co. Ltd, London.<br />

Ueno H, Horie S, Nishi Y, Shogawa H, Kawasaki M, Suzuki S, Hayashi T, Arisawa M, Shimizu<br />

M, Yoshizaki M, et al. 1988. Chemical <strong>and</strong> pharmaceutical studies on medicinal plants in Paraguay,<br />

Geraniin, an angiotensin-converting enzyme inhibitor from “Paparai mi”, Phyllanthus niruri.<br />

Journal of Natural Products 51(2): Pp. 357–359.<br />

193


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Rafflesia hasseltii Suringar<br />

Family : Rafflesiaceae<br />

2.0 Vernacular Name : Bunga pakma (Malaysia)<br />

3.0 Plant Description<br />

Parasitic herb growing on the roots or branches of other plants. The plant body is almost wholly<br />

within the host plant. The flower <strong>and</strong> fruit are the only parts of the plant outside the tissue of the<br />

host plant. The bud breaking through the bark of the host looks like a large brown cabbage. The<br />

flower is very large, very thick <strong>and</strong> fleshy, but not long lasting. The average size of the flower is<br />

30–40 cm across, radially symmetrical, epigynous; the ovary inferior or partly so. Sepals very<br />

large, 4–16; petals none; stamens numerous, without stalk arranged round a fleshy column, the<br />

top of which forms the stigma. The pollen chamber opening by slits or apical pores; carpel 4–<br />

8; the ovary 1-chambered; placenta parietal; ovules numerous. Fruit is a berry.<br />

4.0 Propagation : Not available<br />

5.0 Geographical Distribution/Ecology<br />

Found throughout Malaysia, Indonesia (Sumatra, Java <strong>and</strong> Kalimantan), Brunei Darussalam,<br />

Thail<strong>and</strong> (southern provinces) <strong>and</strong> the Philippines. It grows only on the roots <strong>and</strong> stems of two<br />

species of vines belonging to the grape family, Terastigma leucostaphylum <strong>and</strong> T. diepenhostii.<br />

6.0 Chemical Constituents<br />

No report found<br />

194


MALAYSIA<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The flower is astringent <strong>and</strong> an aphrodisiac for women. It is reported to be used as afterbirth<br />

medication for (purifies uterus), after menstruation <strong>and</strong> to expedite delivery.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill I. H. 1966. The Dictionary of the Economic Products of the Malay Peninsula.<br />

Ministry of Agriculture, Malaysia, Kuala Lumpur. I & II: Pp. 1894–1895.<br />

Burkill, I. H. & Haniff, M. 1930. Malay Village Medicine, Garden Bulletin Straits Settlement.<br />

6: Pp. 240.<br />

Dawn, J. 1994. Rafflesia in Temenggor. Malayan Naturalist 47: Pp. 26–27.<br />

Meijer, W. & Wong, M. 1993. Rafflesia cantleyl <strong>and</strong> R. hasseltii compared. Malayan<br />

Naturalist.47: Pp. 10–12.<br />

195


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Smilax myosotiflora A. DC.<br />

Family : Smilacaceae<br />

2.0 Vernacular Names : Ubi jaga, ubi besi, keranting, itah besi, akar ding (Malaysia)<br />

3.0 Plant Description<br />

Herbaceous climber; stem slender but very tough <strong>and</strong> rigid; branching loosely, light green <strong>and</strong><br />

very smooth. Presence of nodes <strong>and</strong> internodes about 2–15 cm long. Occasionally rooting occurs<br />

at the nodes <strong>and</strong> adheres to the ground. Leaves lanceolate or broadly elliptic. Base of leaf is<br />

broad <strong>and</strong> gradually cuneated or suddenly accuminated apex, 8–17 cm long, 2–15 cm broad,<br />

grass green on adaxial side while paler green on abaxial side of leaf; densely veined; marginal<br />

nerves slightly thickened; petiole 7–25 mm long. Tendrils 6–13 cm, long, slender, often becoming<br />

brownish. Inflorescence umbels <strong>and</strong> axillary together with tendrils; peduncles 1–4 cm long;<br />

pistilate umbels 8–14 flowered; staminate perianth yellow-green 3.5–4.2 mm long, 4–5 mm<br />

wide, connate, lobed to 2.5 from top; outer lobes oblong, 1.5 mm wide, inner lobes half as long as<br />

outer ones.<br />

4.0 Propagation : Not available<br />

5.0 Geographical Distribution/Ecology<br />

It is common in lowl<strong>and</strong>s <strong>and</strong> in the hills forest.<br />

6.0 Chemical Constituents<br />

No report found<br />

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MALAYSIA<br />

7.0 Reports on Medical Usage<br />

7.1 Uses supported by clinical data:<br />

Not available<br />

7.2 Uses described in traditional medicine:<br />

The tuber has an aphrodisiac property <strong>and</strong> it is used to treat syphilis.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Burkill, I. H. 1966. A Dictionary of the Economic Products of the Malay Peninsula,<br />

Ministry of Agriculture, Malaysia I & II: Pp. 2075.<br />

Gimlette, J. D.& Burkill, I. H. 1930. The Garden Bulletin Straits Settlement. Pp. 470.<br />

197


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Stemona tuberosa Lour.<br />

Family : Stemonaceae<br />

2.0 Vernacular Names : Galak tua, janggut adam (Malaysia)<br />

3.0 Plant Description<br />

Herb with upright, twining slender stems. Leaves alternate, heart shaped in outline with an<br />

abrupt, narrow pointed end, dark green, usually about 10 x 7 cm, sometimes reaching twice this<br />

size; leaf stalk about 7 cm long; leaf has prominent longitudinal ribs <strong>and</strong> fine, close cross-veins;<br />

rib about 7–13. Flower arises from leaf axils; individual flower stalk is about 3 cm long, jointed<br />

in the middle, long narrow, deep purple to pink; lobes narrowly elliptical in outline.<br />

4.0 Propagation : Root tuber<br />

5.0 Geographical Distribution/Ecology<br />

It is found throughout Peninsular Malaysia to South Thail<strong>and</strong>, Central China, Taiwan, India <strong>and</strong><br />

Indo-China.<br />

6.0 Chemical Constituents<br />

Root tuber: Fluoride, stemonal, stemonone, stemonidine, stemotinine, iso-stemotinine, stemonine,<br />

stenine, tuberostemonine, tuberostemonone<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The root tubers are used as antiparasitic <strong>and</strong> antimicrobial towards Streptococcus<br />

pneumoniae, b-haemolytic Streptococcus, Neisseria meningitidis <strong>and</strong> Staphylococcus<br />

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MALAYSIA<br />

aureus. Various preparations of the tubers also showed better than 85% effectiveness in<br />

treating pertussis. The tuber is useful for pulmonary tuberculosis, coughs, skin diseases<br />

<strong>and</strong> as a vermifuge.<br />

7.2 Uses in traditional medicine:<br />

Not available<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bensky, D. & Gamble, A. 1986. Chinese <strong>Herbal</strong> Medicine: Materia Medica. revised edition,<br />

Eastl<strong>and</strong> Press Inc., USA. Pp. 202–203.<br />

Chu, J. H. & Young, P. T. 1955. Hua Hsueh Hsueh Pao 21: Pp. 173–177.<br />

Etude botanique, clinique et pharmacodynamique de la racine de ‘Stemona tuberosa’ (drogue<br />

vermifuge sinoannamite).<br />

Journal of crystallographic <strong>and</strong> spectroscopic research. Pp. 26–34.<br />

Keys, J. D. 1976. Chinese Herbs: Their Botany, Chemistry <strong>and</strong> Pharmacodynamics.<br />

Charles E. Tuttle Co., Japan. Pp. 71.<br />

Lin, W. H., Xu, R. S., Wang, R. J., Mak, T. C. W. 1991. Crystal <strong>and</strong> molecular structure of<br />

tuberostemonone. Journal Crystallogr. Spectrosc. Refs. 21: Pp. 189–194.<br />

Lobstein, J. E. & Grumbach, J. 1932. Bulletin Science Pharmacology. 39: 26.<br />

Malaysian Monograph Committee. 1999. Malaysian <strong>Herbal</strong> Monograph. Pp. 71–73.<br />

Perry, L. M. 1980. <strong>Medicinal</strong> <strong>Plants</strong> of East <strong>and</strong> Southeast Asia. MIT Press, Massachusetts.<br />

Pp. 397.<br />

Roengsamran, S. 1973. Master thesis, Faculty of Science, Chulalongkorn University, Thail<strong>and</strong>.<br />

Pp. 43.<br />

Sakai, T., Kobashi, K., Tsunezuka, M., Hattori, M. & Namba, T. 1985. Studies on dental caries<br />

prevention by traditional Chinese medicines (Part VI). On the fluoride contents in crude drugs.<br />

Shoyakugaku Zasshi. 39: Pp. 165–169.<br />

Willaman, J. J. & Li, H. L. 1970. Alkaloid-bearing plants <strong>and</strong> their contained alkaloids. Lloydia.<br />

33: 286.<br />

Xu, R. S., Lu, Y. J., Chu, J. H., Iwashita, T., Naoki, H., Naya, Y. & Nakanishi, K. 1982. Studies<br />

on some new stemona alkaloids: A diagnostically useful 1 H-NMR line-broadening effect.<br />

Tetrahedron. 38: 2667–2670.<br />

199


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Zingiber officinale Rosc.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Halia (Malaysia); kinkh, khing-daen (Thail<strong>and</strong>);<br />

gung, sinh khuong (Viet Nam), luya (Philippines)<br />

3.0 Plant Description<br />

An upright herb; soft non-woody stem. Rhizome is light yellow in whorl, aromatic smell <strong>and</strong><br />

slightly hot in taste; the stem grows from the rhizome <strong>and</strong> may reach up to 50 cm tall, covered<br />

with leaf-sheath. Leaf is linear-lanceolate, about 17 cm long, 1.8 cm wide, dark green, smooth<br />

on the upper surface <strong>and</strong> slightly rough on the underneath which is covered with very fine hairs;<br />

ligule light green in colour. Flower in the axil of each bract; the bracts are arranged in whorl;<br />

corolla tube is 2–2.5 cm long that is slightly longer than bractea <strong>and</strong> consists of 3 separated<br />

lobes, the dorsal lobe broader 12 mm by 10 mm, light purple with yellow spots. The other two<br />

lobes are 6 mm by 4 mm, yellowish green.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

It is cultivated in all tropical countries.<br />

6.0 Chemical Constituents<br />

Acetaldehyde, acetone, n-butyraldehyde, diethyl sulfide, ethyl acetate, n-heptane, methyl acetate,<br />

n-nonane, n-nonanol, nonyl aldehyde, n-octane, propionaldehyde, ethyl isopropyl sulfide, methyl<br />

allyl sulfide, isovaleraldehyde, (+)-borneol, chavicol, benzaldehyde, 2-hydroxy-1,8-cineol, cisgeranic<br />

acid, trans-geranic acid, 6-methylhept-5-en-2-ol, hexanol, linalool oxide, p-<br />

mentha-1,5-dien-7-ol, p-mentha-2,8-dien-1-ol, p-mentha-1-5-dien-8-ol, p-metha-1,8-dien-7-ol,<br />

nerol oxide, 2,6-dimethylocta-2,6-diene-1,8-diol, 2,6-dimethylocta-3,7-diene-1,6-diol, octan-2-ol,<br />

n-octanol, cis-selinen-4-ol, 1,8-terpinen hydrate, 4-terpineol, a-ylangene, acetic acid,<br />

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MALAYSIA<br />

aromadendrene, 3-phenylbenzaldehyde, 4-phenylbenzaldehyde, bornyl acetate, a-cadinol,<br />

calamenene, camphene hydrate, d-car-3-ene, cedorol, citronellyl acetate, ethyl myristate, farnesol,<br />

geranyl acetate, guaiol, 6-methylhept-5-en-2-one, 2,2,4-trimethylheptane, cis-hexan-3-ol, hexanol,<br />

b-himachalene, b-ionone, juniper camphor, trans-linalool oxide, menthol acetate, methyl nonyl<br />

ketone, a-muurolene, g-muurolene, 9-oxonerolidol, trans-octen-2-al, patchouli alcohol, pirellen,<br />

n-propanol, neoisopulegol, a-selinene, b-selinen, cis-sesquiabinene hydrate, sesquiphell<strong>and</strong>rene,<br />

terpinen-4-ol, b-thujone, alloaromadendrene, d-cadinene, p-cymen-8-ol, b-elemene, g-eudesmol,<br />

isoeugenol methyl ether, farnesal, a-farnesene, trans-b-farnesene, fluoride, furfural, heptan-2-one,<br />

hexanal, trans-nerolidol, nonan-2-one, octanal, perillene, myrtenal, rosefuran, selina-3,7(11)-diene,<br />

tricyclene, undecan-2-ol, sabinene, heptan-2-ol, undecan-2-one, borneol, nonan-2-ol, ß-bisabolol,<br />

camphor, b-caryophyllene, p-cymen, lauric acid, a-phell<strong>and</strong>rene, g-terpinene, terpinolene,<br />

xanthorrhizol, asparagine, trans-trans-a-farnesene, b-sesquiphell<strong>and</strong>rene, a-zingiberene, b-<br />

bisabolene, curcumere, zingiberol, n-nonanone, b-phell<strong>and</strong>rene, csitronellal, methylheptenone,<br />

borneol acetate, elemol, b-eudesmol, isoborneol, b-sesquiphell<strong>and</strong>rol, myrcene, b-pinene, citronellol,<br />

cineol, a-cadinene, caffeic acid, p-coumaric acid, camphene, citral, caprylic acid, capsaicin,<br />

car-3-ene, a-terpineol, a-terpinene, geraniol acetate, nerol, a-copaene, a-curcumene,<br />

3,5-diacetoxy-1-(4-hydroxy-3,5-dimethoxy-phenyl)-7-(4-hydroxy-3-methoxy-phenyl)heptane,<br />

meso-3,5-diacetoxy-1,7-bis-(4-hydroxy-3-methoxyphenyl) heptane, hexahydrocurcumin,<br />

farnesene, furanogermenone, geranial, a-pinene, neral, limonene, linalool, geraniol, germanium,<br />

10-gingediol, 6-gingediol, 6-gingediol diacetate, 6-gingediol diacetate methyl ether, 6-gingediol<br />

methyl ether, 8-gingediol, gingerol methyl ether, 10-methylgingerol, 12-methylgingerol, 6-<br />

methylgingerol, 8-methylgingerol, paradol, 4-gingerol, 10-gingerdione, 6-dihydrogingerdione, 6-<br />

dehydrogingerdione, gingerenone B, isogingerenone B, gingerenone C, gingerenone A, gingerol,<br />

10-gingerol, shogaol, 12-gingerol, 14-gingerol, 16-gingerol, 7-gingerol, gingerol, 9-gingerol, 8-<br />

gingerol, glanolactone, 8b,17-epoxylabd-trans-12-ene-15,16-dial, 6-paradol, 6-gingerol, nerolidol,<br />

pentan-2-ol, pipecolic acid, cis-b-sesquiphell<strong>and</strong>rol, trans-b-sesquiphell<strong>and</strong>rol, cis-sesquisabinene<br />

hydrate, 10-shagaol, shagaol derivatives, starch, n-undecanone, zingerone, zingiberene,<br />

zingiberenol, zingiberone, Zingiber officinale var. macorhizomum galanolactone, 6-gingerol, 8-<br />

gingerol, 10-gingerol, trans-8b,17-epoxylabd-12-ene-15, 16-dial. Zingiber officinale var. rubens<br />

galanolactone, 6-gingerol, 8-gingerol, 10-gingerol, trans-8-b-17-epoxylabd-12-ene-15, 16-dial,<br />

8b, 17-epoxylabd-trans-12-ene-15, 16-dial<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The rhizome is carminative <strong>and</strong> stimulant. It is useful as after-birth medication <strong>and</strong> for<br />

menstrual pain, coughs, constipation, rheumatism, colic, body-ache, leucorrhea/puerperal<br />

infection, tonic/sexual debility, sea-food poisoning, nausea <strong>and</strong> cold stomach.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Malaysian Monograph Committee. 1999. Malaysian <strong>Herbal</strong> Monograph. Pp. 85–88.<br />

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202


MYANMAR<br />

1.0 Scientific Name : Barleria prionitis L.<br />

Family : Acanthaceae<br />

2.0 Vernacular Name : Leik-Su-Shwe (Myanmar)<br />

3.0 Plant Description<br />

A much-branched shrub, about 5 ft, usually prickly at the stem branches, leaves opposite, ovateelliptic,<br />

tip acute, margin entire or slightly wavy, mid-vein distinct. Flowers bisexual, pentamerous,<br />

funnel shaped, yellow or purple.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is found in tropical regions.<br />

6.0 Chemical Constituents<br />

Scutellarein – 7 – rhammosyglucoside, barlerin <strong>and</strong> acety-balerin<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The leaves are applied for swellings, aches, skin diseases, as hair tonic <strong>and</strong> antiseptic<br />

(cleans, boils <strong>and</strong> abscesses). The discharge of blood in urine can be cured by giving theit<br />

juice or the powder of the whole plant mixed with sugar. The decoction of the whole plant<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

is given for piles, melena diuretic action <strong>and</strong> eodema. The dried powder is taken with<br />

honey to increase spermatogenesis, <strong>and</strong> is also used as antiseptic. The decoction of the<br />

leaf is famous for tuberculosis, used externally for swellings <strong>and</strong> inflammation.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Department of Traditional Medicine. 2001. <strong>Medicinal</strong> <strong>Plants</strong> of Myanmar. Department of<br />

Traditional Medicine, Yangon.<br />

Rastogi, R.P. & Mehrotra, B.N. 1993. Compendium of Indian <strong>Medicinal</strong> <strong>Plants</strong>. Vol. 3.<br />

CDRI Lucknow & Publication <strong>and</strong> Information Directorate, New Delhi.<br />

State Traditional Medical Council, Myanmar Traditional Medicine Manual for Health Basic<br />

Training Course (WHO/MMR/TRM/003).<br />

Thidar Swe. et al. 2000. Ethnobotany of Yangon Division, Myanmar, Myanmar Health Research<br />

Congress. Program & Abstract.<br />

206


MYANMAR<br />

1.0 Scientific Name : Dioscorea esculenta (Lour.) Burkill<br />

Family : Dioscoreaceae<br />

2.0 Vernacular Names : Wet-ka (Myanmar); ubi torak (Malaysia)<br />

3.0 Plant Description<br />

Annual herb with perennial underground large tuber. Spiny climber 3–5.5 m high. Base of the<br />

stem produces many white roots, log, woody with numerous sharp, painted, whitish spines 1–2<br />

cm arising from the surface, surrounding the tuber. Leaves broadly orbicular (or) cordate,<br />

acuminate, glabrous above, slightly hairy below, 8–11 nerved. Male flower in spike form <strong>and</strong><br />

female is minute in raceme.<br />

4.0 Propagation : Tuber<br />

5.0 Geographical Distribution/Ecology<br />

It grows in lowl<strong>and</strong> to hilly regions, preferring subtemperate areas (Myanmar). It is found wild<br />

in open areas in Malaysia.<br />

6.0 Chemical Constituents<br />

The tuber has the toxic principle, dioscorine.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

It is used as tonic, <strong>and</strong> has antioxidant properties (prolongs longevity of life <strong>and</strong> youth)<br />

<strong>and</strong> a rich source of vitamin E. The tuber is applied to ulcers <strong>and</strong> swellings. In certain<br />

species of Dioscorea, the leaves are used for intermittent fevers.<br />

8.0 Bibliography<br />

Ashin-nagathein. Encyclopedia of <strong>Medicinal</strong> <strong>Plants</strong>.<br />

Hooker, J. D. 1879. The Flora of British India. Vol. L. Reeve <strong>and</strong> Company, London.<br />

Hyndley, H. G. 1987. List of Trees, Shrub <strong>and</strong> Principal Climbers etc. Recorded with<br />

Vernacular Names. Forest Department, Burma.<br />

Kirtikar, K. R. & Basu, B. D. 1933. India <strong>Medicinal</strong> <strong>Plants</strong>. Vol. II, 12th edition. The Prabasi<br />

Press, Calcutta.<br />

208


MYANMAR<br />

1.0 Scientific Name : Elettaria cardamomum Maton<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Hpalar, phalar-thein, phalar-nge (Myanmar);<br />

buah pelaga (Malaysia)<br />

3.0 Plant Description<br />

Perennial herb with a large <strong>and</strong> fleshy rhizome; the flowering stems spread horizontally near the<br />

ground. Leaves oblong-lanceolate. Fruit capsule, subglobose or oblong, marked with fine vertical<br />

striations.<br />

4.0 Propagation : Rhizomes<br />

5.0 Geographical Distribution/Ecology<br />

It grows wildly in rich moist soil <strong>and</strong> cultivated in tropical regions.<br />

6.0 Chemical Constituents<br />

The fruit contains fixed oil, volatile oil. The principal constituents of volatile oil are cineol, terpeneol,<br />

limonene <strong>and</strong> sabinene, D-borneol, bornylacetate, d-camphor, nerolidol, linalool.<br />

7.0 Report on <strong>Medicinal</strong> Usage:<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

209


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

It is antiseptic, antimicrobial, aphrodisiac, astringent, antispasmodic, digestive, diuretic,<br />

settles digestive discomfort, helps with flatulence, stimulates saliva <strong>and</strong> is used in tonic.<br />

The fruit is used mostly as spice <strong>and</strong> flavouring agent. It is used as carminative in traditional<br />

practice.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Ashin-nagathein. Encyclopedia of <strong>Medicinal</strong> <strong>Plants</strong>.<br />

Hooker, J. D. 1879. The Flora of British India. Vol. L. Reeve <strong>and</strong> Company, London.<br />

Hyndley, H. G. 1987. List of Trees, Shrub <strong>and</strong> Principal Climbers etc. Recorded with<br />

Vernacular Names. Forest Department, Burma.<br />

Kirtikar, K. R. & Basu, B. D. 1933. India <strong>Medicinal</strong> <strong>Plants</strong>. Vol. II, 12th editon. The Prabasi<br />

Press, Calcutta.<br />

210


MYANMAR<br />

1.0 Scientific Name : Gloriosa superba L.<br />

Family : Colchicaceae<br />

2.0 Vernacular Name : Si-mee-dauk (Myanmar)<br />

3.0 Plant Description<br />

Herbaceous, tall, stout climbing herb. Root-stock of arched, solid, fleshy-white cylindric tubers.<br />

Leaves sessile. Ovate lanceolate, tip ending in a tendril-like spiral. Flowers large solitary, axillary,<br />

changing colours from greenish yellow, orange, scarlet to crimson from blooming to fading.<br />

Fruits capsule.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

It grows widely in tropical regions.<br />

6.0 Chemical Constituents<br />

Seed contains high level of colchicines. Cornigerine, 3-demethyl-N-formyl-N-deacetyl-blumicolchicine,<br />

3-demethyl-g-lumicolchicine, 3-demethyl colchicines have been isolated from<br />

the plant. b-sitosterol, its glucoside, a long chain fatty acid, b <strong>and</strong> g-lumiccolchicines from fresh<br />

tubers <strong>and</strong> luteolin, colchicines, N-formyldeacetylcolchicines <strong>and</strong> glucosides of 3-<br />

demethylcolchicine have been isolated from flowers.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

It is indicated for asthma, tussis <strong>and</strong> amenorrhoea, <strong>and</strong> used as antiinflammatory agent, in<br />

arthritis. Dried flowers mixed with other ingredients are used to cure asthma. The powder<br />

of dried tubers mixed with roasted salt is also used to treat asthma <strong>and</strong> arthritis.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Rastogi, R. P. & Mehrotra, B. N. 1993. Compendium of Indian <strong>Medicinal</strong> <strong>Plants</strong>. Vol. 1–5.<br />

CDRI Lucknow & Publication <strong>and</strong> Information Directorate, New Delhi.<br />

212


MYANMAR<br />

1.0 Scientific Name : Millettia extensa (Benth.) Baker<br />

Family : Fabaceae<br />

2.0 Vernacular Name : Wun-u<br />

3.0 Plant Description<br />

A large climbing shrub about 9 m. Stem finely downy. Leaves pinnate compound; leaflets 3–5<br />

abovate-oblong, tip acute, long petioled, elongated, glabrous rachis. Flowers short-pedicelled,<br />

close axillary racemes; sepals bell-shaped; petals densely silky, red. Pod hard <strong>and</strong> woody.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It occurs naturally in tropical areas.<br />

6.0 Chemical Constituents<br />

Nil<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots <strong>and</strong> stem are used to treat bone fractures <strong>and</strong> skin diseases, i.e itches <strong>and</strong><br />

scabies.<br />

213


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Hooker, J. D. 1879. The Flora of British India. Vol.L. Reeve <strong>and</strong> Company, London.<br />

Hundley, H. G. 1987. List of Trees, Shrub <strong>and</strong> Principal.<br />

Kirtikar, K. R. & Basu, B. D. 1933. India <strong>Medicinal</strong> <strong>Plants</strong>. Vol II, 12th edition. The Prabasi<br />

Prees, Calcutta.<br />

Watt, G. 1889. A Dictionary of the Economic Products of India. Vol.C. Government Printing<br />

Press, India.<br />

214


MYANMAR<br />

1.0 Scientific Name : Nervilia fordii (Hance) Schltr<br />

Family : Orchidaceae<br />

2.0 Vernacular Name : Ta-bin-shwe-hti (Myanmar)<br />

3.0 Plant Description<br />

Perrenial herb with fleshy tuber. Tuber globular, 5–20 mm in diameter, with fibrous roots <strong>and</strong> 1–<br />

2 blades. Leaf ovate-cordate, about 6–12 cm in length <strong>and</strong> width; with several obvious arched<br />

parallel veins; petiole long, tubular at the lower part, surrounded by the purple-red leaf sheath;<br />

flower rare. Inflorescence spike; flower white with pinkish-violet spots. Capsule rhomboid striate.<br />

4.0 Propagation : Tuber<br />

5.0 Geographical Distribution/Ecology<br />

It is found in tropical <strong>and</strong> subtropical regions, growing mostly in hill regions of evergreen forests,<br />

often in rich soil under shade.<br />

6.0 Chemical Constituents<br />

Not available<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

It is used as depurative, especially in the case of mushroom intoxication. The leaves are<br />

used for alleviating coughs <strong>and</strong> relieving pain. It clears away heat <strong>and</strong> toxic material. It<br />

215


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

is used for skin infection of intense heat type, sorethroat, summer-heat syndrome with<br />

fever <strong>and</strong> thirst, scrofula. It moisturizes the lungs to relieve coughs.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 2. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

http://herb.damo-qigong.net/b024.htm - 24 August 2003.<br />

216


MYANMAR<br />

1.0 Scientific Name : Piper betle L.<br />

Family : Piperaceae<br />

2.0 Vernacular Names : Kun (Myanmar); sirih (Malaysia, Indonesia, Brunei Darussalam)<br />

3.0 Plant Description<br />

A perennial aromatic creeper. Stem long, slender, producing small roots at the nodes. Leaves<br />

alternate; long petiolate, coiled at the base; leaves shaped broadly ovate; tip acute; base cordate;<br />

margin entire; 5–7 nerved; palmately veined; upper surface bright green, lower pale; thick, long<br />

stalk. Inflorescence spikes; flowers minute. Fruit small berries, one-seeded.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Tropical regions<br />

6.0 Chemical Constituents<br />

Leaf contains aromatic essential volatile oil of sharp burning taste, aromatic odour containing<br />

betel-phenols, starch, sugars <strong>and</strong> tannin. Essential oil: eugenol, methyleugenol, a-terpineol, terpinyl<br />

acetate <strong>and</strong> caryophyllene.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

217


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The leaves are used for the treatment of low pressure <strong>and</strong> irregular movements of the<br />

heart. They have been used successfully for colds, loss of voice, coughs <strong>and</strong> asthma.<br />

They cure throat disorders, loss of appetite, indigestion, constipation <strong>and</strong> germ diseases.<br />

The decoction of leaves is taken orally for the treatment of fever. They are also widely<br />

used to treat asthma <strong>and</strong> inflammation. The fresh leaves are eaten together with jaggery<br />

for the treatment of hypertension. The decoction of leaves combined with sugar <strong>and</strong><br />

jaggery is given for diarrhoea.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Nadkarni, K. M. 1993. Indian Materia Medica. Popular Prakashan Private Limited, Mumbai.<br />

Rastogi, R. P. & Mehrotra, B. N. 1993. Compendium of Indian <strong>Medicinal</strong> <strong>Plants</strong>. Vol.3.<br />

CDRI Lucknow & Publication <strong>and</strong> Information Directorate, New Delhi.<br />

State Traditional Medical Council, Myanmar Traditional Medicine Manual for Health Basic<br />

Training Course. (WHO/MMR/TRM/003).<br />

218


MYANMAR<br />

1.0 Scientific Name : Rauvolfia serpentina Benth. ex Kurz.<br />

Family : Apocynaceae<br />

2.0 Vernacular Name : Bon-ma-ya-zar (Myanmar)<br />

3.0 Plant Description<br />

Roots up to 15 cm in length <strong>and</strong> 2 cm in diameter, stout, thick, tortuous. Surface is slightly<br />

wrinkled, rough with coarse longitudinal marking. External colour greyish yellow to brown, wood<br />

pale yellow. Fracture short, irregular. Odourless, taste very bitter.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Tropical regions<br />

6.0 Chemical Constituents<br />

Alkaloid-ajmaline, serpentine, serpentinine<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The root is used as anthelmintic <strong>and</strong> febrifuge. It is also used as a remedy for snakebites<br />

<strong>and</strong> stings of insects <strong>and</strong> in dysentery. Its powder is combined with other ingredients for<br />

treatment of hypertension, fevers, high blood pressure, hypochondria, insanity, insomnia,<br />

painful bowel disorders.<br />

219


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Chopra, R. N., Nayar, S. L. & Chopra, I. C. 1956. Glossary of Indian <strong>Medicinal</strong> plants.<br />

Council of Scientific & Industrial Research, New Dehli.<br />

Department of Traditional Medicine. 2001. <strong>Medicinal</strong> <strong>Plants</strong> of Myanmar. Ministry of Health.<br />

Rastogi, R. P. & Mehrotra, B. N. 1993. Compendium of Indian <strong>Medicinal</strong> <strong>Plants</strong>. Vol. 2 &<br />

3. CDRI Lucknow & Publication <strong>and</strong> Information Directorate, New Delhi.<br />

State Traditional Medical Council, Myanmar Traditional <strong>Medicinal</strong> Manual for Health Basic<br />

Training Course (WHO/MMR/TRM003). The Union of Myanmar.<br />

Thidar Swe et al. 2000. Ethnobotany of Yangon Division, Myanmar. Myanmar Health<br />

Research Congress Programme & Abstract.<br />

http://www.pharm.kumamoto-u.ac.jp/yakusoen/rauorufia-e.html - 24 August 2003.<br />

220


MYANMAR<br />

1.0 Scientific Name : Vitex negundo L.<br />

Family : Lamiaceae<br />

2.0 Vernacular Name : Kyaung-pan-gyi<br />

3.0 Plant Description<br />

A large shrub or small tree, branches quadrangular. Leaves compound opposite; long petiolate;<br />

leaflets penta-foliate, lanceolate, glabrous above, tomentose below. Inflorescence terminal thyrse.<br />

Flowers bisexual, bluish purple, tomentose outside, hairy inside. Fruits drupe, globose, black<br />

when ripe.<br />

4.0 Propagation : Stem cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

It grows in warmer place <strong>and</strong> is found mostly in waste places.<br />

6.0 Chemical Constituents<br />

Vanillic <strong>and</strong> p-hyroxybenzoic acids <strong>and</strong> luteolin isolated from bark. Roots contain hentriacontance,<br />

â-sitopsterol, â-sitopsterol acetate <strong>and</strong> stigmasterol. Leaves contain essential oil.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The leaf juice is taken in treatment of swelling of joints, weakness of brain, paucity of<br />

menses <strong>and</strong> ailments connected with childbirth. It cures itches <strong>and</strong> ailments caused by<br />

221


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

heat. The decoction of the plant is given in the treatment of fever as well as malaria. The<br />

decoction of the leaves is useful for dysentery <strong>and</strong> gastric ulcer.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Rastogi, P. T. & Mehrotra, B. N. 1993. Compendium of Indian <strong>Medicinal</strong> <strong>Plants</strong>. Vol. 2 &<br />

3. CDRI Lucknow & Publication <strong>and</strong> Information Directorate, New Delhi.<br />

Chopra, R. N., Nayar, S. L. & Chopra, I. C. 1956. Glossary of Indian <strong>Medicinal</strong> plants.<br />

Council of Scientific & Industrial Research, New Dehli.<br />

State Traditional Medical Council, Myanmar Traditional Medicine Manual for Heatlh Basic<br />

Training Course. (WHO/MMR/TRM/003) Union of Mynmar.<br />

Department of Traditional Medicine. 2001. <strong>Medicinal</strong> <strong>Plants</strong> of Myanmar. Ministry of Health.<br />

222


MYANMAR<br />

1.0 Scientific Name : Vitis repens Lam. Wight & Arn.<br />

Family : Vitaceae<br />

2.0 Vernacular Name : Ta-bin-taing-mya-nan (Myanmar)<br />

3.0 Plant Description<br />

Tendrillar climber, slender, sc<strong>and</strong>ent. Stem 6-angled with ridges <strong>and</strong> furrows. Rhizome glaucous,<br />

fusiform to tuberculous. Leaves alternate, simple; margin serrulate; white patch in pale-greencoloured<br />

leaf blade. Cymose, small yellowish green flowers are borne on the peduncle. Fruits<br />

berries.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

It is widely distributed in hill regions.<br />

6.0 Chemical Constituents<br />

Glycosides <strong>and</strong> flavonoids.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The root is used for sores, ulcers <strong>and</strong> tumours. The whole plant is used for hepatitis,<br />

jaundice <strong>and</strong> hypertension. It is used mostly for sores, ulcers <strong>and</strong> tumours.<br />

223


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

San, S. Y. 1989. Taxonomical, Pharmacognostical <strong>and</strong> Antitubercular Studies of Two<br />

Species of Vitis. M.Sc. thesis, Yangon University.<br />

Department of Traditional Medicine. <strong>Medicinal</strong> <strong>Plants</strong> of Myanmar. A Selection of 60<br />

commonly used species compiled by the Ministry of Health.<br />

224


PHILIPPINES<br />

1.0 Scientific Name : Aloe barbadensis Mill.<br />

Synonym : Aloe vera (L.) Burm. f.<br />

Family : Liliaceae<br />

2.0 Vernacular Names : Aloe, curacao aloe (English); sabila, sabila-pinya (Tagalog);<br />

dilang-halo (Bisakol); dilang-boaia (Bikol); acibar (Spanish)<br />

3.0 Plant Description<br />

A short-stemmed herb cultivated both as ornamental <strong>and</strong> medicinal. The thick, sword-shaped<br />

leaves form a rosette immediately above the ground. They are 30 to 40 cm long, pale green with<br />

white spots <strong>and</strong> smooth except for weak marginal spines. The flower cluster (raceme), about<br />

30 cm long, has a long stalk with distant acute scales. The yellow flowers without calyx are<br />

drooping, 2.5 cm long, tube shaped, tipped with short lobes which are curved outward. The<br />

capsule (fruit) bears angular seeds.<br />

4.0 Propagation : Commonly propagated by suckers<br />

5.0 Geographical Distribution/Ecology<br />

Aloe is commonly found in the Philippines as an ornamental.<br />

6.0 Chemical Constituents<br />

Histochemical findings are as follows: tannin in leaves (detectable); calcium oxalate in leaves<br />

(abundant); sulphur, fats, iron formic acid <strong>and</strong> glycoside in leaves (detectable).<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

227


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

Leaf juice is used for treating burns, abrasions <strong>and</strong> skin irritations; also purgative, vermifuge;<br />

tonic <strong>and</strong> remedy for kidney pains; cathartic; juice of leaves applied to the scalp prevents<br />

falling hair, <strong>and</strong> is said to be good for the complexion. Crushed leaves as poultice for<br />

contusions. Juice mixed with water is a remedy for indigestion <strong>and</strong> peptic ulcers. It is<br />

usually combined with other antispasmodic drugs; vermifuge; emmenagogue.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1981. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. III. Technical Bulletin Vol. V, No.2. University Publication Office, Las Banos,<br />

Laguna, Philippines. Pp. 66.<br />

228


PHILIPPINES<br />

1.0 Scientific Name : Anacardium occidentale L.<br />

Synonym : Cassuvium reniforme Blanco<br />

Family : Anacardiaceae<br />

2.0 Vernacular Names : Balubad, kasoy, balugo (Phillipines); Gajus, jambu bongkok<br />

(Malaysia)<br />

3.0 Plant Description<br />

Small tree with gnarled trunk. Leaves simple, alternate, ovate or obovate, 10–20 cm long <strong>and</strong> 7–<br />

12 cm wide, with slightly rounded apex. Flowers small crowded at the tip of branches; petals<br />

yellowish to white sometimes with pink stripes. Fruit is a nut, ash-colored, kidney-shaped, about<br />

2 cm long, with its receptacle or torus fleshy, juicy yellow <strong>and</strong> pear shaped, about 5–7 cm long.<br />

4.0 Propagation : Seed, stem cutting, marcotting, inarching, budding <strong>and</strong><br />

grafting<br />

5.0 Geographic Distribution/Ecology<br />

The cashew is a native of northeastern Brazil in tropical America, where it occurs wild in<br />

extensive isl<strong>and</strong>s. From its native home, it became well dispersed throughout the tropics in the<br />

lowl<strong>and</strong>s of Central <strong>and</strong> South America, Mexico <strong>and</strong> the West Indies where it was thoroughly<br />

naturalized <strong>and</strong> became abundant. In the 16th century, Portuguese traders introduced cashew<br />

into India where it was planted along the seashores to bind the soil <strong>and</strong> check erosion. Soon, the<br />

species spread throughout India, Sri Lanka, Malaysia <strong>and</strong> other Asian countries. The early<br />

Spanish missionaries are credited to have introduced cashew into the Philippines from tropical<br />

America <strong>and</strong> India. At present, the cashew is an important nut crop in India, Mozambique,<br />

Tanzania, Brazil, Madagascar, Kenya, Sri Lanka, Nigeria, Senegal, the Philippines <strong>and</strong> other<br />

tropical countries. The greater bulk of cashew kernel is consumed in the United States, Russia,<br />

United Kingdom, Canada, Australia, Federal Republic of Germany <strong>and</strong> Japan.<br />

229


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0 Chemical Constituents<br />

Alkaloids, glycosides, saponin, tannin <strong>and</strong> calcium oxalate<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Decoction of the bark is used to treat diarrhea, diabetes, syphylitic swellings <strong>and</strong> ulcerations<br />

in the mouth. Infusion of the leaves <strong>and</strong> bark acts as astringent, relieves toothache, sore<br />

gums <strong>and</strong> for dysentery. Juice from the pericarp is diuretic <strong>and</strong> sudorific. The bruised nut<br />

is used in abortion. Oil from the nut is used for warts, blisters, corns <strong>and</strong> ulcers. Tincture<br />

of the pericarp is vermifuge.<br />

8.0 Contraindications<br />

Not available.<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. I. University Publication Office, Las Banos, Laguna, Philippines.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Bureau of Printing, Manila.<br />

230


PHILIPPINES<br />

1.0 Scientific Name : Annona reticulata L.<br />

Family : Annonaceae<br />

2.0 Vernacular Names : Anonas, nona (Malaysia)<br />

3.0 Plant Description<br />

A tree, 10 m high or less. Leaves oblong to oblong-lanceolate, acuminate, 20 cm long or less,<br />

glabrous; petioles 1–1.5 cm long. Flowers greenish-yellow, fragrant, 2–2.5 cm long, 2 or 3<br />

together on lateral peduncles. Fruit subglobose or ovoid, large, fleshy edible, with pentagonal<br />

areolae on the outside.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Anonas is widely distributed after the discovery of the New World <strong>and</strong> is now found in all<br />

tropical <strong>and</strong> subtropical regions. It has been long established in India.<br />

6.0 Chemical Constituents<br />

Alkaloids, tannin, formic acid, peroxidases <strong>and</strong> calcium oxalate<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

231


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

Fresh leaves are applied onto the stomach of children suffering from indigestion. Fresh<br />

leaves <strong>and</strong> fruits are anthelmintic. Young fruits <strong>and</strong> bark act as astringent in dysentery<br />

<strong>and</strong> diarrhea.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. II. University Publication Office, Las Banos, Laguna, Philippines.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Bureau of Printing, Manila.<br />

232


PHILIPPINES<br />

1.0 Scientific Name : Areca catechu L.<br />

Synonym : Areca alba Bory.<br />

Family : Arecaceae<br />

2.0 Vernacular Names : Areca nut, betel nut palm, boa, bunga, dapiau, hua, lugos, luyos,<br />

pasa, takobtob, vua, va<br />

3.0 Plant Description<br />

The trunk is erect <strong>and</strong> solitary, up to 25 m high, <strong>and</strong> marked with annular scars. The leaves are<br />

up to 4 m long; with numerous leaflets, 60 to 90 cm long, with the upper ones confluent. The<br />

spadixis much branched <strong>and</strong> compressed, with branched filiform bearing numerous, somewhat<br />

distichous male flowers which are yellow <strong>and</strong> about 5 mm long. The female flowers are at the<br />

base of the branches <strong>and</strong> in axils, about 1 cm long or more. The fruit is ovoid, smooth, orange or<br />

red (when ripe), 4 to 6 cm long, with the pericarp somewhat fleshy, <strong>and</strong> the mesocarp fibrous.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is often cultivated throughout the Philippines. Possibly it is native to the country,<br />

having been found once, spontaneous in primary forests in Palawan. It also occurs in the Old<br />

World Tropics generally, <strong>and</strong> has been introduced into the New World.<br />

6.0 Chemical Constituents<br />

The first chemical analysis of the seed was performed in 1886 <strong>and</strong> isolated a liquid volatile<br />

alkaloid called arecaine. Other alkaloids isolated from the seeds are in the following proportions<br />

- arecaine 0.1% <strong>and</strong> arecoline 0.07-0.1%; arecaidine, guvacoline <strong>and</strong> choline occur only in<br />

traces. Arecolidine is another alkaloid obtained. The seed contains 15% of tannin <strong>and</strong> 14% of<br />

fat.<br />

233


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Tannin is located almost entirely in the kernel. However, the husk contains only traces. As the<br />

green nuts ripen, the amount of tannin in the kernels decreases. Analyses of full-grown betel nut<br />

(kernel) yielded 12.98–26.89% of tannin.<br />

The kernel has gallic acid <strong>and</strong> gum. The most important of all the alkaloids <strong>and</strong> the one which<br />

has anthelmintic property is arecoline (C 8<br />

H 13<br />

NO 2<br />

). Arecoline is a colourless, oily liquid with a<br />

boiling point of 230° C, <strong>and</strong> forms crystalline salt with acids.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in the traditional medicine:<br />

In the Philippines, as well as in the Indo-Malayan <strong>and</strong> Polynesian regions, the areca nut is<br />

extensively chewed with lime <strong>and</strong> the leaves of betel piper (Piper betle) which is locally<br />

known as ikmo. The buyo, is generally regarded as a tonic <strong>and</strong> a general stimulant, but<br />

its excessive use is certainly harmful. The fruit in decoction is considered an abortifacient<br />

<strong>and</strong> the nut as an emmenagogue. Excessive use of buyo causes loss of appetite, salivation,<br />

<strong>and</strong> general degeneration of the organism. The tender seeds are said to be purgative <strong>and</strong><br />

grated ripe ones are vermifuge, <strong>and</strong> externally used as an astringent.<br />

The fresh nut is somewhat intoxicating <strong>and</strong> produces giddiness in some persons. The<br />

dried nut is a stimulant, astringent <strong>and</strong> taenifuge. It increases the flow of saliva, sweetens<br />

the breath, strengthens the gum, <strong>and</strong> produces mild exhilaration. Arecoline is a highly<br />

toxic substance, <strong>and</strong> its pharmacological action resembles that of muscarine, pelletierine,<br />

<strong>and</strong> pilocarpine. It violently stimulates the peristaltic movements of the intestines <strong>and</strong><br />

produces a marked constriction of the bronchial muscles which can, however, be overcome<br />

by adrenaline or atropine. It is a powerful sialogogue <strong>and</strong> stimulates the secretion of<br />

sweat in the same way as pilocarpine.<br />

The young nut is useful in bowel complaints. The tincture forms an astringent gargle<br />

when diluted with water, which is useful for bleeding gums. It may also be injected to stop<br />

water discharges from the vagina. It is useful in checking the pyrosis during pregnancy.<br />

The young green shoots act as an abortifacient in early pregnancy. Large doses of areca<br />

nut can cause vomiting <strong>and</strong> diarrhoea. The roots (shredded, steeped in water, pounded<br />

<strong>and</strong> the juice extracted) are used as poison.<br />

The tannic <strong>and</strong> gallic acids in young nuts are responsible for the astringent properties.<br />

The burned <strong>and</strong> powdered nuts make an excellent dentifrice. The juice of young leaves<br />

mixed with oil is used externally for lumbago. It has been found to be useful to cure<br />

urinary disorders. It is also reported to possess aphrodisiac properties. The powdered<br />

nuts have long been known to be antihelmintic in man <strong>and</strong> animals <strong>and</strong> are useful in the<br />

expulsion of tapeworms from human, as well as in combating round worms. The nut is<br />

regarded as a nervine tonic.<br />

8.0 Contraindications<br />

Not available<br />

234


PHILIPPINES<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1977. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. I. Technical Bulletin Vol. 11(3). University Publication Office, Las Banos, Laguna,<br />

Philippines. Pp. 63.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

235


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Basella rubra L.<br />

Synonyms : Basella alba L., Basella lucida L., Basella cordifolia Lam.<br />

Family : Basellaceae<br />

2.0 Vernacular Names : Alugbati, arogbati, dundula, grana; ilaibakir, libato, malabar<br />

nightshade, Lok’uei<br />

3.0 Plant Description<br />

The plant is a succulent, branched, smooth, twining, herbaceous vine reaching a length of several<br />

meters. The stems are green or purplish. The leaves are somewhat fleshy, ovate or heartshaped,<br />

5–12 cm in length stalked, tapering to a pointed tip, <strong>and</strong> cordate at the base. The spikes<br />

are axillary, solitary, <strong>and</strong> 5–29 cm in length. The flowers are pink, <strong>and</strong> about 4 mm long. The<br />

fruit is fleshy, stalkless, ovoid or nearly spherical, 5–6 mm in length, <strong>and</strong> purple when mature.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

The plant is widely cultivated <strong>and</strong> found at low <strong>and</strong> midl<strong>and</strong> elevations throughout the Philippines.<br />

It is certainly not a native of the archipelago but is a prehistoric introduction. It also occurs in<br />

tropical Asia, Africa <strong>and</strong> Malaysia.<br />

6.0 Chemical Constituents<br />

Histochemical test analysis indicates that calcium oxalate in leaves is abundant <strong>and</strong> in stems<br />

detectable. Starch in leaves is detectable <strong>and</strong> in stems abundant, while saponin in leaves is<br />

detectable.<br />

236


PHILIPPINES<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots are employed as rubefacient, <strong>and</strong> as a poultice to reduce local swelling. The<br />

sap is used to anoint any part of the body affected by acne to reduce irritation. It is<br />

demulcent, diuretic <strong>and</strong> emollient. It makes wholesome <strong>and</strong> is most easily digested <strong>and</strong><br />

acts as a mild laxative. The leaves are reduced to a pulp <strong>and</strong> applied to boils, ulcers <strong>and</strong><br />

abscesses to hasten suppuration. The juice of the leaves together with sugar is useful in<br />

catarrhal infections in children. It is useful in treating gonorrhea <strong>and</strong> balanitis. The juice<br />

from the leaves, thoroughly rubbed <strong>and</strong> mixed with butter, is a soothing <strong>and</strong> cooling<br />

application for burns <strong>and</strong> scalds. The mucilaginous liquid obtained from the leaves <strong>and</strong><br />

tender stalks of this plant is a popular remedy for habitual headaches. The leaves are<br />

considered good maturation as cataplasm. A decoction of the leaves is a good laxative<br />

for pregnant women <strong>and</strong> children. The fruit is used as rouge for the cheeks <strong>and</strong> lips <strong>and</strong><br />

also as a dye.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1981. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. I. Technical Bulletin Vol. 5(2). University Publication Office, Las Banos, Laguna,<br />

Philippines. Pp. 66.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

237


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Bixa orellana L.<br />

Family : Bixaceae<br />

2.0 Vernacular Names : Achuete, asuite, achiti, atsuite, sotis (Philippines)<br />

3.0 Plant Description<br />

A tree, 4–6 m high. Leaves ovate, entire, 8–20 cm long, 5–12 cm wide; base broad, more or less<br />

cordate; apex acuminate. Flowers white to pinkish, 4–6 cm in diameter. Capsules ovoid or<br />

subglobose, green or reddish purple, about 4 cm long, covered with long, slender, rather soft<br />

spines <strong>and</strong> containing many small, dark red seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is usually planted around towns throughout the Philippines. It is a native of tropical<br />

America <strong>and</strong> is now pantropic in cultivation.<br />

6.0 Chemical Composition:<br />

Tannin, saponin, fats <strong>and</strong> calcium oxalate<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

238


PHILIPPINES<br />

7.2 Uses in traditional medicine:<br />

Febrifuge, leaf infusion is used in treating dysentery. When pounded <strong>and</strong> macerated in<br />

water, the leaves are diuretic. Decoction of the bark is employed in febrile catarrhs, to<br />

relieve period pain <strong>and</strong> stomach-ache. Dye from this plant mixed with lime is applied<br />

externally in treating erysipelas. The seed is an efficient remedy for certain skin diseases.<br />

They are said to be an antidote to cassava <strong>and</strong> Jatropha curcas poisoning.<br />

8.0 Contraindications<br />

Not available.<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippines <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. 2. University Publication Office, Las Banos, Laguna, Philippines.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Bureau of Printing, Manila.<br />

http://www.nativehabitat.com/Bixaorellana.asp - 26 August 2003.<br />

239


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Caesalpinia pulcherrima (L.) Sw.<br />

Synonym : Poinciana pulcherrima L.<br />

Family : Caesalpiniaceae<br />

2.0 Vernacular Names : Bulaklak ng paraiso (Philippines)<br />

3.0 Plant Description<br />

An erect, glabrous sparingly spiny shrub or small tree, 1.5–8 m high. Leaves bipinnate, pinnae<br />

4–8 pairs, 6–12 cm long; leaflets sessile, 7–11 pairs, obtuse, elliptic, 1–2 cm long. Racemes<br />

terminal lax; pedicels long, slender. Flowers red yellow or yellow, about 4 cm in diameter; petals<br />

crisped, clawed; stamens long-exserted. Pods 5–9 cm long, 1.5 cm wide.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It was introduced from tropical America. It is popular in other regions of the world. Introduced<br />

into the Philippines at an early date, it is now spontaneous in ab<strong>and</strong>oned areas <strong>and</strong> vacant lots.<br />

Native of Madagascar.<br />

6.0 Chemical Composition:<br />

Alkaloids, saponin, tannin, glucosides <strong>and</strong> calcium oxalate.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

240


PHILIPPINES<br />

7.2 Uses in traditional medicine:<br />

Plant decoction or infusion is used as purgative <strong>and</strong> emmenagogue. Decoction of the<br />

leaves is used to treat liver infections <strong>and</strong> ulcers of the mouth <strong>and</strong> throat. Infusion of the<br />

leaves, roots or bark is employed for colds <strong>and</strong> skin diseases <strong>and</strong> is even said to induce<br />

abortion. Root decoction is used to cure intermittent fever. The flower is a popular remedy<br />

for erysipelas <strong>and</strong> for inflammation of the eyes. It is also used as a tonic. The seeds are<br />

an effective abortifacient. The fruit is employed against diarrhea <strong>and</strong> dysentery.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. 2. University Publication Office, Las Banos, Laguna, Philippines.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Bureau of Printing. Manila.<br />

241


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Carmona retusa (Vash.) Masam.<br />

Synonyms : Ehretia microphylla Lam., Ehretia buxifolia Roxb.<br />

Family : Boraginaceae<br />

2.0 Vernacular Names : Putputai, alangit, tsaang gubat (Philippines)<br />

3.0 Plant Description<br />

A shrub or much-branched small tree, 1–4(–10) m tall; young branches hispid, with buds or<br />

short shoots producing clusters of leaves <strong>and</strong> inflorescences. Leaves simple, alternate obovate<br />

to spatulate, 1–6(–10) cm x 0.5–2.5(–4) cm, thick gradually narrowing towards base, toothed or<br />

crenate towards apex with short rigid hairs; lateral veins about 5 arching; petiole 0.1–0.5(–1)<br />

cm long, stipules absent. Inflorescence in fascicles of 2–6 or in a cyme. Flowers actinomorphic,<br />

bisexual, (4–) 5 merous, pedicelled; calyx 3–6 mm long, with (–) 5 linear lobes densely hairy<br />

inside; corolla sub-rotate, white 6–9 mm in diameter, tube about 2 mm long, widening, lobes<br />

spreading 2.5–4.5 mm long; stamens (4–) 5 with filaments 2.5–3.5 mm long <strong>and</strong> anthers oblong;<br />

ovary superior, globose about 1 mm in diameter style deeply bifid 4.5–6 mm long. Fruits<br />

drupaceous globose 5–6 mm in diameter, red or yellow, with 1–4 seeds not breaking up into<br />

pyrenes. Seeds with straight or slightly curved embryo, embedded in thin albumen. Seedling<br />

with epigeal germination; cotyledons leafy, green, hypocotyl elongated.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Found from India eastward to southern China, Taiwan, Japan, <strong>and</strong> further south throughout<br />

Malesia to New Guinea <strong>and</strong> to Solomon Isl<strong>and</strong>. The plant is often grown as ornamental.<br />

242


PHILIPPINES<br />

6.0 Chemical Constituents<br />

Boraginaceae commonly contain pyrrolizidine alkaloids, biosynthesized from the amino acid<br />

ornithine, <strong>and</strong> quinoid or phenolic compounds derived from C-prenylated, C-geranylated or C-<br />

farnesylated 4-hydrobenzoic acid. The isomeric red pigments alkannin <strong>and</strong> shikonin are best<br />

known representatives of such hydroxybenzoic acid derivatives. Specifically C. retusa contains<br />

alkaloids, glycocides <strong>and</strong> tannin.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

In the Philippines, the leaves are taken as a substitute for tea. It is considered as stomachic,<br />

antidiarrhea <strong>and</strong> as remedy for dysentery <strong>and</strong> coughs. Infusions of the leaves are taken<br />

as febrifuge. A decoction of the leaves is consumed to cure stomach-ache <strong>and</strong> coughs.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L.S. 1999. Plant Resources of South-East Asia. <strong>Medicinal</strong> <strong>and</strong> Poisonous<br />

<strong>Plants</strong> 1. Backhuys, Leiden, The Netherl<strong>and</strong>s. Pp. 52.<br />

243


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Cassia fistula L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Golden shower, Indian laburnum, purging cassia, pudding pipe<br />

tree, (English); bitsula (C. Bis.); cana fistula (Spanish); kanapestula<br />

(Ibn.); kana-pistula (Tagalog); fistula (C. Bis., Tagalog);<br />

ibabau (Bis.); lombayong (Bis.); lapad-lapad (Tagb.)<br />

3.0 Plant Description<br />

This is a moderate-sized, erect, deciduous tree. The leaves are pinnate smooth, <strong>and</strong> 30 to 40 cm<br />

long. The leaflets are 8 to 16, ovate, <strong>and</strong> average 10 cm in length. The flowers are borne in<br />

long, lax racemes (30 to 50 cm long), <strong>and</strong> are fragrant, bright yellow, on stalks, <strong>and</strong> 3 to 5 cm in<br />

length. The calyx is 6 to 8 mm long, smooth, <strong>and</strong> deciduous. The petals are veined, obovate, 18<br />

to 25 mm long, bright yellow, <strong>and</strong> short-clawed at the base. The stamens are all furnished with<br />

anthers, the 2 or 3 lower ones being longer. The pod is cylindric, 30 to 60 cm long, about 2.5 cm<br />

thick, pendulous, smooth, shining, <strong>and</strong> dark brown. The seeds are numerous, embedded in<br />

black, sweet pulp, completely separated by thin, transverse dissepiments, small, ovoid, slightly<br />

compressed, smooth, shining <strong>and</strong> yellowish brown.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Golden shower is found from northern Luzon to Mindanao <strong>and</strong> Palawan. Most often cultivated<br />

as an ornamental flowering tree <strong>and</strong> is sometimes planted for its medicinal properties. A native<br />

of tropical Asia, it was introduced into the Philippines <strong>and</strong> is now pantropic in cultivation.<br />

244


PHILIPPINES<br />

6.0 Chemical Constituents<br />

Pulp analysis: 20 parts of the pulp consist of sugar, 12.00; gum, 1.35; astringent matter; gluten;<br />

colouring matter; <strong>and</strong> water, the latter amounting to about 3.80. The root-bark <strong>and</strong> root-wood<br />

analysis results:<br />

Root-bark Root-wood<br />

Water (%) 10.01 8.21<br />

Ash (%) 8.92 2.29<br />

Petroleum ether extract (%) 0.32 0.52<br />

Ether extract (%) 2.17 0.45<br />

Absolute alcohol extract (%) 17.62 4.56<br />

Manganese was absent from the ash of both the root-bark <strong>and</strong> the root-wood; the former<br />

contained iron in a very marked amount. No alkaloidal principle was detected; resins were<br />

present. A bitter principle was also present to which the taste of the wood is probably due. As<br />

reported, oxymethyl-anthraquinone was isolated from the entire fruit, 0.95%; from the fruit pulp,<br />

1.05 %; <strong>and</strong> from the bark of the twigs, 1.20 %. In addition, saccharose (53-66 %), viscient<br />

sugar, citric acid, <strong>and</strong> pectin were present.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots are useful in fever, heart diseases, retained excretions, <strong>and</strong> biliousness; they<br />

are a strong purgative, tonic <strong>and</strong> laxative.<br />

The leaves are purgative. Externally the leaves, ground into a paste, are applied to ringworm.<br />

The juice of the young leaves is used to cure ringworm. The tender leaves are employed<br />

in rheumatic fever as a mild purgative. The powdered leaves are also laxative. The bark<br />

<strong>and</strong> leaves, mixed with oil, are applied to pustules, ringworm, insect bites, facial paralysis,<br />

<strong>and</strong> rheumatism. The bark is used as dye material.<br />

The flowers are purgative <strong>and</strong> are said to have demulcent properties. In decoction they<br />

are given in stomach affections. The pulp of the fruit is employed as a cathartic; extract<br />

of fruit-pulp proved to be good laxative.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

245


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Ceiba pent<strong>and</strong>ra (L.)<br />

Synonyms : Bombax pent<strong>and</strong>rum L., Eriodendron anfractuosum DC.<br />

Family : Bombacaceace<br />

2.0 Vernacular Names : White silk cotton tree (English); basanglai (Iloko); boboi<br />

(Bikol, Tagalog); boi-boi (Bisakol); buboi (Tagalog); bulak<br />

(Tagalog, Pampango); bulak-dondol, gapas, dogdol (Bisakol);<br />

kasanglai, bulak-kastila (Pampango); bulak-kahoi, balios, bulaksina<br />

(Tagalog); daldol (Bisakol); doldol (Bisakol); dondol (Iloko);<br />

gataoua (If.); kayo (Bikol, Bisakol); kapas-sanglai (Iloko);<br />

kapok (Bisakol, Sulawesi); kapas (Pang.); kapuk (Sulawesi);<br />

kulak (Iloko)<br />

3.0 Plant Description<br />

It is an erect, deciduous tree 15 m or less in height. The trunk is cylindric, usually bearing<br />

scattered, large spines. The branches are in distant whorls, <strong>and</strong> spread horizontally. The leaves<br />

are compound, with 5 to 8 leaflets which are whitish <strong>and</strong> about 3 cm long. The capsules are<br />

pendulous, oblong, about 15 cm in length, <strong>and</strong> 5 cm thick. They contain numerous black seeds,<br />

which are compressed-globose, smooth, <strong>and</strong> embedded in fine, silky hairs.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Kapok is widely distributed in the Philippines. It is possibly a native of tropical America <strong>and</strong> is<br />

now pantropic.<br />

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6.0 Chemical Constituents<br />

Histochemical test indicates: tannin in leaves <strong>and</strong> stems (detectable-abundant); fats in stem<br />

(detectable); calcium oxalate in leaves <strong>and</strong> stems (detectable-abundant); peroxidase in leaves<br />

<strong>and</strong> stems (detectable).<br />

The seeds have been reported with the following composition: oil – 24.20%; water – 11.85%;<br />

ash – 5.22%; crude fiber – 23.91%; albuminoids – 18.52%; carbohydrates – 15.90%. Kapok<br />

oil has the following constants: specific gravity at 15º C – 0.9235%; solidifying point – 29.6%;<br />

saponification value (Mgrms KOH) – 181 – 205%; Iodine value – 117.9%; maumene test –<br />

95%; refractive index – 51.3%. The oil consists of a mixture of fatty acids about 70% of which<br />

is liquid, while 30% is palmitic acid, which is solid.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The bark is employed as vomitive <strong>and</strong> aphrodisiac. When brewed into decoction it is<br />

regarded as febrile catarrh. The root decoction is used for chronic dysentery, diarrhea,<br />

ascites <strong>and</strong> anasarca. The gum is sometimes given in bowel complaints. The leaves are<br />

used for coughs, hoarseness, intestinal catarrh <strong>and</strong> urethritis. Tender leaves are<br />

administered for gonorrhea. Flower decoction is used for constipation. The tender fruit is<br />

used as emollient. The unripe fruit is regarded as demulcent <strong>and</strong> astringent.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. 2. Technical Bulletin Vol. III, No.3. University Publication Office, Las Banos,<br />

Laguna, Philippines. Pp. 67.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippine. Manila Blue Printing.<br />

247


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Hibiscus rosa-sinensis L.<br />

Family : Malvaceae<br />

2.0 Vernacular Names : Shoeflower, hibiscus, china rose (English); gumamela (Tagalog);<br />

gumamela (Tagalog, Bisakol, Pampango); kayangan (Iloko,<br />

Bikol, Bisakol); aratongan (Pampango)<br />

3.0 Plant Description<br />

The plant is an erect, much branched, smooth shrub, 1 to 4 m in height. The leaves are ovate<br />

<strong>and</strong> 7 to 12 cm long, with coarsely toothed margins. The flowers are solitary, axillary, very large,<br />

about 10 cm long, <strong>and</strong> 12 cm in diameter. The clyx is green <strong>and</strong> about 2 cm long, with ovate<br />

lobes. The petals are red, orange, or rose-white, obovate, rounded, <strong>and</strong> imbricate. The staminal<br />

tube is slender <strong>and</strong> longer that the corolla. There are many hybrids of different coloured, simple<br />

flowers in addition to a few doubles.<br />

4.0 Propagation : Cutting<br />

5.0 Geographical Distribution/Ecology<br />

Gumamela is found in cultivation for ornamental purposes, but nowhere spontaneous, throughout<br />

the Philippines. It is a native of the Old World <strong>and</strong> is now pantropic in cultivation.<br />

6.0 Chemical Constituents<br />

Histochemical findings are as follows: calcium oxalate in leaves <strong>and</strong> stem (detectable to abundant);<br />

sulphur in stem (detectable); peroxidase in leaves <strong>and</strong> stem (detectable to abundant); fats in<br />

leaves <strong>and</strong> stem (detectable to abundant); protein in leaves <strong>and</strong> stem (detectable to abundant).<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The plant possesses antiinfection <strong>and</strong> antiinflammation properties. Decoction of dried<br />

plant is used for infection of urinary tract. Roots, bark, leaves <strong>and</strong> flowers in decoction<br />

are used as emollient. Fresh leaves are crushed <strong>and</strong> applied as poultice to abscesses <strong>and</strong><br />

carbuncles. The bark is used as an emmenagogue. Flower buds, beaten into a paste, are<br />

applied as poultice to boils, cancerous swellings <strong>and</strong> mumps. The red flowers regulate<br />

menstruation; they are somewhat purgative <strong>and</strong> are sometimes said to cause abortion.<br />

Infusion of flowers used as an expectorant in bronchitis. Decoction of flowers is effective<br />

for coughs. The dark red petals are administered in the form of a mucilaginous infusion<br />

in irritable conditions of the genito-urinary tract; also a refrigerant drink in fevers. The<br />

seeds, pounded into a pulp <strong>and</strong> mixed with water, are given with much benefit in gonorrhea.<br />

Decoction of roots is used for sore eyes.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S., Lugod, G. C. & Pancho, J. V. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong><br />

<strong>Plants</strong>. Vol. 2. Technical Bulletin Vol. III, No.3. University Publication Office, Las Banos,<br />

Laguna, Philippines. Pp. 67.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

249


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Jatropha curcas L.<br />

Family : Euphorbiaceae<br />

2.0 Vernacular Names : Physic nut tree, purging nut tree, big-purge nut (English); tubangbakod,<br />

kirisol, taba-taba (Tagalog); galumbang (Pampanga);<br />

kasla (Bisakol); tagumbau, tagumbau-na-purau, tauua (Iloko);<br />

tangan-tangan-tuba (Tagalog); taua-taua (Iloko); tuba (Bikol,<br />

Tagalog)<br />

3.0 Plant Description<br />

This is a smooth, erect, branched shrub 2 to 5 m in height. The leaves are entire, angular or<br />

somewhat three-to five-lobed, orbicular-ovate <strong>and</strong> 10 to 18 cm long; the apex is pointed <strong>and</strong> the<br />

base heart-shaped. The petioles are long. The flowers are greenish or greenish white, 7 to 8<br />

mm in diameter, <strong>and</strong> borne on axillary cymes. The capsules are at first fleshy but later become<br />

dry, are rounded <strong>and</strong> are composed of two or three one-seeded divisions which are 3 to 4 cm<br />

long.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographic Distribution/Ecology<br />

Tubang-bakod is found throughout the Philippines. It was introduced at an early date in colonial<br />

history from Mexico, <strong>and</strong> is now pantropic in distribution.<br />

6.0 Chemical Constituents<br />

It contains 29 to 40 percent of a yellow fixed oil, known variously as hell oil, pinheon oil, oleum<br />

infernale, <strong>and</strong> oleum ricini majoris. The oil consists principally of glycerides of palmitic, oleic,<br />

<strong>and</strong> linolic acids. The bark contains a considerable amount of chlorophyll, reducing sugars or<br />

other reducing substances, saponin, a small amount of tannin, resin <strong>and</strong> a trace of volatile oil.<br />

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PHILIPPINES<br />

The bark yields wax which is a mixture of melissyl alcohol <strong>and</strong> its melissinic acid ester. It<br />

consists of the glyceride of a characteristic acid, belonging to the same group as ricinoleic <strong>and</strong><br />

crotonoleic acids, but is not identical with either.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

A decoction of the leaves is a good antidiarrhetic. A decoction of the roots is also used as<br />

a cure for diarrhoea, while that of the leaves is employed as a cough remedy <strong>and</strong> to excite<br />

secretion of milk. The bark of this plant is pounded slightly <strong>and</strong> placed in the mouth as a<br />

cure for snake-bite. It is also used as a poultice for sprains <strong>and</strong> dislocations, <strong>and</strong> the sap<br />

is a cure for toothache. The fresh, viscid juice flowing from the stem is employed to<br />

arrest bleeding or haemorrhage from wounds, ulcers, cuts <strong>and</strong> abrasions; it is said to<br />

promote healing by coagulating the blood <strong>and</strong> forming an air-tight film when dry, like that<br />

produced by collodion. It is a successful local remedy for scabies, eczema <strong>and</strong> ringworm.<br />

8.0 Contraindications<br />

A dose of 1 to 4 seeds is a mild purgative; an overdose is a drastic purgative – causing vomiting,<br />

purging - <strong>and</strong> violent inflammation of the mucous membrane of the stomach <strong>and</strong> intestines.<br />

9.0 Bibliography<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

251


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Mimosa pudica L.<br />

Synonym : Mimosa asperanta Blanco<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Bashful mimosa, humble plant, sensitive plant (English); babain<br />

(Iloko); damohia (Tagalog); dilgansusu (Iloko); harupai<br />

(Bisakol); huya-huya (Bisakol); kiromkirom (Bisakol); makahia<br />

(Pang., Tagalog); tuyag-huyag (Bisakol); torog-torog (Bikol)<br />

3.0 Plant Description<br />

The species is a diffusedly spreading, half-woody herb, with branched stems up to 1 meter in<br />

length, sparingly prickly with numerous deflexed, bristly hairs. The leaves are very sensitive,<br />

both the pinnae <strong>and</strong> the leaflets closing when touched. The pinnate are usually 4, digitately<br />

arranged at the end of each petiole, 4–9 cm long. The leaflets are narrowly oblong, inequilateral,<br />

1–1.5cms long, sessile, sparingly bristly, with pointed tip. The heads are long-peduncled, solitary<br />

or 2 or 3 in each axil, nearly 1 cm in diameter. The flowers are pink <strong>and</strong> very numerous. The<br />

pods are flat, slightly recurve, numerous, 1–2 cm long made up of 3–5 one-seeded joints that at<br />

maturity fall away.<br />

4.0 Propagation<br />

Propagation is by seed <strong>and</strong> produced in dense population once mature pods opened up.<br />

5.0 Geographical Distribution/Ecology<br />

Makahiya is abundant throughout the Philippines in open, waste places at low <strong>and</strong> medium<br />

altitudes in settled areas. It was introduced from tropical America <strong>and</strong> is now a pantropic weed.<br />

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PHILIPPINES<br />

6.0 Chemical Constituents<br />

The roots contain tannin 10% <strong>and</strong> ash 5.5%.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The root is administered as a diuretic, <strong>and</strong> is used against dysentery <strong>and</strong> dismenorrhoea.<br />

The entire plant is considered as an adulterant <strong>and</strong> antiasthmatic. The root decoction is<br />

aphrodisiac <strong>and</strong> for urinary complaints; useful in diseases arising from corrupt blood <strong>and</strong><br />

bile. The leaves <strong>and</strong> root in powdered form with milk is given in cases of piles <strong>and</strong> fistula.<br />

The leaves rubbed into a paste are applied to hydrocel <strong>and</strong> gl<strong>and</strong>ular swellings. The juice<br />

of the leaves is used to impregnate cotton wool for dressing in any form of sinus difficulty.<br />

The leaves are employed as a bath for pains of the hips <strong>and</strong> kidneys. The infusion of the<br />

leaves is considered tonic, given for dysentery <strong>and</strong> as bitter tonic. The seeds constitute a<br />

good emetic <strong>and</strong> for sore throat <strong>and</strong> hoarseness.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

253


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Moringa oleifera Lam.<br />

Synonyms : Guil<strong>and</strong>ina moringa L. Moringa pterygosperma Gaertn.,<br />

Moringa nux-ben Perr.<br />

Family : Moringaceae<br />

2.0 Vernacular Names : Horse-radish tree, arunggai, balungai, dool, kalamungai,<br />

kamalongan, kalungai, kamalungai, kompompilan, malomgai,<br />

malungai, malungit, marongoi, marungai<br />

3.0 Plant Description<br />

The plant is a small tree, 8 m or less in height, with corky bark <strong>and</strong> soft, white wood. The leaves<br />

are alternate; usually thrice pinnate <strong>and</strong> 25–50 cm long; 3–9 leaflets on the ultimate pinnules,<br />

thin, ovate to elliptic <strong>and</strong> 1–2 cm long. The flowers are white <strong>and</strong> 1.5–2 cm long, on spreading<br />

panicles. The pod is 15–30 cm long, pendulous, 3-angled <strong>and</strong> 9-ribbed. The seeds are 3-angled<br />

<strong>and</strong> winged on the angles.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

The plant is planted throughout the Philippines in settlement areas at low <strong>and</strong> medium altitudes.<br />

It was introduced from tropical Asia in the prehistoric period, <strong>and</strong> is now pantropic in cultivation.<br />

It is drought resistant <strong>and</strong> grows in practically all kinds of well-drained soils. The plant conserves<br />

water by shedding its leaves during dry season.<br />

6.0 Chemical Constituents<br />

Histochemical test indicates the following: tannin in stem (abundant); sulphur in stem (detectable);<br />

calcium oxalate in leaves <strong>and</strong> stem (detectable-abundant); pectin substances in leaves <strong>and</strong> stem<br />

(detectable).<br />

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PHILIPPINES<br />

The bark contains white crystalline alkaloid (occurring in the spirituous extract), 2 resins (one<br />

soluble <strong>and</strong> the other insoluble in ammonia), <strong>and</strong> inorganic acid, mucilage <strong>and</strong> ash 8%. The root<br />

yields an essential oil which is very pungent <strong>and</strong> has offensive odor. The seed contains traces of<br />

an acrid <strong>and</strong> pungent alkaloid ben or behen, <strong>and</strong> is said to contain the glycerides of margaric,<br />

oleic <strong>and</strong> behenic acid. Ben oil consists largely of the glycerides of oleic, palmitic <strong>and</strong> stearic<br />

acids. It also contains a solid acid of high melting point. The husked seeds yield a fixed oil,<br />

30.20%. The gum contains bassorin, dextrin, enzymes myrosin <strong>and</strong> emulsin. The astringent<br />

property of the gum is due to the presence of moringo-tannic acid. This substance differs from<br />

bassorin <strong>and</strong> contains some arabin.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The flowers, tender leaves, <strong>and</strong> young pods are eaten as vegetables <strong>and</strong> contain abundance<br />

of calcium <strong>and</strong> iron. The bark, flowers <strong>and</strong> the oil from the seeds are of medicinal value.<br />

The oil, known as ben oil, is used as an ointment base <strong>and</strong> an absorbent in the enfleurage<br />

process of extracting volatile oils from flowers. The oil is particularly valuable for ointments<br />

since it can be kept for almost any length of time without undergoing oxidation. The oil is<br />

used externally in treating rheumatism. Essential oil from the root is used externally as a<br />

rubefacient. The root juice has been used as a dog poison.<br />

The young leaves are used as a galactagogue. Decoction of the roots is used to cleanse<br />

sores <strong>and</strong> ulcers, also considered antiscorbutic <strong>and</strong> is given to delirious patients. The bark<br />

is used as a rubefacient remedy. It is said that the roots of the tree, if chewed <strong>and</strong> applied<br />

to snake-bite can prevent the poison from spreading.<br />

The leaves as a poultice are useful in reducing gl<strong>and</strong>ular swelling. They are said to have<br />

purgative property. Eating the leaves is also recommended in the treatment of gonorrhea<br />

on account of their diuretic action.<br />

The roots have a taste somewhat like that of horse-radish, <strong>and</strong> in India are eaten by<br />

Europeans as a substitute for the latter. The fresh root is regarded as an acrid, pungent<br />

remedy, which is stimulant <strong>and</strong> diuretic.<br />

The roots are regarded as antiscorbutic <strong>and</strong> when pounded are considered an effective<br />

poultice for inflammatory swelling. The roots are rubefacient applied externally in the<br />

form of a plaster as a counter-irritant. The juice of the roots mixed with milk is also useful<br />

as a decoction to treat hiccough, asthma, gout, lumbago, rheumatism, enlarged spleen or<br />

liver, internal <strong>and</strong> deep-seated inflammations, <strong>and</strong> calculous affections. Decoction or<br />

infusion of the root is an effective gargle <strong>and</strong> can cause abortion. A decoction of the bark<br />

of the roots is used as a fomentation to relieve spasm. The gum is also good for intestinal<br />

complains. The gum mixed with sesame oil is recommended for the relief of otalgia.<br />

The flowers are useful for catarrh, with or in lieu of young leaves or young pods. The<br />

pods have anthelmintic property <strong>and</strong> are administered to treat infections of the liver <strong>and</strong><br />

spleen, articular pains, etc.<br />

8.0 Contraindications<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

9.0 Bibliography<br />

1971. <strong>Plants</strong> of the Philippines. UP Science Education Center. Pp. 96.<br />

De Padua, L.S. et. al. 1978. H<strong>and</strong>book on Philippines <strong>Medicinal</strong> <strong>Plants</strong>. Volume 2 Technical<br />

Bulletin Vol. III, No. 3,. UPLB, College, Laguna. Pp. 34.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

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PHILIPPINES<br />

1.0 Scientific Name : Premna odorata Blanco<br />

Synonyms : Premna curranii H.J.Lam, Premna benthamiana Domin,<br />

Premna inaequilateralis E. Beer & H.J.Lam<br />

Family : Lamiaceae<br />

2.0 Vernacular Names : Alagao, anobran (Philippines)<br />

3.0 Plant Description<br />

A shrub of small tree up to 10(–12) m tall, with up to 25(–30) cm in diameter, bark finely flaky<br />

fissured; leaves ovate to ovate rotundate, sometimes ovate lanceolate (–)6.5 – 16(–20) cm x 4–<br />

10(13.5) cm, mostly entire, sometimes serrate-denticulate in upper half, pubescent all over<br />

especially beneath petiolate; flowers with pedicel 0.5–1.5 mm long; corolla greenish white or<br />

pinkish white; fruit obovoid, 3.5 mm long, green turning black.<br />

4.0 Propagation : Stem cutting <strong>and</strong> seedling<br />

5.0 Geographic Distribution/Ecology<br />

Asia, Southeast Asia, China, Taiwan, Japan <strong>and</strong> Australia<br />

6.0 Chemical Constituents<br />

Alkaloids <strong>and</strong> glucosides in leaves <strong>and</strong> stem<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicines:<br />

The leaves are used as diuretic; decoction with sugar <strong>and</strong> little ‘calamansi’(Citrofortunella<br />

microcarpa) juice is consumed to treat coughs. An infusion is considered carminative<br />

<strong>and</strong> useful to treat beri-beri. A decoction of leaves or flowers is considered to be a<br />

febrifuge <strong>and</strong> is also used to cure abdominal pains <strong>and</strong> dysentery. Masticated roots are<br />

prescribed against cardiac problem.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L.S. 1999. Plant Resources of South-East Asia. <strong>Medicinal</strong> <strong>and</strong> Poisonous<br />

<strong>Plants</strong> 1. Backhuys, Leiden, The Netherl<strong>and</strong>s. Pp. 52.<br />

De Padua et al. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong> <strong>Plants</strong>, Volume 1. Published by<br />

Documentation <strong>and</strong> Information Section, Office of the Director of Research. University of the<br />

Philippines Los Banos.<br />

258


PHILIPPINES<br />

1.0 Scientific Name : Streblus asper Lour.<br />

Synonyms : Calius lactescens Blanco, Streblus lactescens Blume<br />

Family : Moraceae<br />

2.0 Vernacular Names : Kalios (Tagalog); ampas (Pampango); buntatai, bagtak<br />

(Bisakol); kakadli (Tagalog); aludig (Iloko); lampataki (Tagalog)<br />

3.0 Plant Description<br />

Kalios is a rigid <strong>and</strong> densely branched tree growing from 4 to 15 m in height. The leaves are<br />

oblong-ovate to subrhomboid, 4 to 12 cm long, very rough on both sides, with finely toothed<br />

margin, the tip blunt or tapering to a point, base narrowed. The male flowers are in rounded<br />

heads, 4 to 7 mm in diameter, short-peduncled, greenish yellow, or nearly white. The female<br />

flowers are peduncled, usually in pairs, green; the sepals accresent <strong>and</strong> nearly enclosing the<br />

fruit. The fruit is ovoid, 8 to 10 mm long, pale yellow; the pericarp soft <strong>and</strong> fleshy. The seed is<br />

ovoid, 5 to 6 mm long.<br />

4.0 Propagation : Kalios is propagated by seed, cutting <strong>and</strong> air layering.<br />

5.0 Geographical Distribution/Ecology<br />

Kalios is found in thickets at low <strong>and</strong> medium altitudes, common in regions with long dry season,<br />

from Northern Luzon to Palawan <strong>and</strong> Mindanao. It also occurs in India to southern China <strong>and</strong><br />

Malaysia.<br />

6.0 Chemical Constituents<br />

Histochemical test indicate the following findings: glucosides in stem (detectable); calcium oxalate<br />

in leaves <strong>and</strong> stem (detectable–abundant); sulphur in leaves <strong>and</strong> stem (abundant); peroxidase in<br />

leaves <strong>and</strong> stem (detectable); hydrocellulose in leaves <strong>and</strong> stem (detectable–abundant).<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Bark decoction is used for disinfecting wound, internally used for skin diseases called<br />

“culebra”, for fever, dysentery <strong>and</strong> diarrhea. Bark is chewed as an antidote in snake<br />

poisoning. Roots are used in epilepsy <strong>and</strong> inflammatory swellings <strong>and</strong> applied to boils;<br />

juice is astringent <strong>and</strong> antiseptic. The latex is applied to sore heels <strong>and</strong> chapped h<strong>and</strong>s, on<br />

gl<strong>and</strong>ular swellings.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L. S. et al. 1981. H<strong>and</strong>book on Philippine <strong>Medicinal</strong> <strong>Plants</strong>. Vol. II. Technical<br />

Bulletin Vol. II , No.3. 6. UPLB, College, Laguna. Pp. 67.<br />

Quisumbing, E. 1954. <strong>Medicinal</strong> <strong>Plants</strong> of the Philippines. Manila Blue Printing.<br />

260


PHILIPPINES<br />

1.0 Scientific Name : Tinospora crispa (L.) Hook f. & Thomson<br />

Synonyms : Tinospora rumphii Boerl., Tinospora tuberlata (Lamk)<br />

Beumee ex K. Heyne<br />

Family : Menispermaceae<br />

2.0 Vernacular Names : Makabuhay (Philippines); patawali, putawali, akar seruntum<br />

(Malaysia)<br />

3.0 Plant Description<br />

A woody climber up to 15 m long; older stems very prominently tuberculate <strong>and</strong> producing very<br />

long filiform aerial roots; leaves broadly ovate to orbicular, 7–14(–25) cm x 6–12(–24) cm,<br />

without domatia; inflorescences appear when plant is leafless; flowers usually with 3 petals;<br />

fruit ellipsoidal, about 2 cm long, orange. The plant occurs primarily in rain forest <strong>and</strong> mixed<br />

deciduous forest but can be very common in secondary vegetation after logging <strong>and</strong> in hedges,<br />

up to 1,000 m altitude.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

India, Myanmar, Cambodia, Lao PDR, Viet Nam, Southern China (Yunnan), Thail<strong>and</strong>, Peninsular<br />

Malaysia, Singapore, Indonesia (Java, Sumbawa) <strong>and</strong> the Philippines (Luzon, Mindoro, Mindanao).<br />

A commonly backyard plant.<br />

6.0 Chemical Constituents<br />

Alkaloid, sapponin, tannin <strong>and</strong> glycosides in leaves <strong>and</strong> stems<br />

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7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicines:<br />

An infusion of the stem is served as vermifuge <strong>and</strong> the whole plant is used to treat<br />

cholera <strong>and</strong> diabetes mellitus. Externally applied to cure scabies <strong>and</strong> to heal wounds.<br />

Powdered stems are used to fatten horses <strong>and</strong> cattle by stimulating their appetite. The<br />

plant is a very commonly used medicinal plant in the Philippines, Thail<strong>and</strong>, Sri Lanka <strong>and</strong><br />

India.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua et al. 1978. H<strong>and</strong>book on Philippine <strong>Medicinal</strong> <strong>Plants</strong>, Volume 1. Published by<br />

the Documentation <strong>and</strong> Information Section, Office of the Director of Research University of<br />

the Philippines Los Banos.<br />

De Padua, L.S. 1999. Plant Resources of South-East Asia. <strong>Medicinal</strong> <strong>and</strong> Poisonous<br />

<strong>Plants</strong> 1. Backhuys, Leiden, The Netherl<strong>and</strong>s.<br />

262


PHILIPPINES<br />

1.0 Scientific Name : Vitex negundo L.<br />

Family : Lamiaceae<br />

2.0 Vernacular Names : Lagundi (Philippines); legundi (Malaysia); kyaung-pan-gyi<br />

(Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

Evergreen or deciduous shrub or small to medium-sized tree, sometimes large, up to 45 m tall;<br />

bole crooked to straight, up to 125(–200) cm in diameter, usually without buttress but sometimes<br />

with distinct buttress, often deeply fluted; bark surface rather smooth to shallowly fissured or<br />

flaky, pale gray to pale yellowish brown, inner bark pale yellow to bright orange; crown often<br />

spreading. Leaves opposite or in whorls of 3; palmately compound with 3–7(–9) leaflets, rarely<br />

reduced to one leaflet without stipules, leaflet entire dentate or lobed. Inflorescence terminal or<br />

axillary, cymose; the cymes sessile or pedunculate, solitary or arranged in racemes, thyrses or<br />

panicles. Flowers bisexual; calyx campanulate to tubular; 5-lobed to truncate corolla usually<br />

with a short tube, 2-lipped, upper lip 2-fid, lower 3-fid often pubescent outside, white to blue or<br />

violet or rarely yellowish; stamens 4 didynamous, inserted on the corolla tube, exserted; ovary<br />

superior usually first to locular <strong>and</strong> later 4 locular with a single ovule in each cell; style 1 filiform;<br />

stigma vivid. Fruit, a juicy or dry drupe, seated on the often enlarged calyx, generally with 4-<br />

seeded pyrene. Seeds obovoid or oblong without endosperm. Seedling with epigeal germination;<br />

cotyledons emergent, leafy; hypocotyls elongated; leaves opposite conduplicate, first ones simple<br />

<strong>and</strong> with toothed margins.<br />

4.0 Propagation : Stem cuttings <strong>and</strong> seeds<br />

5.0 Geographical Distribution/Ecology<br />

It grows well in tropical regions, commonly in thickets <strong>and</strong> wastel<strong>and</strong>s.<br />

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6.0 Chemical Constituents<br />

The active constituents are probably the flavonoids casticin, chresoplenol D, luteolin <strong>and</strong><br />

isooreintin, <strong>and</strong> p-hydroxybenzoic acid.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Lagundi is the only extensively studied cough remedy <strong>and</strong> antiasthma herbal preparation<br />

in the Philippines today. The National Integrated Research Program on <strong>Medicinal</strong> <strong>Plants</strong><br />

(NIRPROMP) has established in both animal <strong>and</strong> human studies the wide margin of<br />

safety <strong>and</strong> efficacy of lagundi as a cough remedy <strong>and</strong> antiasthma medicine. Phase IIIdouble<br />

blind placebo controlled trial has shown bronchodilator effect <strong>and</strong> anttitussive<br />

effect.<br />

7.2 Uses in traditional medicine:<br />

The bark, leaves, flowers, fruits or roots of various Vitex species are used as general<br />

tonic, antihelmintic <strong>and</strong> in the treatment of gastro-intestinal disorders. General applications<br />

are as anodyne, febrifuge, expectorant <strong>and</strong> diuretic. A poultice of the leaves is applied to<br />

relieve rheumatic pains, inflammations <strong>and</strong> sprains. An infusions of the leaves is used in<br />

the treatment of dermatitis <strong>and</strong> eczema. The leaves are traditionally placed between<br />

pages of books <strong>and</strong> clothes as well as in rice stores to ward off insects. In the Philippines<br />

the plant is applied in veterinary medicine to treat internal parasite.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

De Padua, L.S. 1999. Plant Resources of South-East Asia. <strong>Medicinal</strong> <strong>and</strong> Poisonous<br />

<strong>Plants</strong> 1. Backhuys, Leiden, The Netherl<strong>and</strong>s.<br />

264


THAILAND<br />

1.0 Scientific Name : Artocarpus lakoocha Roxb.<br />

Family : Moraceae<br />

2.0 Vernacular Names : Ma haat, kaa-yae, taa-pae, taa-paeng, mahaat baiyai, haat, puaghaad<br />

(Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

The plant is a large-sized tree, 15–20 m tall; crown is dense, rounded; bark is brownish grey or<br />

dark brown <strong>and</strong> scaly. Young shoots covered with a tawny or rusty dense, villous tomentum.<br />

Leaves simple, alternate, 10–30 cm long, 5–20 cm wide, surface rough beneath; petiole 2–4 cm<br />

long, hairy or glabrous; blade oblong, elliptic or ovate; base rounded or cordate, unequal; apex<br />

acute or acuminate; mature leaf margin entire but young leaves serrulate. Flowers are monoecious,<br />

the males <strong>and</strong> females crowded on separate receptacles. The male inflorescences are irregularly<br />

oblong, yellow, solitary in the axils of the leaves; consisting of short peduncles; perianth 2-3-4<br />

parted; stamen 1 only, excerted; filament complanate. The female inflorescences usually<br />

irregularly globular; consisting of peduncle slightly longer than the male one; perianth tubular,<br />

entire; ovary free, 1-very rarely 2- or 3-celled, the cells with solitary pendulous ovule. Fruit,<br />

compound fleshy syncarp, irregularly rounded, about 5–8 cm in diameter, velvety puberulous,<br />

when fully ripe yellow, edible. Seeds oblong, lodged within the fleshy enlarged perianth parts.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Not common in evergreen forests in peninsular, southeastern <strong>and</strong> southwestern parts of Thail<strong>and</strong>.<br />

It is cultivated for medicinal uses.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

6.0 Chemical Constituents<br />

The whole plant contains 2,3,4,5-tetrahydroxystil-bene. The stem contains 5-hydroxy-2,4,7-<br />

trimethoxyflavone, 2,34,5-tetrahydroxystilbene, while the bark contains amyrin acetate, lupeol<br />

acetate, tannin. Root bark contains 5,7-dihydroxyflavone-3-O-a-L- rhamnoside, galangin-3-Oa-b-D-galactosyl-(1-4)-a-L-rhamnoside,<br />

kaempferol-3-O-b-L-xylopyranoside, lupeol, quercetin-<br />

3-O-a-L-rhamnopyranosied, b-sitosterol. The plant is also known to contain 2,4,3,5-<br />

tetrahydroxystilbene.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The aerial parts showed hypotensive activity when administered intravenously at 50%<br />

alcohol extract to dogs at a dose of 50.0 mg/kg. The heartwood (powdered) showed an<br />

anthelmintic activity against Taenia saginata. The 2,4,3,5-tetrahydroxystilbene, found in<br />

the stem bark, is responsible for the anthelmintic activity. A formula is being developed at<br />

the National Institute of Hygienic Sciences, Bangkok.The plant is also effective against<br />

pig ascaris. It managed to decrease helminth-eggs in faeces of both dogs <strong>and</strong> humans.<br />

The plant showed an antibacterial activity where a 95% alcohol extract of dried stemwood<br />

(91.0 mg/disc) exhibited the antibacterial activity against Bacillus subtilis. Antituberculosis<br />

activity was observed when 95% alcohol extract (1.0 mg/disc) was effective against<br />

Mycobacterium smegmatis.<br />

The bark showed an antiviral activity when an aqueous extract inhibited the growth of<br />

potato virus X when grown on Nicotiana tobacum leaves at 1:1 dilution.<br />

7.2 Uses in traditional medicine:<br />

The root is antipyretic <strong>and</strong> antihelmintic. It is also used for alleviation of toxic symptoms<br />

<strong>and</strong> treatment of urinary stones. The wood is antiflatulent, <strong>and</strong> used as carminative <strong>and</strong><br />

laxative. It is used in the treatment of skin rash, chronic gastrointestinal ailments of children<br />

characterized by marked malnutrition <strong>and</strong> usually associated with intestinal parasitism<br />

<strong>and</strong> round worm infestation, <strong>and</strong> also in the treatment of menstrual disorders, fainting,<br />

tapeworm, any disorders or diseases which cause cachexia, disorders of flatulence <strong>and</strong><br />

tendomyopathy. The bark is known to be antipyretic. The pith is used in the treatment of<br />

menstrual disorders, any disorders or diseases which cause cachexia, nephropathy,<br />

distension of abdomen due to peritonitis or paralytic ileus, <strong>and</strong> also in treating insomnia;<br />

malnutrition syndrome in children due to intestinal parasitism; splenomegaly; eye irritation;<br />

dissipate hematoma; oropharyngeal symptom from gastroenteric disease; dyspepsia caused<br />

by wind element; cramp; clouded mind; incontinent urination. It is also known to be<br />

antidiarrheal, anthelmintic, febrifuge, antituberculosis <strong>and</strong> analgesic, <strong>and</strong> for increasing<br />

appetite.<br />

In the treatment of right-sided thoraco-abdominal spasm <strong>and</strong> cholesystopathy <strong>and</strong> as<br />

taenifuge, the powdered plant is suspended in lemon juice or water <strong>and</strong> taken orally.<br />

8.0 Contraindications<br />

Not available<br />

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THAILAND<br />

9.0 Bibliography<br />

Buathong, M., Suvithayawat, V., Pavaro, C. & Huntrakul, T. 1976. Chemical Study of the<br />

Active Compound from the Wood of Artocarpus lakoocha. B.Sc. (Pharm.). Faculty of<br />

Pharmacy, Mahidol University.<br />

Bhakuni, D. S., Dhar, M. L., Dhar, M. M., Chawan, B. N., Gupta, B. & Srimali, R. C. 1971.<br />

Screening of Indian plants for biological activity. Part III. Indian Journal Experimental<br />

Biolology. 9: Pp. 91.<br />

Chauhan, J. S. & Kumari, G. 1979. A new glycoflavanol from the root bark of Artocarpus<br />

lakoocha. Planta Medica. 37: Pp. 85–88.<br />

Chauhan, J. S., Kumari, G. & Saraswat, M. 1980. A new flavanol glycoside from the root bark<br />

of Artocarpus lakoocha. Indian Journal Chemistry Ser B. 18: Pp. 473–475.<br />

Chauhan, J. S., Kumari, G., Kumar, S. & Chaturvedi, R. 1982. Chemical examination of the root<br />

bark of Artocarpus lakoocha. Product Natural Academy Science India Sect A. 52(2):217–<br />

218.<br />

Charoenlarp, P., Radomyos, P. & Bunnag, D. 1989. The optimum dose of puag-haad in the<br />

treatment of taeniasia. Ibid. 72(2):71–73.<br />

Choroenlarp, P., Shaipanich, C., Subhanka, S., Lakkantinaporn, P. & Tanunkat. 1991. A.<br />

pharmacokinetics of the active constituent of puag-haad in man. Symposium on Mahidol University<br />

Research <strong>and</strong> Development.<strong>ASEAN</strong> Institute Health Development, Salaya, Nakhon Pathom,<br />

Thail<strong>and</strong>, February 25–29, 1991.<br />

Kapel, R. S. & Joshi, S. S. 1960. Chemical constiuents of Artocapus lakoocha. Journal<br />

Science Indian Research 19B: Pp. 498.<br />

Khalique, M. A. & Mofizerd, D. A. 1955. Indigenous tanning materials of E. Pakistan. I. Leaching<br />

of goran, sonail, <strong>and</strong> dahua barks. Pakistan Journal Science Research 7(2): Pp. 51–53.<br />

Manmontri, M. 1949. Report on the anthelmintic activity of puak-haad against tape-worm. Journal<br />

Medical Association Thail<strong>and</strong>. 32(6): Pp. 1–9.<br />

Mongkolsuk, S., Alex<strong>and</strong>er, R. & Towers, R. 1956. 2,3,4,5 Tetrahydroxy- stilbene from<br />

Artocarpus lakoocha. Journal Chemistry Society. Pp. 2231–2233.<br />

Mahati, S. B., Banerjee, S. K. & Chakravarti, R. N. 1966. Triterpenes of Artocarpus lakoocha<br />

Roxb. Bulletin Calcutta School of Tropical Medicine 14(1): Pp. 16.<br />

Nilvises, N., Panyathanya, R. & Wamnutchinda, W. 1985. Toxicity test of Puag Haad (Artocarpus<br />

lakoocha). Bulletin Department of Medical Science 27(1): Pp. 49.<br />

Pavaro, C. & Reutrakul, V. 1976. A study of a new flavonol in puak-huad. Mahidol University<br />

Journal of Phamaceutical Sciences. 3: Pp. 161–164.<br />

Pongpan, A., Chumsri, P. & Taworasate, T. 1982. The antimicrobial activity of some Thai<br />

medicinal plants. Mahidol University Journal of Pharmaceutical Sciencies 9(4): Pp. 82–<br />

91.<br />

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Sambh<strong>and</strong>haraksa, C., Thantivatana. P. & Ratanachai, T. 1965. Pharmacognostical <strong>and</strong><br />

phytochemical studies of Artocapus lakoocha Roxb. Journal Natural Resource Council<br />

Thail<strong>and</strong>. 3: Pp. 68–78.<br />

Singh, R. 1981. Inactivation of potato virus x by plant extracts. Phytopathology Mediterranean<br />

10(2): Pp. 211–212.<br />

Tiptssiankarn, L. I. 1967. The antioxidant action of 2,4,3,5 Tetrahydroxystilbene <strong>and</strong><br />

some of its Derivatives. M.Sc. thesis (Pharmacology), Mahidol University.<br />

Wisutsonthorn, J., Sukprasert, A. & Aareekul, S. et al. 1985. Formulation of Some Thai<br />

Folkloric Anthelmintic Preparations. Seminar on <strong>Medicinal</strong> <strong>Plants</strong> Development, Bangkok,<br />

Thail<strong>and</strong>. July 17-19, 1985.<br />

Yodhab<strong>and</strong>u, C. 1960. A Pharmacopoeial Study on “Puag Haad” (2,4,3,5-<br />

tetrahydroxystilbene). B.Sc. (Pharm), Chulalongkorn University.<br />

270


THAILAND<br />

1.0 Scientific Name : Boesenbergia rotunda (L.) Mansf.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Kra chaai, ka aen, ra aen, chee-puu, see-phuu, poh-so-roh, pohsee,<br />

waan phra aa thit (Thail<strong>and</strong>); temu kunci (Malaysia)<br />

3.0 Plant Description<br />

The plant is a rhizomatous herb; having roots cylindrical, fascicled, 6–10 cm long; tip acute,<br />

outside light brown, inside yellow, scented. Shoot leafy <strong>and</strong> very short, consisting of 3–4 leaves;<br />

petioles 12–25 cm long, 5–10 cm wide; apex acute; base cuneate or obtuse; margin entire.<br />

Inflorescence terminal, subsessile, enclosed by leaf-sheaths bearing 2-ranked bracts each<br />

subtending a single flower; bracts are linear-lanceolate up to 5 cm long; bracteoles are as long<br />

as the bracts but narrower. The uppermost flower opens first; calyx about 2 cm, bifid; corolla<br />

pink, tube exceeding the bracts; lobes about 1.5 cm, oblong; labellum bag-shaped about 2.5 cm<br />

long, 2 cm wide; lateral staminodes slightly shorter than corolla lobes <strong>and</strong> mottled purple. Fruits<br />

are ellipsoid.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographic Distribution/Ecology<br />

It is grown in almost all soil types but it grows best in s<strong>and</strong>y soil. It is widely cultivated throughout<br />

the country.<br />

6.0 Chemical Constituents<br />

Boesenbergin A, boesenbergin B, cardamonin, chavicinic acid, 2, 6-dihydroxy-4-methoxychalcone,<br />

2, 4-dihydroxy-6-methoxychalcone, 5, 7-dimethoxy-flavone, essential oil, 2-hydroxy-4, 4, 6-<br />

trimethoxychalcone, 2-ydroxy-4, 6’-dimethoxy-chalcone, 5-hydroxy 7, 4-dimethoxyflavanone,<br />

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p<strong>and</strong>uratin A, p<strong>and</strong>uratin B1, p<strong>and</strong>uratin B2, 3, 5, 7, 3, 4-pentamethoxyflavone, dl-pinocembrin(2,<br />

3-dihydroxychrysin) (1), dl-pinostrobin(5-hydroxy-7-methoxyflavanone) 4-tetramethoxyflavone<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The rhizome has antibacterial, antifungal, mutagenic, antiinflammatory, antipyretic,<br />

antispasmodic <strong>and</strong> insecticidal activities.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Achararit, C., Panyayong, W. & Ruchatakomut, E. 1983. Inhibitory Action of Some Thai<br />

Herbian (<strong>Medicinal</strong> <strong>Plants</strong>) to Fungi. Special project for the degree of B.Sc. (Pharm.).<br />

Faculty of Pharmacy, Mahidol University, Thail<strong>and</strong>.<br />

Apisariyakul, A. & Anantasarn, V. 1984. A Pharmacological Study of the Thai <strong>Medicinal</strong> <strong>Plants</strong><br />

Used As Cathartics <strong>and</strong> Antispasmodics. 10th Symposium on Science <strong>and</strong> Technology of Thail<strong>and</strong>,<br />

Chiang Mai, Thail<strong>and</strong>. 25–27 October 1984.<br />

Apisariyakul, A., Puddhasukh, D. & Niyomka, P. 1987. Pharmacological Screening of Thai<br />

Natural Products. The First Princess Chulabhorn Science Congress I, Bangkok, Thail<strong>and</strong>.<br />

Areekul, S., Sinchaisri, P. & Tigvatananon, S. 1987. Effect of Thai plant extract on the Oriental<br />

fruitfly I. Toxicity test. Kasetsart Journal (Natural Science), 21(4): Pp. 395–407.<br />

Hirunsalee, A., Pancharoen, O. & Tantiwachwuttikul, P. 1987. Further Studies of Flavonoids of<br />

the Black Rhizome of Boesenbergia p<strong>and</strong>urata. Journal Science Society Thail<strong>and</strong>. 13(2):<br />

Pp. 119–122.<br />

Iamthammachard, S. 1982. Study on the Effects of Some <strong>Medicinal</strong> <strong>Plants</strong> in the Family<br />

Zingiberaceae on the Growth of Some Bacteria. M.Sc. (Teaching Biology) thesis, Chiang<br />

Mai University, Thail<strong>and</strong>.<br />

Jaipetch, T., Kanghae, S., Pancharoen, O. et al. 1982. Constituents of Boesenbergia p<strong>and</strong>urata<br />

(Syn. Kaempferia p<strong>and</strong>urata): Isolation, Crystal Structure <strong>and</strong> Synthesis of (DL) — boesenbergin<br />

A. Australia Journal Chemistry. 35: Pp. 351–361.<br />

Laorpaksa, A., Amnuoypol, S. & Jongbunprasert, V. 1988. Preliminary Study on Antibacterial<br />

Action of Thai <strong>Medicinal</strong> <strong>Plants</strong> for Respiratory Tract Infection (I). Thai Journal Pharm<br />

Science. 13(1): Pp. 23–36.<br />

272


THAILAND<br />

Mahidol, C., Tuntiwachwuttikul, P., Pakawatchai, C. et al. 1988. Constituents of the Zingiberaceae.<br />

Crystal Structure of (+) — E- l [5-hydroxy-7’-methoxy-2-methyl=2-(-4-methylpent-3-enyl)-<br />

2’H-l-benzopyran-6’—YL]-3-Phenylprop-en-l-one. Journal Science Society Thail<strong>and</strong>. 14:<br />

Pp. 301–311.<br />

Pancharoen, A., Kelvin, P., Reutrakul. V, Taylor, W. C. & Tantiwachwuttikul, P. 1987. Constituents<br />

of the Zingiberaceae. X. Diastereomers of [17-hydroxy-5-methoxy-2-methylbut-2(4-methylpent-<br />

3-enyl)-2H-chromen-8-yl] [3-methylbut-2-enyl)-6-phenylcyclohex-3-enyl] methanone (p<strong>and</strong>uratin<br />

B) a Constituent of the Red Rhizomes of a Variety of Boesenbergia p<strong>and</strong>urata. Australia<br />

Journal Chemistry. 40(3): Pp. 455–459.<br />

Suphat, P. 1964. Active Principle in Bosenbergia p<strong>and</strong>urata. M.Sc. thesis, Chulatongkorn<br />

University, Thail<strong>and</strong>.<br />

Tasneeyakul, W. A. 1984. Study on Anti-inflammatory Activity of 5,7-Dimethoxyflavone<br />

Isolated from Boesenbergia p<strong>and</strong>urata Extract in Albino Rats. M.Sc. thesis, Chiangmai<br />

University, Thail<strong>and</strong>.<br />

Thamaree, S., Pachotilarn, C., Tankeyoon, M. & Itthipanichpong, C. 1985. Effects on intestinal<br />

motility of thirty herbal medicines used in the treatment of diarrhea <strong>and</strong> dysentery. Chula Medical<br />

Journal. 29(1): Pp. 39–51.<br />

Tuntiwachwuttikul, P., Kanghae, S., Jaipetch, T. & Reutrakul, V. 1980. Chemical Constituents<br />

of Bosenbergia p<strong>and</strong>urata. Abstract 4 th Asian Symposium <strong>Medicinal</strong> <strong>Plants</strong> Spices, Bangkok,<br />

Thail<strong>and</strong>, 15–19 September 1980. pg 77.<br />

Ultee, A. J. 1928. The Essential Oil from Gastrochilus p<strong>and</strong>uratum. Ridl. Proceedings<br />

Academy Science Amsterdam. 31: Pp. 62–64.<br />

Ultee, A. J. 1957. The Ethereal Oil of Gastrochilus p<strong>and</strong>uratum. Ridl. Verslag Academy<br />

Wetenschappen Amsterdam. 36: Pp. 1262–1264.<br />

Ungsurngsie, M., Suthienkul, D. & Paovalo, C. 1982. Mutagenicity screening of popular Thai<br />

spices. Food Cosmet Toxicology 120: Pp. 527–530.<br />

273


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Cassia fistula L.<br />

Family : Leguminosae<br />

2.0 Vernacular Name : Khuun (Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

Small to medium-sized, upright tree, about 10–15 m tall. Trunk short, <strong>and</strong> branches slender,<br />

upright <strong>and</strong> spreading. Bark smooth, ash-coloured when young, becomes dark brown when<br />

mature. Stipules small <strong>and</strong> caducous. Leaves compound pinnate, rachis about 15–25 cm long,<br />

bears 3–8 pairs of leaflets about 7–12 cm long <strong>and</strong> 4–8 cm broad, smooth above <strong>and</strong> covered<br />

with fine veins, more distinct on the under-surface; petiolule about 5–10 mm long. Flowers<br />

racemes about 20–40 cm long, 1–3 racemes drooping from the axil; stalk about 15–35 mm long,<br />

slender, slightly hairy or quite smooth; 5 tender green sepals; 5 yellow petals, egg-shaped <strong>and</strong><br />

distinctly veined; 10 stamens with thread-like filaments, the 3 longest stamens about 3 cm long,<br />

much curled <strong>and</strong> bear about 5 mm oblong anthers, the 4 smaller ones are quite straight, the 3<br />

remaining stamens are quite short <strong>and</strong> erect; ovary <strong>and</strong> style are hairy. Fruit is a straight<br />

cylindrical pod, 20–60 cm long <strong>and</strong> about 1.5–2 cm in diameter, quite smooth <strong>and</strong> dark green<br />

when young, turning dark brown <strong>and</strong> then black with age; seeds numerous, oval, shining, yellowish<br />

brown, embedded in a dark-coloured, sweetish pulp.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is found in mixed deciduous forests <strong>and</strong> cultivated for ornamental purpose throughout<br />

the country.<br />

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6.0 Chemical Constituents<br />

The sapwood contains 1-8-dihydroxy-3-methyl anthraquinone, (+)-catechin, dihydrokaempferol,<br />

(-)-epiafzelchin, kaempferol, procyanidin CF-1.<br />

The leaves contain anthraquinones, carbohydrates, carotene, cellulose, chitorin, chlorophyll A,<br />

chlorophyll B, chrysophanic acid, hemicelluloses, inorganic elements kaempferol-3-O-b-Dglucoside,<br />

kaempferol-3-O-b-D-neohesperidoside, kaempferlo-3-glucoside, kaempferol-3-<br />

rhamnosied, kaempferol-3-robinobioside-7-rhamnoside, lignins, myricetin, 3-neohesperidoside,<br />

phenolic ester <strong>and</strong> ethers, alcohol, pigments, protein, quercetin, quercetin-3-rutinoside, quercetin-<br />

3-xyloside, rhein, rhein glucoside, sennoside, sennoside A, sennoside B, steroids, tannins, vicein(6,<br />

8-di-C-glucosylapigenin, xylose D.<br />

The flower contains 28-isofucosterol, gibberellin A-3, b-sitosterol, stigmasterol.<br />

The pod contains anthraquinones, arginine, aspartic acid, n-butyric acid, carbohydrates, citric<br />

acid, fistulic acid, formic acid, glutamic acid, hydroxymethylanthraquinone, leucine, lignoceric<br />

acid, d-(+)-malic acid, methionine, pectins, phenylalanine, protein, rhein, sucrose, tannins,<br />

terpenoids, triacontan-1-ol, n-triacontyl lignocerate, tryptophan, waxes.<br />

The seed contains amino acid. The plant is also known to contain alcohol, phenolic ester <strong>and</strong><br />

ethers, steroids, triterpenes.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The fruit has antiviral, antitumour, antifertility, hypoglycemic, antiinflammatory, antibacterial<br />

<strong>and</strong> antifungal activities.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Agarwal, C. D., Rizvi, S. A. I., Gupta, P. C. & Tewari, J. D. 1970. Chemical examination of<br />

Cassia fistula pods. Proceedings Natural Academy Science, India, Sect. A. 40(3):338–340.<br />

Agarwal, C. D., Rizvi, S. A. I., Gupta, P. C. & Tewari, J. D. 1972. Structure of fistulic acid, a<br />

new coloring matter from the pods of Cassia fistula. Planta Medica. 21(2):150–155.<br />

Babbar, J. P., Joshi, M. N. & Madan, A. R. 1982. Evaluation of plants for antiviral activity.<br />

Indian Journal of Medical Research (Suppl). 76:54–65.<br />

Babbar, O. P. 1982. Protective patterns of different interferons: Possible efficacy of chick<br />

embryo <strong>and</strong> plant interferons against microbial infections <strong>and</strong> malignancies of animals. Ibid.<br />

20(8): Pp. 451–454.<br />

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<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Babber, O. P., Bajpai, S. K., Chowdhury, B. L. & Khan, S. K. 1979. Occurrence of interferonlike<br />

antiviral <strong>and</strong> antitumor factor(s) in extract of some indigenous plants. Indian Journal<br />

Experimental Biology. 17(5): Pp. 451–454.<br />

Bhardwaj, S., Mathur, R. & Agarwal, O. P. 1980. Estrogenicity of fruit of Cassia fistula Linn.<br />

<strong>and</strong> its effect on implantation in female albino rats. Bulletin Medical Ethnobotany Res. 1:<br />

Pp. 281–286.<br />

Bhardwal, S. & Mathur, R. 1979. Anti-fertility screening of fruit of Cassia fistula in female<br />

albino rats. Comp Physiol. Ecology. 4(4): Pp. 277–279.<br />

Billore, S. K, Mehta, S .C. & Mall, L. P. 1976. Changes in chlorophyll A, B <strong>and</strong> carotenoid in<br />

summer leaves of tree species in a dry deciduous forest. Journal Indian Botany Society.<br />

55(1): Pp. 56–59.<br />

Chutiyasantyanon, C., Sirikul, S., Buntaweekul, S. & Temrattansirikul, A. A. 1984. Study of<br />

<strong>Medicinal</strong> <strong>Plants</strong> Used for Skin Diseases. Special Project for B.Sc. (Pharm.), Faculty of<br />

Pharmacy, Mahidol University.<br />

Dhar, M. L., Dhar, M. M., Dhawan, B. N., Mehrotra, B. N. & Ray, C. 1968. Screening of<br />

Indian plants for biological activity: Part I. Indian Journal Experimental Biology. 6: Pp.<br />

232-247.<br />

Estevez, A., Marquina, G., Polanco, N., Contreras, D., Vergara, A., Perez, I. & Kekoura, K.<br />

1976. Antitumor substances from twenty two Cuban plants. Revision Cubana Farm. 10: Pp.<br />

223–227.<br />

Ghosh, P., Thankur, S., Itoh, T. & Matsumoto, T. 1982. Sterols from flowers of Cassia siamea,<br />

Cassia sophera <strong>and</strong> Cassia fistula. Indian Journal Chemistry Series B. 21: Pp. 796–797.<br />

Gritsanapan, W. & Chulasiri, M. 1988. A Preliminary study of anti-diarrheal plants: I Antibacterial<br />

activity. Mahidol University Journal Pharmacology Science. 10(4): Pp. 119–123.<br />

Gupta, P. C., Singh, H., Sangwan, D. C. & Pradhan, K. 1975. Chemical composition <strong>and</strong> in<br />

vitro nutrient digestibility of some of the Tree Leaves. Indian Forest 101(11): Pp. 674–680.<br />

Kaji, N. N., Khorana, M. L. & Sanghavi, M. L. 1968. Studies on Cassia fistula Linn. Indian<br />

Journal Pharmacology 30(1): Pp. 8–11.<br />

Kamboo, V. P., Setty, S. S., & Khanna, V. M. 1977. Semen coagulation a potential approach to<br />

contraception. Contraception. 15: Pp. 601–610.<br />

Karim, M. A. & Guha Sircar, S. S. 1964. The fruit-pulp of Cassia fistula. Science Culture.<br />

12(4): Pp. 194.<br />

Katiyar, S. K. & Niranjan, G. S. 1981. Studies on carbohydrates <strong>and</strong> amino acids of some noncultivated<br />

leguminous seeds. Journal Indian Chemistry Society. 85: Pp. 98–100.<br />

Khan, M. R., Ndaalio, S., Nkunya, M. H., Wevers, H. & Sawhney, A. N. 1980. Studies on<br />

African medicinal plants. Part I. Preliminary screening of African medicinal plants. Part I.<br />

Preliminary screening of medicinal plants for antibacterial activity. Planta Medica Supplement.<br />

40: Pp. 91–97.<br />

276


THAILAND<br />

Menon, T. V., Pillai, N. G. K., Pillai, K. G. B., Kurup, P. B. & Nair, C. P. R.1980. A detailed<br />

study on Pama (Scabies) with Aragwatha Kwatham <strong>and</strong> Pamari Ointment. Journal of Science<br />

Research on <strong>Plants</strong> Medicine 1(3): Pp. 29–31.<br />

Mitscher, L. A., Leu, R. P., Bathala, M. S., WU, W. & Beal, J. L. 1972. Antimicrobial agent<br />

from higher plants. I. Introduction, Rationale, <strong>and</strong> Methodology. Lloydia. 35: Pp. 157–166.<br />

Naokata, M., Arisawa, M., Nagaes, M., Hsu, H. & Chen, Y. 1977. Studies on the constituents of<br />

Formosan leguminosae: III. On the flavonoids from Leucaena glauca (I). Benth, Cassia fistula<br />

L. <strong>and</strong> 8 other varieties. Syoyakugaku Zasshi 31(2): Pp. 172–174.<br />

Nayudamma, Y., Rajadurai, S., Bhanu, K.U., Xeddy, K. K. & Banerji, S. 1962. Some Recent<br />

Studies in the Chemistry of Indigenous Condensed Tannins. Seminar on Vegetable Tannins,<br />

Madras. Pp. 55–61.<br />

Patil, A. & Deshap<strong>and</strong>e, V. H. 1982. A new dimeric proanthocyanidin from Cassia fistula<br />

sapwood. Indian Journal Chemistry Series B. 21:626–628.<br />

Plengvidhya, P. & Suvagondha, C. 1957. A study of diagnostic constants of leaves of some<br />

members in genus Cassia. Journal Pharmacology Association of Siam, Third Series. 10(1):<br />

10–12.<br />

Pongpan, A., Chumsri, P. & Taworasate, T. 1982. The antimicrobial activity of some Thai<br />

medicinal plants. Mahidol University Journal Pharmacology Science. 9(4):88–91.<br />

Prasav, V. & Gupta, S. C. 1967. Inhibitory effect of bark <strong>and</strong> leaf decoctions on the activity of<br />

pectic enzymes of Alternaria tenuis. Indian Journal Experimental Biology. 5(3):192–193.<br />

Pumsaard, U. 1979. The Isolation of Steroids in Cassia fistula L. M.Sc. thesis, Chiang Mai<br />

University, Thail<strong>and</strong>.<br />

Quryamatity, P. 1980. Isolation of Rhein from Pudding Pipetree (Cassia fistula Linn.).<br />

M.Sc. thesis, Chiang Mai University, Thail<strong>and</strong>.<br />

Rai, A. & Seti, M. S. 1972. Screening of some plants for their activity against Vassinia <strong>and</strong><br />

Fowl-pox viruses. Indian Journal Animal Science. 41(12): Pp. 1066–1070.<br />

Reauchianchai, S., Wacharothayangkul, W. & Chumsri, P. 1980. Quantitative Determination<br />

of Antraquinones in Cassia spp. Special project for the degree of B.Sc. (Pharm.), Faculty of<br />

Pharmacy, Mahidol University.<br />

Richter, G. & Hauenstein, H. 1967. Chemical quantitative determination of Senna drugs, extracts,<br />

<strong>and</strong> preparations by separate quantitative analysis of anthraquinone glycosides <strong>and</strong> aglycones.<br />

Deut Apoth-Ztg. 107(48): Pp. 1751–1756.<br />

Ros, S. A., Megalla, S. E., Bishay, D. W. & Awad, A. H. 1980. Studies for determining antibiotic<br />

substances in some Egyptian plants. Part I. Screening for antimicrobial activity. Fitoterapia<br />

51: Pp. 303–308.<br />

Sacco, T. 1958. Researches on Cassia fistula of Somalil<strong>and</strong>. Rev. Agriculture Subtrop<br />

Tropical. 52: Pp. 119–126.<br />

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Sburlati, A. 1940. The Heteroxides of Senna. Arch Ital. Science Farmcology 9: Pp. 143–150.<br />

Schmidt, H. J. & Dittrich, C. 1960. Senna Extracts. Ger. (East) Patent. 23:397.<br />

Shah, R. R., Subbaiah, K.V. & Mehta, A. H. 1978. Carbohydrate influence on polyphenol<br />

accumulation in Cassia <strong>and</strong> Datura tissues cultured In-vitro. Biol Plant (Prague). 1978.<br />

20(1): Pp. 5–13.<br />

Singh, K. P. & Singh, R. P. 1977. The chlorophyll content of sun <strong>and</strong> shade leaves of common<br />

trees growing at Varanasi, India. Indian Journal Ecology 4(1):46–54.<br />

Sircar, P. K., Dey, S., Sanyal, T., Ganguly, S. N. & Sircar, S. N. 1970. Gibberellic acid in the<br />

floral parts of Cassia fistula. Phytochemistry. 735–736.<br />

Vasi, I.G. & Kaalintha, V. P. 1980. Chemical examination of the fruit pulp of Cassia fistula<br />

Linn. Journal Institute Chemistry (India). 52(2): Pp. 85–86.<br />

278


THAILAND<br />

1.0 Scientific Name : Cassia tora L.<br />

Family : Leguminosae<br />

2.0 Vernacular Names : Chumhet thai, ki-kia, no-panaa-noe, chumhet khwaai, chumhet<br />

naa, chumhet lek, phrom daan, lapmuen noi, yaa luek luen<br />

(Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

The plant is a herb or undershrub up to 1 m high, nearly glabrous. Leaves paripinnate, with 3<br />

pairs of leaflets; petiole about 1–4 cm long; rachis is 2–3 cm long with a subulate, 2 mm long<br />

gl<strong>and</strong> between the 2 lower pairs of leaflets; stipules setaceous, 10–15 mm long, more or less<br />

cuducous; leaflets 2–5 x 1.5–2 cm obovate, membranous, with a short petiolule, broadly rounded<br />

apex <strong>and</strong> cuneate-rounded base. Flowers axillary, short; 1–3 flowered racemes; bracts linearacute,<br />

2–3 mm long; pedicels 4–10 mm long; 5 sepals, ovate, subequal, 5 x 2–4 mm; 5 petals,<br />

yellow, unequal, obobate, short-clawed with rounded apex, up to 10x6 mm; 7 stamens, nearly<br />

equal; filaments 1.5–2 mm; anthers 1.5–2.5 mm long, opening by apical pores; ovary densely<br />

pubescent having glabrous style <strong>and</strong> truncate stigma. Fruit is a terete linear, more of less falcate<br />

pod, 10–15 x 0.5 cm, having 20–30 seeds which are glossy, rhomboidal, 5 mm in diameter.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

The plant grows around villages, frequently on lower altitudes. It is a common weed throughout<br />

Thail<strong>and</strong>.<br />

6.0 Chemical Constituents<br />

The whole plant contains D-mannitol, myricyl alcohol, b-sitosterol. The leaves contain chlorophyll,<br />

chrysophanic acid, inorganic elements, emodin, protein, <strong>and</strong> 1,6,8 trihydroxy-3-methyl<br />

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anthraquinone. The seeds contain alcohols, aloe emodin, aloe emodin glucoside, amino acid,<br />

anthraquinones, D-arabinose, aurantioobtusin, carbohydrates, chrysoobtusin, chrysophanic acid,<br />

chrysophanic acid-9-anthrone, chrysophanol diglucoside, chrysophanol triglucoside, chrysophanol-<br />

1-O-g-D-gentiobioside, emodin, D-galactose, D-glucose, gum, inorganic element, D-mannose,<br />

1-methionine, 2-naphhtho-g-pyrones, norrubrofusarin, obtusin, oligosaccharides, physcion, physcion<br />

diglucoside, polysaccharides, protein, D-rhamnose, rhein, rubrofusarin, rubrofusarin-6-O-b-Dgentiobioside,<br />

b-sitosterol, sitosterols, toralactone, 1-tryptophan, D-xylose. Oil from seeds contains<br />

linoleic, oleic, palmitic <strong>and</strong> stearic acids. The plant is also known to contain anthraquinones,<br />

carotene, chlorophyll A, chlorophyll B, <strong>and</strong> Vitamin C.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The entire plant is known to have an antiviral activity, phygocytosis stimulation,<br />

antispasmodic activity, cytotoxic <strong>and</strong> toxic activities. The leaves have antimalarial,<br />

antibacterial <strong>and</strong> antifungal activities. The leaves <strong>and</strong> stems have an antihelminthic activity.<br />

The seeds have an antibacterial, antifungal, hypotensive activity, a smooth muscle<br />

stimulation <strong>and</strong> relaxation, diuretic <strong>and</strong> toxicity activities.<br />

7.2 Uses in traditional medicine:<br />

The whole plant is used to treat skin diseases, fever, yaws, acute gastrointestinal ailments<br />

in children characterized by marked malnutrition, usually associated with intestinal<br />

parasitism. It is also used as a laxative, diuretic <strong>and</strong> expectorant. The stem is used to treat<br />

coughs. The leaves are used as a laxative, diuretic for neurotonic, <strong>and</strong> in the treatment of<br />

skin diseases <strong>and</strong> detoxication. The seeds are used in the treatment of disorders in urination,<br />

fever, asthma, yaws, skin diseases, constipation, as a diuretic, antihelmintic, kidney tonic,<br />

cardiotonic <strong>and</strong> demulcent.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Acharya, T. K. & Chatterjee, I. B. 1974. Isolation of chrysophanic scid-9-anthrone, a fungicidal<br />

compound from Cassia tora. Science Cultivation 40(7):316.<br />

Acharya, T. K. & Chatterjee, I. B. 1975. Isolation of Chrysophanic Acid-9-anthrone, the major<br />

antifungal principle of Cassia tora. Lloydia 38(3): Pp. 218–220.<br />

Bhakuni, O. S., Dhar, M. L., Dhar, M. M., Dhawan, B. N. & Mehrotra, B. N. 1969. Screening<br />

of Indian <strong>Plants</strong> for Biological Activity. Part II. Indian Journal of Experimental Biology<br />

7: Pp. 250–262.<br />

Bhatia, R.K. & Clawan, D.D. 1976. Occurrence of phenolic substances in seed coat of Cassia<br />

species <strong>and</strong> their effect on early seedling growth. Geobios (Jodhpur) (6): Pp. 214.<br />

Broker, R. & Rhat, J. V. 1952. Phagocytic coefficient as a measure for evaluating plant antibiotics.<br />

Indian Journal of Medical Research 40(3):361.<br />

280


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Broker, R. & Bhatt, J. V. 1953. Symposium on Antibacterial Substances From Soil, <strong>Plants</strong> <strong>and</strong><br />

Chan, S. H., Koo, A. & Li, K.M. 1976. The involvement of medullary reticular formation in the<br />

hypotensive effect from seed of Cassia tora. American Journal of Chinese Medicine 1:383.<br />

Desai, H. B. & Shukla, P. C. 1978. Note on chrysophanic acid in Cassia tora seeds <strong>and</strong> its<br />

removal by different treatments. Gujarat Agriculture University Research Journal 4(1):60.<br />

Dhar, M. L., Dhar, M. M., Dhawan, B. N., Mehrotra, B. N. & Ray, C. 1968. Screening of<br />

Indian plants for biological activity: Part 1. Indian Journal Experimental Biology 6: Pp. 232–<br />

247.<br />

Ito, K. & Ota, N. 1951. Effects of vegetable drugs on pathogenic fungi, Effect of Anthraquinoneglycoside<br />

Containing Crude Drugs Upon the Growth of Pathogenic Fungi. Bulletin of<br />

Pharmacology Research Institute Japan 2: Pp.23.<br />

Joshi, S. B. & Varma, K. C. 1964. Panevar (Cassia tora) gum as a suspending <strong>and</strong> emulsifying<br />

agent. Indian Journal of Pharmacology 26:175–177.<br />

Joshi, S. S. & Nigam, S. S. 1976. Amino acid composition of wild legumes. Curr. Science<br />

45(12): Pp. 450–451.<br />

Julkarat, P. 1972. Pharmacological Study of Cassia tora. Siriraj Hospital Gazette 24(10): Pp.<br />

1559.<br />

Katiyar, S.K. & Niranjan, G.S. 1982. Studies on carbohydrates <strong>and</strong> amino acids of some noncultivated<br />

leguminous seeds. Journal of Indian Chemistry Society 58: Pp. 98.<br />

Kawazu, K., Nishii, Y., Ishii, K. & Tada, M. 1980. A convenient screening method for nematicidal<br />

activity. Agriculture Biology Chemistry 44: Pp. 631.<br />

Kehar, N. D. & Murty, V. N. 1950. Investigation on famine rations: Panevar (Cassia tora)<br />

seed, a protein-rich feed for livestock. Journal of Science Indian Research 9(3): Pp. 77.<br />

Ketsingh, U. 1950. Clinical Trial on the Antimalarial Effect of Some <strong>Plants</strong>. Proceedings of<br />

Siriraj Symposium, Thail<strong>and</strong>. Pp. 275–281.<br />

Kimura, Y., Takido, M. & Takahashi, S. 1964. On the constituents of the seed of Cassia tora.<br />

Syoyakugaku Zasshi 18(1): Pp. 28–29.<br />

Kolatat, T. & Julkarat, P. 1973. Effect of Cassia tora on kidney blood circulation. Siriraj<br />

Hospital Gazatte 25(3): Pp. 434.<br />

Koo, A., Chan, W. S. & Li, K. M. 1976. A possible reflex mechanism of hypotensive action of<br />

extract from Cassis tora seeds. Ibid 4: Pp. 249.<br />

Koo, A., Wang, J. C. C. & Li, K. M. 1976. Extraction of hypotensive principles from seeds of<br />

Cassia tora. Ibid 4: Pp. 245.<br />

Koshioka, M., Hotta, N., Ishii, Y. & Takino, Y. 1978. Studies on the evaluation of crude drug. III.<br />

Quantiative estimation of fatty acids in Cassia seeds. Ibid 32: Pp. 173.<br />

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Koshioka, M., Ikemoto, C., Nishimura, M., Ishii, Y. & Takino, Y. 1978. Studies on the evaluation<br />

of crude drug. VII. Separation <strong>and</strong> quantitative estimation of anthraquinones in Cassia seeds on<br />

column of Sephadex LH-20. Shoyakugaku Zasshi 32(4): Pp. 267.<br />

Koshioka, M. & Takino, Y. 1978. Studies on the evaluation of crude drug: 1. Quantitative<br />

estimation of anthraquinones in Cassia seeds. Chemistry Pharmacology Bulletin 26(5): Pp.<br />

1343.<br />

Lohakajornpun, P. 1978. The Study on Antibacterial <strong>and</strong> Antifungal Activity of Some<br />

<strong>Medicinal</strong> <strong>Plants</strong>. M.Sc. thesis, Chulalongkorn University.<br />

Mall, L. P., Singh, V. P. & Ramarao, S. V. 1977. Influence of industrial pollutants on pigment<br />

concentration of some Angiosperm flora. Indian Journal of Environmental Health 19(4):<br />

Pp. 365.<br />

Manjursree, P. A.L., Roy, D. K. & Pal, P. R. 1977. Emodin from the leaves of Cassia tora<br />

Linn. Indian Journal of Pharmacology 39(5): Pp. 116–117.<br />

Morimoto, I., Watanabe, F., Osawa, T., Okitsu, T. & Kada, T. 1982. Mutagenicity screening of<br />

crude drugs with Bacillus subtilis Rec-assay <strong>and</strong> Salmonella/Microsome Reversion Assay.<br />

Mutat. Research 97: Pp. 81.<br />

Murty, V. N. 1962. Cassia tora Leaf Meal as a Component in Poultry Rations. Poultry Science<br />

41: Pp. 1026–1028.<br />

Nazir, B. N., Tej, S. & Rao P. R. 1962. Chlorophyll from the leaves of Cassia tora. Bulletin<br />

Regional Research Laboratory Jammu, India 1: Pp. 57.<br />

Nath, Y., Chopra, I. C. & Rao, P. R. 1962. Oxytocic principle from the seeds of Cassia tora.<br />

Curr. Science 31(7): Pp. 285–286.<br />

Negi, S.S. 1962. Studies on the whole plant <strong>and</strong> the seeds of Cassia tora. Agricultural<br />

Research (India) 2(4): Pp. 301.<br />

Niranjan, G. S. & Katiyar, S. K. 1981. Chemical examination <strong>and</strong> biological evaluation of proteins<br />

isolated from some wild legumes. Journal of Indian Chemistry Society 58: Pp. 70.<br />

Other Sources. XV. Phagocytic coefficient as a measure for evaluating plant antibiotics. Indian<br />

Journal of Pharmacology 15: Pp. 309.<br />

P<strong>and</strong>ey, D. K., Tripathi, N. N., Tripathi, R. D. & Dixit, S. N. 1983. Antifungal activity of some<br />

seed extracts with special reference to that of Pimpinella diversifolia DC. International<br />

Journal of Crude Drug Research 21(4): Pp. 177.<br />

Patel, B. M. & Patel, C. A. 1972. Partial replacement of concentrate mixture by products<br />

mixture in the ration of bullocks. Indian Journal of Nutrient Diet 9(3): Pp. 157–160.<br />

Patel, B. M., Thakore, V. R., Patel, C. A. & Shukla, P. C. 1971. Molybdenum <strong>and</strong> Zinc contents<br />

of some common fodders <strong>and</strong> concentrates. Indian Journal of Agricultural Science 41(12):<br />

Pp. 1084–1087.<br />

282


THAILAND<br />

Patel, R. P. & Patel, K. C. 1957. Antibacterial activity of Cassia tora <strong>and</strong> Cassia obovata.<br />

Indian Journal of Pharmacology 19: Pp. 70–73.<br />

Plengvidhya, P. & Suvagondha, C. 1957. A study of diagnostic constants of leaves of some<br />

members in genus Cassia. Journal of Pharmaceutical Association Siam 10(1): Pp. 10.<br />

Poethke, W., Rao, D.N. & Loescher, K.D. 1968. Chromatographic characterization of the<br />

contents of Cassia tora L. seeds. Pharmacology Zentr 107(8): Pp. 571.<br />

Raewthianchai, S., Watcharothayanggoon, W. & Chumsri, P. 1980. Determination of<br />

Anthraquinones in Cassia spp. Special Project for the Degree of B.Sc. (Pharm.), Faculty of<br />

Pharmacy, Mahidol University.<br />

Raghunathan, K., Hariharan, V. & Rangaswami, S. 1974. Chrysophanol-l b-gentiobioside, a<br />

new anthraquinone glycoside from Cassia tora. Indian Journal of Chemistry 12(12): Pp.<br />

1251–1253.<br />

Rangaswami, S. 1963. Crystalline chemical components of the seeds of Cassia tora. Identity<br />

of tora substance C with rubrofusarin <strong>and</strong> tora substance B with norrubrofusarin. Proceedings<br />

of the Indian Academy Science Section A 57(2):88.<br />

Rizvi, S. J. H., Mukerji, D. & Mathur, S. N. 1980. A new report of possible source of natural<br />

herbicide. Indian Journal of Experimental Biology 18: Pp. 777–781.<br />

Sastry, M. A. 1965. ChemicalInvestigations on Cassia tora. Curr. Science 34 (16): Pp. 481.<br />

Shah, C. S. & Shinde, M. V. 1960. Phytochemical studies of seeds of Cassia tora <strong>and</strong> Cassia<br />

occidentalis. Indian Journal of Pharmacology 31(1): Pp. 27-8.<br />

Shibata, S. 1972. Some Chemical Studies on Chinese Drugs. Ranqaswani. Some Recent<br />

Developments in the Chemistry of Natural Products, S, Rav NVS, Eds. Prentice Hall,<br />

New Delhi.<br />

Singh, N. 1964. Leaf protein extraction from some plants of Northern India. Journal of Food<br />

Science Technology (Mysore) 1(3): Pp. 37–39.<br />

Tabata, M.T., Hiroka, N., Ikenque, M., Samno, Y. & Konoshima, M. 1975. The production of<br />

anthraquinones in callus cultures of Cassia tora. Lloydia 38:131.<br />

Takahashi, S. & Takido, M. 1973. Purgative Crude Drugs. VII. Constituents of the Seeds of<br />

Cassia tora. II. Structure of the New Naphtho-a-pyrone derivative, toralactone. Yakugaku<br />

Zasshi 93(9):261.<br />

Varshney, S. C., Rizvi, S. A. I. & Gupts, P. C. 1973. Structure of a polysaccharide from Cassia<br />

tora seeds. Food Chemistry 21(2): Pp. 222–226.<br />

Varshney, S. C., Rizvi, S. A. I. & Gupts, P. C. 1976. Structure of a polysaccharide from the<br />

seeds of Cassia tora. Part II. Partial Acidic Hydrolysis. Journal of Chemistry Society, 1<br />

1(15): Pp. 161–168.<br />

Yun, H. S. & Chang, I. M. 1977. <strong>Plants</strong> with liver protective activities(1). Korean Journal<br />

Pharmacognocy 8: Pp. 125.<br />

283


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Clinacanthus nutans (Burm. f.) Lindau<br />

Family : Acanthaceae<br />

2.0 Vernacular Names : Phayaa yo, Phak man kai, Phak lin khiat, Phayaa plong thong,<br />

Phayaa plong kham, Pho-so-chaang (Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

The plant is a shrub 1–3 m high with pubescent branches. Leaves are simple, opposite, narrowly<br />

elliptic oblong or lanceolate, 2.5–13 cm long, 0.5–1.5 cm wide. The leaves have apex acute or<br />

acuminate; margin exsculptate-dentate or subentire; base cuneate, obtuse, rounded or truncate<br />

often oblique; pubescence on the nerves; petiole 3–15 mm long. Flowers are in dense cymes at<br />

the top of the branches <strong>and</strong> their branchlets; cymes 5–8 flowered, often terminating with drooping<br />

horizontal branches but themselves erect, subsecund, combined into a large lax, leafy panicle.<br />

Each flower has calyx densely patently gl<strong>and</strong>ular-pubescent, about 1 cm long; corolla gl<strong>and</strong>ularpubescent,<br />

about 3.5 cm, dull red with green base; lower lip (turned upwards) with yellow<br />

streaks, apically sordidly yellow or greenish yellow; stamens 2, inserted in the throat, more or<br />

less appressed against the upper lip. Ovary is compressed, 2-celled, 2 ovules in each cell; having<br />

style filiform, shortly bidentate. Capsule is oblong, basally contracted into a short, solid stalk, 4-<br />

seeded (B2, B38).<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

It is cultivated <strong>and</strong> found in deciduous forests.<br />

6.0 Chemical Constituents<br />

Roots contain betulin, lupeol, b-sitosterol, stigmasterol. The leaves contain lupeol, b-sitosterol,<br />

stigmasterol, <strong>and</strong> flavonoid compound.<br />

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7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The leaves are effective against snake venom. It is effective against aphthous ulcers <strong>and</strong><br />

herpes simplex. The extract accelerated wound healing <strong>and</strong> lowered the inflammation<br />

activity.<br />

7.2 Uses in traditional medicine:<br />

The leaves are antipyretic (E80) <strong>and</strong> antiinflammatory. Fresh leaves are pounded with<br />

arrack <strong>and</strong> used as poultice over burns.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Cherdchu, C., Poopyruchpong, N., Adchariya, R., Patanabanangkoon, S. & Patanabanangkoon,<br />

K. 1977. The absence of antagonism between extracts of Clinacanthus nutans Burm. <strong>and</strong><br />

Naja Naja siamensis venom. Journal of Tropical Medicine Public Health 8 (2): Pp. 249–<br />

254.<br />

Chotikieat, U. & Pitiporn, S. 1989. Clinical Trials on the Treatment of Herpes simplex, Herpes<br />

zoster <strong>and</strong> Apthous Ulcer with Clinacanthus nutans. Workshop “Pharmacist <strong>and</strong><br />

Development of <strong>Medicinal</strong> <strong>Plants</strong>”, 23–25 May 1989.<br />

Chuakul, W. 1986. Chemical Study of the Antiinflammatory Agents from the Leaves of<br />

Phayaa Plong Thong (Clinacanthus nutans Lindau). M.Sc. thesis, Faculty of Pharmacy,<br />

Mahidol University.<br />

Dampawan, P. 1976. Studies of the Chemical Constituents of Clinacanthus nutans<br />

(Acanthaceae) <strong>and</strong> Zingiber cassumunar Roxb. (Zingiberaceae). M.Sc. thesis, Faculty of<br />

Science, Mahidol University.<br />

Kittisiripornlul, S. 1984. The Antiinflammatory Action <strong>and</strong> Toxicological Studies of Extract<br />

From Clinacanthus nutans. M.Sc. thesis, Faculty of Science, Mahidol University.<br />

Lin, J., Li, H. & Yu, J. 1983. Studies on the chemical constituents of Niu Xu Hua (Clinacanthus<br />

nutans). Zhongcaoyao 14 (8): Pp. 337–338,340.<br />

Tanasomwang, W. 1986. The Screening of Antiinflammatory Action of Clinacanthus nutans<br />

Lindau: A Critical Evaluation of Carrageenan Induced Hind Paw Edema Model. M.Sc.<br />

thesis, Faculty of Science, Mahidol University.<br />

Thongharb, C. & Teijasen, P. 1977. The effect of slaed pang porn (Clinacanthus nutans) on<br />

Thail<strong>and</strong> cobra venom (Naja Naja siamensis). Thai Journal of Pharmacology Science<br />

2(6): Pp. 1057.<br />

285


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Curcuma longa L.<br />

Family : Zingiberaceae<br />

2.0 Vernacular Names : Khamin (Thail<strong>and</strong>); kunyit (Malaysia); temu kuning (Indonesia)<br />

3.0 Plant Description<br />

The plant is a stemless rhizomatous herb; rhizome fleshy, much branched, bright orange or<br />

yellow within <strong>and</strong> scented. Leaves emerge directly from the underground stem; with overlapping<br />

petioles 8–15 cm long or more, light green, 30–40 by 8–10 cm; having thin ellipse-shaped or<br />

elongate lance-shaped blades. A cylindrical inflorescence about 10–15 by 5–7 cm appears with<br />

the leaves; develops from the centre, pale green, pouchlike, curved bracts, each with two or<br />

more pale yellow flowers except in the upper part, the bracts are white <strong>and</strong> green or pink <strong>and</strong><br />

without flowers; the tube-shaped calyx is split on one side to unequal teeth; the corolla tube is<br />

more or less funnel-shaped, not exerted beyond the bract, with 3-lobed limb <strong>and</strong> white; the<br />

lateral staminode petaloid is rather long <strong>and</strong> folded under the dorsal petal; there is a central<br />

yellow b<strong>and</strong> at the labellum. A fertile stamen with short filament, broad <strong>and</strong> constricted at the<br />

apex is found in the floret; the anther is versatile <strong>and</strong> usually spurred at the base, sometimes with<br />

a small crest at the connective. The ovary consists of 3-locules; each locule contains 2 ovules;<br />

the capsules are ellipsoid; seeds are rare.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

The plant is cultivated throughout the tropics. It grows very well in rather hot climate with high<br />

humidity at night. It grows well on well-drained loam but clay or s<strong>and</strong>y soil is unsuitable. Heavy<br />

rain may cause damage to rhizomes.<br />

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6.0 Chemical Constituents<br />

Arabinose, atlantone, bisdesmethoxycurcumin, b-bisabolene, borneol, campesterol, camphene,<br />

camphor, caryophyllene, cineole, curcumin, L-b-curcumens, curdione, curone, curzerenone,<br />

cycloisoprenemyrcene, cymene, desmethoxycurcumin, 2, 5-dihydroxybisabola-3, 10-diene,<br />

dihydrocurcunim, dihydroxycurcumin, essential oil, eugenol, fatty acids, fructose, germacron-<br />

13-al, glucose, glutamic acid, 4-hydroxybisabola-2, 10-dien-9-one, isoborneol, limonene, linalool,<br />

4-methoxy-5-hydroxy-bisabola-2, 10-dien-9-one, D-g-phell<strong>and</strong>rene, a-pinene, b-pinene,<br />

procurcumadiol, D-sabinene, b-sesquiphell<strong>and</strong>rene, tocopherol, p-tolylmethycarbinol, arturmerone,<br />

turmerone, terpinene, zingiberene, zingerene.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The rhizome is an antipeptic for ulcer, antiinflammatory, cholagogue, antibacterial,<br />

antifungal, antiyeast, antispasmodic, antiparasitic, <strong>and</strong> has hypocholesterolemic,<br />

immunological, mutagenic, insecticidal <strong>and</strong> insect repellant activities. It also has effect on<br />

the cardiovascular system.<br />

7.2 Uses in traditional medicine:<br />

Not available<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Bainiam, N. 1985. Effect of Potassium <strong>and</strong> Phosphorus on the Contents of Anti-Microbial<br />

Constituents, Volatile Oil, Total Curcuminoid <strong>and</strong> Curcuminoid Ratio of Curcuma longa.<br />

M.Sc. thesis (Pharmacognosy), Chiang Mai University, Thail<strong>and</strong>.<br />

Chavalittumrong, P. & Dechatiwongse, T. 1988. Quality evaluation of turmeric. Thail<strong>and</strong> Journal<br />

Pharmacological Science. 13(3): Pp. 317–327.<br />

Choiu, J. W. & Chang, W. H. 1983. Preliminary study on the antioxidative components of some<br />

spices grown in Taiwan. Chung-kuo Nung Yeh Hua Hsueh Hui Chih 21(1–2): Pp. 97–103.<br />

Dixit, R. S. & Perti, S. L. 1963. Indigenous insecticides. III. Insecticidal properties of some<br />

medicinal <strong>and</strong> aromatic plants. Bulletin Regional Reserach Laboratory Jammu, India. 1:<br />

Pp. 169–172.<br />

Franquelo, E. 1933. Active constituents of curcuma (Temoelavac). Münch Med. Wochchr.<br />

80: Pp. 524–526.<br />

Gonda, R., Tomoda, M., Shimizu, N. & Kanari, M. 1990. Characterization of polysaccharides<br />

having activity on the reticuloendothelial system from the rhizome of Curcuma longa.<br />

Chemistry Pharmaco. Bulletin. 38(2): Pp. 482–486.<br />

Huhtanen, C. N. 1980. Inhibition of Clostridium botulinum by spice extracts <strong>and</strong> alibhatic<br />

alcohols. Journal Food Protein 43(3): Pp. 195–196.<br />

287


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Kelkar, N. C. & Rao, B. S. 1933. Indian essential oils. V. Essential oil from the rhizomes of<br />

Curcuma longa L. (turmeric). Journal Indian Institute Science 17A: Pp. 7–24.<br />

Keshavar, K. 1971. The influence of turmeric <strong>and</strong> curcumin on cholesterol concentration of<br />

eggs <strong>and</strong> tissues. Poultry Science 9(2): Pp. 167–169.<br />

Khalique, A. & Amin, M. N. 1967. Curcuma longa. I. Constituents of the rhizome. Science<br />

Research (Dacca, Pakistan) 4(4): 193–197.<br />

Khurana, A. & Ho, C. T. 1988. High Performance Liquid Chromatographic analysis of<br />

curcuminoids <strong>and</strong> their photooxidative decomposition compounds in Curcuma longa L. Journal<br />

Liquid Chromatography 11(11): Pp. 2295–2304.<br />

Krishnamoorthy, M. & Rahiman, M. A. 1987. Cytogenetic effects of curcumin salt on the<br />

meiotic chromosomes of Poecilocera picta. Journal Environmental Biology 8(1): Pp. 11–<br />

24.<br />

Mondon, J. M., Guerere, M. & Rajamaye, A. 1986. Comparison of Curcuma longa from<br />

Reunion Isl<strong>and</strong> with imported curcuma. Annal Falsif. Expert Chim. Toxicology. 79(847):<br />

Pp. 153–165.<br />

Rouseff, R. L. 1988. High Performance Liquid Chromatographic separation <strong>and</strong> spectral<br />

characterization of the pigments in turmeric <strong>and</strong> annatto. Z Food Science 53(6): Pp. 1823–<br />

1826.<br />

Rupe, H., Clar, G., St. Pfau, A. & Plattner, P. l. 1934. Volatile plant constituents. II. Tumerone,<br />

the aromatic principle of turmeric oil. Helv Chim Acta 17: Pp. 372–389.<br />

Saarbrucken, F. K. 1975. Schnelle Kennzeichnung von Curcuma-Rhizomen mit Dem TAS-<br />

Verfahren. Deutsche Apotheker-Zeitung 115(10): Pp. 325–327.<br />

Sinha, M., Mukherjee, B. P., Sikdar, S., Mukherjee, B. & Dasgupta, S. R. 1972. Further studies<br />

on the pharmacological properties of curcumin. Indian Journal Pharmacology 4: Pp. 135.<br />

Srinivasan, K. R. 1952. The coloring matter in turmeric. Current Science (India) 21: Pp. 311–<br />

312.<br />

Srinivasan, K. R. 1953. Chromatographic study of the curcuminoids in Curcuma longa. Journal<br />

Pharmacology 5: Pp. 448–457.<br />

Toda, S., Miyase, T., Arichi, H., Tanizawa, H. & Takino, Y. 1985. Natural antioxidants. III.<br />

Antioxidative components isolated from rhizome of Curcuma longa L. Chemistry<br />

Pharmacology Bulletin 33(4): Pp. 1725–1728.<br />

Toennesen, H. H., Karlsen, J., Adhikary, S. R. & P<strong>and</strong>ey, R. 1989. Studies on curcumin <strong>and</strong><br />

curcuminoids. Part 17. Variation in the content of curcuminoids in Curcuma longa from Nepal<br />

during one season Z. Lebensm-Unters Forsch. 189(2): Pp. 116–118.<br />

Yang, M., Dong, X. & Tang, Y. 1984. Studies on the chemical constituents of common turmeric<br />

(Curcuma longa). Zhongcaoyao. 15(5): Pp. 197–198.<br />

Zhao, D. & Yang, M. 1986. Separation <strong>and</strong> determination of curcuminoids in Curcuma longa<br />

L. <strong>and</strong> its preparation by HPLC. Yaoxue Xuebao 21(5): Pp. 382–385.<br />

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THAILAND<br />

1.0 Scientific Name : Eurycoma longifolia Jack<br />

Family : Simaroubaceae<br />

2.0 Vernacular Names : Plaa lai phueak, krung badaan (Surat Thani), kha-hnaang, chanaang,<br />

trueng baadaan, tu-wu-boh-ming, tuu-wu-wo-ming, tung<br />

so, haae phan chan, phiak, yik bo thong, yik mai thueng, ian<br />

don, lai phueak<br />

3.0 Plant Description<br />

Eurycoma longifolia is a small tree up to 10 m high with blackish stem <strong>and</strong> without stipule.<br />

Leaves are imparpinnte, up to 1 m long <strong>and</strong> numerous crowded at the tips of rather thick, pithy<br />

branches leaving large scars; leaflets are opposite or subopposite,lanceolate to abovate-lanceolate,<br />

rarely ovate-oblong sometimes slightly acuminate with a bluntish or acute apex; slightly oblique<br />

at the base: 0.5–20 by 1.5–6 cm. Flowers are reddish; branches of inflorescence, pedicles,<br />

sepals, <strong>and</strong> calyx are puberulous <strong>and</strong> with capitate - gr<strong>and</strong>ular hairs; bracts are triangular, very<br />

small, up to 1 mm long, caduceus; pedicels are rather thick, up to 7 mm long. Calyces are small,<br />

consisting of lobes 1 mm long. Petals are puberulous on both surfaces, lanceolate to ovate- or<br />

obovate-oblong, 4.5–5.5 by 2-3 mm; stamens usually are longer than the calyces, 1.5–2.5 mm<br />

long consisting of anthers 0.25 mm long; staminodes are 0.5 mm in female flowers to 2 mm in<br />

male flowers. Styles are rather long, with a peltate 5(6) - lobed stigma, elevated 1 mm above the<br />

ovaries. Fruits are ellipsoid or ovoid, 10–17 by 5–12 mm.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

The plant is found in primary <strong>and</strong> secondary, evergreen <strong>and</strong> mixed deciduous forests as understorey<br />

trees, typically growing on s<strong>and</strong>y soil, up to 700 m above sea level, but more frequently at<br />

lower altitude. It is found all over the country.<br />

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6.0 Chemical Constituents<br />

Root<br />

Campesterol, campesterol acetate, 13, 18-dihydroxy-13,18-dihydroeurycomanone,<br />

eurycomalactone, eurycomanol, eurycomanol-12-O-â-D-glycopyranoside, eurycomanone, 10-<br />

hydroxycanthin-6-one, 15-hydroxyklaineanone, longilactone, palmitic acid, scopoletin, â-sitosterol,<br />

stigmasterol, stigmasterol acetate, unidentified saponins<br />

Root bark<br />

Eurycomalactone<br />

Whole plant<br />

Eurycomalactone, laurycolactone A, laurycolactone B<br />

Stem bark<br />

Campesterol, eurycomalactone, dihydroeurycomalactone, 2,6-dimethoxybenzoquinone, oil, resin,<br />

b-sitosterol<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Root<br />

Parasympathomimetic activity<br />

Strong activity was shown when the 50% alcoholic extract was tested in vitro using<br />

guinea pig ileums (0.01 g/ml).<br />

Antimalarial activity<br />

Extracts of the roots of E. longifolia were tested for antimalarial activity against a multidrug<br />

resistant Thail<strong>and</strong> strain (12-1) of Plasmodium falciparum, in vitro. The highest<br />

activities were shown in the chloroform extract (IC 50<br />

0.5–5 mg/ml) <strong>and</strong> 1-butanol extracts<br />

(IC 50<br />

0.5–5 mg/ml). Subsequent fractionation of the chloroform <strong>and</strong> the 1-butanol extracts<br />

yielded eurycomanone from one of the 1-butanol fractions, which was more active than<br />

chloroquin (relative potency of 1.52 compared to chloroquin); eurycomalactone(from the<br />

chloroform extract) <strong>and</strong> eurycomanol (from the same fraction that contained<br />

eurycomanone) were 60–70% as active as chloroquin (relative potencies of 0.68 <strong>and</strong><br />

0.60 respectively).<br />

The stem <strong>and</strong> root extracts of E. longifolia also showed antimalarial activity against P.<br />

falciparum, in vitro with an IC 50<br />

of 4.5 x 10 -7 g/ml. It was shown in another study that an<br />

ethanol fraction of E. longfolia exhibited better inhibition of the growth of P. berghei, in<br />

vitro, than the chloroform or the hexane fraction. Both ethanol fraction <strong>and</strong><br />

eurycomalactone were less active than chloroquin<br />

Antifungal activity<br />

An alcohol extract of roots was effective against Microsporum gypseum.<br />

Toxicity assessment<br />

An alcohol extract was administered by gastric incubation or s.c.in mice at a dose of 10<br />

g/kg. Toxic symptoms were as follows: always in lying position, deep breathing <strong>and</strong> chronic<br />

convulsions. In another study, an 34% ethanol extract given either i.p. or p.o. to mice,<br />

produced higher toxicity than a water extract. The LD 50<br />

of the 34% ethanol extract have<br />

been reported to be 15–20 mg/kg i.p. <strong>and</strong> 1,500–2,000 mg/kg p.o. An ethanol fraction<br />

containing eurycomalactone was found to be the most toxic fraction.<br />

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In order to study the acute toxicity of E. longifolia, male mice were given a suspension<br />

of dried ethanol extract by gavage. Mice showed the following symptoms: sedation, faint<br />

breathing, convulsions <strong>and</strong> death. The LD 50<br />

was 2.6 g/kg. A subchronic toxicity was<br />

carried out in both mice <strong>and</strong> rats by giving the suspension of the extract every two days<br />

for three months. It was reported that at a dose of 0.43 g/kg p.o., the extract caused 85%<br />

mortality in mice with weight gained in liver, kidneys, spleen <strong>and</strong> testis. But in rats receiving<br />

the extract at 0.35–0.5 g/kg p.o., no toxicity was observed.<br />

Root bark<br />

Antimalarial activity<br />

Both the 50% alcohol <strong>and</strong> water extracts of dried root bark were shown to be active<br />

against the growth of P. falciparum in broth cultures. Bioactive compound:<br />

eurycomalactone.<br />

No antibacterial activity of the glucoside, eurycomalactone, from E. longifolia, was<br />

detected at a dose as high as 1,000 mg/disk against the following bacteria: Staphylococcus<br />

aureus, Streptococcus faecalis, Escherichia coli <strong>and</strong> Salmonella typhosa.<br />

In conclusion, studies on the pharmacological actions of E. longifolia are still incomplete.<br />

Antipyretic activity testing showed negative results. A remark should be made that a 50%<br />

alcoholic extract had been used in the experimental study while a water extract was used<br />

in traditional Thai recipes for the same activity. Therefore, more studies on antipyretic<br />

activity should be carried out. Since toxicity has been shown at high dose, special caution<br />

should be emphasized.<br />

7.2 Uses described in traditional medicine:<br />

Root<br />

Treatment of sore throat <strong>and</strong> tonsillitis; as antipyretic, expectorant, antituberculosis,<br />

anthelmintic, diaphoretic, antimalarial <strong>and</strong> for detoxication.<br />

Bark<br />

As antipyretic <strong>and</strong> antimalarial.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Awiruthnunt, W. & Wuthiudomlert, M. 1983. Antifungal activity of some medicinal plants.<br />

Mahidol Univ J Pharm Sci, Thail<strong>and</strong> 10(3):87–89.<br />

Brockelman, C., Thanomsapaya, B., Somnabh<strong>and</strong>hu, A. & Tanaree, P. 1989. In vitro study of<br />

antimalarial activity of some Thai medicinal plant extracts. Symposium on Antimalarial from<br />

<strong>Plants</strong>, Government Pharmaceutical Organization, Nov, 1989.<br />

Chan, K. L., Lee, S. P., Sam, T. W. & Han, B. H. 1989. A quassinoid glycoside from the roots<br />

of Eurycoma longifolia. Phytochemistry 28(10): 2857–2859.<br />

Chan, K. L., O’Neill, M. J., Philipson, J. D. & Warhurst, D. C. 1986. <strong>Plants</strong> as sources of<br />

antimalarial drugs. Part 3 . Eurycoma longifolia. Planta Medica 52: 105–107.<br />

Darise, M., Kohda, H., Mizutani, K. & Tanaka O. 1982. Eurycomanone <strong>and</strong> eurycomanol,<br />

quassinoids from the roots of Eurycoma longifolia. Phytochemistry 21: 2091–2093.<br />

291


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Dhammaupakorn P, Somnabh<strong>and</strong>hu A, Ruengransee N. & Suppakun N. 1989. Toxicity of<br />

Eurycoma longifolia root extact. Symposium on Antimalarial from <strong>Plants</strong>, Government<br />

Pharmaceutical Organization, Nov. 1989.<br />

Gilling, C. 1908. The constituents of Simaruba bark. Res Lab, Pharm Soc, Gt Brit A Pharm<br />

J. 80: 510–513.<br />

Mokkhasmit, M., Ngarmwathana, W., Sawasdimongkol, K. & Permphiphat, U. 1971.<br />

Pharmacological evaluation of Thai medicinal plants.(Continued). J Med Assoc Thail<strong>and</strong> 54(7):<br />

490–504.<br />

Mokkhasmit, M., Sawasdimongkol, K. & Sartravaha, P. 1971. Toxicity study of some Thai<br />

medicianl plants. Bull Dep Med Sci Thail<strong>and</strong> 12(2): 36–65.<br />

Morita, H., Kishi, E., Takeya, K., Itokawa, H. & Tanaka, O. 1990. New quassinoids from the<br />

roots of Eurycoma longifolia. Planta Medica 56:551.<br />

Oei-Kock, A. & Kraus, L. 1978. Constituents of Eurycoma longifolia. I Sterols <strong>and</strong> saponins.<br />

Planta Medica 34: 339.<br />

Oei-Koch, A. & Kraus, L. 1979. Components of Eurycoma longifolia Jack. II. Lipophilic<br />

constituents (sterolester, fatty acids). Science Pharm. 47(3): 243–245.<br />

Oei-Koch, A. & Kraus, L. 1980. Contents of Eurycoma longifolia Jack.III Bitter principle<br />

(Eurycomalactone). Science Pharm 48: 110–117.<br />

Suong, N. N., Bhatnagar, S., Polonsky, J., Vuilhorgne, M., Prange, T. & Pascard, C. 1982.<br />

Structure of laurycolactone A <strong>and</strong> B, new C18-quassinoids from Eurycoma longifolia <strong>and</strong><br />

revised structure of eurycomalactone(X-Ray analysis). Tetrahedron Lett. 23: 5159–5162.<br />

Suppakun, N., Somanab<strong>and</strong>hu, A., Theptaranonth, Y. & Pavanon, K. 1982. An antimalarial<br />

principle from Eurycoma longifolia jack. NRCT-JSPS Rattanakosin bicentennial joint seminar<br />

on chemistry of natural products, Bangkok, Thail<strong>and</strong>, Aug 2–6,1982 , p 48.<br />

Suppakun, N., Satayawiwat, J., Thepthranont, Y. & Somnabh<strong>and</strong>hu, A. 1989. Antimalarial <strong>and</strong><br />

toxicity studies of Eurycoma longifolia roots. Conference of Division of Malarial Control,<br />

3rd, Ministry of Public Health, Chiangmai, Oct 18–20 Oct 1989.<br />

Temcharoen, P., Glinsukon, T., Suksamrarn, A. & Bunyapraphatsaan .1988. Lack of antibacterial<br />

activity of four glucosides, eurycomalactone <strong>and</strong> hispidulin from Barleria lupulina, Eurycoma<br />

longifolia <strong>and</strong> hisidulin from Barleria lllupulina, Eurycoma longifolia <strong>and</strong> Milingtonia<br />

hortenisis . Thai J Toxicol. 4: 43–46.<br />

Thoi, L. V. & Suong, N. N. 1963. Chemical constituents from the bark of Eurycoma longifolia,<br />

II. Isolation of ß-sitosterol, campeserol, <strong>and</strong> 2, 6–dimethoxybenzoquinone. Ann Fac Sci, Univ<br />

Saigon 1: 43–51.<br />

Thoi, L. V. & Suong, N. N. 1970. Constituents of Eurycoma longifolia. J Drg Chem. 35:<br />

1104.<br />

Thoi, L.V., Suong, N. N. & Thu Van, L. T. 1986. Structure of laurycolactone A <strong>and</strong> B–two C 18<br />

quassinoids from Eurycoma longifolia. Tap Chi Huo Hoc 24(2):7–10.<br />

292


THAILAND<br />

1.0 Scientific Name : Hibiscus sabdariffa L.<br />

Family : Malvaceae<br />

2.0 Vernacular Name : Krachiap (Thail<strong>and</strong>); roselle (English)<br />

3.0 Plant Description<br />

The plant is an erect annual herb with reddish, cylindrical stem, nearly or quite glabrous. Leaves<br />

are simple, having petiole, blade 3–5 lobed or parted, the lobes serrate or obtusely toothed.<br />

Flowers are solitary, axillary, nearly sessile, 5–7 cm in diameter; consisting of epicalyx-segments<br />

8–12, distinct, lanceolate to linear, adnate at base of the calyx; calyx thick, red, <strong>and</strong> fleshy, cuplike,<br />

deeply parted, prominently 10-nerved; petals 5, yellow, twice as long as calyx; stamens<br />

numerous, the filaments united into a staminal column; style single, 5-branched near summit;<br />

stigma capitate. Fruit is capsule, ovoid, pointed, 1–2 cm long, shorter than calyx, having densely<br />

sharp <strong>and</strong> stiff hairs, dehiscent.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is native to the Old World tropics. It is extensively cultivated for its succulent, fleshy, edible<br />

calyx <strong>and</strong> the stem yields a fairly strong fibre.<br />

6.0 Chemical Constituents<br />

The leaf contain amino acids, anthocyanin, caprylic acid, a-carotene, B-carotene, formic acid,<br />

galactose, D-(+)-malic acid, oleic, pelargonic <strong>and</strong> propionic acids, protein, b-sitosterol, b-sitosterol-<br />

1-3-b-D-galactoside, stearic acid, steroidal glycoside, sucrose, tetrahydroxysteroid, vitamin A,<br />

vitamin C.<br />

293


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

The flower contains alkaloid, anthoxanthin, lascorbic acid, aspartic acid, chrysanthemin, citric<br />

acid, cyanidin-3(2(G)-glycosyl)-rutinoside, cyanidin-3, 5-diglucoside, cynidin-3-b-D-glucoside,<br />

cyanidin-3-sambubioside, cyanin, delphinidin, delphindin-3-O-b-D-glucoside, delphinidin-3-<br />

monoglucoside, delphinidin-3-sambubioside, galactose, galacturonic acid, glycolic acid, gossypetin,<br />

gossypetin-3-O-b-D-glucoside, gossypin, gossypitrin, gossytrin, heterosides, hibiscetin, hibiscic<br />

acid, hibiscin, hibiscitrin, hibiscus acid, malic acid, malvin, myrtillin oxalic acid, pectin, protocatechuic<br />

acid, quercetin, resin, sabdaretin, sabdaretrin, B-sitosterol, tartaric acid, waxes.<br />

The fruit contains acetic acid, anthocyanin, L-arabinose, calcium oxalate, caprylic acid, cellulose,<br />

citric <strong>and</strong> formic acids, D-galactose, gossypetin, malic, oleic, oxalic <strong>and</strong> pelargonic acids, protein,<br />

L-rhamnose, B-sitosterol, vitamin C, D-xylose.<br />

The seed contains calcium, cellulose, cis-12, 13-epoxy-cis-9-octadecenoic acid, epoxyoleic acid,<br />

gossypol, hibiscetin, hibiscic acid, hibiscin, inorganic elements, isoleucine, leucine, malvalic <strong>and</strong><br />

myristic acids, oil, oleic, palmitic <strong>and</strong> palmitoleic acids, pentosans, phenylalanine, potassium,<br />

protein, B-sitosterol, sodium, starch, stearic <strong>and</strong> sterculic acids, threonine, tryptophan, valine.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The calyx showed antibacterial, antifungal, hypotensive, cytotoxic, diuretic, choleretic<br />

activities. It also has urinary acidifying, uterine relaxation, <strong>and</strong> laxative effects. It is known<br />

to have effects on urinary uric acid <strong>and</strong> citrate excretion.<br />

7.2 Uses in traditional medicine:<br />

Not available<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Buogo, G. & Picchinenna, D. 1937. Chemical characteristics of roselle hemp. Ann Chim<br />

Applicata. 27: Pp. 557–582.<br />

Busson, F., Garnier, P. & Deniel, P. 1957. Amino-acid content of the calyces of Hibicus<br />

sabdariffa. Journal Agriculture Tropical Etno Botany Applied. 4: Pp. 265–266.<br />

Castiiiglioni, A. 1934. Chemical composition of Hibiscus sadariffa L. <strong>and</strong> its cultivation in<br />

Eritrea. Atti Acad Science Torino, Classe Science Fis, Mat Nat. 69:97–105.<br />

Copertini, S. 1936. Chemical <strong>and</strong> technological researches on karkade. Agriculture Colonial<br />

e1. 30:182–184.<br />

Du, C. T. & Francis, F. J. 1974. Anthocyanins of roselle (Hibiscus sabdariffa). Journal Food<br />

Science. 38: Pp. 810.<br />

El-Hadidy, Z. A., El-Ghobashy, R. & Haridi, S. M. 1980. Biochemical changes of anthocyanins,<br />

protein <strong>and</strong> amino acids in roselle (Hibiscus sabdariffa) plants. Ain Shams University Faculty<br />

Agriculture Res Bulletin. 0(1420): Pp. 1–21.<br />

294


THAILAND<br />

Indovina, R. & Capotummino, G. 1938. Chemical investigation of some products which can be<br />

obtained from Hibiscus sabdariffa L. Boll Studi informaz Palermo. 15:24.<br />

Kerharo, J. 1971. Senegal bisap (Hibiscus sabdariffa) of Guinia sorrel or red sorrel. Plant<br />

Medica Phytotherapy. 5(4):277–281.<br />

Khafaga, E. P. & Koch, H. 1980. Stage of maturity <strong>and</strong> quality of roselle (Hibiscus sabdariffa<br />

L. var. savdariffa). I. Organic acids. Angew Botany. 54(5-6): Pp. 287–293.<br />

La Gaetano, B. & Bruno, E. 1960. Presence of vitamin C (ascorbic acid) in Habiscus sabdariffa.<br />

Ann Chim (Rome). 50: Pp. 1357–1362.<br />

Leupin, K. 1935. Karkade. Pharm Acta Helv. 10: Pp. 138-142.<br />

Lorenxini, G. 1937. Vitamin C content of Karkaddde’ (Hibiscus sabdariffa). Arch Ist Biochim<br />

Italy. 9: Pp. 123–130.<br />

Minuto, N. 1937. Specificity of vitamin C determination; its determination in karkadé. Arch Ist<br />

Biochim Italy. 9: Pp. 383–388.<br />

Osman Am, Younes Me & Mokhtar, A. 1975. Chemical examination of local plants. VIII.<br />

Comparative studies between constituents of different parts of Egyptian Hibiscus sabdariffa.<br />

Indian Journal Chemistry 13(2): Pp. 198–199.<br />

Osman, A. M., Younes Me, Mokhtar, A. 1975. Sitosterol b-D- galactoside from Hibiscus sabdariffa.<br />

XIII. Phytochemisty. 14(3): Pp. 829–830.<br />

Pankajamani, K. S. & Seshadri, T.R.1955. Anthoxanthins. VIII. Journal Science India Res<br />

(India). 14B: Pp. 93–98.<br />

Penteado, M. de V. C., Minazzi, R. S. & Bicudo de Almeida, L. 1986. Carotenoids <strong>and</strong> provitamin<br />

A activity of vegetable leaves consumed in northen Brazil. Revision Farm Bioquim University<br />

Sao Paulo. 22(2): Pp. 97–102.<br />

Pratt, Ds. 1913. Roselle. Philip Journal Science. (A)7: Pp. 201–205.<br />

Sharaf, A. 1962. The pharmacological characteristics of Hibiscus sabdariffa. Planta Medica<br />

10: Pp. 48–52.<br />

Shibata, M. & Furukara, M. 1969. Reexamination of the structure of so-called hiviscin.<br />

Shokubutsugaku Zasshi. 82(974-975): Pp. 341–347.<br />

Tung, C. S. 1966. The determination of L-ascorbic acid in Hibiscus sabdariffa. Chung Kuo<br />

Nung Yeh Hua Hsueh Hui Chih 4 (1-2): Pp. 22–24.<br />

Tung, J. 1963. The non-nitrogenous organic acids of roselle by paper chromatogrphy. Journal<br />

Chinese Agriculture Chemistry Society (Taiwan). 1(1-2): Pp. 1–3.<br />

295


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Impatiens balsamina L.<br />

Family : Balsaminaceae<br />

2.0 Vernacular Names : Thian dok (Thail<strong>and</strong>); kaembong (Malaysia)<br />

3.0 Plant Description<br />

The plant is an erect, annual herb up to 60 cm high, pubescent or nearly glabrous. Leaves are<br />

alternate, narrowly or broadly lanceolate, 8–10 by 2–3 cm, tapering at the tip <strong>and</strong> base, consisting<br />

of deeply serrate margin; the petiole gl<strong>and</strong>ular. Flowers are large, short peduncled, borne in the<br />

axils of the leaves along the main stem below the leafy tip, in many colours from white to dark<br />

red or spotted, with a long spur curving up. The fruit is a long wooly capsule, opens when ripe,<br />

with many seeds.<br />

4.0 Propagation : Seed<br />

5.0 Geographic Distribution/Ecology<br />

The plant is distributed throughout the tropics <strong>and</strong> subtropics. It is widely cultivated <strong>and</strong> especially<br />

grown ornamentally in shaded parts of gardens.<br />

6.0 Chemical constituents<br />

The whole plant contains lawsone. The roots contain cyanidin monoglycoside. The stem contains<br />

cyanidin monoglycoside. The leaves contain cinnamic acid esters, galactolipids, kaempferol,<br />

kaempferol-3-arabinoside, phospholipids, proteins. The flower contains anthocyanins, p-coumaric<br />

acid, cyanidin, delphinidin, ferulic acid, flavonols, glucosidase, galactosidase, 3b-D-glucosidase,<br />

hydroxycinnamic acid, kaempferol, leucoanthocyanins, myriscetin, pelargonidin, pelargonidin<br />

monoglucoside, pelargonidin-3-O-a-L-rhamno-glucosyl-5-O-b-D-rhamnoside, pelargonidin-3-Oa-L-rhamnosyl<br />

glucoside, pelargonidin-3-O-b-D-feruloyl glucoside, pelargonidin-3-O-b-D-pcoumaroy<br />

1-5-O-b-D-glucoside, pelargonidin-3-O-b-D-p-coumaroyl glucoside, pelargonidin-3,<br />

296


THAILAND<br />

5-O-b-D-diglucoside, peargonidin-3-O-b-D-glucoside, pelargonidin-5-O-b-D-glucoside,<br />

pelargonins, peonidin, pigments, quercetin. The seeds contain lobids, b-sitosterol, <strong>and</strong> the seed<br />

oil contains parinaric acid.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Antifungal <strong>and</strong> antibacterial activities.<br />

7.2 Uses in traditional medicine:<br />

Not available<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Alston, R. E. & Hagen, C. W. 1955. Relation of leuco-anthocyanins to anthocyanin synthesis.<br />

Nature 175: Pp. 990.<br />

Beth, S. C. 1958. Flavonols of Impatiens balsamina. Arch Biochemistry Biophysiology 76:<br />

Pp. 131–138.<br />

Boylen, C. W., Hagen, C. W. & Mansell, R. L. 1969. Differentiation of pigmentation of flower.<br />

Parts. V. Partial purification <strong>and</strong> characterization of a flavonoid 3-B-D-glucosidase from petals<br />

of Impatiens balsamina. Phytochemistry 8(12): Pp. 2311–2315.<br />

Grotzinser, E. W. 1974. Metabolism of lawsone in Impatiens balsamina. Diss Abstract Int B.<br />

35:1542.<br />

Hayashi, K., Ade, Y., Noguchi, T. & SuZushino, K. 1953. Anthocyanins. XXII. Analyses by<br />

paper chromatography of natural anthocyanins <strong>and</strong> its application to the investigation of dyes of<br />

the red impatiens application to the blood-red peach fruit. Pharmacology Bulletin (Japan): Pp.<br />

130–134.<br />

Manseil, R. L. & Kemerer, V. L. 1970. Differentiation of pigmentation in flower parts. VI.<br />

Qualitative <strong>and</strong> quantitative comparisons of hydroxycinnamic acid derivatives in petals of the<br />

(LLHHP’P’), white (llhhpp) <strong>and</strong> purple (LLhhP r P r ) genotypes of Impatiens balsamina.<br />

Phytochemistry 9(8): 1751–1755.<br />

Miles, C. D. & Hagen, C. W. 1968. The differentiation of pigmentation in flower parts. IV.<br />

Flavonoid elaborating enzymes from petals of Impatiens balsamina. Plant Physiology. 43(9):<br />

Pp. 1347–1354.<br />

Muller Wu & Leistner, E. 1976. 1,4-Naphtoquinone, an intermediate in juglone (5-hydroxy-1,4-<br />

naphthoquinone) biosynthesis. Phytochemistry 15: Pp. 407.<br />

Pepkin, A. G. & Shulman, I. 1914. Coloring matters contained as glucosides in flowers of some<br />

Indian plants. Proceedings Chemistry Society 30: Pp. 200–201.<br />

297


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Pothiyanonth, P., Prasertwityakarn, S. & Suwakool, W. et al. 1989. Formulation of Dermatological<br />

Preparations from Extract of Impatierns balsamina Leaves. Eighth Conference of the Faculty<br />

of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thail<strong>and</strong>.<br />

Sawhney, S., Sawhney, N. & N<strong>and</strong>a, K. K. 1976. Gel electrophorertic studies of proteins in<br />

photo-induced <strong>and</strong> vegetative plants of Impatiens balsamina. Plant Cell Physiology. 17(4):<br />

751–755.<br />

Sharma, J. N. & Seshadri, T.R. 1955. Survey of anthocyanins from Indian sources. II. Journal<br />

Science India Reserach (India) 14B: Pp. 211–214.<br />

Tevini, M. 1976. Changes of glyco- <strong>and</strong> phospholipid contents during leaf senescence. Planta<br />

Med. 128(2): Pp. 167–171.<br />

Thungsuwan, S., Wiroonphol, S., Yingyong, O., Lipiphant, W., Phothiyanont, P. & Saipha, A.<br />

1985. Report on the Preparation of Dermatological Ointment From Impatiens balsamina Leaves.<br />

Faculty of Pharmacy, Chulalongkorn University.<br />

Weissenboeck, G., Tevini, M. & Reznik, H. 1971. Occurrence of flavonoids in chloroplasts of<br />

Impatiens balsamina. Z Pflanzenphysiol. 64(3) 274.<br />

298


THAILAND<br />

1.0 Scientific Name : Solanum violaceum Ortega<br />

Family : Solanaceae<br />

2.0 Vernacular Names : Ma waeng ton, ma khwaeng, ma khwaeng khom, ma khwaeng<br />

dam, ma waeng, waeng khom, sa-kang-khae, maak-haengkhong<br />

(Thail<strong>and</strong>)<br />

3.0 Plant Description<br />

The plant is a much-branched shrub, up to 1 m high; stem <strong>and</strong> branches are covered with<br />

stellate hairs <strong>and</strong> stout, recurved prickles. Leaves are simple, alternate of subopposite, usually<br />

crowned at the top of the branch; the blade is ovate, unlobed or shallowly 2 or 3-lobed on each<br />

side, 3–10 x 2–6 cm, subcoriaceous, having densely stellate hairs on both surfaces <strong>and</strong> prickly<br />

along the nerves. Inflorescences are lateral; flowers wheel-shaped, showy, 5-parted, violet;<br />

yellow stamens in the middle, about 2 cm in diameter; calyx campanulate with lanceolate acute<br />

lobes, tomentose, prickly; corolla short, tubular, 5-lobed, densely pubsecent outside; stamens 5;<br />

filament very short; anther oblong; style straight longer than the stamen. Fruit is globose, subtended<br />

by the spreading calyx lobes, about 1 cm in diameter, glabrous, red when ripe, having numerous<br />

seeds inside.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

It is widely spread in tropical <strong>and</strong> subtropical Asia <strong>and</strong> commonly found along wastel<strong>and</strong>s <strong>and</strong><br />

roadsides.<br />

6.0 Chemical Constituents<br />

The roots contain solanine, while the stem contains solasodine. The leaves contain diosgenin, b-<br />

sitosterol, solanine, solasodine <strong>and</strong> the fruits contain carbohydrates, diosgenin, a-glucosidase,<br />

maltase, pseudoglucosidase, b-sitosterol, solanine <strong>and</strong> solasodine.<br />

299


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Report on <strong>Medicinal</strong> Usages:<br />

7.1 Uses supported by experimental/clinical data:<br />

The plant showed hypotensive, antitumour, anticonvulsant, CNS depressant activities. On<br />

toxicity assessment, an LD 50<br />

of the 50% ethanol extract of entire plant was 900.0 mg/kg,<br />

i.p. in mice. The roots have antimicrobial <strong>and</strong> anticonvulsant activities, <strong>and</strong> are used in the<br />

treatment of anal haemorrhage, fever due to abnormality of combination of three of the<br />

following origins (Semha, Pitta, Wata, Kamdao, Lohita), as expectorant <strong>and</strong> anticough.<br />

The leaves showed an antimicrobial activity, used in the treatment of coughs, as tonic <strong>and</strong><br />

antituberculosis. The fruits showed anticonvulsant, antimicrobial, <strong>and</strong> hypoglycemic<br />

activities, used in the treatment of anal haemorrhage, dry throat <strong>and</strong> coughs, as cholagogue,<br />

antidiabetes, expectorant, <strong>and</strong> diuretic. The seeds have an anticancer activity against<br />

sarcoma 180 (ASC) cells. Little information about its toxicity <strong>and</strong> no information is available<br />

to support its claimed antitussive effect.<br />

7.2 Uses in traditional medicine:<br />

It is taken as an anticough by chewing the fruits <strong>and</strong> taking only the juice, or by pounding<br />

the fruits to obtain the juice, <strong>and</strong> mixing the juice with salt.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Hong Vareewatana, U. 1975. Study on the Alleged Hypoglycemic Activity of Solanum<br />

sanitwongsei Craib <strong>and</strong> Solanum trilobatum L. M.Sc. thesis, Faculty of Pharmaceutical<br />

Science, Chulolongkorm University, Bangkok, Thail<strong>and</strong>.<br />

Karunyavanich, P. & Suvagondha, C. 1949. Primary investigation for the insulin-like constituent<br />

of Mawaeang’s Berries. Journal of Pharmacology Association Siam 11(4): Pp. 151–158.<br />

Laorpaksa, A., Amnuoyphol, S. & Jongbunprasert, V. 1988. Preliminary study on antibacterial<br />

action of Thai medicinal plants for respiratory tract infection (I). Thai Journal of<br />

Pharmaceutical Science 13(1): Pp. 23–36.<br />

Mokkhasmit, M., Ngarmwathana, W., Sawasdimongkol, K. & Permphiphat, U. 1954.<br />

Pharmacological evaluation of Thai medicinal plants. Journal of Medical Association, Thail<strong>and</strong><br />

54(7): Pp. 490–504.<br />

Purushothaman, K. K. & Narayanaswami, V. 1976. Isolation of tomatid-3-bata-ol from the<br />

leaves of Solanum trilobatum. Indian Patent 140: 381.<br />

Tasnawijitwongs, S. 1979. Chemical <strong>and</strong> Biochemical Studies of Antidiabetic Drugs in<br />

Some <strong>Plants</strong>. M.Sc. thesis (Chemistry) Chiangmai, University, Chiangmai, Thail<strong>and</strong>.<br />

300


VIET NAM<br />

1.0 Scientific Name : Abrus precatorius L.<br />

Family : Fabaceae<br />

2.0 Vernacular Names : Cam thao day, chi chi<br />

3.0 Plant Description<br />

Evergreen perennial twine, young twigs slender, covered with sparse. Leaves paripinnate,<br />

alternate, 5–10 cm long; leaflets 8–15 pairs, opposite, increasing slightly in size from the base,<br />

oblong-linear, base rounded, apex apiculate, dark green above, pale glaucous beneath, thin silky<br />

on both sides. Inflorescence in axillary <strong>and</strong> terminal peduculate raceme, 3–6 long; flowers pink<br />

closely clustered; calyx campanulate villous outside; corolla glabrous, st<strong>and</strong>ard broad, unguiculate<br />

wings linear; stamens 9–10 monodelphous; anthers oblong; ovary villous. Pod turgid, thinly<br />

pubescent, with a sharp deflected beak; seeds 3–7, polished bright scarlet with black patch.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Abrus precatarius occurs at lowl<strong>and</strong> to medium altitude (hill), especially in the coastal areas<br />

from Quang Binh to Ninh Thuan provinces, Phu Quoc <strong>and</strong> Con Dao isl<strong>and</strong>s. It can not tolerate<br />

droughts to some extent when growing in poor coastal soil together with other shrubs. In the<br />

north, it is winter deciduous, but behaves as an evergreen in the south, where it grows vigorously<br />

in the rainy season from June to October. Owing to good regenerative capacity after being cut,<br />

it can be collected twice or three times a year.<br />

6.0 Chemical Constituents<br />

The roots <strong>and</strong> leaves have been reported to contain glycyrrhizin at a percentage of 1.25 <strong>and</strong><br />

10% respectively. The whole plant contains the triterpenoids: abruslactone A, me-abrusgenate<br />

<strong>and</strong> abrusgenic acid.<br />

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The seeds contain a toxalbumin: abrin, an alkaloid: 1-abrin, trigonelline, precatorin, N, N-dimethyl<br />

tryptophan methyl ester, hypaphorine, the sterols: stigmasterol, brassicasterol, cycloartenol,<br />

squalene <strong>and</strong> ß-cholanis acid. The seeds also yield carbohydrates (9.91%), haemoglutinin, urease,<br />

abralin (a glucoside) <strong>and</strong> fatty oil (6%). The seed coat contains a coloured compound, abarnin<br />

(lanthocyane monoglucoside).<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The whole plant <strong>and</strong> leaves are employed for the cure of coughs <strong>and</strong> cold <strong>and</strong> to counteract<br />

intoxication, modulate other drugs <strong>and</strong> relieve jaundice derived from viral hepatitis. The<br />

daily oral dose is 8–16 g in the form of a decoction. The seeds are also used in veterinary<br />

medicine as purgative, vomitory, aphrodisiac <strong>and</strong> to cure nervous troubles in animals.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

304


VIET NAM<br />

1.0 Scientific Name : Abutilon indicum (L) Sweet<br />

Family : Malvaceae<br />

2.0 Vernacular Names : Coi xay, co to ep<br />

3.0 Plant Description<br />

Perennial shrub, 1–1.5 m high; stems cylindrical <strong>and</strong> hairy. Leaves alternate; long-petioled;<br />

base cordate; apex acute; margins toothed; pubescent on both sides, glaucous beneath; main<br />

nerves 5–7, stipules filiform. Flower yellow, solitary in the axils of the leaves; pedicel long,<br />

jointed near the top; calyx tomentose outside, villous inside; sepals triangular, grayish; petals<br />

cuneiform; stamens numerous clustered on a column hairy at the base; carpels usually 20. Fruit<br />

consists of many capsules separately radiated as a rice-hulling mill; capsules hairy, dark brown,<br />

with a small acute point; seed reniform, glabrous, dull black.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Abutilon indicum occurs wild from lowl<strong>and</strong>s to mountains. The plant is hygrophilous <strong>and</strong> can<br />

be slightly shade-enduring. It is frequently mixed with other shrubs around villages <strong>and</strong> on<br />

hillsides. In the mountains, it is deciduous <strong>and</strong> grows vigorously in summer, sheds its leaves in<br />

winter or in dry season.<br />

6.0 Chemical Constituents<br />

The leaves contain mucilaginous substances. The plant yields essential oil consisting of ß-<br />

pinene, caryophyllene, caryophyllene oxide, cineole, geraniol, geranyl acetate, elemene, eudesmol,<br />

farnesol <strong>and</strong> borneol. The seed contains the glycerides of palmitic, stearic, oleic, linoleic <strong>and</strong><br />

linolenic acids. The roots contain fatty oil, ß-sitosterol, ß-amyrin <strong>and</strong> an unidentified alkaloid.<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The alcohol extract of A. indicum exhibits a pronounced effect on the central nervous<br />

system. It induces hypothermia in treated animals. It also exhibits a marked inflammation<br />

inhibitory effect in kaolin-induced rat paw oedema.<br />

7.2 Uses in traditional medicine:<br />

In Vietnamese traditional medicine, A. indicum is used to treat influenza, coryza, headache<br />

<strong>and</strong> dysuria. It is used on its own or in combination with other drugs. The juice extracted<br />

from pounded fresh leaves <strong>and</strong> seed is taken orally on furunculous <strong>and</strong> snake-bites <strong>and</strong><br />

the residue is used as poultice. A decoction of dried leaves of A. indicum Adenosma<br />

cacruleum <strong>and</strong> Prenma integrifolia L. is used for postpartum jaundice. The preparation<br />

is taken daily in dose of 5–10 g of dry or 10–40 g of fresh materials.<br />

8.0 Contraindication:<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

306


VIET NAM<br />

1.0 Scientific Name : Acanthopanax gracilistylus W.W. Smith<br />

Family : Araliaceae<br />

2.0 Vernacular Name : Ngu gia bi huong<br />

3.0 Plant Description<br />

Rigid shrub, a few meters high. Bark grayish, sparsely spiny. Leaves alternate or 2–3 clustered,<br />

palmifoliate; leaflets 5 obovate or oblong; 2–6 cm long, 1–3 cm wide, the middle large; margins<br />

toothed <strong>and</strong> coarsely hairy; glabrous on both sides, shining dark above; petiole 2–6 cm long,<br />

glabrous. Inflorescence solitary in axillary umbels; peduncle 2–2.5 cm long, flowers greenish to<br />

yellow. Fruit globose compressed, black when ripe, 2 seeded.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Acanthopanax gracilistylus is an evergreen, heliophilous <strong>and</strong> hygrophilous shrub. It is adaptable<br />

to humid to cool climatic conditions in high mountainous areas, at an altitude of 1,500–1,600 m.<br />

It often grows in clusters on rocky forest edges, <strong>and</strong> is also cultivated in gardens for medicinal<br />

purposes. It is winter deciduous. Acanthopanax gracilistylus is listed in the Red Data Book of<br />

Viet Nam for conservation.<br />

6.0 Chemical Constituents<br />

The root bark contains syringin, kauronic acid <strong>and</strong> 16a.17 – dihydroxykauran – 19 oic acid <strong>and</strong><br />

saponins.<br />

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7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

It is reported to be antibacterial against Staphylococcus aureus <strong>and</strong> Bacillus pyocyaneus.<br />

7.2 Uses in traditional medicine:<br />

It is commonly used as tonic to strengthen the tendons. It is administered orally in the<br />

form of an elixir, taken daily in doses of 6–12 g dried bark.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

308


VIET NAM<br />

1.0 Scientific Name : Acanthopanax trifoliatus (L.) Merrill<br />

Family : Araliaceae<br />

2.0 Vernacular Name : Ngu gia bi gai<br />

3.0 Plant Description<br />

Rigid shrub, diffuse 17 m high. Stems ascending, spiny. Leaves alternate, 3–5 palmifoliate,<br />

almost 3; leaflets oblong - oval; 5–8 cm long, 2–4 cm wide; base rounded; apex acuminate;<br />

margins toothed; <strong>and</strong> nerves spiny, the middle larger; glabrous on both side, shining dark above;<br />

petiole 4–5 cm long, spiny. Inflorescence in terminal panicle of 3–10 umbels; peduncle 3–4 cm<br />

long; flowers small, greenish white. Petals triangular; stamens 5; filaments filiform; ovary inferior,<br />

2-celled. Fruit globose compressed, 2–5 mm in diameter, black when ripe, 2 seeded. Flowering<br />

period: September to November.<br />

4.0 Propagation : Stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

The plant has only been found in Northern Viet Nam. It is hygrophilous <strong>and</strong> heliophilous, <strong>and</strong><br />

often grows in clusters in forest edges or near watersides in limestone mountains areas (500–<br />

1,500 m). It is a valuable medicinal species in Viet Nam. It is listed in the Red Data Book of Viet<br />

Nam for conservation.<br />

6.0 Chemical Constituents<br />

The root <strong>and</strong> stem bark contains 3á-, 11á-dihydroxy – 23 – oxolup –20 (29)- ene – 28 oic acid,<br />

24-nor – 3á, 11á-dihydroxylup – 20 (29) ene- 28 oic acid; 24-nor-3á. 11á-hydroxylup – 20(29)<br />

– en 25oic acid.<br />

The leaf contains 3á-, 11á-dihydroxy –20 (29)- ene – 28 oic acid <strong>and</strong> 3á, 11á-23- trihydroxylup<br />

– 20-(29) ene- 28 oic acid. In addition other components viz-nevadensin, taraxerol <strong>and</strong> taraxerol<br />

acetic ester are also present.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Acanthopanax trifoliatus is used as tonic <strong>and</strong> effective in the treatment of rheumatism,<br />

back <strong>and</strong> knee pains, male impotence <strong>and</strong> vulvas of women. It is good for children in<br />

early stage of walking. It is administered in the form of a decoction or elixir. The herbal<br />

preparation is taken daily in doses of 6–12 g of dried material.<br />

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8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

310


VIET NAM<br />

1.0 Scientific Name : Achyranthes aspera L.<br />

Family : Amaranthaceae<br />

2.0 Vernacular Names : Co xuoc, co nha lin ngu<br />

3.0 Plant Description<br />

Herbaceous plant, about 1 m high. Stems <strong>and</strong> branches quadrangular, striate, pubescent, swollen<br />

at the nodes. Leaves opposite, elliptic or obovate; margins entire, waxy with pubescent on both<br />

sides. Inflorescence in elongate terminal spike, 20–30 cm long; flowers numerous, greenishwhite,<br />

deflected against the pubescent rachis; perianth glabrous; lobes subequal; stamens 5.<br />

Achence, utricle oblong-cylindrical, enclosed in the hardened perianth, brown, seeds oblongovoid.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

In Viet Nam this plant is widespread up to 1500 m. It often grows together with other herbs in<br />

gardens <strong>and</strong> ab<strong>and</strong>oned grounds. During summer, it produces a lot of flowers <strong>and</strong> fruits.<br />

6.0 Chemical Constituents<br />

The root contains saponin, the aglycone of which is characterized as oleanolic acid. It also<br />

contains pentatricontane, â- pentatriacontanone, hexatriacontane <strong>and</strong> triacontane. The seeds<br />

contain hentriacontane, 10-octacosanone, 10-triacocsanone <strong>and</strong> 4-tritriacontanone.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The roots produce antiinflammatory <strong>and</strong> thymolytic effects in rats. They stimulate uterine<br />

contractions <strong>and</strong> exhibit mild oeterogenic action. They have also antibacterial <strong>and</strong><br />

hypoglycaemic properties.<br />

7.2 Uses in traditional medicine:<br />

Achyranthes aspera is used to treat cold, fever, rheumatism, lumbago, osteodynia, arthritis,<br />

menstrual disorders, haematometra, rheumatoid poly-arthritis, limbs curling-up, oliguria,<br />

micturition <strong>and</strong> urodynia. It is also used to expel dead foetus <strong>and</strong> treat chronic malarial.<br />

The daily oral dose is 12–40 g of root, in the form of a decoction. It is effective against<br />

impetigo when used externally, kept in the mouth to treat stomatitis. The leaf juice is<br />

effective against dysentery.<br />

8.0 Contraindications<br />

Not available<br />

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9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

312


VIET NAM<br />

1.0 Scientific Name : Aconitum fortunei Hemsl.<br />

Family : Ranunculaceae<br />

2.0 Vernacular Names : Au tau, o dau<br />

3.0 Plant Description<br />

Perennial herba, 0.6–1 m high. Roots paired, tuberous, conical, including mother-tuber <strong>and</strong><br />

daughter-tuber, glabrous outside <strong>and</strong> blackish. Stems erect, cylindrical less-branched. Leaves<br />

alternate of two kinds: the lower cordate-rotundate, coarsely crenate, the upper 3-palmatipartite,<br />

sharply denticulate; blade glabrous or pubescent; shining green above <strong>and</strong> pale below.<br />

Inflorescence in terminal loose raceme; flowers blue; perianth of 5 sepals, the upper broad<br />

helmet-shaped, the lateral somewhat obliquely obovate; corolla reduced; stamens numerous;<br />

ovary 3-celled with numerous carpels. Follicles, 5, sessile, oblong <strong>and</strong> divergent, seed winged.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

In Viet Nam, A. fortunei has been recorded to grow wild in Sa Pa. However, according to<br />

IMM specialists, it is cultivated.<br />

6.0 Chemical Constituents<br />

All parts of A. fortunei growing in Viet Nam contain alkaloids. The percentage of total alkaloids<br />

is highest in rootlets, the main alkaloid being aconitine. The percentage of aconitine is 0.28% in<br />

the mother root <strong>and</strong> 0.12% in the flower. The highest aconitine content is obtained at flowering.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The decoction of prepared daughter-tubers of A. fortunei has blood pressure lowering<br />

effect.<br />

7.2 Uses in traditional medicine:<br />

In modern medicine, A. fortunei is recommended as antitussive analgesic <strong>and</strong> diaphoretic.<br />

It is effective for sore throat, but caution is needed because of its high toxicity. It is used<br />

in the form of tincture. For adults the dose at a time is 5–10 drops, <strong>and</strong> the dose for 24<br />

hours is 40 drops. For children over 30 months old, the daily dose ranges 5–10 drops.<br />

8.0 Contraindications<br />

Not available<br />

313


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

314


VIET NAM<br />

1.0 Scientific Name : Acorus gramineus Sol<strong>and</strong><br />

Family : Acoraceae<br />

2.0 Vernacular Names : Thach xuong bo, bo hoang<br />

3.0 Plant Description<br />

Perennial, semi-aquatic marsh herb, about 0.5 m high. Rhizome aromatic, creeping, 5–30 cm<br />

long. Leaves linear, sheathed amplexicaul in fascicles, 10–50 cm long, 0.4–0.8 cm wide; basal<br />

short <strong>and</strong> narrow; upper apex attenuate acute; glabrous on both sides; main nerves parallel.<br />

Inflorescence terminal spadix on a compressed scape, surrounded by a broad <strong>and</strong> long leaf-like<br />

spathe; spadix cylindrical, attenuate <strong>and</strong> slightly curved, 5-10 cm long; flowers numerous, small,<br />

bisexual, yellowish green; perianth in 6 lobes; sepals 3; petals 3; stamens 6; filaments short;<br />

ovary oblong, ovate. Seed berry elongated, bright red when ripe.<br />

4.0 Propagation : Rhizome<br />

5.0 Geographical Distribution/Ecology<br />

Acorus gramineus is widely distributed in the tropical <strong>and</strong> subtropical regions of <strong>ASEAN</strong> including<br />

Viet Nam. It is scattered in mountain areas, mainly along the streams or climbing on rocks by a<br />

fibrous root system. Seeds are usually dispersed by water <strong>and</strong> often observed between the<br />

rocks along streams. The plant has been continuously overexploited.<br />

6.0 Chemical Constituents<br />

In Viet Nam, the rhizome of A. gramineus yields 0.34–0.41% essential oil including myrcene,<br />

camphor, cis-methyl isoeugenol, á-asarone, â-asarone <strong>and</strong> shyobunone.<br />

315


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The rhizome exhibits sedative, antispasmodic <strong>and</strong> hypotensive actions, <strong>and</strong> aids sleep. It<br />

improves the memory in alcohol amnesia. The active trans-4-propenyl veratrol exerts<br />

inhibitive effect on the central nervous system.<br />

7.2 Uses in traditional medicine:<br />

Acorus gramineus is employed as a tonic; it warms the stomach benefitting the digestion,<br />

relieves pain, improves eyesight <strong>and</strong> hearing, <strong>and</strong> counteracts rheumatism <strong>and</strong> osteodynia.<br />

It is taken daily in doses of 3–8 g, in the form of a decoction, pills or powder. Acorus<br />

gramineus can be combined with other herbal drugs.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

316


VIET NAM<br />

1.0 Scientific Name : Acronychia laurifolia Blume<br />

Family : Rutaceae<br />

2.0 Vernacular Names : Buoi bung, co dong danh<br />

3.0 Plant Description<br />

Small tree about 4–6 m high or more. Branches zigzag, greenish when young, then reddish<br />

brown. Leaves opposite, coriaceous; base narrowed; apex slightly acute; shining dark green<br />

above, first pubescent, then glabrous; petiole 2–3 cm long swelling at both ends. Inflorescence<br />

in axillary or teminal corymb; bracts <strong>and</strong> bracteoles in minute scales; flower bisexual white, very<br />

fragrant; sepals short; petals linear-oblong, spreading; stamens 8 inserted beneath the disk;<br />

ovary tomentose. Drupe globose, fleshy, 4-angled, pale yellow when ripe, seed black. Flowering<br />

period: July-September.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution/Ecology<br />

Acronychia laurifolia is light - dem<strong>and</strong>ing <strong>and</strong> fairly shade - enduring when young. The plant<br />

can grow in different sites <strong>and</strong> tolerates drought to some extent, frequently associated with<br />

other shrubs <strong>and</strong> small trees in the hills, secondary forests around villages.<br />

6.0 Chemical Constituents<br />

The leaves yield an essential oil <strong>and</strong> the alkaloid acronycine.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

It is used to treat rheumatism; pains of the limbs, knees <strong>and</strong> back; dyspepsia; abdominal<br />

pains; fever <strong>and</strong> coughs.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

317


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Adenosma glutinosum (L.) Druce<br />

Family : Scrophulariaceae<br />

2.0 Vernacular Names : Nhan tran, Che noi<br />

3.0 Plant Description<br />

Annual herb, 40–70 cm high or more to 1 m. Stems cylindrical, covered with a dense pubescence.<br />

Leaves opposite, oval-shaped; apex obtuse or slightly acuminate; 4–6 cm long, 2–3 cm wide;<br />

pubescent on both sides; margins serrate; petiole 0.5–1.2 cm long. Inflorscence in axillary or<br />

terminal spiciform raceme about 30 cm long; flowers violet-blue; calyx campanulate, 5-toothed,<br />

pubescent, the outer lanceolate, broad <strong>and</strong> elongate, the inner strictly narrow; corolla 2-lipped,<br />

1–1.4 cm long, the upper triangular, truncate or slightly concave, the lower nearly longer, 3-<br />

lobed; stamens 4. Capsule as long as the calyx, ovoid, apiculate, seeds numerous yellow.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

This plant is concentrated in some northern provinces such as Bac Can, Cao Bang, Tuyen<br />

Quang, Ha Giang, <strong>and</strong> Son La. In the south, it is only scattered at the height of more than 500<br />

m. The plant is hygrophilous <strong>and</strong> often occurs in association with other herbs <strong>and</strong> small shrubs.<br />

Seedlings appear in late spring. They grow vigorously for about three months <strong>and</strong> then flower<br />

<strong>and</strong> wither in September or October.<br />

6.0 Chemical Constituents<br />

The whole plant yields 1% essential oil. The oil content in the leaves <strong>and</strong> flowers is 1.86%. The<br />

essential oil distilled from flower bearing aerial part gives the flowing characteristics: d 25<br />

.0.8042.<br />

n D<br />

20<br />

. 1.4705. |á | D. 20 +4.8.<br />

The main composition of the oil is paracymene, limonene, á-pinene, cineole <strong>and</strong> anethole. Analysis<br />

of the 40° alcohol extract of the drug gave, besides essential oil, saponins, flavonoids <strong>and</strong> aromatic<br />

acids.<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

In modern medicine, A. glutinosum is employed for curing viral hepatitis. In a clinical<br />

trial, all patients taken Adenosum medication have typical acute hepatitis signs. increase<br />

in bilinrubinaemia. The drug is used in the form of syrup, in a daily dose of 100 ml, divided<br />

into two split doses. After a period of medication, A. glutinosum normalized the amount<br />

of bilirubin in blood <strong>and</strong> the activities of SGPT <strong>and</strong> all the clinical symptoms are improved.<br />

7.2 Uses in traditional medicine:<br />

In traditional medicine, it is used for treating jaundice in hepatitis, fevers <strong>and</strong> oliguria.<br />

318


VIET NAM<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

319


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Alisma plantago-aquatica L.<br />

Family : Alismataceae<br />

2.0 Vernacular Names : Trach ta, ma de nuoc<br />

3.0 Plant Description<br />

Marsh herb, 40–50 cm high. Rhizome stout, globular, fleshy <strong>and</strong> whitish. Leaves long-petioled<br />

<strong>and</strong> sheathed, forming a rosette; blade oval-shaped or ovate, entire, slightly, undulate; base<br />

rounded; apex acuminate; nerves 5–7, curved. Inflorescence in terminal, umbelliform cyme,<br />

scape reaching 1 m long; flowers white or rosy, hermaphrodite; sepals 3, persistent in fruit;<br />

petals 3; stamens 6–9, flat; ovary many-celled. Achence compressed with persistent calyx.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

In Viet Nam, this plant is grows in the north. The plant is a small marsh or, aquatic herb, growing<br />

in marsh fields or ponds. Its rhizomes are submerged in the mud. Flowers on long pseudostems<br />

emerging above the water. Leaves wither after fruit-ripening in June or July, <strong>and</strong> rhizomes<br />

re-sprout in the next spring.<br />

6.0 Chemical Constituents<br />

The rhizomes contain starch (23%) <strong>and</strong> triterpenes including alisol A, alisol B, alisol C, alisol A<br />

monocetate, alisol B monocetate, alisol C acetate, epialisol A, 24-acetylalisol A, 25- acetyl alisol B,<br />

23-acetyl alisol C.<br />

320


VIET NAM<br />

7.0 Reports on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

The plant is reported to be diuretic, antilipidosis, hypocholesterolaemic <strong>and</strong><br />

antiatherosclerosis, hypotensive <strong>and</strong> hypoglycaemic.<br />

7.2 Uses in traditional medicine:<br />

In traditional medicine, A. plantago - aquatica is used as diuretic. It is beneficial for<br />

treating oliguria, dysuria, urodynia <strong>and</strong> oedema in nephritis <strong>and</strong> urinary lithiasis. The drug<br />

is also effective against headache, dizziness, dry mouth <strong>and</strong> thirst. It is likewise prescribed<br />

as antidiabetic <strong>and</strong> a galactagogue in hypogalactia.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

National Institute of Materia Medica Ha Noi, Viet Nam 1999. Selected <strong>Medicinal</strong> <strong>Plants</strong> in<br />

Viet Nam. Volume 1. Le Van Truyen et al. (Eds.). Science <strong>and</strong> Technology Publishing House,<br />

Ha Noi.<br />

321


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Aquilaria crassna Pierre ex Lacomte<br />

Family : Thymelaeaceae<br />

2.0 Vernacular Names : Tram huong, do bau<br />

3.0 Plant Description<br />

A large evergreen, 15–20 cm high, with a diameter of 40–50 cm. Bark grayish brown, easy to<br />

peel off, smooth, inner bark with much water. Crown open. Leaves corracears, oval, upper<br />

surface glossy <strong>and</strong> green, lower surface light-coloured. Inflorescence yellow; fruit a capsule,<br />

obovoid, 4 x 3 cm in size, hard when dry. Furnished with short, grayish yellow hairs <strong>and</strong> persisient<br />

calyx.<br />

4.0 Propagation : Seed<br />

5.0 Geographic Distribution/Ecology<br />

It is found mostly in Viet Nam, Lao PDR <strong>and</strong> Cambodia, <strong>and</strong> abundantly in primary <strong>and</strong> secondary<br />

forests on typical ferralitic soils with shallow to moderately deep surface layers.<br />

6.0 Chemical Constituents<br />

The wood of the tree contains 13% oil. The main components are benzylacetone (26%);<br />

Metoxybenzylaceton (53%); Terpinen-ol 11% <strong>and</strong> cinnamic acid.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

322


VIET NAM<br />

7.2 Uses in traditional medicine:<br />

The species is used as antiemetic <strong>and</strong> diuretic <strong>and</strong> to treat sedative palpitation, asthma,<br />

chest-ache <strong>and</strong> stomach-ache.<br />

8.0 Contraindication:<br />

Not available<br />

9.0 Bibliography<br />

Forest Inventory <strong>and</strong> Planning Institute. 1996. Viet Nam Forest Trees. Agricultural Publishing<br />

House.<br />

Loi, D. T. 1995. <strong>Medicinal</strong> <strong>Plants</strong> <strong>and</strong> Pharmaceutical Prescriptions of Viet Nam. Science<br />

<strong>and</strong> Technological Publishing House, Ha Noi.<br />

Ministry of Science, Technology & Environment. 1996. Red Data Book of Viet Nam. Vol. 2,<br />

<strong>Plants</strong>. Science <strong>and</strong> Technics Publishing House, Ha Noi.<br />

323


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

1.0 Scientific Name : Artocarpus tonkinensis A. Chev.<br />

Family : Moraceae<br />

2.0 Vernacular Name : Chay bac bo (Viet Nam)<br />

3.0 Plant Description<br />

A small or medium tree, 20–25 m high <strong>and</strong> 30 cm in diameter; crown wide <strong>and</strong> open. Bark graybrown,<br />

inner bark pink with milky sap. Twigs yellow-brown, tomentose, then glabrous. Leaves<br />

big sized, lanceolate or ovate; base obtuse; apex mucronate; 20–25 cm long <strong>and</strong> 9–12 cm wide;<br />

upper surface glabrous when mature, brown-yellow tomentose on the veins beneath 10–12<br />

pairs, evident beneath.; petiole slender, tomentose, 2 cm long; stipules small. Male inflorescence<br />

axillary, ablong, slightly curved, 12–20 mm long <strong>and</strong> 8–12 mm wide; peducle slender, 10–15 mm<br />

long. Female inflorescence obovate, 15 mm long <strong>and</strong> 12 mm wide. Flowers numerous, laxly<br />

arranged with peltate bracts, tomentose on the surface; sepals 3, obovate, tubular; stamen 1,<br />

style extruded from 5 small holes.<br />

4.0 Propagation : Seed<br />

5.0 Geographic Distribution/Ecology<br />

It is distributed in the northern part of Viet Nam <strong>and</strong> Lao PDR.<br />

6.0 Chemical Constituents<br />

Bark <strong>and</strong> root contain tannin.<br />

7.0 Report on Medical Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

Root <strong>and</strong> bark are chewed with betel for maintaining healthy teeth. Leaves <strong>and</strong> roots are<br />

used for backache, rheumatism <strong>and</strong> arthritis.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Forest Inventory <strong>and</strong> Planning Institute. 1996. Viet Nam Forest Trees. Agricultural Publishing<br />

House.<br />

Loi, D. T. 1995. <strong>Medicinal</strong> <strong>Plants</strong> <strong>and</strong> Pharmaceutical Prescriptions of Viet Nam. Science<br />

<strong>and</strong> Technological Publishing House, Ha Noi.<br />

324


VIET NAM<br />

1.0 Scientific Name : Illicium verum Hook. f.<br />

Family : Illiciaceae<br />

2.0 Vernacular Names : Hoi, Dai hoi (Viet Nam); dok chan, poy kak bua, chinpaetklip,<br />

poikak bua (Thail<strong>and</strong>); bunga lawang, adas china (Malaysia);<br />

bunga lawang (Indonesia); star anise (English)<br />

3.0 Plant Description<br />

A small or medium tree, 6–8 m height, diameter up to 15–36 cm. Trunk straight, terete. Bark<br />

grey-brown; branchlets green; crown conical to globose, looks beautiful. All parts of the tree<br />

have an agreeable aromatic smell. Leaves simple, usually clustered at branch-tips into<br />

pseudoverticils of 3–4 leaves. Leaves ovate, 6–12 cm long, 2–5 cm wide; leaf blade thick <strong>and</strong><br />

brittle, dark-green above, paler beneath. Petiole glabrous, 7–10 mm long. Flower big, pinkwhite.<br />

Peticil stout <strong>and</strong> short. Sepals 6, pink at margin, green at back. Petals 16–20; broadelliptic<br />

sepal, white outside, red inside, dark-red at the middle of flower. Stamens 10–20, shorter<br />

than petals, elliptic; carpels 6–8. Fruit consists of 6–8 follicles, spreading woody <strong>and</strong> brown<br />

when mature, dehiscent by ventral side. Seed solitary in each follicle, brown, glossy <strong>and</strong> glabrous.<br />

4.0 Propagation : Seed<br />

5.0 Geographical Distribution/Ecology<br />

Originating from North Viet Nam <strong>and</strong> South of China, the tree can be found on red, brown-red<br />

or yellow ferralitic soil, developed from schist-s<strong>and</strong>stone with deep, fertile <strong>and</strong> well-drained<br />

soils.<br />

6.0 Chemical Constituents<br />

Essential oils contained in fruits, leaves <strong>and</strong> seeds – anethol (80–90%), terpene (10–20%),<br />

pinene, dipentene, limonene, estradol, phell<strong>and</strong>rene, safrole <strong>and</strong> terpineol.<br />

325


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The essential oil is used for treating rheumatism, dyspepsia, fish poisoning, neuritis, colic<br />

<strong>and</strong> as antiemetic. Star anise has carminative, stomachic, stimulant <strong>and</strong> diuretic properties.<br />

It is a common flavouring for medicinal teas, cough mixtures <strong>and</strong> pastilles.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Forest Inventory <strong>and</strong> Planning Institute. 1996. Viet Nam Forest Trees. Agricultural Publishing<br />

House.<br />

Loi, D. T. 1995. <strong>Medicinal</strong> <strong>Plants</strong> <strong>and</strong> Pharmaceutical Prescriptions of Viet Nam. Science<br />

<strong>and</strong> Technological Publishing House, Ha Noi.<br />

Ministry of Science, Technology & Environment. 1996. Red Data Book of Viet Nam. Vol. 2,<br />

<strong>Plants</strong>. Science <strong>and</strong> Technics Publishing House, Ha Noi.<br />

326


VIET NAM<br />

1.0 Scientific name : Litsea cubeba (Loureiro) Pers.<br />

Family : Lauraceae<br />

2.0 Vernacular Names : Mang tang, man tang (Viet Nam); lindos (Malaysia)<br />

3.0 Plant Description<br />

A small tree, 8–10 m high <strong>and</strong> 7–15 cm in diameter. Stem <strong>and</strong> branches green or yellowish<br />

green when young. Twigs glabrous, black when dry. Leaves simple, alternate, oblong-ovate,<br />

soft <strong>and</strong> thin, 6–9 cm long, 2–3 cm wide, glabrous. Veins evident on both surfaces. Leaves <strong>and</strong><br />

bark smell of citronella. Inflorescence of compound. Axis slender, very short (0.1–0.2 cm). Fruit<br />

globose, about 0.4–0.7 cm in diameter, succulent, yellowish green when young, black when<br />

mature.<br />

4.0 Propagation : Stem cutting <strong>and</strong> seed<br />

5.0 Geographical Distribution/Ecology<br />

It is distributed in Lao PDR, China, Cambodia, Viet Nam, Malaysia, <strong>and</strong>m is found abundantly in<br />

secondary forests.<br />

6.0 Chemical Constituents<br />

Rich in essential oil. The fruits <strong>and</strong> leaves contain 6–15% <strong>and</strong> 0.2–0.4% oil respectively. The<br />

major components are composed of 70–90% citral, methyheptenone, cineol <strong>and</strong> aldehyde.<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

327


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.2 Uses in traditional medicine:<br />

The essential oil is used as a deodorant <strong>and</strong> for diarrhoea, snake-bite, dyspepsia, flu,<br />

coughs <strong>and</strong> cold.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Biblioraphy:<br />

Forest Inventory <strong>and</strong> Planning Institute. 1996. Viet Nam Forest Trees. Agricultural Publishing<br />

House.<br />

Loi, D. T. 1995. <strong>Medicinal</strong> <strong>Plants</strong> <strong>and</strong> Pharmaceutical Prescriptions of Viet Nam. Science<br />

<strong>and</strong> Technological Publishing House, Ha Noi.<br />

http://research.kahaku.go.jp/botany/Tail<strong>and</strong>/plant/picture_page/10.html - 24 August 2003.<br />

328


VIET NAM<br />

1.0 Scientific Name : Schefflera octophylla (Loureiro) Harms<br />

Family : Araliaceae<br />

2.0 Vernacular Names : Chan chim, dang, sam nam (Viet Nam)<br />

3.0 Plant Description<br />

Evergreen medium-sized tree, up to 10–20 m high; wide umbrella crown. Trunk cylindrical<br />

straight, reaching 40 cm in diameter. Bark white-grey, glabrous with many lenticels <strong>and</strong> horizontal<br />

stipule scars. Inner bark 6 mm thick, yellowish, aromatic. Leaflets 6–8, elliptic or oval 10–15 cm<br />

long, 3–5 cm wide. Lateral nerves 69 pairs. Petiole 25 cm long. Lateral leaflets with petiolules<br />

1.5–2.5 cm long <strong>and</strong> middle leaflet with petiolules 3.5–5 cm long. Inflorescence broadly paniculate,<br />

consisting of many umbels. Flowers minute white, aromatic <strong>and</strong> pedunculate. Calyx 5, lobed,<br />

tomentosa outside. Petals 5, white. Stamens 5, ovary inferior 5–8 locular, style very short. Fruit<br />

a globose berry, 4–5 mm in diameter, with 5–7 seeds.<br />

4.0 Propagation : Seed <strong>and</strong> stem cutting<br />

5.0 Geographical Distribution:/Ecology:<br />

It is found throughout China, Lao PDR, Indonesia <strong>and</strong> Viet Nam. In both tropical <strong>and</strong> subtropical<br />

forest areas, it commonly grows in secondary forests below 1,000 m.<br />

6.0 Chemical Constituents<br />

Glycosides: scheffoleoside A, scheffoleoside D, scheffoleoside E, scheffursoside B, scheffursoside<br />

C, scheffoleoside D, scheffoleoside E, oplopananaxogenin A<br />

329


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

7.0 Report on <strong>Medicinal</strong> Usage<br />

7.1 Uses supported by experimental/clinical data:<br />

Not available<br />

7.2 Uses in traditional medicine:<br />

The roots <strong>and</strong> leaves are used as tonic.<br />

8.0 Contraindications<br />

Not available<br />

9.0 Bibliography<br />

Forest Inventory <strong>and</strong> Planning Institute. 1996. Viet Nam Forest Trees. Agricultural Publishing<br />

House.<br />

Loi, D. T. 1995. <strong>Medicinal</strong> <strong>Plants</strong> <strong>and</strong> Pharmaceutical Prescriptions of Viet Nam. Science<br />

<strong>and</strong> Technological Publishing House, Ha Noi.<br />

Kitajima, J. & Tanaka, Y. 1989. Two new triterpenoid glycosides from the leaves of Schefflera<br />

octophylla. Chemical Pharm. Bulletin 37(10):2727–2730.<br />

http://www.bio.ncue.edu.tw/native/plant/p10.htm - 25 August 2004.<br />

330


LIST OF CONTRIBUTORS<br />

LIST OF CONTRIBUTORS<br />

BRUNEI DARUSSALAM<br />

1 Mr. Muhd Safwan Bin Abdullah Bibi<br />

Forestry Officer<br />

Forestry Department<br />

Ministry of Industry <strong>and</strong> Primary Resources<br />

Jalan Menteri Besar, Berakas BB3910<br />

B<strong>and</strong>ar Seri Begawan, Brunei Darussalam<br />

Tel: 673-2381678<br />

Fax: 673-2381012<br />

forestrybrunei@hotmail.com<br />

2 Mr. Mulyadi Hj. Mohd. Ali<br />

Agriculture Officer<br />

Agriculture Department<br />

Ministry of Industry <strong>and</strong> Primary Resources<br />

Jalan Menteri Besar, Berakas BB3910<br />

B<strong>and</strong>ar Seri Begawan, Brunei Darussalam<br />

Tel: 673-2663346<br />

Fax: 673-2661354<br />

mulyadi_ali@agriculture.gov.bn<br />

CAMBODIA<br />

3 Mr. Hung Suntra<br />

Deputy Head<br />

Forest <strong>and</strong> Wildlife Science Research<br />

Institute<br />

Forest Administration<br />

Ministry of Agriculture Forestry <strong>and</strong> Fisheries<br />

#40 Preah Norodom Boulevard<br />

Phnom Penh, Cambodia<br />

Tel: 855-23-219282, 855-12-802699<br />

Fax: 855-23-214282<br />

hsuntra@yahoo.com<br />

4 Mr. Chann Sophal<br />

Deputy Director<br />

Department of Forestry <strong>and</strong> Wildlife<br />

Forest Wildlife Research Institute<br />

#40 Preah Norodom Boulevard<br />

Phnom Penh, Cambodia<br />

Tel/Fax: 855-23-213612<br />

ffpri_fwri@online.com.kh<br />

INDONESIA<br />

5 Dr. Yetti Rusli<br />

Senior Advisor to Ministry of Forestry<br />

Ministry of Forestry<br />

Jakarta, Indonesia<br />

Tel: 62-21-5730205, 62-21-5730222<br />

Fax: 62-21-5700226<br />

yettir@dephut.cbn.net.id<br />

6 Dr. Nurliani Bermawie<br />

Head of <strong>Medicinal</strong> <strong>Plants</strong> Programme<br />

Indonesian <strong>Medicinal</strong> <strong>and</strong> Aromatic<br />

Crops Research Institute (IMACRI)<br />

Ministry of Agriculture<br />

Jl. Tentara Pelajar No.3, Bogor<br />

Indonesia<br />

Tel: 62-251-321879, 62-251-342891<br />

Fax: 62-251-327010<br />

nurlianib@yahoo.com<br />

LAO PDR<br />

7 Dr. Bounhong Southavong<br />

Director<br />

Traditional Medicine Research Center<br />

Ministry of Health<br />

Vientianne, Lao PDR<br />

Tel: 856-21-315693<br />

Fax: 856-21-312354<br />

laotmrc@laotel.com<br />

bsouthavong@hotmail.com<br />

8 Assoc. Prof. Kongmany Sydara<br />

Deputy Director<br />

Traditional Medicine Research Center<br />

Ministry of Health<br />

Ban Phon Papao Tha<br />

Sisattanak District<br />

Vientianne, Lao PDR<br />

Tel: 856-21-315693<br />

Fax: 856-21-315693<br />

ksydara@gmail.com<br />

333


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

MALAYSIA<br />

9 Dr. Rasadah Mat Ali<br />

Director<br />

<strong>Medicinal</strong> <strong>Plants</strong> Programme<br />

Biotechnology Division<br />

Forest Research Institute Malaysia (FRIM)<br />

52109 Kepong, Selangor Darul Ehsan,<br />

Malaysia<br />

Tel: 60-3-62797329<br />

Fax: 60-3-62728905<br />

rasadah@frim.gov.my<br />

10 Mr. Zainon Abu Samah<br />

Research Officer<br />

<strong>Medicinal</strong> <strong>Plants</strong> Programme<br />

Biotechnology Division<br />

Forest Research Institute Malaysia (FRIM)<br />

52109 Kepong, Selangor Darul Ehsan,<br />

Malaysia<br />

Tel: 60-3-62797330<br />

Fax: 60-3-62728905<br />

zainon@frim.gov.my<br />

MYANMAR<br />

11 Mr. Myo Myat<br />

Director<br />

Planning & Statistics Department<br />

Ministry of Forestry<br />

Yankin P.O. Yangon, Myanmar<br />

Tel: 95-67-405012<br />

Fax: 95-62-405378<br />

trincertcom@mptmail.net.mm<br />

PHILIPPINES<br />

12 Mr. Celso P. Diaz<br />

Ecosystems Research & Development Bureau<br />

Department of Environment & Natural<br />

Resources (DENR)<br />

College, Laguna, Phillipines<br />

Tel: 63-49-5362269<br />

Fax: 63-49-5362269<br />

erdb@laguna.net<br />

THAILAND<br />

13 Ms. Benjavon Caruhapattana<br />

Chief of Forest Products Chemistry<br />

Subdivision<br />

Forest Products Research Division<br />

Royal Forest Department<br />

Bangkok 10900, Thail<strong>and</strong><br />

Tel: 66-22-561-4292/66-22-561-4293, ext-480<br />

Fax: 66-22-579-5412<br />

benjavon@forest.go.th<br />

VIET NAM<br />

14 Dr. Pham Duc Tuan<br />

Vice-Director General<br />

Department of Forestry<br />

Ministry of Agriculture <strong>and</strong> Rural<br />

Development<br />

2 Ngoc Ha - Ha Noi, Viet Nam<br />

Tel: 84-4-7332154<br />

Fax: 84-4-8438793<br />

pham-tuan@hn.unn.vn<br />

334


INDEX<br />

INDEX<br />

Abelmoschus moschatus, 1<br />

Abrus precatorius, 303<br />

Abutilon indicum, 305<br />

Acanthopanax gracilistylus, 307<br />

Acanthopanax trifoliatus, 309<br />

Achyranthes aspera, 311<br />

Aconitum fortunei, 313<br />

Acorus calamus, 85<br />

Acorus gramineus, 315<br />

Acronychia laurifolia, 317<br />

Adenosma glutinosum, 318<br />

Aegle marmelos, 43, 107<br />

Agathis borneensis, 3<br />

Alisma plantago-aquatica, 320<br />

Aloe barbadensis, Aloe vera, 5, 87, 227<br />

Alstonia scholaris, 109<br />

Amaranthus spinosus, 7<br />

Anacardium occidentale, 229<br />

Andrographis paniculata, 9<br />

Annona reticulata, 231<br />

Aquilaria crassna, 45, 322<br />

Arcangelisia flava, 89<br />

Ardisia elliptica, 147<br />

Areca catechu, 233<br />

Artocarpus lakoocha, 267<br />

Artocarpus tonkinensis, 324<br />

Asparagus cochinchinensis, 111<br />

Asplenium nidus, 11<br />

Barleria prionitis, 205<br />

Basella rubra, 236<br />

Bixa orellana, 238<br />

Blumea balsamifera, 13<br />

Boesenbergia rotunda, 271<br />

Caesalpinia crista, 15<br />

Caesalpinia pulcherrima, 240<br />

Caesalpinia sappan, 47, 113<br />

Calotropis gigantea, 115<br />

Cananga latifolia, 49<br />

Capparis micracantha, 51<br />

Carmona retusa, 242<br />

Cassia alata, 53, 117<br />

Cassia fistula, 244, 274<br />

Cassia tora, 279<br />

Ceiba pent<strong>and</strong>ra, 246<br />

Centella asiatica, 91<br />

Centratherum intermedium, 17<br />

Chromolaena odorata, 149<br />

Clinacanthus nutans, 284<br />

Codonopsis pilosa, 119<br />

Combretum quadrangulare, 55<br />

Corchorus capsularis, 19<br />

Coscinium fenestratum, 21<br />

Coscinium usitatum, 57<br />

Costus speciosus, 121<br />

Curcuma longa, 23, 286<br />

Curcuma mangga, 93<br />

Curcuma zedoaria, 59, 95<br />

Curcuma xanthorhiza, 152<br />

Cymbopogon citratus, 155<br />

Cymbopogon nardus, 159<br />

Dioscorea esculenta, 207<br />

Dioscorea persimilis, 123<br />

Donax gr<strong>and</strong>is, 25<br />

Dracaena cambodiana, 61<br />

Eclipta prostrata, 125<br />

Elephantopus scaber, 127, 162<br />

Elettaria cardamomum, 209<br />

Eleutherine subaphylla, 129<br />

Etlingera solaris, 27<br />

Euodia lepta, 131<br />

Eurycoma longifolia, 63, 164, 289<br />

Fibraurea tinctoria, 166<br />

Gloriosa superba, 211<br />

Gynura procumbens, 168<br />

Hibiscus rosa-sinensis, 248<br />

Hibiscus sabdariffa, 293<br />

Hopea odorata, 65<br />

Hydnocarpus anthelminticus, 67<br />

Illicium verum, 325<br />

Impatiens balsamina, 296<br />

Jatropha curcas, 250<br />

Justicia gendarusa, 97<br />

Kaempferia galanga, 171<br />

Labisia pothoina, 173<br />

Languas galanga, 29, 175<br />

Litsea cubeba, 327<br />

335


<strong>ASEAN</strong> HERBAL AND MEDICINAL PLANTS<br />

Macaranga gigantea, 31<br />

Melastoma malabathricum, 33<br />

Melastoma sanguineum, 69<br />

Melodorum fruticosum, 71<br />

Millettia extensa, 213<br />

Mimosa pudica, 252<br />

Mitragyna speciosa, 177<br />

Momordica charantia, 180<br />

Morinda citrifolia, 99, 133<br />

Moringa oleifera, 254<br />

Nervilia fordii, 215<br />

Ocimum bacilicum, 185<br />

Orthosiphon aristatus, 35, 101<br />

Passiflora foetida, 135<br />

Phyllanthus amarus, 190<br />

Phyllanthus emblica, 73<br />

Piper betle, 217<br />

Plumeria alba, 75<br />

Polygonum multiflorum, 137<br />

Portulaca oleracea, 37<br />

Premna odorata, 257<br />

Rafflesia hasseltii, 194<br />

Rauvolfia serpentina, 139, 219<br />

Sauropus <strong>and</strong>rogynus, 103<br />

Schefflera octophylla, 329<br />

Smilax myosotiflora, 196<br />

Solanum procumbens, 141<br />

Solanum violaceum, 299<br />

Stemona tuberosa, 198<br />

Stephania rotunda, 143<br />

Streblus asper, 259<br />

Syzygium jambos, 77<br />

Terminalia chebula, 79<br />

Terminalia triptera, 81<br />

Tinospora crispa, 261<br />

Vitex negundo, 221, 263<br />

Vitis repens, 223<br />

Zingiber aromaticum, 39<br />

Zingiber officinale, 200<br />

336

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